Timothy T Cornell

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, F 6882, 1500 East Medical Center Dr, Ann Arbor, MI 48109 0243, USA
    J Thorac Cardiovasc Surg 143:1160-1166.e1. 2012
  2. pmc Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Dept of Pediatrics and Communicable Diseases, Univ of Michigan Medical School, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 303:L251-8. 2012
  3. pmc Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 296:L849-56. 2009
  4. pmc Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, and CS Mott Children s Hospital, Ann Arbor, Michigan 48109 0243, USA
    Infect Immun 78:2868-76. 2010
  5. pmc Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 40:2694-9. 2012
  6. pmc Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Healthc Mater 2:965-75. 2013
  7. pmc Multiplexed Nanoplasmonic Temporal Profiling of T-Cell Response under Immunomodulatory Agent Exposure
    Bo Ram Oh
    Department of Mechanical Engineering, Department of Pediatrics and Communicable Diseases, Department of Biomedical Engineering, Department of Cell and Developmental Biology, Michigan Center for Integrative Research in Critical Care, and Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Sens 1:941-948. 2016
  8. pmc Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge
    Lei Sun
    Division of Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109
    J Immunol . 2016
  9. doi request reprint Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Intensive Care Med 40:1481-8. 2014
  10. pmc Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury
    Walker M McHugh
    Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, and C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan
    Am J Physiol Lung Cell Mol Physiol 311:L903-L912. 2016

Collaborators

Detail Information

Publications17

  1. pmc Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, F 6882, 1500 East Medical Center Dr, Ann Arbor, MI 48109 0243, USA
    J Thorac Cardiovasc Surg 143:1160-1166.e1. 2012
    ..We assessed the impact of CPB on histone methylation as a potential mechanism for altering gene expression necessary for the immune system's capacity to defend against infections...
  2. pmc Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Dept of Pediatrics and Communicable Diseases, Univ of Michigan Medical School, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 303:L251-8. 2012
    ..These data suggest that altering MKP-2 activity may have therapeutic potential to reduce lung inflammation in ALI without impacting pathogen clearance...
  3. pmc Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 296:L849-56. 2009
    ..In summary, our data suggest that in respiratory epithelium, TNFalpha induces ceramide accumulation, resulting in subsequent activation of PP2A, which targets those kinases responsible for transcriptional activation of IL-8...
  4. pmc Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, and CS Mott Children s Hospital, Ann Arbor, Michigan 48109 0243, USA
    Infect Immun 78:2868-76. 2010
    ..These data support a mechanism by which MKP-2 targets ERK deactivation, thereby decreasing MKP-1 and thus removing the negative inhibition of MKP-1 on cytokine production...
  5. pmc Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 40:2694-9. 2012
    ....
  6. pmc Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Healthc Mater 2:965-75. 2013
    ....
  7. pmc Multiplexed Nanoplasmonic Temporal Profiling of T-Cell Response under Immunomodulatory Agent Exposure
    Bo Ram Oh
    Department of Mechanical Engineering, Department of Pediatrics and Communicable Diseases, Department of Biomedical Engineering, Department of Cell and Developmental Biology, Michigan Center for Integrative Research in Critical Care, and Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Sens 1:941-948. 2016
    ..The capability to monitor cellular functional response demonstrated in this study has great potential to ultimately permit personalized immunomodulatory treatment...
  8. pmc Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge
    Lei Sun
    Division of Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109
    J Immunol . 2016
    ..Thus, we demonstrate that PP2A plays an important role in regulating inflammation and survival in the setting of septic insult by targeting MyD88- and Toll/IL-1R domain-containing adaptor inducing IFN-β-dependent pathways...
  9. doi request reprint Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Intensive Care Med 40:1481-8. 2014
    ....
  10. pmc Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury
    Walker M McHugh
    Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, and C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan
    Am J Physiol Lung Cell Mol Physiol 311:L903-L912. 2016
    ..Pharmacologic PP2A activation both limited and prevented inflammation and tissue injury in two direct injury models of ARDS. These results suggest modulation of PP2A activity as a therapeutic target in ARDS...
  11. pmc Rapid, automated, parallel quantitative immunoassays using highly integrated microfluidics and AlphaLISA
    Zeta Tak For Yu
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Sci Rep 5:11339. 2015
    ..Together, the microfluidic immunoassay chip provides a promising high-throughput, high-content platform for rapid, automated, parallel quantitative immunosensing applications...
  12. pmc An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping
    Nien Tsu Huang
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Lab Chip 12:4093-101. 2012
    ....
  13. pmc Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Intensive Care Med 37:1166-73. 2011
    ..We hypothesized that a weight-based definition of FO at CRRT initiation would correlate with the fluid balance method and prove predictive of outcome...
  14. pmc Mechanisms and regulation of the gene-expression response to sepsis
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Pediatrics 125:1248-58. 2010
    ..We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies...
  15. pmc Management and Treatment Guidelines for Sepsis in Pediatric Patients
    Nidal El-Wiher
    Division of Critical Care Medicine, C S Mott Children s Hospital at the University of Michigan, Ann Arbor, MI
    Open Inflamm J 4:101-109. 2011
    ..Our overall goal is to provide the bedside clinician with an updated systematic approach to treat sepsis in children...
  16. pmc Challenges during repeat extracorporeal life support in a patient with pulmonary alveolar proteinosis
    Hemanth Lingadevaru
    Pediatric Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    ASAIO J 57:473-4. 2011
    ..Our case illustrates standard cannulation may not be possible for children requiring a second ECLS course and the importance of considering alternative modes of cannulation and ECLS support when conventional methods are not possible...
  17. ncbi request reprint Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit
    Matthew Mischler
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA
    Pediatrics 119:e1212-8. 2007
    ....