- Rap1b is required for normal platelet function and hemostasis in miceMagdalena Chrzanowska-Wodnicka
Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Clin Invest 115:680-7. 2005..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...
- Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient miceMagdalena Chrzanowska-Wodnicka
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
Blood 111:2647-56. 2008..These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells...
- Rap1b regulates B cell development, homing, and T cell-dependent humoral immunityHaiyan Chu
Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 181:3373-83. 2008..However, absence of Rap1b did not affect splenic B cell proliferation, BCR-mediated activation of Erk1/2, p38 MAPKs, and AKT. Thus, Rap1b is crucial for early B cell development, MZ B cell homeostasis and T-dependent humoral immunity...
- A critical role of Rap1b in B-cell trafficking and marginal zone B-cell developmentYuhong Chen
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
Blood 111:4627-36. 2008..Thus, we have discovered a critical and distinct role of Rap1b in mature B-cell trafficking and development of MZ B cells...