Pinchas Cohen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Insulin-like growth factor binding protein-3: insulin-like growth factor independence comes of age
    Pinchas Cohen
    Division of Pediatric Endocrinology, Mattel Children s Hospital, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Endocrinology 147:2109-11. 2006
  2. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
  3. ncbi request reprint Controversy in clinical endocrinology: problems with reclassification of insulin-like growth factor I production and action disorders
    Pinchas Cohen
    Mattel Children s Hospital, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1752, USA
    J Clin Endocrinol Metab 91:4235-6. 2006
  4. doi request reprint Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels
    Pinchas Cohen
    Department of Paediatric Endocrinology, Mattel Children s Hospital at UCLA, Los Angeles, CA 90095, USA
    Clin Endocrinol (Oxf) 78:405-14. 2013
  5. ncbi request reprint Transforming growth factor-beta induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells: abnormalities in cells cultured from benign prostatic hyperplasia tissues
    P Cohen
    Pediatric Endocrinology, UCLA, Los Angeles, California 90095, USA
    J Endocrinol 164:215-23. 2000
  6. doi request reprint Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children
    Pinchas Cohen
    Pediatric Endocrinology, Mattel Children s Hospital at University of California, Los Angeles, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 95:2089-98. 2010
  7. doi request reprint Optimizing growth hormone dosing in children with idiopathic short stature
    Jyotsna Keni
    Pediatric Endocrinology, Mattel Children s Hospital and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, Calif, USA
    Horm Res 71:70-4. 2009
  8. doi request reprint Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop
    P Cohen
    Department of Endocrinology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue MDCC 22 315, Los Angeles, California 90095 1752, USA
    J Clin Endocrinol Metab 93:4210-7. 2008
  9. ncbi request reprint Overview of the IGF-I system
    Pinchas Cohen
    Pediatric Endocrinology, UCLA, Los Angeles, CA 90095 1752, USA
    Horm Res 65:3-8. 2006
  10. ncbi request reprint Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy
    Omar Ali
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, Los Angeles, Calif 90095, USA
    Horm Res 60:115-23. 2003

Research Grants

  1. IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    Pinchas Cohen; Fiscal Year: 2007
  2. IGF AXIS IN ASTHMA
    Pinchas Cohen; Fiscal Year: 2002
  3. Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    Pinchas Cohen; Fiscal Year: 2004
  4. The Role of IGF2 in Fetal Growth Restriction
    Pinchas Cohen; Fiscal Year: 2008

Detail Information

Publications99

  1. ncbi request reprint Insulin-like growth factor binding protein-3: insulin-like growth factor independence comes of age
    Pinchas Cohen
    Division of Pediatric Endocrinology, Mattel Children s Hospital, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Endocrinology 147:2109-11. 2006
  2. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
    ....
  3. ncbi request reprint Controversy in clinical endocrinology: problems with reclassification of insulin-like growth factor I production and action disorders
    Pinchas Cohen
    Mattel Children s Hospital, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1752, USA
    J Clin Endocrinol Metab 91:4235-6. 2006
    ..Recent developments in the IGF field have raised questions on whether this is the right time to redefine IGF deficiency...
  4. doi request reprint Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels
    Pinchas Cohen
    Department of Paediatric Endocrinology, Mattel Children s Hospital at UCLA, Los Angeles, CA 90095, USA
    Clin Endocrinol (Oxf) 78:405-14. 2013
    ..The current study validates the usefulness of IGF-based GH dosing for GH therapy in nonGH-deficient (nonGHD) children and its relationship with pretreatment serum IGF-I concentration...
  5. ncbi request reprint Transforming growth factor-beta induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells: abnormalities in cells cultured from benign prostatic hyperplasia tissues
    P Cohen
    Pediatric Endocrinology, UCLA, Los Angeles, California 90095, USA
    J Endocrinol 164:215-23. 2000
    ....
  6. doi request reprint Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children
    Pinchas Cohen
    Pediatric Endocrinology, Mattel Children s Hospital at University of California, Los Angeles, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 95:2089-98. 2010
    ..We recently showed that, in IGF-based GH therapy, the IGF-I target chosen affects GH dose requirements, and higher IGF-I targets are associated with more robust growth parameters...
  7. doi request reprint Optimizing growth hormone dosing in children with idiopathic short stature
    Jyotsna Keni
    Pediatric Endocrinology, Mattel Children s Hospital and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, Calif, USA
    Horm Res 71:70-4. 2009
    ....
