Kathleen Conway

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer Epidemiol Biomarkers Prev 24:921-30. 2015
  2. ncbi request reprint Prevalence and spectrum of p53 mutations associated with smoking in breast cancer
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 62:1987-95. 2002
  3. pmc The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 7:R871-80. 2005
  4. pmc DNA-methylation profiling distinguishes malignant melanomas from benign nevi
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pigment Cell Melanoma Res 24:352-60. 2011
  5. pmc Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation
    Kathleen Conway
    Department of Epidemiology, School of Public Health, CB 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Breast Cancer Res 9:R36. 2007
  6. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
  7. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
  8. ncbi request reprint No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 15:175-7. 2006
  9. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
  10. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004

Research Grants

  1. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005

Collaborators

Detail Information

Publications28

  1. pmc Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer Epidemiol Biomarkers Prev 24:921-30. 2015
    ..Analysis of DNA methylation, an epigenetic mechanism that can regulate gene expression, could help to explain racial differences in breast tumor clinical biology and outcomes...
  2. ncbi request reprint Prevalence and spectrum of p53 mutations associated with smoking in breast cancer
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 62:1987-95. 2002
    ..Moreover, the difference in mutational spectra observed between smokers and nonsmokers is suggestive of the genotoxic effects of smoking in breast tissue...
  3. pmc The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 7:R871-80. 2005
    ..This mutation was initially reported in one-third of hyperplastic benign breast lesions, although several recent studies failed to detect it in benign or malignant breast tissues...
  4. pmc DNA-methylation profiling distinguishes malignant melanomas from benign nevi
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pigment Cell Melanoma Res 24:352-60. 2011
    ..This first report of a DNA-methylation signature discriminating melanomas from nevi indicates that DNA methylation appears promising as an additional tool for enhancing melanoma diagnosis...
  5. pmc Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation
    Kathleen Conway
    Department of Epidemiology, School of Public Health, CB 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Breast Cancer Res 9:R36. 2007
    ..We recently detected this mutation at a low frequency of 6% in invasive breast tumors of the Carolina Breast Cancer Study (CBCS)...
  6. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
    ..The association of BRAF mutations with early-life UV exposure provides evidence in support of childhood sun protection for melanoma prevention...
  7. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
    ..However, two recent studies showed a stronger association among postmenopausal white women with the inducible M2 polymorphism in the cytochrome P450 1A1 (CYP1A1) gene...
  8. ncbi request reprint No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 15:175-7. 2006
  9. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
    ..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
  10. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004
    ..The finding of tandem mutations in thin melanomas makes it more likely that they arise as a simultaneous rather than sequential event...
  11. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004
    ..Previous epidemiologic studies suggest that women with variant cytochrome P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer...
  12. pmc Grilled, Barbecued, and Smoked Meat Intake and Survival Following Breast Cancer
    Humberto Parada
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC HPJr, LSE, KC, MDG Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC SES Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA PTB Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY SLT Department of Epidemiology AIN, Department of Medicine AIN, and Department of Environmental Health RMS, Columbia University, New York, NY
    J Natl Cancer Inst . 2017
    ..However, no studies have examined whether intake of this PAH source influences survival after breast cancer...
  13. pmc Environmental Tobacco Smoke Exposure and Survival Following Breast Cancer
    Humberto Parada
    Department of Epidemiology, University of North Carolina at Chapel Hill
    Cancer Epidemiol Biomarkers Prev . 2016
    ..Environmental tobacco smoke (ETS) exposure is hypothesized to influence survival after breast cancer, but few studies have examined this association...
  14. pmc Polycyclic aromatic hydrocarbons and postmenopausal breast cancer: An evaluation of effect measure modification by body mass index and weight change
    Nicole Niehoff
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Environ Res 152:17-25. 2017
    ..No previous studies have evaluated whether obesity modifies associations between multiple measures of PAHs and breast cancer incidence...
  15. pmc DNA methylation profiles in primary cutaneous melanomas are associated with clinically significant pathologic features
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Pigment Cell Melanoma Res 27:1097-105. 2014
    ..Our findings provide support for the existence of methylation-defined subsets in melanomas with increased methylation associated with Breslow thickness. ..
  16. pmc Melanoma molecular subtypes: unifying and paradoxical results
    Nancy E Thomas
    Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 130:12-4. 2010
    ..The authors did not find an association between somatic BRAF-mutant melanoma and germline melanocortin-1 receptor (MC1R) gene status. We discuss this seeming paradox in light of previous studies demonstrating strong associations...
  17. ncbi request reprint IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study Project
    Rebecca J Cleveland
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Carcinogenesis 27:758-65. 2006
    ..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype...
  18. ncbi request reprint HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites
    Robert Millikan
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 79:355-64. 2003
    ..Results of previous studies have been mixed, with most studies showing no association but some suggesting an association in younger women or women with a family history of breast cancer...
  19. pmc Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence
    Alexandra J White
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Environ Int 89:185-92. 2016
    ....
  20. pmc IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma
    Craig C Carson
    Department of Dermatology, The University of North Carolina, Chapel Hill, North Carolina
    Clin Cancer Res 21:2167-76. 2015
    ..IL2 inducible T-cell kinase (ITK) promoter CpG sites are hypomethylated in melanomas compared with nevi. The expression of ITK in melanomas, however, has not been established and requires elucidation...
  21. pmc Body mass index is associated with gene methylation in estrogen receptor-positive breast tumors
    Brionna Y Hair
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer Epidemiol Biomarkers Prev 24:580-6. 2015
    ..The goal of this study, therefore, was to investigate associations between obesity and gene methylation in breast tumors...
  22. ncbi request reprint Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  23. pmc Body mass index associated with genome-wide methylation in breast tissue
    Brionna Y Hair
    Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, 2101 McGavran Greenberg Hall, Chapel Hill, NC, 27599 7435, USA
    Breast Cancer Res Treat 151:453-63. 2015
    ..Our results suggest that BMI is associated with genome-wide methylation in non-diseased breast tissue and may influence epigenetic pathways involved in inflammatory and other carcinogenic processes...
  24. pmc Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors
    Irina Mordukhovich
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Environ Health Perspect 118:511-8. 2010
    ..However, the carcinogenicity of PAHs on the human breast remains unclear. Certain carcinogens may be associated with specific mutation patterns in the p53 tumor suppressor gene, thereby contributing information about disease etiology...
  25. pmc Rational Manual and Automated Scoring Thresholds for the Immunohistochemical Detection of TP53 Missense Mutations in Human Breast Carcinomas
    Nicholas J Taylor
    Department of Cancer Epidemiology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL Translational Pathology Laboratory, School of Medicine Lineberger Comprehensive Cancer Center Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill Department of Pathology, Duke University School of Medicine, Durham, NC
    Appl Immunohistochem Mol Morphol 24:398-404. 2016
    ..Validation of the automated intensity scoring threshold suggests a role for such algorithms in detecting TP53 missense mutations in high throughput studies. ..
  26. pmc Active smoking and risk of Luminal and Basal-like breast cancer subtypes in the Carolina Breast Cancer Study
    Ebonee N Butler
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, CB 7435, 2101 McGavran Greenberg Hall, Chapel Hill, NC, 27599 7435, USA
    Cancer Causes Control 27:775-86. 2016
    ..However, the weak magnitude of association and conflicting results have yielded uncertainty and it is unknown whether associations differ by breast cancer subtype...
  27. pmc Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer
    Alexandra J White
    Department of Epidemiology University of North Carolina, Chapel Hill, NC, USA Electronic address
    Environ Res 145:93-100. 2016
    ..We aimed to evaluate the role of methylation in the association between PAHs and breast cancer...
  28. ncbi request reprint Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Mutat Res 559:143-51. 2004
    ..In conclusion, our results do not support an increased level of germline minisatellite mutations but suggest a modest increase in germline mutations in tetranucleotide repeats. Small sample size, however, limited statistical power...

Research Grants1

  1. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    ..If breast cancer can be attributed, in part, to cigarette smoking, then smoking prevention or cessation should reduce exposure and thus decrease the incidence of breast cancer. ..