Robert A Clark

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Activation of the neutrophil respiratory burst oxidase
    R A Clark
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7870, USA
    J Infect Dis 179:S309-17. 1999
  2. ncbi request reprint Regulation of calreticulin expression during induction of differentiation in human myeloid cells. Evidence for remodeling of the endoplasmic reticulum
    Robert A Clark
    Department of Medicine, South Texas Veterans Health Care System and University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 277:32369-78. 2002
  3. ncbi request reprint Nuclear factor kappa B activation by NADPH oxidases
    Robert A Clark
    Department of Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229 3900, USA
    Mech Ageing Dev 125:799-810. 2004
  4. ncbi request reprint Mechanisms of activation of NADPH oxidases
    Robert A Clark
    Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, Texas, USA
    Jpn J Infect Dis 57:S22-3. 2004
  5. pmc Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
    Syed Z Imam
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 31:157-63. 2011
  6. pmc Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Free Radic Biol Med 60:125-35. 2013
  7. pmc Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, and South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 48:798-810. 2010
  8. pmc Role of CCL3L1-CCR5 genotypes in the epidemic spread of HIV-1 and evaluation of vaccine efficacy
    Hemant Kulkarni
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA
    PLoS ONE 3:e3671. 2008
  9. pmc Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:868-81. 2008
  10. pmc Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy
    Tuan Le
    Veterans Affairs Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA
    N Engl J Med 368:218-30. 2013