  8. doi request reprint Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop
    P Cohen
    Department of Endocrinology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue MDCC 22 315, Los Angeles, California 90095 1752, USA
    J Clin Endocrinol Metab 93:4210-7. 2008
    ..Our objective was to summarize important advances in the management of children with idiopathic short stature (ISS)...
  9. ncbi request reprint Overview of the IGF-I system
    Pinchas Cohen
    Pediatric Endocrinology, UCLA, Los Angeles, CA 90095 1752, USA
    Horm Res 65:3-8. 2006
  10. ncbi request reprint Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy
    Omar Ali
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, Los Angeles, Calif 90095, USA
    Horm Res 60:115-23. 2003
    ..As in other indications for GH, a rational monitoring approach (focusing on maintaining IGF levels in the high normal range) is prudent...
  11. ncbi request reprint Does the GH-IGF axis play a role in cancer pathogenesis?
    P Cohen
    Department of Pediatrics, Mattel Children s Hospital, UCLA, Los Angeles, CA 90095 1752, USA
    Growth Horm IGF Res 10:297-305. 2000
    ..At present, the data that are available do not warrant a change in our current management of approved indications for GH therapy...
  12. ncbi request reprint Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study
    Pinchas Cohen
    Department of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 92:2480-6. 2007
    ..Weight-based dosing of GH is the standard of care for short children, although IGF-I is thought to be the main mediator of GH actions on growth...
  13. ncbi request reprint Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety
    Pinchas Cohen
    Department of Pediatrics, University of California Los Angeles, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 87:90-8. 2002
    ..These results suggest that the efficacy and theoretical safety of GH therapy can be optimized by modulating the GH dose in a gender-specific manner, based on the growth response and serum growth factor levels...
  14. ncbi request reprint Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital at University of California at Los Angeles, David Geffen School of Medicine, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, CA 90095, USA
    Carcinogenesis 28:1653-8. 2007
    ..Taken together, our results verify an important role for the orphan nuclear receptor Nur77 in the apoptotic actions of IGFBP-3...
  15. pmc Humanin: a harbinger of mitochondrial-derived peptides?
    Changhan Lee
    University of Southern California Davis School of Gerontology, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    Trends Endocrinol Metab 24:222-8. 2013
    ..The study of humanin and other mitochondrial-derived retrograde signal peptides will aid in the identification of genes and peptides with therapeutic and diagnostic potential in treating human diseases...
  16. ncbi request reprint Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 280:16942-8. 2005
    ..This unique nongenotropic nuclear pathway supports an emerging role for IGFBP-3 as a novel, multicompartmental signaling molecule involved in induction of apoptosis in malignant cells...
  17. pmc Chemoprevention of prostate cancer with lycopene in the TRAMP model
    Ramdev Konijeti
    Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Prostate 70:1547-54. 2010
    ..We hypothesized that tomato paste would have greater chemopreventive effects in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice relative to equivalent lycopene doses provided from lycopene beadlets...
  18. pmc Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis
    Yue Jia
    Division of Endocrinology, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    J Biol Chem 285:1726-32. 2010
    ..This represents a novel pathway regulating germ call homeostasis that may have significance for male fertility and testicular disease...
  19. pmc Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation
    Laura J Cobb
    Division of Pediatric Endocrinology, Mattel Children s Hospital at University of California, Los Angeles, California, USA
    Mol Endocrinol 23:1624-33. 2009
    ..Understanding such intrinsic regulation of IGFBP-3 action may enhance the development of potential cancer therapies...
  20. pmc Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts
    Ramdev Konijeti
    Department of Urology, School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Mol Cancer Ther 11:1539-46. 2012
    ..Whereas the combination of low-fat diet and IGF-1R blockade did not have additive inhibitory effects on tumor weight, it led to reduced tumor cell proliferation and a reduction in serum insulin and TNF-α levels...
  21. pmc Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression
    Makoto Anzo
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 68:3342-9. 2008
    ....
  22. ncbi request reprint Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival
    Tung H Ngo
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    Endocrinology 144:2319-24. 2003
    ..DE results in a decrease in serum IGF-I with increased IGFBP-1 in vivo that is associated with apoptosis and reduced LNCaP and LAPC-4 prostate cancer cell growth in vitro...
  23. ncbi request reprint Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo
    Bingrong Liu
    Division of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, California, USA
    Clin Cancer Res 11:4851-6. 2005
    ..Taken together, these observations suggest that combination therapy with IGFBP-3 and RXR ligands may have therapeutic potential for prostate cancer treatment...
  24. pmc Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model
    Ashley Gray
    Department of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, California, USA
    J Endocrinol 211:297-304. 2011
    ..Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass. Further studies are required to understand the underlying mechanisms for these metabolic effects...
  25. doi request reprint Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis
    Yanhe Lue
    Division of Endocrinology, Department of Medicine, Los Angeles Biomedical Research Institute and Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 151:350-7. 2010
    ..Perturbation of this interaction is important in enhancing or preventing germ cell death, providing new targets for future therapies...
  26. pmc Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism
    Yong Fan
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 284:19937-44. 2009
    ..We propose that circulating IGF-I serves to amplify the growth-promoting effects of GH, while simultaneously dampening the catabolic effects of GH...
  27. ncbi request reprint Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:469-76. 2004
    ..Suppression of IGFBP-3 internalization by TfR1 blockade inhibited IGFBP-3-induced apoptosis. Together, these data indicate that the actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways...
  28. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
    ..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity...
  29. pmc Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer
    William J Aronson
    Urology Section, Department of Surgery, Veterans Administration, Greater Los Angeles Healthcare System, Los Angeles, California 90095 1738, USA
    J Urol 183:345-50. 2010
    ..We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer...
  30. pmc IGFBP-3 is a metastasis suppression gene in prostate cancer
    Hemal H Mehta
    Mattel Children s Hospital, CA, USA
    Cancer Res 71:5154-63. 2011
    ....
  31. ncbi request reprint Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis
    Tung H Ngo
    Departments of Physiological Science, University of California, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 9:2734-43. 2003
    ....
  32. pmc PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions
    Kenichi Miyako
    David Geffen School of Medicine at University of California, Los Angeles, California 90095 1752, USA
    Mol Endocrinol 23:169-75. 2009
    ..These studies suggest that the growth-promoting role of IGFBP-2 in prostate cancer is inhibited by its intracellular interaction with PAPA-1...
  33. pmc Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis
    Satomi Koyama
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, University of California, Los Angeles, USA
    Growth Horm IGF Res 20:55-62. 2010
    ..These studies revealed novel interactions between the IGF system and pomegranate-induced apoptosis...
  34. pmc IGFBP-3 nuclear localization predicts human prostate cancer recurrence
    David B Seligson
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1738, USA
    Horm Cancer 4:12-23. 2013
    ..High nuclear IGFBP-3 is amongst the strongest predictors of cancer recurrence in patients with low-grade prostate cancers and may therefore play an important role in risk stratification...
  35. pmc Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
    Edoardo Parrella
    Longevity Institute, Davis School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Aging Cell 12:257-68. 2013
    ..These results indicate that periodic protein restriction cycles without CR can promote changes in circulating growth factors and tau phosphorylation associated with protection against age-related neuropathologies...
  36. pmc Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA)
    Junxiang Wan
    Department of Pediatrics, University of California, Los Angeles, Los Angeles, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
    J Clin Endocrinol Metab 98:E77-81. 2013
    ....
  37. pmc Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy
    William J Aronson
    Department of Urology, School of Medicine, University of California Los Angeles, Box 951738, Los Angeles, CA 90095, USA
    Cancer Prev Res (Phila) 4:2062-71. 2011
    ..These results support further studies evaluating reduction of dietary fat with fish oil supplementation on modulating prostate cancer biology...
  38. ncbi request reprint A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer
    R James Barnard
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1606, USA
    Eur J Cancer Prev 16:415-21. 2007
    ....
  39. ncbi request reprint Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3
    Laura J Cobb
    Division of Pediatric Endocrinology, Mattel Children s Hospital at University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
    Cancer Res 66:10878-84. 2006
    ..These studies reveal a novel regulatory mechanism for the actions of IGFBP-3 in prostate cancer and show phosphorylation of Ser(156) to be functionally critical in its apoptosis-inducing actions...
  40. pmc Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
    Changhan Lee
    Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, Los Angeles, California 90089 0191, USA
    Cancer Res 70:1564-72. 2010
    ..We conclude that normal cells and mice can be protected against chemotherapy-dependent damage by reducing circulating IGF-I levels and by a mechanism that involves downregulation of proto-oncogene signals...
