Raul Coimbra

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 57:1157-63. 2004
  2. pmc Abdominal damage control surgery and reconstruction: world society of emergency surgery position paper
    Laura Godat
    Division of Trauma, Surgical Critical Care, and Burns, University of California, San Diego, 200 West Arbor Dr, 8896, San Diego CA 92103 8896, United States of America
    World J Emerg Surg 8:53. 2013
  3. doi request reprint Hemorrhage is More Prevalent than Brain Injury in Early Trauma Deaths: The Golden Six Hours
    Vishal Bansal
    Division of Trauma, Burns and Critical Care, Department of Surgery, University of California San Diego, San Diego, CA, USA
    Eur J Trauma Emerg Surg 35:26-30. 2009
  4. pmc World society of emergency surgery study group initiative on Timing of Acute Care Surgery classification (TACS)
    Yoram Kluger
    Department of Surgery, Rambam Health Care Center, Haifa, Israel
    World J Emerg Surg 8:17. 2013
  5. pmc 2013 WSES guidelines for management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:3. 2013
  6. pmc Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:1. 2013
  7. pmc Vagal stimulation modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury
    Vishal Bansal
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego, 200 W Arbor Drive 8896, San Diego, CA 92103, USA
    Inflammation 35:214-20. 2012
  8. pmc Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury
    Ana Maria Gonzalez
    College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Fluids Barriers CNS 8:6. 2011
  9. pmc A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices
    Ritsuko Sawada
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego School of Medicine, 200 W, Arbor Dr, San Diego, CA 92103 8236 USA
    Fibrogenesis Tissue Repair 4:7. 2011
  10. pmc Children at danger: injury fatalities among children in San Diego County
    Andrea M A Fraga
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, UCSD School of Medicine, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103 8896, USA
    Eur J Epidemiol 25:211-7. 2010

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 57:1157-63. 2004
    ..We hypothesized that LPS-induced TNF-alpha synthesis and subsequent PMN beta2-integrin expression and oxidative burst are downregulated by concomitant treatment with the non-specific phosphodiesterase inhibitor pentoxifylline (PTX)...
  2. pmc Abdominal damage control surgery and reconstruction: world society of emergency surgery position paper
    Laura Godat
    Division of Trauma, Surgical Critical Care, and Burns, University of California, San Diego, 200 West Arbor Dr, 8896, San Diego CA 92103 8896, United States of America
    World J Emerg Surg 8:53. 2013
    ..In the rare cases of inability to primarily close the abdomen, there are a number of reconstructive strategies that may be used in the acute and chronic phases of abdominal closure. ..
  3. doi request reprint Hemorrhage is More Prevalent than Brain Injury in Early Trauma Deaths: The Golden Six Hours
    Vishal Bansal
    Division of Trauma, Burns and Critical Care, Department of Surgery, University of California San Diego, San Diego, CA, USA
    Eur J Trauma Emerg Surg 35:26-30. 2009
    ..Determination of cause of death without autopsy review is inaccurate. The goal of this study is to determine cause of death, in hourly intervals, in trauma patients who died in the first 24 h, as determined by autopsy...
  4. pmc World society of emergency surgery study group initiative on Timing of Acute Care Surgery classification (TACS)
    Yoram Kluger
    Department of Surgery, Rambam Health Care Center, Haifa, Israel
    World J Emerg Surg 8:17. 2013
    ..Standardizing timing of interventions in surgical emergencies will promote clinical investigation as well as a commitment by administrative authorities to proper operating theater provision for acute care surgery...
  5. pmc 2013 WSES guidelines for management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:3. 2013
    ..The 2013 update of the World Society of Emergency Surgery (WSES) guidelines for the management of intra-abdominal infections contains evidence-based recommendations for management of patients with intra-abdominal infections...
  6. pmc Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:1. 2013
    ..7%) patients.The overall mortality rate was 10.1% (71/702). The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013...
  7. pmc Vagal stimulation modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury
    Vishal Bansal
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego, 200 W Arbor Drive 8896, San Diego, CA 92103, USA
    Inflammation 35:214-20. 2012
    ..In conclusion, VNS increased serum ghrelin and decreased TNF-α following TBI. This was abrogated with GRa. Our data suggests that ghrelin plays an important role in the anti-inflammatory effects of VNS following TBI...
