Simon R Cherry

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Multimodality imaging: beyond PET/CT and SPECT/CT
    Simon R Cherry
    Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California Davis, Davis, CA 95616, USA
    Semin Nucl Med 39:348-53. 2009
  2. ncbi request reprint In vivo molecular and genomic imaging: new challenges for imaging physics
    Simon R Cherry
    Department of Biomedical Engineering, University of California, Davis, CA, USA
    Phys Med Biol 49:R13-48. 2004
  3. ncbi request reprint Multimodality in vivo imaging systems: twice the power or double the trouble?
    Simon R Cherry
    Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California, Davis, California 95616, USA
    Annu Rev Biomed Eng 8:35-62. 2006
  4. ncbi request reprint The 2006 Henry N. Wagner Lecture: Of mice and men (and positrons)--advances in PET imaging technology
    Simon R Cherry
    Center for Molecular and Genomic Imaging, Department of Biomedical Engineering, University of California Davis, Davis, California, USA
    J Nucl Med 47:1735-45. 2006
  5. pmc Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays
    Sara St James
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 54:4605-19. 2009
  6. pmc A prototype PET scanner with DOI-encoding detectors
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
    J Nucl Med 49:1132-40. 2008
  7. ncbi request reprint High-resolution voxelation mapping of human and rodent brain gene expression
    Ram P Singh
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 23 120 CHS, 90095 1735, Los Angeles, CA, USA
    J Neurosci Methods 125:93-101. 2003
  8. pmc Tapered LSO arrays for small animal PET
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 56:139-53. 2011
  9. pmc Initial characterization of a dedicated breast PET/CT scanner during human imaging
    Spencer L Bowen
    Department of Biomedical Engineering, UC Davis, Davis, California, USA
    J Nucl Med 50:1401-8. 2009
  10. pmc Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys
    Alice F Tarantal
    California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616 8542, USA
    Mol Imaging Biol 14:197-204. 2012

Research Grants

  1. A MICRO CT/PET SCANNER FOR IN VIVO SCREENING IN MICE
    SIMON CHERRY; Fiscal Year: 2001
  2. UC Davis Mouse Cancer Imaging Program
    SIMON CHERRY; Fiscal Year: 2008
  3. A microSPECT scanner for Molecular Imaging
    SIMON CHERRY; Fiscal Year: 2007
  4. UC Davis Mouse Cancer Imaging Program
    SIMON CHERRY; Fiscal Year: 2006
  5. IEEE Medical Imaging Conference
    SIMON CHERRY; Fiscal Year: 2005
  6. A MICRO CT/PET SCANNER FOR IN VIVO SCREENING OF MICE
    SIMON CHERRY; Fiscal Year: 2006
  7. HIGH RESOLUTION PET IMAGING OF MOUSE MODELS OF CANCER
    SIMON CHERRY; Fiscal Year: 2004
  8. APD BASED PET DETECTOR MODULES FOR BREAST IMAGING
    SIMON CHERRY; Fiscal Year: 2003
  9. HIGH RESOLUTION PET IMAGING
    SIMON CHERRY; Fiscal Year: 2001
  10. Hyperspectral Optical Tomography for Molecular Imaging
    SIMON CHERRY; Fiscal Year: 2009

Detail Information

Publications92

  1. pmc Multimodality imaging: beyond PET/CT and SPECT/CT
    Simon R Cherry
    Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California Davis, Davis, CA 95616, USA
    Semin Nucl Med 39:348-53. 2009
    ..fusion of PET and SPECT with CT the ultimate answer in multimodality imaging, or is it just the first example of a more general trend toward harnessing the complementary nature of the different modalities on integrated imaging platforms?..
  2. ncbi request reprint In vivo molecular and genomic imaging: new challenges for imaging physics
    Simon R Cherry
    Department of Biomedical Engineering, University of California, Davis, CA, USA
    Phys Med Biol 49:R13-48. 2004
    ..It also provides a brief review of the imaging technology (particularly for x-ray, nuclear and optical imaging) that is being developed to support this new field...
  3. ncbi request reprint Multimodality in vivo imaging systems: twice the power or double the trouble?
    Simon R Cherry
    Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California, Davis, California 95616, USA
    Annu Rev Biomed Eng 8:35-62. 2006
    ....
