W C Culp

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi Gas embolisms revisited
    William C Culp
    Anesthesiology 107:850-1; author reply 853-4. 2007
  2. doi Ultrasound enhanced thrombolysis in acute arterial ischemia
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Suite 226, RWUHM, 1719 6th Avenue South, Birmingham, AL 35294, USA
    Ultrasonics 48:303-11. 2008
  3. doi Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model
    W C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA
    Mol Neurobiol 52:979-84. 2015
  4. pmc Pain and efficacy of local anesthetics for central venous access
    William C Culp
    Division of Cardiothoracic Anesthesiology, Scott and White Hospital, The Texas A and M University College of Medicine, Temple, TX, USA
    Local Reg Anesth 1:11-5. 2008
  5. pmc Decreased Serum Levels of S-100B Protein Reflect Successful Treatment Effects in a Rabbit Model of Acute Ischemic Stroke
    Sean D Woods
    Departments of Radiology, at the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Open Neurol J 5:55-7. 2011
  6. pmc Progress in dodecafluoropentane emulsion as a neuroprotective agent in a rabbit stroke model
    S D Woods
    Department of Radiology, University of Arkansas for Medical Sciences UAMS, Little Rock, AR, 72205, USA
    Mol Neurobiol 48:363-7. 2013
  7. pmc Three variations in rabbit angiographic stroke models
    William C Culp
    Department of Radiology, 4301 West Markham Street, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    J Neurosci Methods 212:322-8. 2013
  8. pmc Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 556, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 23:116-21. 2012
  9. ncbi Selective intracranial magnification angiography of the rabbit: basic techniques and anatomy
    Benjamin C Culp
    College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 18:187-92. 2007
  10. pmc Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Stroke 42:2280-5. 2011

