G G Choudhury

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e42316. 2012
  2. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012
  3. ncbi c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
    Goutam Ghosh Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cell Signal 18:1854-64. 2006
  4. ncbi Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells
    Goutam Ghosh Choudhury
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio and Geriatrics Research, Education and Clinical Center, Mail Code 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Cell Signal 16:31-41. 2004
  5. ncbi PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells
    Goutam Ghosh Choudhury
    Geriatric Research, Education and Clinical Center, San Antonio, TX, USA
    Cell Signal 15:161-70. 2003
  6. ncbi Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis
    G Ghosh Choudhury
    Geriatric Research, Education and Clinical Center, San Antonio, Texas, USA
    Biochem Biophys Res Commun 286:1183-90. 2001
  7. ncbi Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: regulation of c-fos AND p27(kip1) gene expression
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Biol Chem 276:35636-43. 2001
  8. pmc Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor
    G G Choudhury
    Department of Medicine, Division of Nephrology, The University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Clin Invest 101:2751-60. 1998
  9. ncbi Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase
    G Ghosh Choudhury
    Audie L Murphy Memorial Veterans Affairs Medical Center, San Antonio, Texas 78284 7882, USA
    J Biol Chem 274:10897-902. 1999
  10. ncbi Bone morphogenetic protein-2 inhibits MAPK-dependent Elk-1 transactivation and DNA synthesis induced by EGF in mesangial cells
    G Ghosh Choudhury
    Geriatric Research, Education, and Clinical Center, South Texas Veteran Health Care System, San Antonio, Texas 78284, USA
    Biochem Biophys Res Commun 258:490-6. 1999