  41. pmc Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model
    Naoko Kobayashi
    Department of Urology, School of Medicine, University of California, Los Angeles, CA 90095 1738, USA
    Cancer Res 68:3066-73. 2008
    ..We conclude that dietary fat reduction delays transition from mPIN to invasive cancer in this Myc-driven transgenic mouse model, possibly through suppression of the IGF-Akt pathway and decreased proliferation of mPIN epithelial cells...
  42. pmc Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts
    Colette Galet
    Department of Urology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Mol Sci 14:13782-95. 2013
    ..In conclusion, whereas ganitumab therapy modestly affected 22Rv1 tumor growth, combining IGF-1R blockade with calorie restriction resulted in a significant decrease in final tumor weight and improved metabolic profile. ..
  43. pmc The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice
    Phuong T Hoang
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Metabolism 59:343-9. 2010
    ..This indicates that Humanin may be useful for islet protection and survival in a spectrum of diabetes-related therapeutics...
  44. pmc Fasting and cancer treatment in humans: A case series report
    Fernando M Safdie
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Aging (Albany NY) 1:988-1007. 2009
    ..Only controlled-randomized clinical trials will determine the effect of fasting on clinical outcomes including quality of life and therapeutic index...
  45. pmc p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia
    Adda Grimberg
    Division of Pediatric Endocrinology, The Children s Hospital of Philadelphia, Abramson Research Center, Room 802, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 4318, USA
    J Clin Endocrinol Metab 90:3568-74. 2005
    ..Because IGFBP-3 can inhibit growth and induce apoptosis in IGF-dependent and IGF-independent manners, its induction by DNA damage and hypoxia suggest IGFBP-3 plays a role in the physiologic protection against aberrant cell growth...
  46. doi request reprint Prepubertal children with growth hormone deficiency treated for four years with growth hormone experience dose-dependent increase in height, but not in the rate of puberty initiation
    Alan D Rogol
    Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, USA
    Horm Res Paediatr 80:28-37. 2013
    ..The effect of low, intermediate, and high-dose rhGH (25, 50, and 100 μg/kg/day, respectively) on growth and puberty in children with GHD was investigated for 48 months...
  47. pmc Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells
    Melanie L Shim
    Department of Pediatrics, Division of Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, The University of California, Los Angeles, CA 90095 1752, USA
    Growth Horm IGF Res 14:216-25. 2004
    ..In conclusion, we have presented the first evidence that IGFBP-3 contributes to cytokine-mediated apoptosis in insulin-secreting cells...
  48. pmc Pharmacodynamic considerations with recombinant human insulin-like growth factor-I in children
    Robert J Ferry
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, Tex, USA
    Horm Res 63:220-7. 2005
    ..To report effects of weight-based recombinant human insulin-like growth factor-I (rhIGF-I) on IGF axis parameters in children with hyperinsulinism...
  49. ncbi request reprint Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells
    Michael G Moore
    Division of Pediatric Endocrinology, University of California at Los Angeles Medical Center, Los Angeles, CA, USA
    Int J Cancer 105:14-9. 2003
    ....
  50. pmc Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
    Laura J Cobb
    Department of Pediatrics, Mattel Children s Hospital, and Division of Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Aging (Albany NY) 8:796-809. 2016
    ..These results suggest that mitochondria play critical roles in metabolism and survival through the synthesis of mitochondrial peptides, and provide new insights into mitochondrial biology with relevance to aging and human biology. ..
  51. pmc Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
    Maaria Ikonen
    Department of Pediatrics, Mattel Children s Hospital, University of California, Los Angeles, CA 90095
    Proc Natl Acad Sci U S A 100:13042-7. 2003
    ..This interaction may prove to be important in neurological disease processes and could provide important targets for drug development...
  52. ncbi request reprint Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study
    Omar Ali
    David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 92:932-7. 2007
    ....
  53. ncbi request reprint The role of insulin-like growth factor I monitoring in growth hormone-treated children
    Patricia Park
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, Los Angeles, CA 90095 1752, USA
    Horm Res 62:59-65. 2004
    ..This review proposes a role for insulin-like growth factor I measurement in optimizing GH dosing...
  54. ncbi request reprint Type Ialpha collagen is an IGFBP-3 binding protein
    Bingrong Liu
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Growth Horm IGF Res 13:89-97. 2003
    ..Physiological effects of IGFBP-3-collagen interactions may include modulation of cell adhesion and migration...
  55. ncbi request reprint Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States)
    Tung H Ngo
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Cancer Causes Control 13:929-35. 2002
    ..This study was conducted to determine whether a low-fat diet and exercise (DE) intervention may modulate the IGF axis and reduce prostate cancer cell growth in vitro...
  56. ncbi request reprint Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 87:4817-20. 2002
    ..04), whereas IGFBP-3 correlated positively with insulin resistance in boys (P = 0.0004) but not girls (P = 0.85). These data suggest that the GH/IGF-I axis is an important contributor to the insulin resistance of puberty...
  57. pmc Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression
    Pei Liang
    Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California
    Prostate 76:1293-302. 2016
    ..Given the importance of tumor-associated macrophages (TAMs) in carcinogenesis, we hypothesized that a fish oil-based diet will inhibit TAM infiltration and delay the growth of prostate cancer...
  58. pmc IGF-I regulates the age-dependent signaling peptide humanin
    Changhan Lee
    Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA
    Aging Cell 13:958-61. 2014
    ..This suggests that humanin represents a circulating mitochondrial signal that participates in modulating the aging process, adding a coordinated mitochondrial element to the endocrine regulation of aging. ..
  59. pmc Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
    Sofiya Milman
    Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA
    Aging Cell 13:769-71. 2014
    ..01) and individuals with a history of cancer (P < 0.01). We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals. ..
  60. ncbi request reprint Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action
    Radhika H Muzumdar
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, New York, USA
    Diabetes 55:2788-96. 2006
    ..Marked, opposing, and independent physiological effects of IGF-I and IGFBP-3 through central mechanisms may have implications on potential strategies in specific modulation of peripheral insulin action...
  61. pmc Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations
    Pinchas Cohen
    University of Southern California, Los Angeles, CA, USA
    Clin Endocrinol (Oxf) 81:71-6. 2014
    ..The objective was to assess the dose-sparing effect and theoretical safety of IGF-I-based GH therapy...
  62. pmc IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice
    Gordon Moody
    Oncology Research Therapeutic Area, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA David Geffen School of Medicine, Los Angeles, California, USA USC Davis School of Gerontology, Los Angeles, California, USA
    J Endocrinol 221:145-55. 2014
    ....
  63. pmc Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy
    Colette Galet
    Department of Urology, University of California Los Angeles, Box 951738, Los Angeles, CA 90095 1738
    Cancer Prev Res (Phila) 7:97-104. 2014
    ..Further studies are warranted to determine whether the LFFO diet antiproliferative effects are mediated through the LTB4/BLT1 and 15(S)-HETE pathways...
  64. ncbi request reprint Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, Pediatric Endocrinology, University of California at Los Angeles School of Medicine, USA
    Blood 104:237-42. 2004
    ..Taken together, these results indicate that IGFBP-3 has antiproliferative activity against myeloid leukemia cells; while it enhances signaling through RXR/RXR, it blunts signaling by activated RAR/RXR...
  65. ncbi request reprint Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee
    Thomas A Wilson
    Division of Pediatric Endocrinology, State University of New York at Stony Brook, Stony Brook, NY 11794 8111, USA
    J Pediatr 143:415-21. 2003
  66. ncbi request reprint Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS)
    Patricia Park
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, CA 90095 1752, USA
    Growth Horm IGF Res 15:S13-20. 2005
    ....
  67. pmc The emerging role of the mitochondrial-derived peptide humanin in stress resistance
    Kelvin Yen
    USC Davis School of Gerontology, University of Southern California, Los Angeles, California 90089 0191, USA
    J Mol Endocrinol 50:R11-9. 2013
    ..In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action...
  68. pmc IGFBP-3 mediates p53-induced apoptosis during serum starvation
    Adda Grimberg
    Division of Pediatric Endocrinology, The Children s Hospital of Philadelphia, Abramson Research Center, Philadelphia, PA 19104, USA
    Int J Oncol 21:327-35. 2002
    ..This is the first demonstration of inhibition of p53 action by antagonizing IGFBP-3...
  69. ncbi request reprint Is treatment with growth hormone effective in children with cerebral palsy?
    Melanie L Shim
    Division of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, 10833 Le ConteAvenue MDCC 22 315, Los Angeles, CA 90095, USA
    Dev Med Child Neurol 46:569-71. 2004
    ..Growth improved to a greater extent in the two children with apparent GH deficiency. In summary, it is felt that GH therapy might be beneficial for children with CP and warrants further investigation...
