Jason Christie

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The outcome of extubation failure in a community hospital intensive care unit: a cohort study
    Christopher W Seymour
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Crit Care 8:R322-7. 2004
  2. pmc Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 175:69-74. 2007
  3. ncbi request reprint Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors
    Jason D Christie
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 21:125-32. 2006
  4. ncbi request reprint Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:2794-800. 2008
  5. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1454-9. 2005
  6. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methods
    Jason D Christie
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1451-3. 2005
  7. ncbi request reprint Impact of primary graft failure on outcomes following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 127:161-5. 2005
  8. pmc Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Crit Care 8:411-3. 2004
  9. pmc The effect of primary graft dysfunction on survival after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 719 Blockley Hall, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 171:1312-6. 2005
  10. ncbi request reprint Clinical risk factors for primary graft failure following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelhia, 19104, USA
    Chest 124:1232-41. 2003

Research Grants

Detail Information

Publications73

  1. pmc The outcome of extubation failure in a community hospital intensive care unit: a cohort study
    Christopher W Seymour
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Crit Care 8:R322-7. 2004
    ..Given the large proportion of critical care delivered in the community setting, our purpose was to determine the impact of extubation failure on patient outcomes in a community hospital ICU...
  2. pmc Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 175:69-74. 2007
    ..We hypothesized that lower protein C and higher type 1 plasminogen activator inhibitor (PAI-1) levels in plasma would be associated with primary graft dysfunction (PGD) after lung transplantation...
  3. ncbi request reprint Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors
    Jason D Christie
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 21:125-32. 2006
    ..Describe initial development and validation of a test battery composed of established instruments designed to detect, via telephone interview, cognitive abnormalities in survivors of acute respiratory distress syndrome...
  4. ncbi request reprint Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:2794-800. 2008
    ..We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients...
  5. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1454-9. 2005
  6. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methods
    Jason D Christie
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1451-3. 2005
  7. ncbi request reprint Impact of primary graft failure on outcomes following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 127:161-5. 2005
    ..Primary graft failure (PGF) is a severe acute lung injury syndrome that occurs following lung transplantation. We compared the clinical outcomes of patients who developed PGF with those who did not...
  8. pmc Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Crit Care 8:411-3. 2004
    ..The application of these findings to future human studies of the genetic influence on ALI risks and outcomes is discussed here...
  9. pmc The effect of primary graft dysfunction on survival after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 719 Blockley Hall, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 171:1312-6. 2005
    ..Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied...
  10. ncbi request reprint Clinical risk factors for primary graft failure following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelhia, 19104, USA
    Chest 124:1232-41. 2003
    ..s: Primary graft failure (PGF) is a devastating acute lung injury syndrome following lung transplantation. We sought to identify donor, recipient, and operative risk factors for its development...
  11. pmc Health-related quality of life in patients with pulmonary arterial hypertension
    Darren B Taichman
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, University of Pennsylvania Medical Center Presbyterian, Philadelphia, PA 19104, USA
    Respir Res 6:92. 2005
    ..However, comparatively little is known about health-related quality of life and its determinants in patients with pulmonary arterial hypertension...
  12. ncbi request reprint Effects of lung allocation score on waiting list rankings and transplant procedures
    Rajiv Lingaraju
    Division of Pulmonary Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 25:1167-70. 2006
    ....
  13. pmc Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
    ..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD...
  14. doi request reprint Update in transplantation 2007
    Paul A Corris
    University of Pennsylvania, Pulmonary and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, 719 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:1062-7. 2008
  15. doi request reprint Risk factors for early primary graft dysfunction after lung transplantation: a registry study
    Catherine L Kuntz
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Transplant 23:819-30. 2009
    ..We sought to identify risk factors for PGD using the United Network for Organ Sharing/International Society for Heart and Lung Transplant (UNOS/ISHLT) Registry...
  16. ncbi request reprint Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity
    Carmel Kealey
    University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics 8:217-25. 2007
    ....
  17. doi request reprint Lung transplant outcomes in white and African American recipients: special focus on acute and chronic rejection