  8. pmc Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury
    Ana Maria Gonzalez
    College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Fluids Barriers CNS 8:6. 2011
    ..The aim of this study was to explore whether Ecrg4 and its product augurin, can be implicated in CNS development and the response to CNS injury...
  9. pmc A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices
    Ritsuko Sawada
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego School of Medicine, 200 W, Arbor Dr, San Diego, CA 92103 8236 USA
    Fibrogenesis Tissue Repair 4:7. 2011
    ....
  10. pmc Children at danger: injury fatalities among children in San Diego County
    Andrea M A Fraga
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, UCSD School of Medicine, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103 8896, USA
    Eur J Epidemiol 25:211-7. 2010
    ..Specific strategies to decrease road-traffic accidents and homicides must be developed and implemented to reduce the burden of injury-related deaths in children...
  11. ncbi request reprint Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 59:575-82. 2005
    ..In addition, we investigated the effects of PTX on nuclear factor (NK)-kappaB activation using lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs) as a model...
  12. ncbi request reprint Nonoperative management reduces the overall mortality of grades 3 and 4 blunt liver injuries
    Raul Coimbra
    Division of Trauma, Critical Care, and Burns, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    Int Surg 91:251-7. 2006
    ..Six patients failed NON-OP management (22.2%). The mortality rate in the NON-OP group was 0%. NON-OP was associated with a 23.5% reduction in mortality. Unnecessary OP management of grades 3 and 4 liver injuries should be discouraged...
  13. ncbi request reprint Reversal of anticoagulation in trauma: a North-American survey on clinical practices among trauma surgeons
    Raul Coimbra
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, CA 92103 8896, USA
    J Trauma 59:375-82. 2005
    ..Recent studies addressing reversal of anticoagulation in trauma have reported conflicting results. We hypothesized that current clinical practice is variable throughout North America...
  14. ncbi request reprint HSPTX protects against hemorrhagic shock resuscitation-induced tissue injury: an attractive alternative to Ringer's lactate
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, 200 W Arbor Drive, San Diego, CA 92103, USA
    J Trauma 60:41-51. 2006
    ..Herein, we hypothesized that HSPTX decreases end-organ injury when compared with RL in an animal model of hemorrhagic shock...
  15. ncbi request reprint Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia
    Raul Coimbra
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    Surg Infect (Larchmt) 6:73-85. 2005
    ..We hypothesized that PTX would preserve liver architecture and function after intravenous lipopolysaccharide (LPS) injection...
  16. ncbi request reprint Recognizing/accepting futility: prehospital, emergency center, operating room, and intensive care unit
    Raul Coimbra
    Department of Surgery, University of California San Diego, School of Medicine, CA 92103 8996, USA
    J Trauma Nurs 14:73-6; quiz 77-8. 2007
    ..Lastly, the intensivist must recognize those patients who may or may not benefit from continued efforts to sustain life...
  17. ncbi request reprint Does sexual dimorphism influence outcome of traumatic brain injury patients? The answer is no!
    Raul Coimbra
    Department of Surgery, University of California San Diego, USA
    J Trauma 54:689-700. 2003
    ....
  18. ncbi request reprint LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression
    Raul Coimbra
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, 200 W Arbor Drive, San Diego, CA 92103 8896, USA
    J Trauma 60:115-25. 2006
    ..We postulated that PTX treatment in acute endotoxemia downregulates the inflammatory response and may decrease lung injury...
  19. ncbi request reprint Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego, School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 56:442-9. 2004
  20. ncbi request reprint Intraarterial pulmonary pentoxifylline improves cardiac performance and oxygen utilization after hemorrhagic shock: a novel resuscitation strategy
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    Anesth Analg 98:1439-46, table of contents. 2004
    ..PTX resuscitation is superior compared with LR solution alone. Intraarterial pulmonary PTX administration is safe, and improves cardiac performance as well as O(2) utilization...
  21. ncbi request reprint Outcome from traumatic injury of the portal and superior mesenteric veins
    Raul Coimbra
    University of California San Diego School of Medicine, CA, USA
    Vasc Endovascular Surg 38:249-55. 2004
    ..The physiologic status upon admission, the number of associated injuries, and the severity of the vascular injury are the most important factors related to mortality in PV and SMV injuries...