Research Grants

Detail Information

Publications42

  1. ncbi request reprint Activation of the neutrophil respiratory burst oxidase
    R A Clark
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7870, USA
    J Infect Dis 179:S309-17. 1999
    ....
  2. ncbi request reprint Regulation of calreticulin expression during induction of differentiation in human myeloid cells. Evidence for remodeling of the endoplasmic reticulum
    Robert A Clark
    Department of Medicine, South Texas Veterans Health Care System and University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 277:32369-78. 2002
    ....
  3. ncbi request reprint Nuclear factor kappa B activation by NADPH oxidases
    Robert A Clark
    Department of Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229 3900, USA
    Mech Ageing Dev 125:799-810. 2004
    ..Collectively, these studies demonstrate the potential for NADPH-dependent induction of NF-kappaB and raise the possibility of a role for this pathway in the biology of aging...
  4. ncbi request reprint Mechanisms of activation of NADPH oxidases
    Robert A Clark
    Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, Texas, USA
    Jpn J Infect Dis 57:S22-3. 2004
    ..Finally, we have provided the first example of how alternative splicing of a NOX co-factor may be involved in the regulation of NADPH oxidase function...
  5. pmc Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
    Syed Z Imam
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 31:157-63. 2011
    ..Moreover, inhibition of c-Abl offers new therapeutic opportunities for blocking PD progression...
  6. pmc Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Free Radic Biol Med 60:125-35. 2013
    ..Thus TRAF3IP2 may represent a potential therapeutic target in ischemic heart disease...
  7. pmc Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, and South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 48:798-810. 2010
    ..This positive feedback regulatory pathway has important implications for amplifying the innate immune response and contributing to oxidative stress in inflammatory disorders...
  8. pmc Role of CCL3L1-CCR5 genotypes in the epidemic spread of HIV-1 and evaluation of vaccine efficacy
    Hemant Kulkarni
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA
    PLoS ONE 3:e3671. 2008
    ..Here, we mathematically modeled the potential impact of these genetic factors on the epidemic spread of HIV, as well as on its prevention...
  9. pmc Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:868-81. 2008
    ..Our data demonstrate for the first time that NOX5 is activated by c-Abl through a Ca(2+)-mediated, redox-dependent signaling pathway and suggest a functional association between NOX5 NADPH oxidase and c-Abl...
  10. pmc Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy
    Tuan Le
    Veterans Affairs Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA
    N Engl J Med 368:218-30. 2013
    ..The relationship between the timing of the initiation of antiretroviral therapy (ART) after infection with human immunodeficiency virus type 1 (HIV-1) and the recovery of CD4+ T-cell counts is unknown...
  11. ncbi request reprint Regulation of NOX1 expression by GATA, HNF-1alpha, and Cdx transcription factors
    Anthony J Valente
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:430-43. 2008
    ..The expression gradients of NOX1 mRNA in the colon paralleled those of GATA-6, HNF-1alpha, and Cdx1. These data indicate that developmental, tissue-restricted transcription factors play a key role in NOX1 regulation in vivo...
  12. pmc The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry
    Hemant Kulkarni
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, USA
    Blood 114:2783-92. 2009
    ....
  13. pmc Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease
    Kc Biju
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Ther 18:1536-44. 2010
    ..These results indicate that macrophage-mediated GDNF delivery is a promising strategy for developing a neuroprotective therapy for PD...
  14. pmc HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles
    Gabriel Catano
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, TX, USA
    PLoS ONE 3:e3636. 2008
    ....
  15. doi request reprint Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge
    Sunil K Ahuja
    Veterans Administration Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, TX78229 Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78229 Microbiology and Immunology, University of Texas Health Science Center at San Antonio, TX 78229 Biochemistry, University of Texas Health Science Center at San Antonio, TX 78229 Electronic address
    J Allergy Clin Immunol . 2016
    ..Conceivably, the immunologic and genomic footprint of this resistance is preserved in nonatopic, nonallergic adults and is unmasked during exposure to an aeroallergen...
  16. pmc Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates
    Gabriel Catano
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA
    J Infect Dis 203:263-72. 2011
    ....
  17. ncbi request reprint NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain
    Anthony J Valente
    Department of Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, Audie L Murphy Division, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 43:384-96. 2007
    ..These studies demonstrate that, in reconstituted NOX1/NOXO1/NOXA1 systems, the NOXA1 SH3 domain is not required for function but, when present, can critically modulate the activity of the enzyme system...
  18. pmc Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease
    K C Biju
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Neurosci Lett 535:24-9. 2013
    ..Thus, bone marrow-derived microglia can serve as cellular vehicles for sustained delivery of neurotrophic factors capable of mitigating dopaminergic injury...
  19. pmc Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18
    Anthony J Valente
    Medicine, University of Texas Health Science Center, San Antonio, USA
    Am J Physiol Heart Circ Physiol 303:H282-96. 2012
    ..The ANG II/Nox1/IL-18 pathway may be critical in hyperplastic vascular diseases, including atherosclerosis and restenosis...
  20. pmc CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy
    Anthony J Valente
    Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    J Mol Cell Cardiol 53:113-24. 2012
    ..CIKS is a potential therapeutic target in cardiac hypertrophy, fibrosis, and congestive heart failure...
  21. ncbi request reprint The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Science 307:1434-40. 2005
    ....
  22. ncbi request reprint Multiple PU.1 sites cooperate in the regulation of p40(phox) transcription during granulocytic differentiation of myeloid cells
    Sen lin Li
    Department of Medicine, University of Texas Health Science Center and the South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, 78229 3900, USA
    Blood 99:4578-87. 2002
    ..1 binding at multiple sites is required for p40(phox) gene transcription in myeloid cells and that granulocytic differentiation is associated with the coordinated up-regulation of PU.1 and p40(phox) expression...
  23. ncbi request reprint NAD(P)H oxidases regulate HIF-2alpha protein expression
    Karen Block
    Division of Nephrology, Department of Medicine, George O Brien Kidney Research Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 282:8019-26. 2007
    ..Collectively, the data demonstrate that VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation...
  24. pmc WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death
    Kaliyamurthi Venkatachalam
    Department of Veterans Affairs, South Texas Veterans Health Care System, TX 78229, USA
    J Biol Chem 284:14414-27. 2009