Collaborators

Detail Information

Publications35

  1. ncbi Gas embolisms revisited
    William C Culp
    Anesthesiology 107:850-1; author reply 853-4. 2007
  2. doi Ultrasound enhanced thrombolysis in acute arterial ischemia
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Suite 226, RWUHM, 1719 6th Avenue South, Birmingham, AL 35294, USA
    Ultrasonics 48:303-11. 2008
    ..Multi-national dose escalation studies of microspheres and the development of an operator independent ultrasound device are underway...
  3. doi Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model
    W C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA
    Mol Neurobiol 52:979-84. 2015
    ..0078. With delayed reperfusion, DDFPe + tPA was more effective than tPA alone in preserving functioning brain after stroke. DDFPe significantly extends the time window for tPA therapy...
  4. pmc Pain and efficacy of local anesthetics for central venous access
    William C Culp
    Division of Cardiothoracic Anesthesiology, Scott and White Hospital, The Texas A and M University College of Medicine, Temple, TX, USA
    Local Reg Anesth 1:11-5. 2008
    ..To compare pain during injection and efficacy of analgesia of local anesthetics during central venous line placement...
  5. pmc Decreased Serum Levels of S-100B Protein Reflect Successful Treatment Effects in a Rabbit Model of Acute Ischemic Stroke
    Sean D Woods
    Departments of Radiology, at the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Open Neurol J 5:55-7. 2011
    ..95% for rabbits treated with tPA (P=0.32 vs. control), and 0.79%±0.99% for rabbits treated with MB+US (P=0.04 vs. control). Twenty-four hour concentrations of S-100B were positively correlated with infarct volume (r=0.59, P=0.0004)...
  6. pmc Progress in dodecafluoropentane emulsion as a neuroprotective agent in a rabbit stroke model
    S D Woods
    Department of Radiology, University of Arkansas for Medical Sciences UAMS, Little Rock, AR, 72205, USA
    Mol Neurobiol 48:363-7. 2013
    ..Blood half-life values are very short. The much longer therapeutic effect, >90 min, suggests multiple compartments. Lowest effective dose and maximum effective therapy duration are not yet defined. Rapid development is warranted...
  7. pmc Three variations in rabbit angiographic stroke models
    William C Culp
    Department of Radiology, 4301 West Markham Street, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    J Neurosci Methods 212:322-8. 2013
    ..To develop angiographic models of embolic stroke in the rabbit using pre-formed clot or microspheres to model clinical situations ranging from transient ischemic events to severe ischemic stroke...
  8. pmc Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 556, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 23:116-21. 2012
    ..To assess the efficacy of dodecafluoropentane emulsion (DDFPe), a nanodroplet emulsion with significant oxygen transport potential, in decreasing infarct volume in an insoluble-emboli rabbit stroke model...
  9. ncbi Selective intracranial magnification angiography of the rabbit: basic techniques and anatomy
    Benjamin C Culp
    College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 18:187-92. 2007
    ..The authors present an overview of current techniques and illustrations of the angiography of cerebral vessels...
  10. pmc Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Stroke 42:2280-5. 2011
    ..Microbubbles (MB) combined with ultrasound (US) have been shown to lyse clots without tissue-type plasminogen activator (tPA) both in vitro and in vivo. We evaluated sonothrombolysis with 3 types of MB using a rabbit embolic stroke model...
  11. ncbi Paravertebral block: an improved method of pain control in percutaneous transhepatic biliary drainage
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cardiovasc Intervent Radiol 29:1015-21. 2006
    ..We present a feasibility study of thoracic paravertebral blocks in an effort to reduce pain during and following the procedure and reduce requirements for intravenous sedation...
  12. ncbi Thoracic paravertebral block for percutaneous transhepatic biliary drainage
    William C Culp
    Department of Anesthesiology, Scott and White Clinic and Memorial Hospital, Texas A and M University Health Science Center College of Medicine, Temple, Texas, USA
    J Vasc Interv Radiol 16:1397-400. 2005
    ..Herein a case is described in which thoracic paravertebral blockade dramatically reduced standard intra- and postprocedural analgesic needs and provided superior pain control...
  13. ncbi Intracranial clot lysis with intravenous microbubbles and transcranial ultrasound in swine
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 556, Little Rock, AR 72205 7199, USA
    Stroke 35:2407-11. 2004
    ..We hypothesized that intravenous platelet-targeted microbubbles with LFUS may be a rapid noninvasive technique to recanalize thrombosed intracerebral vessels...
  14. ncbi Nuts and bolts count, too!
    William Culp
    Department of Radiology, UAMS, Little Rock, AR 72205 7199, USA
    Cardiovasc Intervent Radiol 27:165. 2004
  15. ncbi Microbubble potentiated ultrasound as a method of stroke therapy in a pig model: preliminary findings
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, Slot 556, 4301 W Markham St, Little Rock, Arkansas 72205 7199, USA
    J Vasc Interv Radiol 14:1433-6. 2003
    ..Low-frequency ultrasound (LFUS) with intraarterial or intravenous microbubbles can recanalize thrombosed dialysis grafts and arteries. A similar method for declotting intracranial arteries in an animal model has been developed...
  16. ncbi Detection of room air contamination of angiographic CO2 with use of a gas analyzer
    William C Culp
    Department of Anesthesia, University of Texas Medical Branch, Galveston, Texas, USA
    J Vasc Interv Radiol 13:735-7. 2002
    ..Measured CO2 values were unreliable with higher-than-true values at all levels except 100%. All clinically important amounts of N2 and O2 contamination were readily detected by this practical method...
  17. ncbi Carbon dioxide in the aortic arch: coronary effects and implications in a swine study
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Slot 556, Little Rock, AR 72205 7199, USA
    Cardiovasc Intervent Radiol 26:128-35. 2003
    ..CO2 angiography is considered dangerous in the aortic arch where bubbles may cause critical cerebral and cardiac ischemia. We investigated CO2 distribution, physiologic effects in the heart, methods of detection and treatments...
  18. ncbi Microbubble-augmented ultrasound declotting of thrombosed arteriovenous dialysis grafts in dogs
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 556, Little Rock, Arkansas 72205 7199, USA
    J Vasc Interv Radiol 14:343-7. 2003
    ....
  19. pmc Successful intravascular ultrasound thrombolysis of dural sinus thrombosis with pre-existing subarachnoid and intraparenchymal hemorrhages
    M E Atherton
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Interv Neuroradiol 16:455-8. 2010
    ..Flow was quickly restored. Our patient recovered from coma to discharge home without worsening of existing hemorrhages...
  20. ncbi Mesenteric vein thrombosis treated successfully with ultrasound augmented thrombolysis
    A Agarwal
    Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Acta Gastroenterol Belg 75:55-7. 2012
    ..Ultrasound can improve efficiency of thrombolysis, decreasing the time required for thrombolysis by half, decrease thrombolytic dose and monitoring time and thus reduce overall costs and complications seen with long thrombolysis times...
  21. ncbi Hemodialysis access success: beyond the operating room
    Gary W Barone
    Surgery Service, Central Arkansas Veterans Healthcare System, John L McClellan Memorial Veterans Hospital, Little Rock, AR 72205, USA
    Am J Surg 194:668-71. 2007
    ..Meeting these KDOQI goals has been the responsibility of individual VHA centers. We responded by organizing a dedicated HD AV clinic to provide preoperative evaluation and postoperative follow-up...
  22. ncbi Complication rate of venous access procedures performed by a radiology practitioner assistant compared with interventional radiology physicians and supervised trainees
    Joseph R Benham
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
    J Vasc Interv Radiol 18:1001-4. 2007
    ..To compare venous access complication rates associated with procedures performed by radiology practitioner assistants (RPAs) versus interventional radiology (IR) faculty members, IR fellows, and radiology residents...
  23. ncbi Insulin, diabetes, and recurrent stenosis: not so sweet
    Timothy C McCowan
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 556, Little Rock, Arkansas 72205, USA
    J Vasc Interv Radiol 16:9-11. 2005
  24. ncbi Aortic prosthetic graft infections: radiologic manifestations and implications for management
    D F Orton
    Department of Radiology, Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Radiographics 20:977-93. 2000
    ..White blood cell scanning is an important complementary test to CT in ambiguous cases, such as in the early postoperative period, and may be more sensitive in detection of early graft infection...
  25. ncbi Thoracic paravertebral block for analgesia following liver mass radiofrequency ablation
    W C Culp
    Department of Anaesthesiology, Texas A and M University System Health Science Centre College of Medicine, Scott and White Hospital, 2401 South 31st Street, Temple, TX 76508, USA
    Br J Radiol 81:e23-5. 2008
    ..Thoracic paravertebral block can provide complete and lasting analgesia following hepatic radiofrequency ablation, and warrants further study for patients undergoing hepatic radiological interventions...
  26. ncbi Popliteal artery disease: diagnosis and treatment
    Lonnie B Wright
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 556, Little Rock, AR 72205, USA
    Radiographics 24:467-79. 2004
    ..Consequently, the radiologist should be familiar with these conditions to direct imaging for accurate diagnosis and treatment and to prevent loss of limb...
  27. ncbi Validation and feasibility of intraoperative three-dimensional transesophageal echocardiographic cardiac output
    William C Culp
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Scott and White Hospital, The Texas A and M University System Health Science Center College of Medicine, Temple, TX 76508, USA
    Anesth Analg 105:1219-23, table of contents. 2007
    ..In this pilot study, we attempted to validate three-dimensional transesophageal echocardiography (3DTEE) cardiac output and assess its feasibility intraoperatively...
  28. ncbi Caval perforation with bronchial communication: a rare complication of long-term venous access
    Larry A Johnson
    Associated Radiologists, Ltd, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 556, Little Rock, AK 72205 7199, USA
    J Vasc Interv Radiol 16:1149-52. 2005
    ..A unique combination of percutaneous techniques was helpful in managing this complication, and surgery was avoided...
  29. ncbi Pericardial tamponade following CT-guided lung biopsy
    Michael J Mitchell
    Department of Anesthesiology, The Texas A and M University System Health Science Center College of Medicine, Scott and White Hospital, 2401 South 31st Street, Temple, TX 76508, USA
    Cardiovasc Intervent Radiol 31:S227-30. 2008
    ..Rapid diagnosis and therapy allowed for complete patient recovery. Physicians who perform this procedure should be aware of the known complications and be prepared to treat them appropriately...
  30. pmc Stroke location and brain function in an embolic rabbit stroke model
    Aliza T Brown
    Department of Radiology, University of Arkansas for Medical Sciences, M1 269, 4301 West Markham Street, Mail Slot 556, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 21:903-9. 2010
    ..In a further refinement of an angiographic embolic stroke model, localized infarctions were correlated to neurologic deficits with the goal to create a rabbit model for long-term studies of therapies after stroke...
  31. ncbi Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis
    Feng Xie
    Internal Medicine Cardiology Department, University of Nebraska Medical Center, Omaha, NE 68196 1165, USA
    Ultrasound Med Biol 31:979-85. 2005
    ..US and microbubbles are capable of recanalizing acute arteriovenous graft thromboses. Higher intensities may be needed in the presence of tissue attenuation...
  32. ncbi Preoperative inspiratory muscle training and postoperative complications
    William C Culp
    JAMA 297:697-8; author reply 698-9. 2007
  33. doi Rabbit subselective angiography stroke model
    Benjamin C Culp
    Stroke 39:e165; author reply e166. 2008
  34. doi Incomplete modeling of the thromboembolectomy technique
    Muhammad Yousaf
    Stroke 39:e127; author reply e128. 2008

Research Grants1

  1. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..