  70. ncbi request reprint IGFs and IGFBPs: role in health and disease
    Roshanak Monzavi
    Mattel Children s Hospital, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, CA 90095 1752, USA
    Best Pract Res Clin Endocrinol Metab 16:433-47. 2002
    ....
  71. ncbi request reprint Individualized growth hormone therapy in children: advances beyond weight-based dosing
    Kuk Wha Lee
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Pediatr Endocrinol Metab 16:625-30. 2003
    ..This approach, studied in large prospective randomized trials, will lead to better patient responses and fewer long-term complications...
  72. pmc Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival
    Sherry Lynn Franklin
    Division of Pediatric Endocrinology and Diabetes, Mattel Children s Hospital, University of California, Los Angeles, California 90095 1752, USA
    J Clin Endocrinol Metab 88:900-7. 2003
    ..VEGF-induced phosphorylation of Akt, as evident by both specific immunoblots and confocal microscopy, was significantly and rapidly reduced in the presence of IGFBP-3, as well as wortmannin...
  73. ncbi request reprint The role of the insulin-like growth factor system in prenatal growth
    Ruvdeep Randhawa
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Genet Metab 86:84-90. 2005
    ....
  74. ncbi request reprint Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation
    Roopmathy Rajah
    Department of Pediatrics, Mattel Children s Hospital at UCLA, 90095, USA
    Cell Growth Differ 13:163-71. 2002
    ..These findings confirm that IGFBP-3 is essential for TNF-alpha-induced apoptosis in PC-3 cells and that this IGFBP-3 effect includes the inactivation of Bcl-2 through serine phosphorylation...
  75. pmc Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit
    David L Hwang
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Growth Horm IGF Res 18:65-74. 2008
    ..Therefore, we developed and validated immunoaassays for murine IGF-I, IGFBP-3 and ALS and studied levels of these analytes in mice...
  76. ncbi request reprint The somatomedin hypothesis 2007: 50 years later
    Solomon A Kaplan
    Department of Pediatrics, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095 1752, USA
    J Clin Endocrinol Metab 92:4529-35. 2007
    ..In this paper, we propose an augmentative/counteractive modification of the existing hypothesis that takes into account all the actions of the GH-IGF system...
  77. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...
  78. ncbi request reprint Control of aging and longevity by IGF-I signaling
    Joshua Yang
    Division of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Exp Gerontol 40:867-72. 2005
    ..Specifically, it is possible that lower levels of IGF-I during early adulthood followed by higher levels of IGF-I later in life may be most beneficial for human longevity by addressing age-specific morbidities...
  79. ncbi request reprint Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children
    Toshiaki Tanaka
    Department of Endocrinology and Metabolism, National Children s Medical Research Center, Tokyo, Japan
    Growth Horm IGF Res 12:323-41. 2002
  80. ncbi request reprint Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency
    Stephen Rosenthal
    Pediatrics, University of California at San Francisco, San Francisco, California, USA
    Pediatr Endocrinol Rev 4:252-71. 2007
  81. ncbi request reprint Spinal bone mineral density, IGF-1 and IGFBP-3 in children with cerebral palsy
    Omar Ali
    Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Horm Res 68:316-20. 2007
    ..We studied the relationship between spinal bone mineral density (BMD) and serum IGF-1 and IGFBP-3 in children with CP...
  82. ncbi request reprint The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone
    Shoshana Yakar
    National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
    J Endocrinol 189:289-99. 2006
    ..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)...
  83. ncbi request reprint Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3
    Mohammed Oufattole
    Department of Animal Sciences, Washington State University, Pullman, 99164 6351, USA
    Endocrinology 147:2138-46. 2006
    ..Its association with IGFBP-3 provides a functional role for IGFBP-3 in the direct modulation of gene transcription...
  84. ncbi request reprint Advances in pediatric growth hormone therapy: IGF-I-based dosing
    Anna Pawlikowska-Haddal
    Indian Pediatr 43:577-81. 2006
  85. ncbi request reprint Statement 1: a serum insulin-like growth factor I (IGF-I) level should be part of the evaluation of children with short stature
    Pinchas Cohen
    Mattel Children s Hospital at UCLA David Geffen School of Medicine at UCLA Los Angeles, California, USA
    Pediatr Endocrinol Rev 5:834-6. 2008
  86. pmc Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina 27710, USA
    Prostate 68:11-9. 2008
    ..Recent evidence suggests carbohydrate intake may influence prostate cancer biology. We tested whether a no-carbohydrate ketogenic diet (NCKD) would delay prostate cancer growth relative to Western and low-fat diets in a xenograft model...
