Kenneth Cooke

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation
    K R Cooke
    Departments of Internal Medicine and Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 165:6612-9. 2000
  2. ncbi request reprint Acute lung injury after allogeneic stem cell transplantation: is the lung a target of acute graft-versus-host disease?
    K R Cooke
    Division of Hematology Oncology, Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan Cancer Center, Ann Arbor, MI, USA
    Bone Marrow Transplant 34:753-65. 2004
  3. ncbi request reprint The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease
    Kenneth R Cooke
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation Program, University of Michigan Cancer Center, Ann Arbor 48109, USA
    J Endotoxin Res 8:441-8. 2002
  4. pmc LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation
    K R Cooke
    Departments of Internal Medicine and Pediatrics, Blood and Marrow Stem Cell Transplantation Program, University of Michigan, Ann Arbor, Michigan 48109 0942, USA
    J Clin Invest 107:1581-9. 2001
  5. pmc TNF-inhibition with etanercept for graft-versus-host disease prevention in high-risk HCT: lower TNFR1 levels correlate with better outcomes
    Sung W Choi
    Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Biol Blood Marrow Transplant 18:1525-32. 2012
  6. pmc CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 166:675-84. 2005
  7. ncbi request reprint Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation
    Charles I Ojielo
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    J Immunol 171:4416-24. 2003
  8. pmc Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival
    Sung W Choi
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Blood 112:1539-42. 2008
  9. pmc Opportunities and challenges of proteomics in pediatric patients: circulating biomarkers after hematopoietic stem cell transplantation as a successful example
    Sophie Paczesny
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Proteomics Clin Appl 8:837-50. 2014
  10. ncbi request reprint Stem cell transplantation in patients with severe congenital neutropenia with evidence of leukemic transformation
    S W Choi
    Division of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    Bone Marrow Transplant 35:473-7. 2005

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation
    K R Cooke
    Departments of Internal Medicine and Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 165:6612-9. 2000
    ....
  2. ncbi request reprint Acute lung injury after allogeneic stem cell transplantation: is the lung a target of acute graft-versus-host disease?
    K R Cooke
    Division of Hematology Oncology, Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan Cancer Center, Ann Arbor, MI, USA
    Bone Marrow Transplant 34:753-65. 2004
    ..This mini review will discuss the definition, risk factors and pathogeneses of noninfectious lung injury that occurs early after allogeneic SCT...
  3. ncbi request reprint The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease
    Kenneth R Cooke
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation Program, University of Michigan Cancer Center, Ann Arbor 48109, USA
    J Endotoxin Res 8:441-8. 2002
    ....
  4. pmc LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation
    K R Cooke
    Departments of Internal Medicine and Pediatrics, Blood and Marrow Stem Cell Transplantation Program, University of Michigan, Ann Arbor, Michigan 48109 0942, USA
    J Clin Invest 107:1581-9. 2001
    ....
  5. pmc TNF-inhibition with etanercept for graft-versus-host disease prevention in high-risk HCT: lower TNFR1 levels correlate with better outcomes
    Sung W Choi
    Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Biol Blood Marrow Transplant 18:1525-32. 2012
    ..These findings suggest that (1) the effectiveness of TNF-inhibition with etanercept may depend on the conditioning regimen, and (2) attenuating the expected rise in TNFR1 levels early posttransplantation correlates with good outcomes...
  6. pmc CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 166:675-84. 2005
    ..This is the first report describing expression of CCR2 on lung fibrocytes and demonstrating that CCR2 regulates both recruitment and activation of these cells after respiratory injury...
  7. ncbi request reprint Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation
    Charles I Ojielo
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    J Immunol 171:4416-24. 2003
    ..Thus, despite restoration of peripheral blood count, phagocytic defects in the AMs of BMT mice persist and may contribute to the increased risk of infection seen in the postengraftment period...
  8. pmc Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival
    Sung W Choi
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Blood 112:1539-42. 2008
    ..Measurement of TNFR1 levels early after transplantation provides independent information in advance of important clinical outcomes, such as GVHD and death...
  9. pmc Opportunities and challenges of proteomics in pediatric patients: circulating biomarkers after hematopoietic stem cell transplantation as a successful example
    Sophie Paczesny
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Proteomics Clin Appl 8:837-50. 2014
    ....
  10. ncbi request reprint Stem cell transplantation in patients with severe congenital neutropenia with evidence of leukemic transformation
    S W Choi
    Division of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    Bone Marrow Transplant 35:473-7. 2005
    ..For SCN patients who progress to AML, HSCT should still be considered, even though the risks appear to be greater...
  11. ncbi request reprint The use of laparoscopic liver biopsies in pediatric patients with hepatic dysfunction following allogeneic hematopoietic stem cell transplantation
    S W Choi
    Department of Pediatrics, Blood and Marrow Stem Cell Transplantation Program, University of Michigan, Ann Arbor, MI, USA
    Bone Marrow Transplant 36:891-6. 2005
    ..While the safety record at our institution appears promising, a larger multi-institutional study would be necessary to more accurately describe the overall efficacy of this procedure in pediatric HSCT patients...