  22. ncbi request reprint Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, CA 92103 8896, USA
    J Trauma 59:257-64; discussion 264-5. 2005
    ....
  23. doi request reprint Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis
    Tercio de Campos
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California School of Medicine, San Diego, CA, USA
    Pancreas 37:42-9. 2008
    ..Pentoxifylline (PTX) has been shown to attenuate neutrophil activation and end-organ injury in shock states such as hemorrhage and sepsis. We hypothesized that PTX would down-regulate AP-induced lung injury...
  24. pmc Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 68:1349-54; discussion 1354-6. 2010
    ....
  25. pmc Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 67:1162-8. 2009
    ..We hypothesized that PTX would limit intestinal barrier breakdown and attenuate inflammatory signaling via the MAPK pathway...
  26. ncbi request reprint Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation
    Jessica Deree
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California School of Medicine, CA, USA
    J Trauma 62:818-27; discussion 827-8. 2007
    ....
  27. doi request reprint Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, United States
    Life Sci 84:18-22. 2009
    ..We hypothesize that PTX prevents the breakdown of ZO-1 and occludin in an in vitro model of immunostimulated intestinal cell monolayers...
  28. pmc Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis
    Vishal Bansal
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego, San Diego, CA 92103, USA
    J Neurotrauma 26:1353-9. 2009
    ..Expression of intestinal tight junction proteins may be an important factor in gastrointestinal dysfunction following brain injury...
  29. pmc Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury
    Carrie Y Peterson
    Division of Trauma, Critical Care and Burns, Department of Surgery, University of California, San Diego, San Diego, California 92103 8896, USA
    Surg Infect (Larchmt) 11:137-44. 2010
    ..We hypothesized that increased intestinal permeability and barrier breakdown after burns is a TLR-4 dependent process; hence, knocking down the TLR-4 gene would have a protective effect on burn-induced intestinal dysfunction...
  30. pmc Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase
    Todd W Costantini
    Department of Surgery, Division of Trauma, Surgical Critical Care, and Burns, University of California, San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 66:17-24; discussion 24-5. 2009
    ..Therefore, we postulate that PTX will attenuate activation of the tight junction protein MLCK, which may decrease intestinal tight junction permeability after severe burn...
  31. doi request reprint Prehospital airway and ventilation management: a trauma score and injury severity score-based analysis
    Daniel P Davis
    Department of Emergency Medicine, UC San Diego, San Diego, California, USA
    J Trauma 69:294-301. 2010
    ..However, recent evidence suggests that the procedure may be associated with increased mortality, possibly reflecting inadequate training, suboptimal patient selection, or inappropriate ventilation...
  32. pmc Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury
    Vishal Bansal
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego, California, USA
    J Trauma 68:1059-64. 2010
    ..Regulation of the gut barrier may involve the central nervous system. We hypothesize that vagal nerve stimulation prevents an increase in intestinal permeability after TBI...
  33. ncbi request reprint Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Surg Res 143:99-108. 2007
    ..We hypothesized that the anti-inflammatory agent pentoxifylline (PTX) attenuates postresuscitative lung injury through modulation of transcription factors after hemorrhagic shock...
  34. pmc Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    Shock 31:416-22. 2009
    ..Therefore, phosphodiesterase inhibition may be a useful adjunct strategy in the attenuation of burn-induced gut barrier injury...
  35. doi request reprint Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California
    Immunopharmacol Immunotoxicol 32:82-91. 2010
    ..We hypothesized that PTX diminishes production of the neutrophil respiratory burst by both PKA-dependent and independent mechanisms...
  36. pmc Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the gut-lung axis
    Michael J Krzyzaniak
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California, San Diego School of Medicine, San Diego, CA, USA
    Surgery 150:379-89. 2011
    ..The purpose of this study was to assess acute lung injury when protection to the gut mucosal barrier offered by vagus nerve stimulation is eliminated by an abdominal vagotomy...
  37. ncbi request reprint Pentoxifylline reduces acute lung injury in chronic endotoxemia
    Christopher Michetti
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Surg Res 115:92-9. 2003
    ..We hypothesized that continuous infusion of PTX reduces acute lung injury (ALI) caused by chronic lipopolysaccharide (LPS) exposure...
  38. ncbi request reprint Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California School of Medicine, San Diego, CA, USA
    J Trauma 62:104-11. 2007
    ..Because the neutrophil plays a major role in postshock inflammation, we hypothesized that HSPTX reduces pulmonary inflammation after resuscitation in comparison to RL...