  87. ncbi request reprint Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:7735-42. 2005
    ..However, hormonal activity and diets vary between races. We examined whether height was significantly associated with biochemical progression following radical prostatectomy and whether there was an interaction between height and race...
  88. pmc SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice
    Feng Ding
    Department of Genetics, Stanford University, Stanford, California, USA
    PLoS ONE 3:e1709. 2008
    ..Prolonged mealtime and increased circulating ghrelin indicate a defect in meal termination mechanism. Snord116del mice, the first snoRNA deletion animal model, reveal a novel role for a non-coding RNA in growth and feeding regulation...
  89. ncbi request reprint Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
    Endocrinology 146:1523-31. 2005
    ..The higher levels of IGF-I and murine IGFBP-3 in the 5012 Tg strain suggest that the growth inhibitory effect of mutant IGFBP-3 may be compensated for by other mechanisms...
  90. ncbi request reprint Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo
    Hae Soon Kim
    Department of Pediatrics, Ewha Womans University, Seoul, 120 750 Korea
    Pediatr Res 61:159-64. 2007
    ....
  91. pmc EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    Alexandre Prieur
    Laboratoire de Pathologie Moléculaire des Cancers, INSERM U509, Section de Recherche, Institut Curie, 75248 Paris, France
    Mol Cell Biol 24:7275-83. 2004
    ..Finally, IGFBP-3-induced Ewing cell apoptosis relies on both IGF-1-dependent and -independent pathways. These findings therefore identify the repression of IGFBP-3 as a key event in the development of Ewing's sarcoma...
  92. pmc Functionally significant insulin-like growth factor I receptor mutations in centenarians
    Yousin Suh
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:3438-42. 2008
    ..Thus, genetic alterations in the human IGF1R that result in altered IGF signaling pathway confer an increase in susceptibility to human longevity, suggesting a role of this pathway in modulation of human lifespan...
  93. ncbi request reprint Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model
    Komal Raina
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cancer Res 67:11083-91. 2007
    ....
  94. ncbi request reprint A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation
    Andrei M Mikheev
    Program in Cancer Biology, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
    Carcinogenesis 25:47-59. 2004
    ..Taken together, our results indicate that somatic cell genetics combining with gene expression profiling may be a useful approach for the identification of functional suppressors of malignant cell growth...
  95. ncbi request reprint Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells
    Lawrence A Wetterau
    Columbus Children s Hospital, Ohio State University College of Medicine, Columbus, Ohio 43205, USA
    J Clin Endocrinol Metab 88:3354-9. 2003
    ....
  96. ncbi request reprint Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 62:3530-7. 2002
    ....
  97. ncbi request reprint Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model
    David J Degraff
    Laboratory for Cancer Ontogeny and Therapeutics, Department of Biological Sciences, University of Delaware, Newark, Deleware 19716, USA
    J Cell Physiol 213:261-8. 2007
    ..Furthermore, our results suggest that either increased levels of intact IGFBP-2 or decreased levels of IGFBP-2 proteolytic fragments could serve as a biomarker to monitor for progression to AI-PCa...
  98. ncbi request reprint Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma
    Stefania Benini
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int J Cancer 119:1039-46. 2006
    ..IGFBP-3 acts mainly through IGF-dependent mechanisms and the protein may therefore represent an alternative strategy to inhibit IGF-IR functions. The data indicate IGFBP-3 as a molecule of therapeutic potential in EWS...
  99. ncbi request reprint Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Pediatr Nephrol 20:255-60. 2005
    ..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...

Research Grants4

  1. IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    Pinchas Cohen; Fiscal Year: 2007
    ....
  2. IGF AXIS IN ASTHMA
    Pinchas Cohen; Fiscal Year: 2002
    ..We believe that these studies may help us understand the dis-regulated growth of asthmatic airway smooth muscle and allow us to optimize our therapeutic approaches to this disease. ..
  3. Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    Pinchas Cohen; Fiscal Year: 2004
    ..If successful our findings may validate novel targets for clinical therapy development for use in men with CaP. ..
  4. The Role of IGF2 in Fetal Growth Restriction
    Pinchas Cohen; Fiscal Year: 2008
    ..abstract_text> ..