  12. ncbi request reprint A role for CD54 (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome
    Armin Gerbitz
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Transplantation 79:536-42. 2005
    ..EC expression of the adhesion molecule CD54 (intercellular adhesion molecule [ICAM]-1) has been shown to be a major regulator of pulmonary inflammation in various experimental models...
  13. ncbi request reprint Pilot trial on the use of etanercept and methylprednisolone as primary treatment for acute graft-versus-host disease
    Joseph P Uberti
    Department of Internal Medicine, Blood and Marrow Stem Cell Transplantation Program, University of Michigan, Ann Arbor, USA
    Biol Blood Marrow Transplant 11:680-7. 2005
    ..In contrast, for 15 responding patients, soluble TNF receptor 1 plasma concentration levels returned to baseline. These data demonstrate the feasibility of using cytokine blockade in the early treatment of aGVHD...
  14. ncbi request reprint Acute lung injury after allogeneic stem cell transplantation: from the clinic, to the bench and back again
    Kenneth R Cooke
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation Program, University of Michigan Cancer Center, MI 48109 0942, USA
    Pediatr Transplant 9:25-36. 2005
    ..This review will outline the clinical spectrum, risk factors, and pathogeneses of IPS and discuss how current approaches to therapy are being influenced by insights generated using animal models of disease...
  15. ncbi request reprint The lung as a target organ of graft-versus-host disease
    Gregory Yanik
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation Program, University of Michigan Cancer Center, Ann Arbor, MI 48109 0942, USA
    Semin Hematol 43:42-52. 2006
    ..Insights generated using animal models suggest that the immunologic mechanisms contributing to lung inflammation after HSCT may be similar to those responsible for graft-versus-host disease (GVHD)...
  16. ncbi request reprint Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease
    Patricia Ewing
    Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany
    Exp Hematol 35:155-63. 2007
    ..Tumor necrosis factor alpha (TNFalpha) is an old foe in allogeneic bone marrow transplantation (allo-BMT) promoting acute graft-versus-host disease (aGVHD). We investigated to what extent donor T cells contribute to TNFalpha production...
  17. ncbi request reprint The absence of donor-derived IL-13 exacerbates the severity of acute graft-versus-host disease following allogeneic bone marrow transplantation
    Gerhard C Hildebrandt
    Department of Hematology and Oncology, University of Regensburg Medical School, D 93053 Regensburg, Germany
    Pediatr Blood Cancer 50:911-4. 2008
    ..Thus, donor-derived IL-13 may have a role in modulating inflammatory cytokine release that is associated with aGVHD...
  18. ncbi request reprint Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation
    Satoshi Yoshihara
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Biol Blood Marrow Transplant 13:749-59. 2007
    ....
  19. pmc CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
    Sung W Choi
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA
    Blood 110:3447-55. 2007
    ....
  20. pmc A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome
    Gerhard C Hildebrandt
    Department of Pediatrics, Division of Hematology and Oncology, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, Michigan, USA
    Biol Blood Marrow Transplant 14:385-96. 2008
    ....
  21. pmc The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
    Gregory A Yanik
    Department of Pediatrics, University of Michigan, Ann Arbor, USA
    Blood 112:3073-81. 2008
    ..The combination of etanercept and corticosteroids is safe and is associated with high response rates and improved survival in patients with IPS...
  22. ncbi request reprint Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation
    Gerhard C Hildebrandt
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA
    Blood 105:2249-57. 2005
    ....
  23. ncbi request reprint A role for tumor necrosis factor-alpha-mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome
    Armin Gerbitz
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Transplantation 78:494-502. 2004
    ..Both TNF-alpha and lipopolysaccharide are known contributors to endothelial injury. Although damage to vascular endothelia has been associated with other complications after BMT, its relationship to lung injury has not been explored...
  24. ncbi request reprint Etanercept (Enbrel) administration for idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
    Gregory Yanik
    Department of Pediatrics, University of Michigan Cancer Center and Mott Children s Hospital, Ann Arbor 48109 0942, USA
    Biol Blood Marrow Transplant 8:395-400. 2002
    ..These data suggest that etanercept may represent a safe, non-cross-reactive, therapeutic option for patients with IPS and that clinical trials studying etanercept for this indication are warranted...
  25. ncbi request reprint Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects
    Pavan Reddy
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, MI 48109 0942, USA
    Blood 101:2877-85. 2003
    ..01). Together these data illustrate that pretreatment of donors with IL-18 prior to allogeneic BMT attenuates acute GVHD in a STAT6-dependent mechanism while preserving GVL effects...
  26. ncbi request reprint Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease
    Takanori Teshima
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, 48109 0942, USA
    Blood 99:1825-32. 2002
    ..01). These data represent a novel strategy that alters host DCs and reduces acute GVHD...