  39. ncbi request reprint Pentoxifylline attenuates stored blood-induced inflammation: A new perspective on an old problem
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA, USA
    Surgery 140:186-91. 2006
    ..Its supernatant fraction has been proven to activate neutrophils. We hypothesized that pentoxifylline (PTX) would attenuate stored blood-induced neutrophil activation and pro-inflammatory mediator production...
  40. ncbi request reprint Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial
    David H Livingston
    Department of Surgery, New Jersey Trauma Center, UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    J Trauma 59:1298-304; discussion 1304. 2005
    ..The purpose of this study was to further investigate the effect of age on outcome at 1 year in all patients surviving isolated TBI...
  41. ncbi request reprint Patient factors and operating room resuscitation predict mortality in traumatic abdominal aortic injury: a 20-year analysis
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego, San Diego, CA, USA
    J Vasc Surg 45:493-7. 2007
    ..The purposes of this study were to identify primary predictors of mortality and to examine the impact of a well-established operating room resuscitation protocol on survival in patients with traumatic aortic injury...
  42. pmc CPSI-121 pharmacologically prevents intestinal barrier dysfunction after cutaneous burn through a vagus nerve-dependent mechanism
    Michael Krzyzaniak
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA 92103, USA
    J Trauma Acute Care Surg 72:355-61; discussion 361-3. 2012
    ....
  43. pmc Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells
    Todd W Costantini
    Department of Surgery, University of California, San Diego School of Medicine, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1308-18. 2010
    ..The vagus nerve may mediate the signaling that occurs from the central nervous system to the enteric nervous system following gastrointestinal injury...
  44. doi request reprint Pentoxifylline attenuates leukoreduced stored blood-induced neutrophil activation through inhibition of mitogen-activated protein kinases
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California, San Diego School of Medicine, San Diego, California, USA
    Immunopharmacol Immunotoxicol 32:74-81. 2010
    ..Transfusion of packed red blood cells is an independent risk factor for postoperative bacterial infections and multiple organ failure...
  45. doi request reprint Hepatic transcription factor activation and proinflammatory mediator production is attenuated by hypertonic saline and pentoxifylline resuscitation after hemorrhagic shock
    Jessica Deree
    Division of Trauma and Critical Care, Department of Surgery, University of California San Diego, USA
    J Trauma 64:1230-8; discussion 1238-9. 2008
    ..We hypothesized that the attenuation in hepatic injury observed with HSPTX is associated with the reduction of transcription factor activation and proinflammatory mediator production when compared with Ringer's lactate (RL)...
  46. pmc Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition
    Jessica Deree
    Department of Trauma and Critical Care, University of California San Diego Medical Center, San Diego, CA, USA
    Clinics (Sao Paulo) 63:321-8. 2008
    ....
  47. pmc Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA, USA
    Mol Imaging 9:30-9. 2010
    ..Our results correlate with traditional, time-consuming, semiquantitative assays of intestinal injury, now allowing the noninvasive, nonlethal assessment of injury over time...
  48. doi request reprint Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California, USA
    Am J Pathol 181:478-86. 2012
    ....
  49. doi request reprint Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury
    Nicole E Lopez
    Division of Trauma, Surgical Critical Care and Burns, Department of Surgery, University of California, San Diego, San Diego, California 92103, USA
    J Trauma Acute Care Surg 72:1562-6. 2012
    ..It is unknown whether VNS may reduce blood-brain barrier (BBB) dysfunction after TBI.We hypothesize that VNS prevents TBI-induced breakdown of the BBB, subsequent brain edema, and neuronal injury...
  50. pmc The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction
    Vishal Bansal
    Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, University of California San Diego, San Diego, California 92103, USA
    J Neurotrauma 27:2255-60. 2010
    ..The mechanism for ghrelin mediating intestinal protection is likely multifactorial, and further studies are needed to delineate these possibilities...
  51. doi request reprint Is contrast exposure safe among the highest risk trauma patients?
    Dennis Y Kim
    Division of Trauma, Surgical Critical Care, and Burns, University of California San Diego Medical Center, San Diego, California, USA
    J Trauma Acute Care Surg 72:61-6; discussion 66-7. 2012
    ..We sought to determine whether IV contrast exposure among high-risk trauma patients resulted in renal dysfunction as defined by the Acute Kidney Injury Network criteria...