    Rajiv Lingaraju
    Division of Pulmonary Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 28:8-13. 2009
    ....
  18. ncbi request reprint Racial differences pertaining to a belief about lung cancer surgery: results of a multicenter survey
    Mitchell L Margolis
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 139:558-63. 2003
    ..Several African-American patients asserted that this belief was common in the African-American community...
  19. pmc Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
    ..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated...
  20. ncbi request reprint Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease
    Selim M Arcasoy
    Division of Pulmonary, Allergy and Critical Care, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Respir Crit Care Med 167:735-40. 2003
    ....
  21. pmc Neighborhood of residence is associated with daily adherence to CPAP therapy
    Alec B Platt
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center Philadelphia, PA, USA
    Sleep 32:799-806. 2009
    ..Risk factors for nonadherence are not well understood but may reflect individual or neighborhood socioeconomic factors. We sought to determine the association of socioeconomic status and initial CPAP adherence...
  22. pmc Effect of work-hours regulations on intensive care unit mortality in United States teaching hospitals
    Meeta Prasad
    Division of Pulmonary, Allergy, and Critical Care Medicine MP, JDC, JMK, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:2564-9. 2009
    ..The United States instituted restrictions on resident work-hours in July 2003. The clinical impact of this reform on critically ill patients is unknown...
  23. pmc Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation
    Steven M Kawut
    Department of Medicine, Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:237-44. 2009
    ..We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation...
  24. ncbi request reprint Minute ventilation recovery time measured using a new, simplified methodology predicts extubation outcome
    Christopher W Seymour
    Department of Medicine, Hospital of the Universeity of Pennsylvania, Philadelphia 19104, USA
    J Intensive Care Med 23:52-60. 2008
    ..45-16.2, P < .02). C statistic was 0.79 +/- 0.17. It was concluded that minute ventilation recovery time, measured using a feasible methodology, can predict extubation outcome in medical and surgical intensive care unit patients...
  25. doi request reprint Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Am Thorac Soc 6:39-46. 2009
    ..Finally, we will summarize efforts at finding genetic and molecular markers for PGD and discuss future directions for PGD research...
  26. pmc The structure of critical care transfer networks
    Theodore J Iwashyna
    Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Med Care 47:787-93. 2009
    ..These transfers may be particularly important in critical care, where small relative improvements can yield substantial absolute changes in survival...
  27. doi request reprint Critical illness outcomes in specialty versus general intensive care units
    Jason P Lott
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 179:676-83. 2009
    ..General intensive care units (ICUs) provide care across a wide range of diagnoses, whereas specialty ICUs provide diagnosis-specific care. Risk-adjusted outcome differences across such units are unknown...
  28. doi request reprint The impact of development of acute lung injury on hospital mortality in critically ill trauma patients
    Chirag V Shah
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 36:2309-15. 2008
    ..We assessed the contribution of acute lung injury to in-hospital mortality in critically ill trauma patients...
  29. doi request reprint Cognitive, mood and quality of life impairments in a select population of ARDS survivors
    Mark E Mikkelsen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Respirology 14:76-82. 2009
    ..This study investigated associations between cognitive impairment, mood disorders and quality of life in a select group of ARDS survivors...
  30. doi request reprint Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
    ..e., refractory hypotension)...
  31. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  32. pmc Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
    ..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy...
  33. pmc Factors associated with the use of corticosteroids in the initial management of idiopathic pulmonary fibrosis
    Jeffrey C Munson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:756-62. 2010
    ..The factors that are associated with the decision to prescribe corticosteroids have not been examined...
  34. ncbi request reprint Relationship of environmental exposures to the clinical phenotype of sarcoidosis
    Mary Elizabeth Kreider
    Division of Pulmonary and Critical Care, University of Pennsylvania School of Medicine, 826 Gates Building, 3400 Spruce St, Philadelphia, PA 19104, USA
    Chest 128:207-15. 2005
    ..We examined the relationship between environmental and occupational exposures, and the clinical phenotype of sarcoidosis...
  35. pmc Effect of treatment guidelines on the initial management of idiopathic pulmonary fibrosis
    Jeffrey C Munson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Br J Clin Pharmacol 70:118-25. 2010
    ..It is not known how the use of corticosteroids and cytotoxic agents in the treatment of IPF has changed over time and whether published guidelines have altered prescribing practices...
  36. pmc Construct validity of the definition of primary graft dysfunction after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 29:1231-9. 2010
