J M Conner
Affiliation: University of California
- Characterization of antibodies to nerve growth factor: assay-dependent variability in the cross-reactivity with other neurotrophinsJ M Conner
Department of Biology, University of California at San Diego, La Jolla 92093 0506, USA
J Neurosci Methods 65:93-9. 1996..These data strongly argue against transferring cross-reactivity data across various assay systems...
- The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injuryJames M Conner
Department of Neurosciences, Unviersity of California, La Jolla, California 92093, USA
Neuron 46:173-9. 2005..These findings raise the intriguing possibility that deficits in cholinergic function may limit functional outcomes following nervous system injury...
- Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learningJames M Conner
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 38:819-29. 2003..These results support the hypothesis that the basal forebrain cholinergic system may be specifically implicated in forms of learning requiring plasticity of cortical representations...
- Developmental profile of NGF immunoreactivity in the rat brain: a possible role of NGF in the establishment of cholinergic terminal fields in the hippocampus and cortexJ M Conner
Department of Biology, University of California, San Diego, La Jolla 92093, USA
Brain Res Dev Brain Res 101:67-79. 1997..Thus, the results of the current investigation clearly identify the presence of transiently occurring zones of NGF-ir during postnatal CNS development, although defining their exact functional role will require additional investigation...
- Unique contributions of distinct cholinergic projections to motor cortical plasticity and learningJ M Conner
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0626, USA
Cereb Cortex 20:2739-48. 2010..More globally acting cholinergic mechanisms provide additional support for the acquisition of skilled motor behaviors, beyond those associated with cortical map reorganization...
- The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticityDhakshin Ramanathan
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
J Neurosci 29:5992-6000. 2009....
- A form of motor cortical plasticity that correlates with recovery of function after brain injuryDhakshin Ramanathan
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
Proc Natl Acad Sci U S A 103:11370-5. 2006..This evidence suggests the existence of complex movement representations in the rat motor cortex that exhibit plasticity after injury and rehabilitation, serving as a relevant predictor of functional recovery...
- Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transportJ M Conner
Department of Biology, 0506, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 17:2295-313. 1997....
- Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervationJ M Conner
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0626, USA
Proc Natl Acad Sci U S A 98:1941-6. 2001..e., administration of growth factors to cholinergic somata significantly increases axon density in terminal fields). These findings are relevant to potential clinical uses of growth factors to treat neurological disorders...
- Nerve growth factor (NGF) content in adult rat brain tissues is several-fold higher than generally reported and is largely associated with sedimentable fractionsM C Hoener
Department of Biology 0506, University of California San Diego, La Jolla 92093, USA
Brain Res 728:47-56. 1996..Further studies should clarify the nature of the association between NGF and the three subsets of pellet NGF and allow the investigation of the pellet molecules responsible for it...
- Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expressionA Blesch
Department of Neurosciences-0626, University of California, San Diego, La Jolla, CA 92093-0626, USA
Gene Ther 8:954-60. 2001..These data constitute the first report of regulated neuronal rescue and axonal growth by controlled neurotrophin gene delivery and long-term, regulated expression using ex vivo CNS gene therapy...
- NGF is essential for hippocampal plasticity and learningJames M Conner
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 29:10883-9. 2009..These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain...
- Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene deliveryAlan H Nagahara
Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
Exp Neurol 215:153-9. 2009..These findings also support the safety and feasibility of lentiviral NGF gene transfer for potential testing in human clinical trials to protect degenerating cholinergic neurons in Alzheimer's disease...
- Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injuryLaura Taylor Alto
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
Nat Neurosci 12:1106-13. 2009..Thus, we report for the first time, to the best of our knowledge, the reinnervation of brainstem targets after SCI and an essential role for chemotropic axon guidance in target selection...