  4. ncbi request reprint The 2006 Henry N. Wagner Lecture: Of mice and men (and positrons)--advances in PET imaging technology
    Simon R Cherry
    Center for Molecular and Genomic Imaging, Department of Biomedical Engineering, University of California Davis, Davis, California, USA
    J Nucl Med 47:1735-45. 2006
    ....
  5. pmc Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays
    Sara St James
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 54:4605-19. 2009
    ..The sensitivity of such a scanner was also simulated using Monte Carlo simulations and was shown to be greater than 10% for a four ring scanner with an inner diameter of 6 cm, employing 20 detectors per scanner ring...
  6. pmc A prototype PET scanner with DOI-encoding detectors
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
    J Nucl Med 49:1132-40. 2008
    ..Detectors with depth-encoding allow a PET scanner to simultaneously achieve high sensitivity and high spatial resolution...
  7. ncbi request reprint High-resolution voxelation mapping of human and rodent brain gene expression
    Ram P Singh
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 23 120 CHS, 90095 1735, Los Angeles, CA, USA
    J Neurosci Methods 125:93-101. 2003
    ..The voxelation instruments and their future iterations represent a valuable approach to the genome scale acquisition of gene expression patterns in the human and rodent brain...
  8. pmc Tapered LSO arrays for small animal PET
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 56:139-53. 2011
    ..Tapered scintillator arrays offer the prospect of improvements in sensitivity and sampling for small-bore scanners, without large increases in manufacturing complexity...
  9. pmc Initial characterization of a dedicated breast PET/CT scanner during human imaging
    Spencer L Bowen
    Department of Biomedical Engineering, UC Davis, Davis, California, USA
    J Nucl Med 50:1401-8. 2009
    ..We have constructed a dedicated breast PET/CT scanner capable of high-resolution functional and anatomic imaging. Here, we present an initial characterization of scanner performance during patient imaging...
  10. pmc Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys
    Alice F Tarantal
    California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616 8542, USA
    Mol Imaging Biol 14:197-204. 2012
    ....
  11. ncbi request reprint A hyperspectral fluorescence system for 3D in vivo optical imaging
    Guido Zavattini
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 51:2029-43. 2006
    ..We also characterize the basic performance of the imaging system...
  12. ncbi request reprint Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner
    Ciprian Catana
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    J Nucl Med 47:1968-76. 2006
    ..We have designed and built a MR-compatible PET scanner based on avalanche photodiode technology that allows simultaneous acquisition of PET and MR images in small animals...
  13. pmc Three-dimensional fluorescence optical tomography in small-animal imaging using simultaneous positron-emission-tomography priors
    Changqing Li
    Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA
    Opt Lett 34:2933-5. 2009
    ..The method and algorithms are validated with numerical simulations and a phantom experiment performed on a combined optical-PET scanner based on a conical mirror geometry...
  14. pmc PET characteristics of a dedicated breast PET/CT scanner prototype
    Yibao Wu
    Department of Biomedical Engineering, University of California, Davis, Genome and Biomedical Sciences, CA, USA
    Phys Med Biol 54:4273-87. 2009
    ..7% and 2.8%, respectively. The impact of the increased reconstructed spatial resolution compared to typical whole-body PET scanners is currently being assessed in a clinical trial...
  15. ncbi request reprint Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography
    Craig K Abbey
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Mammary Gland Biol Neoplasia 11:137-49. 2006
    ..We conclude with a brief survey of emerging approaches in small-animal PET imaging...
  16. pmc Cerenkov luminescence tomography for small-animal imaging
    Changqing Li
    Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA
    Opt Lett 35:1109-11. 2010
    ....
  17. pmc Comparison of four depth-encoding PET detector modules with wavelength shifting (WLS) and optical fiber read-out
    Huini Du
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 53:1829-42. 2008
    ....
  18. ncbi request reprint Depth of interaction resolution measurements for a high resolution PET detector using position sensitive avalanche photodiodes
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 51:2131-42. 2006
    ..These results provide a detailed characterization of the DOI response of these PSAPD-based PET detectors which will be important in the design and calibration of a PET scanner making use of this detector approach...