  27. ncbi request reprint Repifermin (keratinocyte growth factor-2) reduces the severity of graft-versus-host disease while preserving a graft-versus-leukemia effect
    Shawn G Clouthier
    Biol Blood Marrow Transplant 9:592-603. 2003
    ..Collectively, these data suggest that repifermin administration may represent a novel strategy to separate the toxicity of GVHD from the beneficial GVL effects after allogeneic BMT...
  28. ncbi request reprint Role of CXCR3-induced donor T-cell migration in acute GVHD
    Ulrich Duffner
    Departments of Internal Medicine and Pediatrics, University of Michigan Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Exp Hematol 31:897-902. 2003
    ..Donor T-cell function was analyzed by cytokine secretion. The severity of acute GVHD was assessed by histopathological analysis of intestine and liver, GVHD clinical scores, and survival after BMT...
  29. ncbi request reprint The pathophysiology of acute graft-versus-host disease
    James L M Ferrara
    University of Michigan Cancer Center, Bone Marrow Transplant Program, Ann Arbor, Michigan, USA
    Int J Hematol 78:181-7. 2003
    ..TNF-alpha and IFN-gamma cause further injury to gastrointestinal epithelium, causing more endotoxin leakage and establishing a positive inflammatory feedback loop. These events are examined in detail in the following review...
  30. ncbi request reprint A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
    Gerhard C Hildebrandt
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
    Blood 103:2417-26. 2004
    ....
  31. ncbi request reprint Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome
    Gerhard C Hildebrandt
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 173:2050-9. 2004
    ..Therefore, approaches focusing on the abrogation of these interactions may prove successful in preventing or treating lung injury that occurs in this setting...
  32. ncbi request reprint Donor-derived TNF-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
    Gerhard C Hildebrandt
    University of Michigan Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Blood 104:586-93. 2004
    ..Collectively, these data demonstrate that donor TNF-alpha is critical to the development of IPS and reveal a heretofore unknown mechanism for T-cell-derived TNF-alpha in the evolution of this process...
  33. ncbi request reprint Graft-versus-host disease of the skin: life and death on the epidermal edge
    Craig C Hofmeister
    Department of Medicine, Division of Hematology Oncology, Loyola University Medical Center Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, USA
    Biol Blood Marrow Transplant 10:366-72. 2004
    ..With new insights designed to better predict and prevent GVHD and novel agents designed to treat GVHD, overcoming this current impediment to successful bone marrow transplantation should become increasingly feasible...
  34. ncbi request reprint Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease
    Ulrich A Duffner
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 172:7393-8. 2004
    ..These results demonstrate that host-derived DCs are critical in priming donor CD4(+) and CD8(+) T cells to cause GVHD, and selective targeting of host DCs may be a promising strategy to prevent GVHD...
  35. ncbi request reprint Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation
    Armin Gerbitz
    Department of Hematology Oncology, University of Regensburg, Germany
    Biol Blood Marrow Transplant 10:461-72. 2004
    ..This resulted in reduced T-cell activation ex vivo. These results demonstrate that the induction of HO-1 before high-dose conditioning protects the host in multiple ways and effectively ameliorates aGVHD...
  36. ncbi request reprint Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation
    Megan N Ballinger
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Immunol 177:5499-508. 2006
    ..Genetic reduction of cyclooxygenase-2 in BMT mice also had similar effects. These data clearly demonstrate that overproduction of PGE2 post-BMT is a critical factor determining impaired host defense against pathogens...
  37. ncbi request reprint Interleukin 18 preserves a perforin-dependent graft-versus-leukemia effect after allogeneic bone marrow transplantation
    Pavan Reddy
    Blood and Marrow Transplantation Program, Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Blood 100:3429-31. 2002
    ..Taken together these data demonstrate that IL-18 can attenuate acute GVHD without impairing the in vitro cytolytic function or the in vivo GVL activity after allogeneic BMT...
  38. ncbi request reprint Impaired thymic negative selection causes autoimmune graft-versus-host disease
    Takanori Teshima
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, USA
    Blood 102:429-35. 2003
    ..These results demonstrate that impaired thymic negative selection can cause lethal autoimmune disease indistinguishable from acute GVHD in the context of a proinflammatory milieu when peripheral regulatory mechanisms are absent...
  39. ncbi request reprint A protective gene for graft-versus-host disease
    Kenneth R Cooke
    Blood and Marrow Transplant Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, USA
    N Engl J Med 349:2183-4. 2003
  40. ncbi request reprint Acute graft-versus-host disease does not require alloantigen expression on host epithelium
    Takanori Teshima
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, Michigan, USA
    Nat Med 8:575-81. 2002
    ..These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD...

Research Grants1

  1. Mechanisms of Leukocyte Recruitment During IPS After BMT
    Kenneth Cooke; Fiscal Year: 2007
    ..lymphocytes --> days 7-21 SA2: CXCR3 / IP-10 (CXCL10) and Mig (CXCL9) SA3: CCR2: / MCP-1 (CCL2) --> monocytes/macrophages --> days 14-28 SA4:CXCR2 / KC and MIP-2 (CXCL1) --> neutrophils --> days 21 to 42 ..