    ..Our results suggest that a TNF-alpha/WISP1 signaling pathway may contribute to post-infarct cardiac remodeling, a condition characterized by fibrosis and progressive cardiomyocyte loss...
  25. doi request reprint Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen
    Weijing He
    Veterans Administration Center for Personalized Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, Tex Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex
    J Allergy Clin Immunol 136:658-66. 2015
    ..The hygiene hypothesis implicates childhood microbial exposure as a protective factor. Cockroach sensitization (C+) might be a proxy for microbial exposure...
  26. pmc CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals
    Sunil K Ahuja
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, 7400 Merton Minter, San Antonio, Texas 78229, USA
    Nat Med 14:413-20. 2008
    ..Furthermore, as reconstitution of CD4(+) cells during HAART is more sensitive to CCL3L1 dose than to CCR5 genotypes, CCL3L1 analogs might be efficacious in supporting immunological reconstitution...
  27. ncbi request reprint Infected cardiac myxoma. Case report and literature review
    S G Revankar
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284, USA
    Medicine (Baltimore) 77:337-44. 1998
    ..Echocardiography, especially by the transesophageal approach, is the diagnostic procedure of choice, and sensitivity approaches 100%. Surgical excision is curative and generally has low morbidity and mortality...
  28. pmc Multimodal MRI Evaluation of the MitoPark Mouse Model of Parkinson's Disease
    Linlin Cong
    Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 11:e0151884. 2016
    ..Multimodal MRI may prove useful for evaluating neuroanatomical correlates of PD pathophysiology in MitoPark mice, and for longitudinally monitoring disease progression and therapeutic interventions for PD. ..
  29. pmc Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet
    Alvaro Souto Padron de Figueiredo
    From the Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900
    J Biol Chem 290:13427-39. 2015
    ..This is the first report to show that Nox2 is a key mediator of insulin resistance in skeletal muscle. ..
  30. pmc Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model
    Syed Z Imam
    Division of Neurotoxicology, US FDA National Center for Toxicological Research, Jefferson, Arkansas, United States of America
    PLoS ONE 8:e65129. 2013
    ..We propose that compounds of the INNO-406 class of Abl inhibitors will be useful new neuroprotective drugs for the treatment of PD-like pathology in preclinical systems that should be easily translated to the clinic...
  31. ncbi request reprint Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 283:4200-9. 2008
    ..Thus, targeting IL-18 expression may enhance adiponectin expression and mitigate disease progression...
  32. pmc Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor
    German G Gornalusse
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, TX 78229 Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, TX 78229 Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 Department of Microbiology, University of Texas Health Science Center, San Antonio, TX 78229
    Proc Natl Acad Sci U S A 112:E4762-71. 2015
    ..Thus, methylation content of CCR5 cis-regions is a central epigenetic determinant of T-cell CCR5 levels, and possibly HIV-related outcomes. ..
  33. ncbi request reprint Regulation of the estrogen receptor alpha minimal promoter by Sp1, USF-1 and ERalpha
    Linda A deGraffenried
    Department of Medicine, The University of Texas Health Science Center, San Antonio, USA
    Breast Cancer Res Treat 85:111-20. 2004
    ..Based upon these findings, we propose a possible model for transcription from the ERalpha minimal promoter...
  34. pmc Role of tuberin in neuronal degeneration
    Samy L Habib
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Neurochem Res 33:1113-6. 2008
    ..Our data provide new information regarding the possible role of tuberin dysfunction in major neurodegenerative disorders, such as AD and PD, whereby inhibition of tuberin function may trigger an onset of neuronal cell death...
  35. ncbi request reprint Development of a synthetic promoter for macrophage gene therapy
    Weijing He
    Department of Medicine, University of Texas Health Science Center at San Antonio, and South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX 78229 3900, USA
    Hum Gene Ther 17:949-59. 2006
    ..Thus, the novel SPs, especially when combined with lentivectors, are useful for macrophage-specific delivery of therapeutic genes...
  36. pmc CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals
    Hemant Kulkarni
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
    PLoS ONE 3:e3165. 2008
    ..Therefore, we determined whether accounting for both genetic and laboratory markers provided an improved means of assessing AIDS risk...
  37. ncbi request reprint PU.1 is essential for p47(phox) promoter activity in myeloid cells
    S L Li
    Department of Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, Texas 78284 7870, USA
    J Biol Chem 272:17802-9. 1997
    ..Finally, PU.1 trans-activated the p47(phox)-luciferase constructs in HeLa cells. We conclude that, similar to certain other myeloid-specific genes, p47(phox) promoter activity in myeloid cells requires PU.1...
  38. ncbi request reprint CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms
    Matthew J Dolan
    Infectious Disease Clinical Research Program, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas 78236, USA
    Nat Immunol 8:1324-36. 2007
    ..These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms...
  39. ncbi request reprint Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
    Botond Banfi
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, Switzerland
    J Biol Chem 278:3510-3. 2003
    ..In conclusion, NOX1 is a superoxide-generating enzyme that is activated by two novel proteins, which we propose to name NOXO1 (NOX organizer 1) and NOXA1 (NOX activator 1)...
  40. doi request reprint NOX enzymes as novel targets for drug development
    J David Lambeth
    Emory University, Atlanta, GA, USA
    Semin Immunopathol 30:339-63. 2008
    ..As most (though not all) NOX-related diseases appear to be mediated by a single member of the NOX family, agents with isoform specificity will be preferred, although broadly active NOX inhibitors may prove to be useful in some settings...
  41. pmc Magnetic resonance imaging of innervational and extraocular muscle abnormalities in Duane-radial ray syndrome
    Joseph L Demer
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:5505-11. 2007
    ..The authors used magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ray (Okihiro) syndrome (DRRS) caused by mutations in the transcription factor SALL4...
  42. ncbi request reprint Effect of aging on human rectus extraocular muscle paths demonstrated by magnetic resonance imaging
    Robert A Clark
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Am J Ophthalmol 134:872-8. 2002
    ..To compare normal functional anatomy of rectus extraocular muscles (EOMs) and pulleys in normal older humans with previously reported findings in younger subjects...

Research Grants3

  1. NEUTROPHIL ACTIVATION OF THE OXIDATIVE BURST
    Robert Clark; Fiscal Year: 2004
    ..non-myeloid tissues and the response to inflammatory stimuli and cell maturation. ..
  2. Nuclear Factor Kappa B activation by NADPH Oxidases
    Robert Clark; Fiscal Year: 2004
    ..Collectively, these studies will establish a scientific basis for the potential role in aging of the activation of NF-KB by the products of NADPH oxidases of phagocytic and non-phagocytic cells. ..