  19. pmc Depth of interaction calibration for PET detectors with dual-ended readout by PSAPDs
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 54:433-45. 2009
    ..A linear crystal DOI calibration provided slightly better image spatial resolution compared with a linear detector DOI calibration...
  20. ncbi request reprint Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications
    Jennifer R Stickel
    Department of Radiology, School of Medicine, University of California Davis Medical Center, Davis, California 95817, USA
    J Nucl Med 48:115-21. 2007
    ..Though there are other contributing factors, the spatial resolution in small-animal PET is still largely determined by the detector pixel dimensions...
  21. pmc Crystal identification in positron emission tomography using nonrigid registration to a Fourier-based template
    Abhijit J Chaudhari
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Phys Med Biol 53:5011-27. 2008
    ..We also present an adaptive method for distortion reduction in flood histograms obtained for PET detectors that use PSAPDs...
  22. ncbi request reprint Cardiac PET imaging in mice with simultaneous cardiac and respiratory gating
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 50:2979-89. 2005
    ..It appears with the current resolution of PET, and the small fraction of the respiratory cycle in which motion occurs, that respiratory gating is probably not necessary for most mouse cardiac studies...
  23. pmc Simulation study of spatial resolution and sensitivity for the tapered depth of interaction PET detectors for small animal imaging
    Sara St James
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 55:N63-74. 2010
    ..Detectors employing the tapered crystal design along with excellent DOI resolution will lead to PET scanners with higher sensitivity and uniform spatial resolution across the field of view...
  24. pmc Signal and noise properties of position-sensitive avalanche photodiodes
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 56:6327-36. 2011
    ..3 ns for the 10 mm and 15 mm PSAPDs, respectively. The results of this work provide useful guidance for selecting the bias voltage and working temperature for scintillation detectors that incorporate PSAPDs as the photodetector...
  25. doi request reprint Experimental assessment of resolution improvement of a zoom-in PET
    Jinyi Qi
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Phys Med Biol 56:N165-74. 2011
    ..Profiles taken through the reconstructed point sources show substantial reduction in full-width-at-half-maximum along the direction parallel to the face of the high-resolution detector...
  26. pmc Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease
    Vanessa M Brown
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Res 12:868-84. 2002
    ....
  27. pmc Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys
    Alice F Tarantal
    Department of Pediatrics, University of California Davis, Davis, California, United States of America Department of Cell Biology and Human Anatomy, University of California Davis, Davis, California, United States of America California National Primate Research Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e77148. 2013
    ..Results suggest that (89)Zr-Df-CD45 was able to identify engrafted hPBSC in the same locations identified by BLI, although the background was high. ..
  28. pmc Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner
    Thomas S C Ng
    Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, CA, USA
    J Nucl Med 53:1102-9. 2012
    ..Here, we evaluated the ability of a first-generation, small-animal MRI-compatible PET scanner to accurately depict heterogeneous patterns of radiotracer uptake in tumors...
  29. pmc In vivo Cerenkov luminescence imaging: a new tool for molecular imaging
    Gregory S Mitchell
    Department of Biomedical Engineering, and Center for Molecular and Genomic Imaging, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Philos Trans A Math Phys Eng Sci 369:4605-19. 2011
    ....
  30. doi request reprint A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, Davis, California Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
    J Nucl Med 57:1130-5. 2016
    ..We developed a prototype small-animal PET scanner based on depth-encoding detectors using dual-ended readout of small scintillator elements to produce high and uniform spatial resolution suitable for imaging the mouse brain...
  31. pmc Characterization of Large-Area SiPM Array for PET Applications
    Junwei Du
    Department of Biomedical Engineering, University of California, Davis, CA 95616 USA
    IEEE Trans Nucl Sci 63:8-16. 2016
    ..Based on our findings, we conclude that this large-area SiPM array can serve as a suitable photodetector for high-resolution small-animal PET or dedicated human brain PET scanners...
  32. ncbi request reprint Measurements of wavelength shifting (WLS) fibre readout for a highly multiplexed, depth-encoding PET detector
    Huini Du
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 52:2499-514. 2007
    ..This light collection efficiency appears to be sufficient for decoding interaction position in these detectors...