  52. pmc Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection
    Arwa Kurabi
    Department of Surgery, University of California, San Diego School of Medicine, La Jolla, California, United States of America
    PLoS ONE 8:e61394. 2013
    ..Taken together, these data support a hypothesis that Ecrg4 plays a role in coordinating the inflammatory and proliferative response to infection of mucosal epithelium suggesting a possible mechanism for its putative anti-tumor activity...
  53. doi request reprint An automatic MEG low-frequency source imaging approach for detecting injuries in mild and moderate TBI patients with blast and non-blast causes
    Ming Xiong Huang
    Radiology, Research, Rehab, and Psychiatry Services, VA San Diego Healthcare System, San Diego, CA, USA
    Neuroimage 61:1067-82. 2012
    ..This study provides a foundation for using MEG low-frequency source imaging to support the clinical diagnosis of TBI...
  54. ncbi request reprint Neutrophil degranulation and the effects of phosphodiesterase inhibition
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA, USA
    J Surg Res 133:22-8. 2006
    ..We hypothesized that PTX down-regulates neutrophil activation by decreasing the surface expression of both CD35 and CD66b, two markers of neutrophil degranulation...
  55. pmc Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    JAMA 304:1455-64. 2010
    ..Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI)...
  56. doi request reprint Postinjury depression is a serious complication in adolescents after major trauma: injury severity and injury-event factors predict depression and long-term quality of life deficits
    Peggy P Han
    San Diego State University, San Diego, California, USA
    J Trauma 70:923-30. 2011
    ..Specific objectives of this report are to identify risk factors for depression onset and the impact of depression on quality of life (QoL) outcomes...
  57. doi request reprint The utility of seat belt signs to predict intra-abdominal injury following motor vehicle crashes
    Vishal Bansal
    Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    Traffic Inj Prev 10:567-72. 2009
    ....
  58. doi request reprint Is bigger better? The effect of obesity on pelvic fractures after side impact motor vehicle crashes
    Vishal Bansal
    Division of Trauma, Surgical Critical Care and Burns, Department of Surgery, University of California at San Diego, San Diego, California 92103, USA
    J Trauma 67:709-14. 2009
    ..This study assesses the role of BMI in predicting pelvic fracture and whether BMI modifies the effect of other potential risk factors...
  59. pmc Postinjury vagal nerve stimulation protects against intestinal epithelial barrier breakdown
    Michael Krzyzaniak
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California, San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 70:1168-75; discussion 1175-6. 2011
    ..Therefore, we postulated that VNS conducted postinjury would also have a similar protective effect on maintaining gut epithelial barrier integrity...
  60. ncbi request reprint Female gender does not protect blunt trauma patients from complications and mortality
    Joseph F Rappold
    Department of Surgery, Division of Trauma, Critical Care, and Burns, University of California San Diego, 92103, USA
    J Trauma 53:436-41; discussion 441. 2002
    ....
  61. pmc Targeting the gut barrier: identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA 92103 8896, USA
    Surgery 146:206-12. 2009
    ..We postulated that mining a peptide library that was displayed on phage would identify peptide sequences that bind and internalize into the gut epithelium following injury...
  62. ncbi request reprint A twelve-year analysis of disease and provider complications on an organized level I trauma service: as good as it gets?
    David B Hoyt
    Division of Trauma, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 54:26-36; discussion 36-7. 2003
    ..The annual incidence of complications in a trauma population has been previously reported but the frequency change over time in a single institution is not well studied...
  63. pmc Role of p38 MAPK in burn-induced intestinal barrier breakdown
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA 92103 8896, USA
    J Surg Res 156:64-9. 2009
    ....
  64. doi request reprint Development of a preliminary risk index to identify trauma patients at risk for an unplanned intubation
    Dennis Kim
    From the Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California
    J Trauma Acute Care Surg 76:167-71. 2014
    ..We also sought to determine the impact of UI on patient outcomes...
  65. ncbi request reprint Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage
    David A Z Frankel
    University of California, San Diego, California, USA
    J Surg Res 143:276-80. 2007
    ..Our hypothesis was that rapid bleeding followed by slower bleeding using a fixed total volume would result in a greater physiologic insult...
