G Bryce Christensen
Affiliation: University of Utah
- Genome-wide linkage analysis for aggressive prostate cancer in Utah high-risk pedigreesG B Christensen
Department of Biomedical Informatics, University of Utah School of Medicine, Utah, USA
Prostate 67:605-13. 2007..We present the results of a genome-scan for predisposition to aggressive PC using the Utah high-risk pedigree resource...
- Extracting disease risk profiles from expression data for linkage analysis: application to prostate cancerG Bryce Christensen
Department of Biomedical Informatics, University of Utah, 391 Chipeta Way Suite D, Salt Lake City, Utah 84108 1266, USA
BMC Proc 1:S82. 2007..Our results do indicate there exists potential to augment our current knowledge about the relationships among genes associated with complex diseases using expression data...
- The sumLINK statistic for genetic linkage analysis in the presence of heterogeneityG B Christensen
Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108 1266, USA
Genet Epidemiol 33:628-36. 2009..Further, loci identified with the sumLINK have good potential for gene localization via statistical recombinant mapping, as, by definition, several linked pedigrees contribute to each peak...
- Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analysesG Bryce Christensen
University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
Prostate 70:735-44. 2010..The recently developed sumLINK and sumLOD statistics are powerful tools for linkage analysis in the presence of heterogeneity...
- Replication of the 10q11 and Xp11 prostate cancer risk variants: results from a Utah pedigree-based studyNicola J Camp
Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
Cancer Epidemiol Biomarkers Prev 18:1290-4. 2009..We also nominally replicated the association of prostate cancer with rs5945619 (Xp11). In particular, it seems that the susceptibility locus at 10q11 maybe involved in familial, early-onset disease...
- Identification of rare recurrent copy number variants in high-risk autism families and their prevalence in a large ASD populationNori Matsunami
Department of Human Genetics, University of Utah, Salt Lake City, UT, USA
PLoS ONE 8:e52239. 2013..Taken together, these data provide strong support for the existence and application of high-impact CNVs in the clinical genetic evaluation of children with ASD...