Genomes and Genes
Sharon A Chung
Affiliation: University of California
- European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosusSharon A Chung
Division of Rheumatology, University of California, San Francisco, CA 94143 0500, USA
Arthritis Rheum 60:2448-56. 2009..To determine whether genetic substructure in European-derived populations is associated with specific manifestations of systemic lupus erythematosus (SLE), including mucocutaneous phenotypes, autoantibody production, and renal disease...
- Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody productionSharon A Chung
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, United States of America
PLoS Genet 7:e1001323. 2011..Lack of strong SNP associations may suggest that other types of genetic variation or non-genetic factors such as environmental exposures have a greater impact on susceptibility to anti-dsDNA - SLE...
- Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosusKimberly E Taylor
Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, California, USA
PLoS Genet 4:e1000084. 2008..We conclude that this common polymorphism of STAT4 contributes to the phenotypic heterogeneity of SLE, predisposing specifically to more severe disease...
- Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypesKimberly E Taylor
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 7:e1001311. 2011..Thus our analysis categorizes SLE subphenotypes into three groups: those having cumulative, single, and no known genetic association with respect to the currently established SLE risk loci...
- Lupus nephritis susceptibility loci in women with systemic lupus erythematosusSharon A Chung
Division of Rheumatology, Rosalind Russell Ephraim P Engleman Medical Research Center for Arthritis, University of California, San Francisco, California
J Am Soc Nephrol 25:2859-70. 2014..Results from this large-scale genome-wide investigation of lupus nephritis provide evidence of multiple biologically relevant lupus nephritis susceptibility loci...
- Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responsesAmanda Mok
Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, Berkeley, California, USA
Lupus Sci Med 3:e000183. 2016..How DNA methylation affects the clinical heterogeneity of SLE has not been fully defined. We conducted this study to identify differentially methylated CpG sites associated with nephritis among women with SLE...
- A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlapPaula S Ramos
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
PLoS Genet 7:e1002406. 2011....
- Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus ErythematosusSharon A Chung
Rosalind Russell Ephraim P Engleman Rheumatology Research Center, Division of Rheumatology, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 10:e0129813. 2015..Thus, studies of epigenetic mechanisms such as DNA methylation represent a complementary method to genetic association studies to identify biologic pathways that may contribute to the clinical heterogeneity of autoimmune diseases. ..
- Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritisSharon A Chung
University of California, San Francisco, CA, USA
Arthritis Rheum 64:3463-71. 2012....
- PTPN22: its role in SLE and autoimmunitySharon A Chung
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA
Autoimmunity 40:582-90. 2007..In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases...