Cathy S Cutler

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177Lu
    Huma Mohsin
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 17:485-92. 2006
  2. doi Nanoparticles and phage display selected peptides for imaging and therapy of cancer
    Cathy S Cutler
    Research Reactor Center, University of Missouri, Columbia, MO 65211 3400, USA
    Recent Results Cancer Res 194:133-47. 2013
  3. ncbi Current and potential therapeutic uses of lanthanide radioisotopes
    C S Cutler
    University of Missouri Research Reactor, Research Park Drive, Columbia, MO 65211, USA
    Cancer Biother Radiopharm 15:531-45. 2000
  4. ncbi Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3
    Huma Mohsin
    Chemistry Department, University of Missouri, Columbia, MO 65211, USA
    Nucl Med Biol 34:493-502. 2007
  5. ncbi Biological comparison of 149Pm-, 166Ho-, and 177Lu-DOTA-biotin pretargeted by CC49 scFv-streptavidin fusion protein in xenograft-bearing nude mice
    Michael R Lewis
    Department of Veterinary Medicine and Surgery, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 31:213-23. 2004
  6. ncbi Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm
    Wen Ping Li
    Department of Chemistry, University of Missouri, Columbia, MO, USA
    Nucl Med Biol 30:241-51. 2003
  7. doi Dithiol Aryl Arsenic Compounds as Potential Diagnostic and Therapeutic Radiopharmaceuticals
    Anthony J Degraffenreid
    Department of Chemistry and Research Reactor Center MURR, University of Missouri, Columbia, Missouri 65211, United States
    Inorg Chem 55:8091-8. 2016
  8. pmc Chromatographic separation of germanium and arsenic for the production of high purity (77)As
    Matthew D Gott
    Department of Chemistry, University of Missouri, Columbia, MO 65211, United States
    J Chromatogr A 1441:68-74. 2016
  9. doi Comparison of pretargeted and conventional CC49 radioimmunotherapy using 149Pm, 166Ho, and 177Lu
    Huma Mohsin
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri, United States
    Bioconjug Chem 22:2444-52. 2011
  10. pmc Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals
    Anthony J Degraffenreid
    Department of Chemistry, University of Missouri, Columbia, MO 65211, USA
    Nucl Med Biol 43:288-95. 2016

Research Grants

Collaborators

  • Michael R Lewis
  • Raghuraman Kannan
  • Evan Boote
  • Jaime Simon
  • Nripen Chanda
  • John R Lever
  • D Scott Wilbur
  • Carolyn J Henry
  • Mark McLaughlin
  • S S Jurisson
  • Jeffrey N Bryan
  • Thomas P Quinn
  • William H Miller
  • Susan Z Lever
  • E Deutsch
  • D B Axworthy
  • Alan R Ketring
  • Anthony J Degraffenreid
  • Matthew D Gott
  • Donald E Wycoff
  • Huma Mohsin
  • Yutian Feng
  • Timothy J Hoffman
  • R Keith Frank
  • Charles L Barnes
  • Michael D Phipps
  • Mary F Embree
  • Michael E Fassbender
  • Sandra M Axiak-Bechtel
  • Kattesh V Katti
  • Anandhi Upendran
  • Ravi Shukla
  • Lisa D Watkinson
  • Terry L Carmack
  • Melchor V Cantorias
  • Geethapriya Sivaguru
  • Fang Jia
  • Phillip S Athey
  • Ethan R Balkin
  • Peter J Pauzauskie
  • Ryan Morrow
  • Connor R Hayes
  • Bennett E Smith
  • Wen Ping Li
  • Jimmy C Lattimer
  • James Kelsey
  • Deborah J Tate
  • Margaret E Bryan
  • Fang Hu
  • Beau Ballard
  • Nebiat Sisay
  • Ryan P Morrow
  • Kim A Selting
  • Charles Caldwell
  • Jatin Vimal
  • Satish Kumar Nune
  • J David Robertson
  • Ajit Zambre
  • Rajesh R Kulkarni
  • Stan W Casteel
  • Hendrik Engelbrecht
  • Charles Jeffrey Smith
  • Kavita Katti
  • Para Kan
  • Louis J Theodore
  • Said D Figueroa
  • Tiffani Shelton
  • Garry E Kiefer
  • Jonathan Fitzsimmons
  • Gyongyi Gulyas
  • Tiffani D Shelton
  • Michael J Hudson
  • C Jeff Smith
  • Timothy Hoffman
  • Wynn A Volkert
  • Gary Sieckman

