Affiliation: University of Arizona
- Randomized, double-blind, placebo-controlled trial of sulindac in individuals at risk for melanoma: evaluation of potential chemopreventive activityClara Curiel-Lewandrowski
College of Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
Cancer 118:5848-56. 2012..However, the ability of NSAIDs to reach melanocytes in vivo and modulate key biomarkers in preneoplastic lesions such as atypical nevi has not been evaluated...
- Screening and prevention measures for melanoma: is there a survival advantage?Clara Curiel-Lewandrowski
The University of Arizona Cancer Center, 1515 N Campbell Ave, Box 245024, Tucson, AZ, 85724, USA
Curr Oncol Rep 14:458-67. 2012....
- Long-term use of nonsteroidal anti-inflammatory drugs decreases the risk of cutaneous melanoma: results of a United States case-control studyClara Curiel-Lewandrowski
Department of Dermatology, BIDMC, Harvard Medical School, Boston, Massachusetts, USA
J Invest Dermatol 131:1460-8. 2011..Clinical intervention studies are warranted to further investigate the potential role of ASA and other NSAIDs as chemopreventive agents for CM...
- Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progressionJanine G Einspahr
Department of Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
Cancer 110:2519-27. 2007..Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers...
- Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinomaJanine G Einspahr
University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
Cancer Prev Res (Phila) 5:403-13. 2012..Pathway activation mapping of SCC compared with AK revealed several interconnected networks that could be targeted with drug therapy for potential chemoprevention and therapeutic applications...
- A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancerSteven P Stratton
Department of Medicine, University of Arizona, Tucson, 85724, USA
Cancer Prev Res (Phila) 3:160-9. 2010..These results suggest that whereas our karyometric analyses can detect a modest effect of POH in sun-damaged skin, improved delivery into the epidermis may be necessary...
- Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinomaAleksandar Sekulic
Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
Cancer Prev Res (Phila) 3:1277-83. 2010..The observed frequency and pattern of loss indicate that INPP5A, a negative regulator of inositol signaling, may play a role in development and progression of cutaneous SCC tumors...
- Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphomaClara Curiel-Lewandrowski
Department of Dermatology, Cutaneous Oncology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 121:4838-49. 2011..Thus, our data indicate that advanced CTCL cell growth is facilitated, at least in part, by mutations in the scaffold protein pro-IL-16, which directly regulates Skp2 synthesis...
- Pilot study on the bioactivity of vitamin d in the skin after oral supplementationClara Curiel-Lewandrowski
University of Arizona Cancer Center, University of Arizona, Tucson, Arizona
Cancer Prev Res (Phila) 8:563-9. 2015..Our findings of significant variability in the range of VDR and CYP24 expression across study samples represent an important consideration in studies evaluating the role of VD as a skin cancer chemopreventive agent...
- Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human SkinYira Bermudez
College of Medicine, University of Arizona, Tucson, Arizona The University of Arizona Cancer Center, Tucson, Arizona
Cancer Prev Res (Phila) 8:720-8. 2015..Understanding the timing of key protein expression changes in response to SSL will aid in development of mechanistic-based approaches for the prevention and control of skin cancers...
- Use of in vivo confocal microscopy in malignant melanoma: an aid in diagnosis and assessment of surgical and nonsurgical therapeutic approachesClara Curiel-Lewandrowski
Department of Dermatology, The Cutaneous Oncology Program, and the Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Arch Dermatol 140:1127-32. 2004..Repeated surgical reexcisions are frequently required to achieve tumor-free margins. The use of reflectance mode confocal microscopy as an noninvasive method has shown to be a promising tool for diagnosing pigmented lesions in vivo...
- A systematic review of advanced practice nurses' skin cancer assessment barriers, skin lesion recognition skills, and skin cancer training activitiesLois J Loescher
The University of Arizona, Tucson, 85721 0203, USA
J Am Acad Nurse Pract 23:667-73. 2011..This systematic review of published literature seeks to describe (a) barriers to APNs' performance of skin examination, (b) APNs' ability to recognize suspicious skin lesions, and (c) APNs' skin cancer detection training activities...
- Melanoma high-risk families' perceived health care provider risk communicationLois J Loescher
University of Arizona College of Nursing Tucson, AZ, USA
J Cancer Educ 24:301-7. 2009..Families with a melanoma history are at risk of melanoma. Melanoma survival improves when people are aware of their risk and ways to modify it. We explored at-risk families' perceived risk communication from healthcare providers...
- Utilization and rationale for the implementation of total body (digital) photography as an adjunct screening measure for melanomaZakiya P Rice
Department of Dermatology, School of Medicine, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
Melanoma Res 20:417-21. 2010..At this point with a documented growing trend in utilization of TBP, more studies are needed to evaluate the efficacy of this screening adjunct to diagnose melanoma early and positively impact survival because of early diagnosis...
- Addressing the knowledge gap in clinical recommendations for management and complete excision of clinically atypical nevi/dysplastic nevi: Pigmented Lesion Subcommittee consensus statementCaroline C Kim
Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts
JAMA Dermatol 151:212-8. 2015....
- Advances in skin cancer early detection and diagnosisLois J Loescher
The University of Arizona College of Nursing and Mel and Enid Zuckerman College of Public Health, PO Box 210203, Tucson, AZ 85721 0203, USA
Semin Oncol Nurs 29:170-81. 2013..To provide an overview of 1) traditional methods of skin cancer early detection, 2) current technologies for skin cancer detection, and 3) evolving practice models of early detection...
- Cross-validation of murine UV signal transduction pathways in human skinJanine G Einspahr
Department of Medicine, University of Arizona, Tucson, AZ, USA
Photochem Photobiol 84:463-76. 2008..Validation of murine models in human skin will aid in development of effective skin cancer chemoprevention and prevention strategies...
- Interleukin-16 as a marker of Sézary syndrome onset and stageJillian Richmond
Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
J Clin Immunol 31:39-50. 2011..It is characterized by skin infiltration of malignant T cells. We examined interleukin-16, a potent T cell chemoattractant and cell-cycle regulator, as a prospective marker of disease onset and stage...
- Understanding visual search patterns of dermatologists assessing pigmented skin lesions before and after online trainingElizabeth A Krupinski
Department of Medical Imaging, University of Arizona Tucson, 1609 N Warren Bldg 211 Rm 112, Tucson, AZ, 85724, USA
J Digit Imaging 27:779-85. 2014..These differences in visual search may have implications for developing tools to teach dermatologists and residents about how to better utilize dermoscopy in clinical practice. ..
- Primary cutaneous melanomas seen as inflamed pigmented lesions in patients undergoing adjuvant interferon treatment: a possible diagnostic clue for physiciansStephanie Hu
Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Dermatol 145:565-8. 2009..Therefore, dermatologists play an important role in detecting multiple primary melanomas and may be required to attempt to identify the primary melanoma in patients with metastatic disease...
- Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindredFrederick P Li
Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 23:2735-43. 2005..A tumor from the proband was analyzed to compare features with sporadic GISTs...
- Inhibition of the elicitation phase of contact hypersensitivity by thymidine dinucleotides is in part mediated by increased expression of interleukin-10 in human keratinocytesClara Curiel-Lewandrowski
Department of Dermatology, Boston University School of Medicine, Boston, MA 02118 2394, USA
Exp Dermatol 12:145-52. 2003..Finally, regardless of mechanism, the data suggest that topical treatment with pTpT may provide a novel means of suppressing contact hypersensitivity or other lymphocyte-mediated reactions in skin...