  33. pmc Evaluation of Matrix9 silicon photomultiplier array for small-animal PET
    Junwei Du
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, California 95616
    Med Phys 42:585. 2015
    ..3 mm(2). Using 8 × 8 polished LSO/LYSO arrays (pitch 1.5 mm) the performance of this detector system (SiPM array and readout electronics) was evaluated with a view for its eventual use in small-animal positron emission tomography (PET)...
  34. pmc Excitation spectroscopy in multispectral optical fluorescence tomography: methodology, feasibility and computer simulation studies
    Abhijit J Chaudhari
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Phys Med Biol 54:4687-704. 2009
    ..We also demonstrate the performance of our method for 3D reconstruction of tumors in a simulated mouse model of metastatic human hepatocellular carcinoma...
  35. pmc Continuous depth-of-interaction encoding using phosphor-coated scintillators
    Huini Du
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 54:1757-71. 2009
    ..Pulse shape discrimination (PSD) methods were studied to extract DOI information from the pulse shape changes. The DOI full-width-half-maximum (FWHM) resolution was found to be approximately 8 mm for this 2 cm thick array...
  36. pmc A three-dimensional multispectral fluorescence optical tomography imaging system for small animals based on a conical mirror design
    Changqing Li
    Department of Biomedical Engineering, UC Davis, Davis, CA 95616, USA
    Opt Express 17:7571-85. 2009
    ..Finally, an in vivo imaging study of a xenograft tumor in a mouse shows good correlation of the reconstructed image with the location of the fluorescence probe as determined by subsequent optical imaging of cryosections of the mouse...
  37. pmc Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system
    Changqing Li
    Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA
    J Nucl Med 52:1268-75. 2011
    ..We have designed, built, and evaluated a simultaneous PET and 3D FOT system. The design of the FOT system is compatible with many existing small-animal PET scanners...
  38. pmc Simultaneous in vivo positron emission tomography and magnetic resonance imaging
    Ciprian Catana
    Department of Biomedical Engineering, University of California, Genome and Biomedical Sciences Facility, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:3705-10. 2008
    ..In vivo simultaneous PET and MRI studies were performed in mice. Proof-of-principle in vivo MR spectroscopy and functional MRI experiments were also demonstrated with the combined scanner...
  39. ncbi request reprint Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain
    Daniel J Rubins
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neuroimage 20:2100-18. 2003
    ..Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures...
  40. pmc Spatial distortion correction and crystal identification for MRI-compatible position-sensitive avalanche photodiode-based PET scanners
    Abhijit J Chaudhari
    A J Chaudhari, Y Wu and S R Cherry are with the Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA Email
    IEEE Trans Nucl Sci 56:549-556. 2009
    ..Our results indicate that our proposed methods lead to a large reduction in manual labor and indeed can routinely be used for calibration and characterization studies in MRI-compatible PET scanners based on PSAPDs...
  41. pmc Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
    Yu Ouyang
    Department of Biomedical Engineering, University of California, Davis
    J Vis Exp . 2015
    ..The method presented here allows one to acquire both diffusion-weighted MRI and [18F]FDG uptake data in the same animal before, during, and after the hypoxic challenge in order to interrogate immediate physiological changes...
  42. doi request reprint Timing properties of phosphor-coated polished LSO crystals
    Jeffrey P Schmall
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 59:N139-51. 2014
    ..Here we present preliminary results demonstrating that good DOI resolution can be achieved with only a modest 26% degradation in CTR. ..
  43. pmc Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture
    David L Boucher
    Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e39350. 2012
    ..We also present the in vivo imaging and immunohistochemical analysis of serial transplantation of one such subline and detail the progressive multifocal loss of the transgene in successive generations...
  44. ncbi request reprint Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI
    Bernd J Pichler
    Department of Biomedical Engineering, University of California, Davis, USA
    J Nucl Med 47:639-47. 2006
    ..Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation...
  45. pmc A study of the timing properties of position-sensitive avalanche photodiodes
    Yibao Wu
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Phys Med Biol 54:5155-72. 2009
    ..1 ns to 22.0 ns or 15.2 ns, respectively. A two-step timing alignment method is proposed for a PET system consisting of multiple PSAPDs. Lastly, the effect of PSAPD size on the timing performance was also evaluated...
  46. pmc Neural correlates of pair-bonding in a monogamous primate
    Karen L Bales
    Department of Psychology, University of California, Davis, CA 95616, USA
    Brain Res 1184:245-53. 2007
    ....