Detail Information

Publications16

  1. ncbi Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177Lu
    Huma Mohsin
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 17:485-92. 2006
    ..When labeled with 149Pm, 166Ho, and 177Lu, MeO-DOTA-CC49 has potential for RIT of colorectal cancer and other carcinomas...
  2. doi Nanoparticles and phage display selected peptides for imaging and therapy of cancer
    Cathy S Cutler
    Research Reactor Center, University of Missouri, Columbia, MO 65211 3400, USA
    Recent Results Cancer Res 194:133-47. 2013
    ..Herein we highlight some initial efforts in combining the enhanced selectivity of nanoparticles and peptides with (68)Ga for use as molecular imaging probes...
  3. ncbi Current and potential therapeutic uses of lanthanide radioisotopes
    C S Cutler
    University of Missouri Research Reactor, Research Park Drive, Columbia, MO 65211, USA
    Cancer Biother Radiopharm 15:531-45. 2000
    ....
  4. ncbi Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3
    Huma Mohsin
    Chemistry Department, University of Missouri, Columbia, MO 65211, USA
    Nucl Med Biol 34:493-502. 2007
    ..All evaluations should be extended to time points relevant to the half-life of the radiometal and the therapy applications...
  5. ncbi Biological comparison of 149Pm-, 166Ho-, and 177Lu-DOTA-biotin pretargeted by CC49 scFv-streptavidin fusion protein in xenograft-bearing nude mice
    Michael R Lewis
    Department of Veterinary Medicine and Surgery, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 31:213-23. 2004
    ..2% ID/g), and (177)Lu (35.4% ID/g) peaked at 1-4 h. Rapid blood disappearance was accompanied by urinary excretion of 59-66% ID within 1 h. Biodistributions of these agents show promise for pretargeted radioimmunotherapy of cancer...
  6. ncbi Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm
    Wen Ping Li
    Department of Chemistry, University of Missouri, Columbia, MO, USA
    Nucl Med Biol 30:241-51. 2003
    ..The biodistribution studies of the NCA complexes with DTPA, DOTA and DTPA-OCT showed that the in vitro model correctly predicted the in vivo stability of the radiolanthanide complexes, with Ln-DOTA > Ln-DTPA > Ln-DTPA-OCT...
  7. doi Dithiol Aryl Arsenic Compounds as Potential Diagnostic and Therapeutic Radiopharmaceuticals
    Anthony J Degraffenreid
    Department of Chemistry and Research Reactor Center MURR, University of Missouri, Columbia, Missouri 65211, United States
    Inorg Chem 55:8091-8. 2016
    ..Various modifications and optimizations resulted in 95% radiochemical yield of nca [(77)As]p-ethoxyphenyl-1,2-ethanedithiolatoarsine. ..
  8. pmc Chromatographic separation of germanium and arsenic for the production of high purity (77)As
    Matthew D Gott
    Department of Chemistry, University of Missouri, Columbia, MO 65211, United States
    J Chromatogr A 1441:68-74. 2016
    ..Subsequently, enriched (76)Ge (98±2) was recovered for reuse by elution with aqueous solution (neutral to basic). Greater than 98% radiolabeling yield of a (77)As-trithiol was observed from methanol separated [(77)As]arsenate [17]. ..
  9. doi Comparison of pretargeted and conventional CC49 radioimmunotherapy using 149Pm, 166Ho, and 177Lu
    Huma Mohsin
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri, United States
    Bioconjug Chem 22:2444-52. 2011
    ..Our results identified (177)Lu as an optimal radiolanthanide for future evaluation of these agents in toxicity and multiple-dose therapy studies...
  10. pmc Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals
    Anthony J Degraffenreid
    Department of Chemistry, University of Missouri, Columbia, MO 65211, USA
    Nucl Med Biol 43:288-95. 2016
    ..Potential radiopharmaceuticals based on radioarsenic require development of suitable bifunctional chelates for stable conjugation of arsenic to vectors under in vivo conditions at high dilution...
  11. doi Development of high-specific-activity (68)Ga-labeled DOTA-rhenium-cyclized alpha-MSH peptide analog to target MC1 receptors overexpressed by melanoma tumors
    Melchor V Cantorias
    University of Missouri Research Reactor Center, Columbia, 65211, USA
    Nucl Med Biol 36:505-13. 2009
    ....
  12. doi Accelerator-based production of the (99m)Tc-(186)Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)
    Matthew D Gott
    Department of Chemistry, University of Missouri, Columbia, MO 65211, United States
    Appl Radiat Isot 114:159-66. 2016
    ..The targets dissolved under mild conditions and were analyzed by γ-spectroscopy. Production rates and potential applications are discussed, including target recovery and recycling schemes for OsS2 and WS2. ..
  13. pmc Chromatographic separation of selenium and arsenic: A potential (72)Se/(72)As generator
    Donald E Wycoff
    Department of Chemistry, University of Missouri, Columbia, MO 65211, United States
    J Chromatogr A 1340:109-14. 2014
    ..At pH 1.5, selenate is retained on strongly basic anion exchange resin as HSeO4(-) and SeO4(2-), while neutral arsenic acid, H3AsO4, is eluted. ..
  14. pmc Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer
    Ravi Shukla
    Department of Radiology, Harry S Truman Veterans Administration Medical Center, and Missouri University Research Reactor, University of Missouri, Columbia, MO 65212, USA
    Proc Natl Acad Sci U S A 109:12426-31. 2012
    ..This novel intratumorally injectable (198)AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors...
  15. ncbi Pm-149 DOTA bombesin analogs for potential radiotherapy. in vivo comparison with Sm-153 and Lu-177 labeled DO3A-amide-betaAla-BBN(7-14)NH(2)
    Fang Hu
    Department of Chemistry, University of Missouri, Columbia, MO 65211, USA
    Nucl Med Biol 29:423-30. 2002
    ..The biological properties of the 149Pm, 153Sm and 177Lu-DO3A-amide-betaAla-BBN complexes were compared in normal mouse biodistribution studies...
  16. pmc Gum arabic-coated radioactive gold nanoparticles cause no short-term local or systemic toxicity in the clinically relevant canine model of prostate cancer
    Sandra M Axiak-Bechtel
    Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA
    Int J Nanomedicine 9:5001-11. 2014
    ..Our objective was to determine the short-term safety profile of GA-(198)AuNPs injected intralesionally. We proposed that a single treatment of GA-(198)AuNPs would be safe with minimal-to-no evidence of systemic or local toxicity...

Research Grants1

  1. Production of High Specific Activity Lutetium-177
    Cathy Cutler; Fiscal Year: 2005
    ..If impurities are present, develop methods to prevent their introduction or to remove them from the final product. Perform radiolabelling of the Lu-177 produced to molecules of interest in therapeutic applications. ..