    ..This study tested the discriminant validity of International Society for Heart and Lung Transplantation (ISHLT) primary graft dysfunction (PGD) grades with lung injury biomarker profiles and survival...
  37. doi request reprint Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 16:943-9. 2010
    ..This definition can be used as an endpoint in translational studies aiming to identify mechanistic pathways leading to a subgroup of liver grafts with clinical expression of suboptimal function...
  38. doi request reprint Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection
    Navkaranbir S Bajaj
    University of Alabama, Ryals School of Public Health, Birmingham, AL, USA
    Transpl Int 23:e26-31. 2010
    ....
  39. pmc The availability of clinical protocols in US teaching intensive care units
    Meeta Prasad
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 25:610-9. 2010
    ..Clinical protocols to standardize care may improve patient outcomes but worsen trainee education. Our objective was to determine the availability of clinical protocols in teaching medical intensive care units (ICUs)...
  40. ncbi request reprint Multiple variables affecting blood usage in lung transplantation
    Yongping Wang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 25:533-8. 2006
    ..A few publications have reported on the role of variables affecting blood component usage during lung transplantation...
  41. ncbi request reprint The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
    ..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
  42. pmc Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    ASAIO J 55:47-52. 2009
    ....
  43. doi request reprint Primary graft dysfunction: definition, risk factors, short- and long-term outcomes
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Respir Crit Care Med 31:161-71. 2010
    ..Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes...
  44. pmc Factors associated with nonadherence to early goal-directed therapy in the ED
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chest 138:551-8. 2010
    ..EGDT appears to be underused, even in centers with formalized protocols. The aim of our study was to identify factors associated with not initiating EGDT in the ED...
  45. ncbi request reprint Association of RBC transfusion with mortality in patients with acute lung injury
    Giora Netzer
    Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, MSTF Bldg, Room 800, 685 W Baltimore St, Baltimore, MD 21201, USA
    Chest 132:1116-23. 2007
    ..RBC transfusion has been associated with increased morbidity and mortality in a variety of clinical settings. We assessed the effect of RBC transfusion on in-hospital mortality in patients with acute lung injury (ALI)...
  46. ncbi request reprint Renal and vestibular toxicity due to inhaled tobramycin in a lung transplant recipient
    Vivek N Ahya
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 24:932-5. 2005
    ..We review the literature regarding the safety of inhaled tobramycin and discuss potential mechanisms that may promote systemic toxicity in transplant recipients...
  47. pmc Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma
    Leonor Thomson
    Stokes Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104 4318, USA
    Am J Respir Cell Mol Biol 36:152-7. 2007
    ..14 versus 0.03 +/- 0.05, and 0.25 +/- 0.15; P < 0.001 and P = 0.006, respectively). These data indicate that tyrosine-nitrated proteins induce the production of specific immunoglobulins during acute phase response and inflammation...
  48. pmc The state of genome-wide association studies in pulmonary disease: a new perspective
    Jamie L Todd
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 184:873-80. 2011
    ....
  49. pmc Validation study of an automated electronic acute lung injury screening tool
    Helen C Azzam
    University of Pennsylvania Medical Center Pulmonary Allergy and Critical Care Division, Philadelphia, PA, USA
    J Am Med Inform Assoc 16:503-8. 2009
    ..CONCLUSIONS An automated electronic system that screens intubated ICU trauma patients, excluding patients with CHF, for ALI based on CXR reports and results of ABGs is sufficiently accurate to identify many early cases of ALI...
  50. doi request reprint Central airways obstruction due to Aspergillus fumigatus after lung transplantation
    Elizabeth Cerceo
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 28:515-9. 2009
    ..All 3 patients presented with atypical features of Aspergillus infection, but all responded to treatments with either steroids, anti-fungals or both...
  51. pmc Uncharted paths: hospital networks in critical care
    Theodore J Iwashyna
    Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Chest 135:827-33. 2009
    ....
  52. pmc Validation of a brief telephone battery for neurocognitive assessment of patients with pulmonary arterial hypertension
    Darren B Taichman
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Respir Res 6:39. 2005
    ..We undertook this study to validate telephone administration of the tests...
  53. pmc Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
    ..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
  54. pmc Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction
    Takekazu Iwata
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 181:5738-47. 2008
    ..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD...
  55. doi request reprint Variants of DENND1B associated with asthma in children
    Patrick M A Sleiman
    Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
    N Engl J Med 362:36-44. 2010
    ..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown...
  56. ncbi request reprint Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice
    Melpo Christofidou-Solomidou
    Division of Pulmonary Medicine, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, USA
    J Investig Med 50:54-60. 2002