  47. ncbi request reprint High-resolution PET detector design: modelling components of intrinsic spatial resolution
    Jennifer R Stickel
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Phys Med Biol 50:179-95. 2005
    ..5 mm and 60% efficiency. This work has shown that detectors with significantly better resolution and sensitivity can be developed for small animal PET applications...
  48. pmc Bismuth germanate coupled to near ultraviolet silicon photomultipliers for time-of-flight PET
    Sun Il Kwon
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    Phys Med Biol 61:L38-L47. 2016
    ..With these values, BGO can be considered as a relevant scintillator for TOF PET scanners, especially if photodetectors with even better near UV/blue response can be developed to further improve the efficiency of Cerenkov light detection...
  49. doi request reprint Validation of the SimSET simulation package for modeling the Siemens Biograph mCT PET scanner
    Jonathan K Poon
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 60:N35-45. 2015
    ..The new block detector model in SimSET offers a fast and reasonably accurate simulation toolkit for PET imaging applications. ..
  50. pmc Simulation of light transport in scintillators based on 3D characterization of crystal surfaces
    Emilie Roncali
    Department of Biomedical Engineering, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 58:2185-98. 2013
    ..This approach is also compatible with existing simulation toolkits and next steps include the implementation in GATE...
  51. doi request reprint Comparison of large-area position-sensitive solid-state photomultipliers for small animal PET
    Jeffrey P Schmall
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, CA 95616, USA
    Phys Med Biol 57:8119-34. 2012
    ..Advantages and drawbacks of PET detector designs using PS-SSPM photodetectors are addressed and comparisons to other small-animal PET detector designs using position-sensitive avalanche photodiodes are made...
  52. pmc Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging
    Amrita V Kamath
    Genentech Research and Early Development, Genentech, Inc, South San Francisco, California, USA
    PLoS ONE 7:e45116. 2012
    ..The tissue biodistribution of anti-oxLDL was also investigated using positron emission tomography (PET) imaging...
  53. pmc Application of silicon photomultipliers to positron emission tomography
    Emilie Roncali
    Department of Biomedical Engineering GBSF 2603, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Ann Biomed Eng 39:1358-77. 2011
    ..SiPMs clearly have the potential to be the photodetector of choice for some, or even perhaps most, PET systems...
  54. doi request reprint 111In-LLP2A-DOTA Polyethylene Glycol-Targeting {alpha}4{beta}1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies
    Sally J DeNardo
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis School of Medicine, Sacramento, California, USA
    J Nucl Med 50:625-34. 2009
    ..6.2]hexadecane ((64)Cu-LLP2A-CB-TE2A)...
  55. pmc A high-sensitivity small animal SPECT system
    Gregory S Mitchell
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Phys Med Biol 54:1291-305. 2009
    ..Simple projection images created by analytically combining the two detectors' data show sufficient resolution to observe the dynamic distribution of the radiotracer in the mouse...
  56. doi request reprint Small-animal preclinical nuclear medicine instrumentation and methodology
    Douglas J Rowland
    Center for Molecular and Genomic Imaging, Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    Semin Nucl Med 38:209-22. 2008
    ....
  57. pmc Studies of the interactions of an MRI system with the shielding in a combined PET/MRI scanner
    Bo J Peng
    Department of Biomedical Engineering, University of California, Davis, CA, USA
    Phys Med Biol 55:265-80. 2010
    ..Data are also presented that suggest ways the shielding could be modified to reduce errors and enable placement closer to the isocenter of the magnet...
  58. ncbi request reprint Small-animal X-ray dose from micro-CT
    John M Boone
    Department of Radiology, UC Davis Medical Center, 4701 X Street, X ray Imaging Laboratory Sacramento, CA 95817, USA
    Mol Imaging 3:149-58. 2004
    ..80, 0.63, 0.52, and 0.44 mGy/mGy for mouse diameters of 10, 20, 30, and 40 mm, respectively. A number of tables and figures are provided for dose estimation over a range of mouse imaging geometries...
  59. pmc A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography
    Eric Berg
    Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, California 95616
    Med Phys 43:939-50. 2016
    ..In support of a project to build a total-body PET scanner with an axial field-of-view of 2 m, the authors are developing simple, cost-effective block detectors with combined time-of-flight (TOF) and depth-of-interaction (DOI) capabilities...
  60. pmc New shielding configurations for a simultaneous PET/MRI scanner at 7T
    Bo J Peng
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, United States
    J Magn Reson 239:50-6. 2014
    ..Moreover, the magnitude of this effect depends on the location of the detector within the magnet bore and which MRI gradient is being switched. These findings have a bearing on future designs of PET/MRI systems. ..
  61. doi request reprint Applications for preclinical PET/MRI
    Martin S Judenhofer
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    Semin Nucl Med 43:19-29. 2013
    ..The article also highlights other research using PET and MRI in combination and highlights potential benefits for integrated systems...
  62. pmc Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectors
    Emilie Roncali
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 57:6571-85. 2012
    ..This novel approach is promising for calculating DOI using pulse shape discrimination in single-ended readout depth-encoding PET detectors...
  63. pmc Optimal whole-body PET scanner configurations for different volumes of LSO scintillator: a simulation study
    Jonathan K Poon
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 57:4077-94. 2012
    ..However, the longest AFOV of approximately 2 m with 20 mm thick detectors resulted in performance gains of 25-31 times higher NECR relative to the current Siemens Biograph mCT scanner configuration...
  64. ncbi request reprint Gene expression tomography
    Vanessa M Brown
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90095, USA
    Physiol Genomics 8:159-67. 2002
    ..A Monte-Carlo analysis confirmed the good quality of the GET image reconstruction. By speeding acquisition of gene expression patterns, GET may help improve our understanding of the genomics of the brain in both health and disease...
  65. pmc In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
    Craig K Abbey
    Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11438-43. 2004
    ..Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points...
  66. ncbi request reprint Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors
    Martin S Judenhofer
    Department of Biomedical Engineering, University of California, Davis, 95616, USA
    Phys Med Biol 50:29-44. 2005
    ..The crystals (1.2 x 1.2 x 12 mm3) within a 9 x 9 LSO block detector could be clearly separated in an acquired position profile. Thus, these boards are well suited for data acquisition with novel detectors developed for nuclear imaging...
  67. ncbi request reprint Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imaging
    Joanne Huang
    Center of Excellence in Translational Human Stem Cell Research, Department of Biomedical Engineering, College of Engineering, School of Medicine, University of California, Davis, CA 95616 8542, USA
    Mol Imaging 7:1-11. 2008
    ..50x10(4) CD34+ cells (1.1 pCi/cell) and 6.25x10(3) rhMSCs (4.4 pCi/cell) could be detected. These studies indicate that CD34+ hematopoietic cells and rhMSCs can be safely radiolabeled with 64Cu-PTSM without adverse cellular effects...
  68. pmc Un-collimated single-photon imaging system for high-sensitivity small animal and plant imaging
    Katherine L Walker
    Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 60:403-20. 2015
    ....
  69. pmc Evaluation of 2-[¹⁸F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemia
    Yu Ouyang
    Department of Biomedical Engineering, University of California, Davis, California, USA
    J Cereb Blood Flow Metab 34:836-44. 2014
    ..We conclude that kinetic modeling of [(18)F]FACE uptake represents a potentially useful tool for interrogation of glial metabolism...
  70. doi request reprint Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation
    Emilie Roncali
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 59:2023-39. 2014
    ..Finally, this approach could easily be extended to the study of timing properties in other scintillation crystals, with a range of treatments and materials attached to the surface...
  71. pmc Performance and limitations of positron emission tomography (PET) scanners for imaging very low activity sources
    Melissa I Freedenberg
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Phys Med 30:104-10. 2014
    ..We conclude that for PET studies in a very low activity range, BGO-based scanners are likely to have better performance because of the lack of significant background...
  72. pmc Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer
    Wenwu Xiao
    Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    Int J Nanomedicine 7:1587-97. 2012
    ..The research reported herein describes the detailed quantitative imaging and biodistribution profiling of nanomicelles loaded with a cargo of paclitaxel...
  73. pmc New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation
    Tolulope A Aweda
    Chemistry Department, University of California, Davis, California 95616, United States
    Bioconjug Chem 22:1479-83. 2011
    ..Cerenkov luminescence imaging uniquely enables sensitive noninvasive in vivo imaging of a β(-) emitter such as (90)Y with an optical imager...
  74. ncbi request reprint Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging
    Yongfeng Yang
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 49:2527-45. 2004
    ..Finally, phantom and in vivo animal studies are presented to demonstrate the capabilities of microPET II for small-animal imaging studies...
  75. ncbi request reprint A comparison of x-ray detectors for mouse CT imaging
    Andrew L Goertzen
    Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA
    Phys Med Biol 49:5251-65. 2004
    ..Despite the higher DQE of the a-Se detector, the reconstructed CT images acquired with the a-Si detector had lower noise levels, likely due to the blurring effects from the phosphor screen...
  76. ncbi request reprint Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys
    Alice F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, University of California, Davis, Davis, CA 95616, USA
    Hum Gene Ther 17:1254-61. 2006
    ..These investigations have shown that HSV-1-sr39tk and firefly luciferase can be used to safely detect transgene expression at multiple time points in fetal and infant monkeys in vivo and without evidence of adverse effects...
  77. pmc X-ray luminescence optical tomography imaging: experimental studies
    Changqing Li
    School of Engineering, University of California, Merced, California 95343, USA
    Opt Lett 38:2339-41. 2013
    ..2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction. ..
  78. ncbi request reprint High-throughput imaging of brain gene expression
    Vanessa M Brown
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles, California 90095, USA
    Genome Res 12:244-54. 2002
    ..The results suggest that voxelation will be a useful approach for understanding how the genome constructs the brain...
  79. ncbi request reprint A multipinhole small animal SPECT system with submillimeter spatial resolution
    Tobias Funk
    Department of Radiology, University of California, San Francisco, California 94107, USA
    Med Phys 33:1259-68. 2006
    ..We expect that this system can perform SPECT with submillimeter spatial resolution, high throughput, and low radiation dose suitable for in vivo imaging of small animals...
  80. ncbi request reprint Monte Carlo simulations of compact gamma cameras based on avalanche photodiodes
    Philippe Despres
    Physics Research Laboratory, University of California, San Francisco, 185 Berry St suite 350, San Franciso, CA 94107, USA
    Phys Med Biol 52:3057-74. 2007
    ..These results suggest that APDs constitute an attractive technology especially suitable to build compact, small field of view gamma cameras dedicated, for example, to small animal or organ imaging...
  81. ncbi request reprint Effect of phantom voxelization in CT simulations
    Andrew L Goertzen
    Crump Institute for Molecular Imaging, University of California at Los Angeles School of Medicine, 90095, USA
    Med Phys 29:492-8. 2002
    ..No substantial improvement was achieved by tracing more than 4 rays per detector pixel...
  82. ncbi request reprint PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology, Clinic of Radiology, University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Radiology 244:807-14. 2007
    ..To prospectively use compact avalanche photodiodes instead of photomultiplier tubes to integrate a positron emission tomographic (PET) detector and a 7-T magnetic resonance (MR) imager...
  83. ncbi request reprint MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging
    Yuan Chuan Tai
    UCLA, Crump Institute for Molecular Imaging, Los Angeles, CA 90095 1770, USA
    Phys Med Biol 48:1519-37. 2003
    ....
  84. doi request reprint Simultaneous PET-MRI: a new approach for functional and morphological imaging
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Nat Med 14:459-65. 2008
    ..Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging...
  85. ncbi request reprint Investigation of different transcript quantitation tools for high-throughput mapping of brain gene expression using voxelation
    Ram P Singh
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Mol Histol 35:397-402. 2004
    ..These data indicate the suitability of a number of transcript profiling tools for various levels of spatial resolution in voxelation...
  86. ncbi request reprint Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging
    Abhijit J Chaudhari
    Signal and Image Processing Institute, Department of Electrical Engineering Systems, University of Southern California, Los Angeles, 90089, USA
    Phys Med Biol 50:5421-41. 2005
    ..Co-registration of the reconstructed 3D bioluminescent image with magnetic resonance images indicated good anatomical localization of the tumour...
  87. pmc Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: a microPET imaging study
    Christopher J Machado
    Department of Psychiatry and Behavioral Sciences, The California National Primate Research Center, 2825 50th Street, UC Davis, Sacramento, CA 95817, USA
    Neuroimage 39:832-46. 2008
    ..These observations raise the possibility that behavioral alterations in animals with neonatal lesions may be due to the intended damage, to consequent brain reorganization or to a combination of both factors...
  88. ncbi request reprint Simultaneous molecular and anatomical imaging of the mouse in vivo
    Andrew L Goertzen
    Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Phys Med Biol 47:4315-28. 2002
    ..We describe the design of this dual-modality imaging system and show, for the first time, simultaneously acquired PET and CT images in a phantom and in mice...
  89. ncbi request reprint Towards in vivo nuclear microscopy: iodine-125 imaging in mice using micro-pinholes
    Freek J Beekman
    Image Sciences Institute, University Hospital Utrecht, Heidelberglaan, The Netherlands
    Eur J Nucl Med Mol Imaging 29:933-8. 2002
    ..Possible future applications and extension to ultra-high-resolution emission tomography are discussed...
  90. ncbi request reprint Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small-animal positron emission tomograph
    Takashi Kudo
    Crump Institute for Molecular Imaging, Laboratory of Structural Biology and Molecular Medicine and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California at Los Angeles, 90095 1735, USA
    Circulation 106:118-23. 2002
    ..We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET)...
  91. ncbi request reprint Statistical analysis of multiplex brain gene expression images
    Alex Ossadtchi
    Department of Electrical Engineering, Signal and Image Processing Institute, School of Engineering, University of Southern California, Los Angeles 90089, USA
    Neurochem Res 27:1113-21. 2002
    ..The results suggest that ANOVA will be a valuable framework for insights into the large number of gene expression patterns obtained from voxelation...
  92. ncbi request reprint Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure
    Shaw Yung Shai
    Department of Physiology, University of California Los Angeles 90095, USA
    Circ Res 90:458-64. 2002
    ..This model provides strong evidence for the importance of beta1 integrin in cardiac form and function and indicates that integrins can be linked to development of cardiomyopathies...

Research Grants10

  1. A MICRO CT/PET SCANNER FOR IN VIVO SCREENING IN MICE
    SIMON CHERRY; Fiscal Year: 2001
    ..Finally, we will integrate a small number of microPET detectors with the CT system and acquire initial PET/CT studies in phantoms and mice. ..
  2. UC Davis Mouse Cancer Imaging Program
    SIMON CHERRY; Fiscal Year: 2008
    ..Finally, the MCIP describes a clear structure for governance and for providing imaging-related services to cancer researchers at UC Davis and beyond. [unreadable] [unreadable]..
  3. A microSPECT scanner for Molecular Imaging
    SIMON CHERRY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. UC Davis Mouse Cancer Imaging Program
    SIMON CHERRY; Fiscal Year: 2006
    ..Finally, the MCIP describes a clear structure for governance and for providing imaging-related services to cancer researchers at UC Davis and beyond. [unreadable] [unreadable]..
  5. IEEE Medical Imaging Conference
    SIMON CHERRY; Fiscal Year: 2005
    ..The exact number of awards and the amount of each award will depend on the number of applications that we receive. ..
  6. A MICRO CT/PET SCANNER FOR IN VIVO SCREENING OF MICE
    SIMON CHERRY; Fiscal Year: 2006
    ..Finally, the reproducibility of imaging anatomy and metabolism will be assessed both in repeat studies of the same subject, and in individual studies across subjects. ..
  7. HIGH RESOLUTION PET IMAGING OF MOUSE MODELS OF CANCER
    SIMON CHERRY; Fiscal Year: 2004
    ..abstract_text> ..
  8. APD BASED PET DETECTOR MODULES FOR BREAST IMAGING
    SIMON CHERRY; Fiscal Year: 2003
    ..Finally, the two detectors will be mounted on rotation/translation stages to perform imaging experiments with different geometry (ring and rotating plate), allowing the performance of an entire PET system to be projected. ..
  9. HIGH RESOLUTION PET IMAGING
    SIMON CHERRY; Fiscal Year: 2001
    ..abstract_text> ..
  10. Hyperspectral Optical Tomography for Molecular Imaging
    SIMON CHERRY; Fiscal Year: 2009
    ..A series of simulations, phantom and animal experiments will be used to validate the approach and the results will be compared to standard broadband methods that utilize high-pass filters. ..