  66. doi request reprint Computerized insulin infusion programs are safe and effective in the burn intensive care unit
    Jeanne Lee
    Division of Trauma, Surgical Critical Care and Burns, Department of Surgery, University of California San Diego, CA 92103, USA
    J Burn Care Res 33:e114-9. 2012
    ..2%). There were no adverse events associated with the hypoglycemic episode. The computer-based protocol is more effective than those previously used at the institution and provides safe, reliable results in the burn patients...
  67. pmc Cell surface localization and release of the candidate tumor suppressor Ecrg4 from polymorphonuclear cells and monocytes activate macrophages
    Andrew Baird
    University of California San Diego School of Medicine, 212 Dickinson St, MC 8236, San Diego, CA 92103, USA
    J Leukoc Biol 91:773-81. 2012
    ....
  68. doi request reprint The influence of vehicle damage on injury severity of drivers in head-on motor vehicle crashes
    Carol Conroy
    Department of Surgery, County of San Diego Emergency Medical Services, University of California San Diego, 6255 Mission Gorge Road, San Diego, CA 92120, USA
    Accid Anal Prev 40:1589-94. 2008
    ..Our study supports that the type of damage distribution across the frontal plane may be an important crash characteristic to consider when studying drivers injured in head-on motor vehicle crashes...
  69. doi request reprint Injury patterns in frontal crashes: the association between knee-thigh-hip (KTH) and serious intra-abdominal injury
    Jeanne Lee
    Department of Surgery, School of Medicine, University of California at San Diego, San Diego, CA, USA
    Accid Anal Prev 42:50-5. 2010
    ..These results may be useful to motor vehicle manufacturers and others who design and test motor vehicle safety systems...
  70. pmc Burn-induced acute lung injury requires a functional Toll-like receptor 4
    Michael Krzyzaniak
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California, San Diego School of Medicine, San Diego, California, USA
    Shock 36:24-9. 2011
    ..Toll-like receptor 4 KO animals were clearly protected and had a much less severe lung injury. Our data suggest that burn-induced ALI is a TLR4-dependent process...
  71. ncbi request reprint Significant injury in cruise ship passengers a case series
    Vishal Bansal
    University of California San Diego, Department of Surgery, Division of Trauma, Burns and Critical Care, San Diego, California 92103, USA
    Am J Prev Med 33:219-21. 2007
    ..This report provides a case series analysis of eight patients identified as suffering from significant cruise ship-related injuries...
  72. pmc Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown
    Gerald A Cheadle
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California, United States of America
    PLoS ONE 8:e69042. 2013
    ..We postulated that EGCs, through the secretion of GSNO, would improve intestinal barrier function through improved expression and localization of intestinal tight junction proteins...
  73. pmc A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock
    Todd W Costantini
    University of California San Diego School of Medicine, California, USA
    Clinics (Sao Paulo) 65:621-8. 2010
    ....
  74. pmc Deletion of scavenger receptor A gene in mice resulted in protection from septic shock and modulation of TLR4 signaling in isolated peritoneal macrophages
    Robert Drummond
    MSTP program Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Innate Immun 19:30-41. 2013
    ..The contribution of Sra to the outcome of sepsis may be a combination of changes in TLR4 signaling pathway and elevated levels of HDL in circulation, but also LPS toxicity...
  75. pmc Intravenous phage display identifies peptide sequences that target the burn-injured intestine
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, CA 92103 8896, United States
    Peptides 38:94-9. 2012
    ..Phage sequence 4-11 demonstrated cross-reactivity with human intestine. In the future, this gut-targeting peptide sequence could serve as a platform for the delivery of biotherapeutics...
  76. pmc Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury
    Nicole E Lopez
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California
    Shock 38:294-300. 2012
    ..In combination, these studies suggest VNS mediates the inflammatory response in peritoneal macrophages by affecting the set point of LPS responsiveness...
  77. pmc Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction
    David M Cauvi
    School of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:19804-15. 2012
    ....
  78. doi request reprint Combat versus civilian open tibia fractures: the effect of blast mechanism on limb salvage
    Jay J Doucet
    University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 70:1241-7. 2011
    ..This study compares open tibia fractures in US Navy and US Marine Corps casualties from the current conflicts with those from a civilian Level I trauma center to analyze the effect of blast mechanism on limb-salvage rates...
  79. doi request reprint Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury
    Daniel P Davis
    Univeristy of California San Diego, Department of Emergency Medicine, San Diego, California, USA
    J Neurotrauma 26:2217-23. 2009
    ..We conclude that both hypoxemia and extreme hyperoxemia are associated with increased mortality and a decrease in good outcomes among TBI patients...
  80. doi request reprint Rib and sternum fractures in the elderly and extreme elderly following motor vehicle crashes
    Vishal Bansal
    Department of Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103 8896, United States
    Accid Anal Prev 43:661-5. 2011
    ..Current safety systems may need to be redesigned to prevent rib and sternum fractures in occupants 80 years and older...
  81. doi request reprint Redefining renal dysfunction in trauma: implementation of the Acute Kidney Injury Network staging system
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 67:283-7; discussion 287-8. 2009
    ..We hypothesize that by using the Acute Kidney Injury Network (AKIN) staging system we would identify smaller changes in renal function that may impact outcome, and may serve as a marker for mortality and other organ dysfunction...
  82. pmc The noninvasive, quantitative, in vivo assessment of adenoviral-mediated gene delivery in skin wound biomaterials
    Carrie Y Peterson
    Division of Trauma, Burns and Critical Care, Department of Surgery, 200 W Arbor Dr, University of California San Diego, San Diego, CA 92103 8236, USA
    Biomaterials 30:6788-93. 2009
    ..Taken together, these results show how a noninvasive and quantitative assessment of gene expression can be used to optimize gene delivery and that the composition of matrices can dramatically influence gene expression in the wound bed...
  83. ncbi request reprint The epidemiology of serious and fatal injury in San Diego County over an 11-year period
    Bruce M Potenza
    Department of Surgery, University of California, San Diego, 92103 8896, USA
    J Trauma 56:68-75. 2004
    ..Analysis of the mechanism and severity of injury over time may permit a more focused planning of acute care and trauma prevention programs...
  84. doi request reprint A new clopidogrel (Plavix) point-of-care assay: rapid determination of antiplatelet activity in trauma patients
    Vishal Bansal
    Division of Trauma, Surgical Critical Care and Burns, Department of Surgery, University of California San Diego, San Diego, California 92103, USA
    J Trauma 70:65-9; discussion 69-70. 2011
    ..We report the use of a new P2Y12 point-of-care assay (VerifyNow; Accumetrics, San Diego, CA) to determine the magnitude of platelet inhibition in trauma patients using clopidogrel...
  85. ncbi request reprint High rates of acute stress disorder impact quality-of-life outcomes in injured adolescents: mechanism and gender predict acute stress disorder risk
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California 92103 8896, USA
    J Trauma 59:1126-30. 2005
    ..The specific objectives of the present report are to examine ASD rates and the association of ASD with QoL outcomes in injured adolescents...
  86. ncbi request reprint The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial
    Anne C Mosenthal
    Department of Surgery, New Jersey Trauma Center, University of Medicine and Dentistry of New Jersey New Jersey, Medical School, Newark, New Jersey, USA
    J Trauma 56:1042-8. 2004
    ..We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization...
  87. ncbi request reprint Phosphodiesterase inhibition attenuates stored blood-induced neutrophil activation: a novel adjunct to blood transfusion
    Rohan N Lall
    Division of Trauma, University of California San Diego, San Diego, CA 92103 8896, USA
    J Am Coll Surg 202:10-7. 2006
    ..We hypothesized that adding PTX to PRBCs would attenuate blood transfusion-induced neutrophil activation...
  88. ncbi request reprint Long-term posttraumatic stress disorder persists after major trauma in adolescents: new data on risk factors and functional outcome
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California, USA
    J Trauma 58:764-9; discussion 769-71. 2005
    ..The specific objectives of the present report are to describe long-term PTSD and to identify risk factors for long-term PTSD and the impact of PTSD on QoL...
  89. ncbi request reprint Resuscitation affects microcirculatory polymorphonuclear leukocyte behavior after hemorrhagic shock: role of hypertonic saline and pentoxifylline
    Margareth M Yada-Langui
    Division of Trauma, 8896, University of California San Diego School of Medicine, 200 West Arbor Drive, San Diego, CA 92103 8896, USA
    Exp Biol Med (Maywood) 229:684-93. 2004
    ..These results support earlier studies that indicated the potential application of HS and PTX in shock therapy and the increase in PMN-endothelial cell interaction and lung injury after LR resuscitation...