Research Grants

  1. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004

Collaborators

Detail Information

Publications30

  1. pmc TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e42316. 2012
    ..Our results uncover an essential role of TGFβ-induced expression of miR-21, which targets PTEN to initiate a non-canonical signaling circuit involving Akt/mTORC1 axis for mesangial cell hypertrophy and matrix protein synthesis...
  2. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012
    ..Our results uncover a layer of post-transcriptional regulation of PTEN by transcriptional activation of miR-21 to force the canonical oncogenic Akt/TORC1 signaling conduit to drive renal cancer cell proliferation and invasion...
  3. ncbi c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
    Goutam Ghosh Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cell Signal 18:1854-64. 2006
    ..Furthermore our results demonstrate that c-Src integrates signals into the nucleus to activate CDK2, which is required for DNA synthesis...
  4. ncbi Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells
    Goutam Ghosh Choudhury
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio and Geriatrics Research, Education and Clinical Center, Mail Code 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Cell Signal 16:31-41. 2004
    ....
  5. ncbi PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells
    Goutam Ghosh Choudhury
    Geriatric Research, Education and Clinical Center, San Antonio, TX, USA
    Cell Signal 15:161-70. 2003
    ....
  6. ncbi Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis
    G Ghosh Choudhury
    Geriatric Research, Education and Clinical Center, San Antonio, Texas, USA
    Biochem Biophys Res Commun 286:1183-90. 2001
    ..These data provide the first evidence that in mesangial cells, ceramide cross-talks with PI 3 kinase-dependent Akt kinase to inhibit PDGF-induced DNA synthesis without inducing apoptosis...
  7. ncbi Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: regulation of c-fos AND p27(kip1) gene expression
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Biol Chem 276:35636-43. 2001
    ....
  8. pmc Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor
    G G Choudhury
    Department of Medicine, Division of Nephrology, The University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Clin Invest 101:2751-60. 1998
    ..Incubation of pure STAT1alpha with autophosphorylated PDGFR resulted in physical association of the two proteins. These data indicate that activated PDGFR may be sufficient to tyrosine phosphorylate and thus directly activate STAT1alpha...
  9. ncbi Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase
    G Ghosh Choudhury
    Audie L Murphy Memorial Veterans Affairs Medical Center, San Antonio, Texas 78284 7882, USA
    J Biol Chem 274:10897-902. 1999
    ..These data provide the first evidence that in mesangial cells, BMP2 signaling cross-talks with MAPK-based transcriptional events to inhibit PDGF-induced DNA synthesis. One target for this inhibition is the early response gene c-fos...
  10. ncbi Bone morphogenetic protein-2 inhibits MAPK-dependent Elk-1 transactivation and DNA synthesis induced by EGF in mesangial cells
    G Ghosh Choudhury
    Geriatric Research, Education, and Clinical Center, South Texas Veteran Health Care System, San Antonio, Texas 78284, USA
    Biochem Biophys Res Commun 258:490-6. 1999
    ..These data provide the first evidence that BMP-2 signaling in mesangial cells initiates a negative regulatory cross-talk with MAPK-based transcription to inhibit EGF-induced DNA synthesis...
  11. ncbi Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Kidney Int 57:908-17. 2000
    ....
  12. ncbi Activation of renal signaling pathways in db/db mice with type 2 diabetes
    D Feliers
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Kidney Int 60:495-504. 2001
    ..Altered regulation of signaling pathways may contribute to the pathogenesis of renal disease. We examined renal cortical signaling pathways in type 2 diabetes...
  13. ncbi Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells
    B K Bhandari
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78299-3900, USA
    Kidney Int 59:866-75. 2001
    ..The requirement for Erk-1/-2 MAP kinase activation for 4E-BP1 phosphorylation by insulin suggests a cross-talk between PI 3-kinase and Erk-1/-2-type MAP kinase pathways...
  14. ncbi Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase
    Y Gorin
    Department of Medicine, Division of Nephrology, The University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA
    FASEB J 15:1909-20. 2001
    ..These data provide the first evidence that Ang II induces protein synthesis and hypertrophy in MCs through AA/redox-dependent pathway and Akt/PKB activation independent of PI3-K...
  15. ncbi Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensin II
    Denis Feliers
    Dept of Medicine, Mail Code 7882, Univ of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 288:F521-9. 2005
    ..Regulation of VEGF translation by ANG II represents a novel pathway of renal response to injury...
  16. ncbi Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element
    N Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Biochem Biophys Res Commun 286:101-8. 2001
    ..Furthermore, we demonstrate for the first time that BMP-2 autoregulates its expression in osteoblasts through the proximal promoter-dependent transcriptional mechanism...
  17. ncbi Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells
    M Arar
    Department of Pediatrics, South Texas Department of Veterans Affairs Health Care System, San Antonio, Texas 78229 3900, USA
    J Biol Chem 275:9527-33. 2000
    ..PDGF B-chain also likely stimulates proliferation of mesangial cell precursors in an autocrine fashion once these cells migrate to the glomerular tuft...
  18. ncbi Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells
    Balachandar Venkatesan
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Cell Physiol 211:457-67. 2007
    ..These results demonstrate that ROS downregulate the expression of catalase in mesangial cells by PI 3 kinase/Akt signaling via FoxO1 as a target...
  19. pmc Angiotensin II inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E-binding protein-1 in proximal tubular epithelial cells
    D Senthil
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
    Biochem J 360:87-95. 2001
    ..Our data provide a mechanistic basis for insulin insensitivity induced by angiotensin II...
  20. ncbi Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species
    Denis Feliers
    Department of Medicine Nephrology, The University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio 78229 3900, USA
    Am J Physiol Renal Physiol 290:F927-36. 2006
    ..These data show that ROS, generated probably through activation of an NAD(P)H oxidase, mediate ANG II stimulation of VEGF mRNA translation...
  21. ncbi Heterogeneous nuclear ribonucleoprotein K contributes to angiotensin II stimulation of vascular endothelial growth factor mRNA translation
    Denis Feliers
    Dept of Medicine Nephrology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, USA
    Am J Physiol Renal Physiol 293:F607-15. 2007
    ..This study shows that hnRNP K augments efficiency of VEGF mRNA translation stimulated by ANG II...
  22. pmc Regulation of mRNA translation in renal physiology and disease
    Balakuntalam S Kasinath
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 297:F1153-65. 2009
    ..Contribution of mRNA translation to physiology and disease is not well understood. Because it is involved in such diverse areas as development and cancer, it should prove a fertile field for investigation in renal science...
  23. ncbi BMP-2 regulates cardiomyocyte contractility in a phosphatidylinositol 3 kinase-dependent manner
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229, USA
    FEBS Lett 544:181-4. 2003
    ..Also we provide the first evidence that BMP-2-induced PI 3 kinase activity regulates this cardiomyocyte function...
  24. ncbi TGFbeta intercepts nuclear glycogen synthase kinase 3beta to inhibit PDGF-induced DNA synthesis in mesangial cells
    Falguni Das
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    FEBS Lett 581:5259-67. 2007
    ..These results provide the first evidence that TGFbeta intercepts Akt kinase activity in the nucleus to block inactivation of GSK3beta, leading to attenuation of PDGF-induced CDK2 activity and DNA synthesis...
  25. pmc The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway
    Duraisamy Senthil
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochem J 368:49-56. 2002
    ..This association may account for some of the increase in VEGF-induced PI 3-kinase activity, and the increase in de novo protein synthesis seen in renal epithelial cells...
  26. pmc AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes
    Assaad A Eid
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 285:37503-12. 2010
    ..The data indicate the potential therapeutic utility of AMPK activators to block Nox4 and reactive oxygen species generation and to reduce urinary albumin excretion in type 1 diabetes...
  27. pmc Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth
    Nayana Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, USA
    Cell Signal 22:749-58. 2010
    ....
  28. pmc PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Cell Physiol 225:27-41. 2010
    ..Thus, our data identify high glucose-induced phosphorylation and inactivation of PRAS40 as a central node for mesangial cell hypertrophy in diabetic nephropathy...
  29. pmc Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation
    Chandi C Mandal
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Endocrinology 150:4989-98. 2009
    ..Together, these data for the first time demonstrate that PI3K-dependent Akt activation regulates BMP-2-induced CSF-1 expression and provides a mechanism for osteoblastic cell-assisted osteoclast differentiation...
  30. pmc TSC2 deficiency increases PTEN via HIF1alpha
    Lenin Mahimainathan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 284:27790-8. 2009
    ..These data suggest that PTEN may safeguard against developing malignant tumors in patients with TSC deficiency...

Research Grants1

  1. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..These studies will identify important signaling mechanisms involved in glomerular pathology and help to establish effective therapeutic modalities for treatment of proliferative forms of GN. ..