    ..By scavenging extracellular actin and modulating the effects of lysophosphatidic acid, plasma gelsolin could serve a critical protective role against oxidant injury...
  57. pmc Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury
    Anita J Reddy
    Duke University Medical Center, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC, USA
    J Cell Mol Med 13:1784-91. 2009
    ..These novel findings may have important implications in diseases with oxidant stress aetiologies...
  58. ncbi request reprint Evaluation of a new method for measurement of minute ventilation recovery time
    Christopher W Seymour
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Respir Care 51:133-9. 2006
    ..To determine if the measurement of minute ventilation recovery time (V (E)RT), a recently proposed predictor of extubation outcome, can be reproduced using a more practical, simpler method...
  59. ncbi request reprint Microarrays
    Jason D Christie
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 33:S449-52. 2005
  60. ncbi request reprint Change in forced expiratory time and spirometric performance during a single pulmonary function testing session
    Adam G Tsai
    Division of General Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Respir Care 51:246-51. 2006
    ..Among patients with obstructive lung disease, the correlation between clinical improvement and bronchodilator response is poor. Forced expiratory time (FET) may explain some discrepancy, but FET has received little attention...
  61. ncbi request reprint Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report-2007
    Elbert P Trulock
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 26:782-95. 2007
  62. pmc A simple clinical predictive index for objective estimates of mortality in acute lung injury
    Colin R Cooke
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 37:1913-20. 2009
    ..We sought to develop a simple point score that would accurately capture the risk of hospital death for patients with acute lung injury (ALI)...
  63. ncbi request reprint Measurement of a baseline minute ventilation for the calculation of minute ventilation recovery time: is a subjective method reliable?
    Christopher W Seymour
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Respir Care 50:468-72. 2005
    ..The purpose of the current study is to evaluate the inter-rater reliability of this subjective method for determining baseline V(E)...
  64. ncbi request reprint Low use of durable medical equipment by chronically disabled elderly
    Theodore J Iwashyna
    Department of Medicine, Leonard Davis Institute, and Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19130, USA
    J Pain Symptom Manage 33:324-30. 2007
    ..Fewer than half the chronically disabled, and less than one-quarter of the newly disabled, received any DME from Medicare. These data suggest underuse of the benefit by the disabled elderly...
  65. ncbi request reprint Lung allograft ischemic time: crossing the threshold
    Jason D Christie
    Am J Respir Crit Care Med 171:673-4. 2005
  66. ncbi request reprint Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
    Jacqui M Marzec
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 21:2237-46. 2007
    ..Furthermore, these findings may have important implications in other oxidative stress related illnesses...
  67. doi request reprint Determinants of the survival benefit of lung transplantation in patients with chronic obstructive pulmonary disease
    Gabriel Thabut
    Service de Pneumologie B et Transplantation Pulmonaire, Hopital Bichat, 46 rue Henri Huchard, 75018 Paris, France
    Am J Respir Crit Care Med 177:1156-63. 2008
    ..Although chronic obstructive pulmonary disease is the first indication for lung transplantation, the benefit of the procedure in terms of survival remains debated...
  68. ncbi request reprint Update in transplantation 2006
    Paul A Corris
    Institute of Cellular Medicine, School of Clinical Medical Sciences, Newcastle University and Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK
    Am J Respir Crit Care Med 175:432-5. 2007
  69. ncbi request reprint The epidemiologist in the intensive care unit
    Gordon D Rubenfeld
    Intensive Care Med 30:4-6. 2004
  70. ncbi request reprint Registry of the International Society for Heart and Lung Transplantation: introduction to the 2007 annual reports--100,000 transplants and going strong
    Marshall I Hertz
    International Society for Heart and Lung Transplantation, Addison, Texas, USA
    J Heart Lung Transplant 26:763-8. 2007
  71. doi request reprint Survival after bilateral versus single lung transplantation for patients with chronic obstructive pulmonary disease: a retrospective analysis of registry data
    Gabriel Thabut
    Service de Pneumologie B et Transplantation Pulmonaire, Hopital Bichat, APHP et Université Paris Diderot, Paris 7, Paris, France
    Lancet 371:744-51. 2008
    ..We aimed to compare survival after each procedure by analysing data from the registry of the International Society for Heart and Lung Transplantation...
  72. ncbi request reprint The interleukin-6 gene and critical illness: is inflammatory gene variation the key to personalized medicine in the intensive care unit?
    Jason D Christie
    Crit Care Med 36:1647-9. 2008
  73. ncbi request reprint Central nervous system infections due to Abiotrophia and Granulicatella species: an emerging challenge?
    Elizabeth Cerceo
    University of Medicine and Dentistry of New Jersey, Newark, NJ 07107 3000, USA
    Diagn Microbiol Infect Dis 48:161-5. 2004
    ..Given the significant negative clinical impact of Abiotrophia/Granulicatella infections, elucidation of the emerging epidemiology of CNS infections with these bacteria is warranted...

Research Grants1

  1. RISK FACTORS & BIOMARKERS OF OX STRESS IN GRAFT FAILURE
    Jason Christie; Fiscal Year: 2004
    ..abstract_text> ..