  90. doi request reprint Integrated imaging approach with MEG and DTI to detect mild traumatic brain injury in military and civilian patients
    Ming Xiong Huang
    Research, Radiology, Rehabilitation, and Psychiatry Services, VA San Diego Healthcare System, San Diego, California, USA
    J Neurotrauma 26:1213-26. 2009
    ....
  91. ncbi request reprint Trauma in adolescents causes long-term marked deficits in quality of life: adolescent children do not recover preinjury quality of life or function up to two years postinjury compared to national norms
    Troy Lisa Holbrook
    Division of Trauma, Department of Surgery, University of California, CA, USA
    J Trauma 62:577-83; discussion 583. 2007
    ..The objectives of the present report are to describe long-term QoL outcomes and compare posttrauma QoL to national norms for QoL in uninjured adolescents from the National Health Interview Survey (NHIS)...
  92. doi request reprint Lessons learned from the institution of the Surgical Care Improvement Project at a teaching medical center
    Bruce Potenza
    Division of Trauma, Critical Care and Burns, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103 8896, USA
    Am J Surg 198:881-8. 2009
    ....
  93. doi request reprint Density of surgeons is significantly associated with reduced risk of deaths from motor vehicle crashes in US counties
    David C Chang
    Department of Surgery, University of California, San Diego, CA, USA
    J Am Coll Surg 212:862-6. 2011
    ..The purpose of this study is to quantify the effect of surgeon availability on deaths from motor vehicle crashes (MVC)...
  94. doi request reprint The unrecognized danger of a new transportation mechanism of injury--pedicabs
    Jay J Doucet
    Division of Trauma, Burns and Surgical Critical Care, Department of Surgery, University of California Medical Center, 200 W Arbor Drive, San Diego, CA 92103 8896, USA
    J Safety Res 42:131-5. 2011
    ..The purpose of this study is to identify the incidence, demographics, morbidity, mortality, and potential for injury prevention of pedicab incidents amongst major trauma admissions at an urban, academic Level I Trauma Center...
  95. ncbi request reprint Osmotic regulation of cell function and possible clinical applications
    Alok Shukla
    Department of Surgery Trauma, University of California San Diego, San Diego, California 92103, USA
    Shock 21:391-400. 2004
    ..Knowledge of how osmotic cues regulate immune cell function will enable us to fully exploit the clinical potential of hypertonic resuscitation to reduce inflammatory and anergic complications in trauma patients...
  96. ncbi request reprint From acute pancreatitis to end-organ injury: mechanisms of acute lung injury
    Tercio de Campos
    Division of Trauma, University of California San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA
    Surg Infect (Larchmt) 8:107-20. 2007
    ..Understanding of the mechanisms by which local inflammation in the pancreas leads to end-organ injury is crucial for the development of new therapeutic strategies...
  97. ncbi request reprint Characterization of two classes of pancreatic shock factors: functional differences exhibited by hydrophilic and hydrophobic shock factors
    William J Kramp
    La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    Shock 20:356-62. 2003
    ....
  98. ncbi request reprint From the trauma surgeon's viewpoint: multiple injuries--which cavity to open first?
    Raul Coimbra
    Division of Trauma, University of California San Diego School of Medicine, San Diego, CA, USA
    J Trauma Nurs 12:7-9. 2005
    ..Several challenging scenarios are common in clinical practice. For discussion purposes these will be divided according to the mechanism of injury either penetrating or blunt...
  99. doi request reprint Hypertonic resuscitation: design and implementation of a prehospital intervention trial
    Karen J Brasel
    Department of Surgery, Division of Trauma Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Coll Surg 206:220-32. 2008
    ..Trauma is the leading cause of death among North Americans between the ages of 1 and 44 years. Resuscitation with hypertonic saline (7.5%) solutions can reduce mortality in hypotensive and brain-injured patients...
  100. ncbi request reprint Trauma systems
    David B Hoyt
    Department of Surgery, University of California, Irvine School of Medicine, City Tower, 333 City Boulevard West, 700, Orange, CA 92868, USA
    Surg Clin North Am 87:21-35, v-vi. 2007
    ..Disaster preparedness also is an important function of trauma systems, and using an established trauma system network facilitates the care of victims of natural disasters or terrorist attacks...