Zhongping Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Reference spectrum extraction and fixed-pattern noise removal in optical coherence tomography
    Sucbei Moon
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 18:24395-404. 2010
  2. pmc Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
    Shanshan Liang
    Dalian University of Technology, School of Physics and Optoelectronic Engineering, Ganjingzi District, Dalian City, Liaoning Province, China
    J Biomed Opt 17:070501. 2012
  3. pmc A comparison of Doppler optical coherence tomography methods
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA
    Biomed Opt Express 3:2669-80. 2012
  4. pmc Phase-resolved acoustic radiation force optical coherence elastography
    Wenjuan Qi
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 17:110505. 2012
  5. pmc The future of medical diagnostics: review paper
    Waseem K Jerjes
    Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
    Head Neck Oncol 3:38. 2011
  6. pmc At the frontiers of surgery: review
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 3:7. 2011
  7. pmc Head & neck optical diagnostics: vision of the future of surgery
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 1:25. 2009
  8. ncbi request reprint Use of polarization-sensitive optical coherence tomography to determine the directional polarization sensitivity of articular cartilage and meniscus
    Tuqiang Xie
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 11:064001. 2006
  9. pmc In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model
    Matthew Brenner
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 13:034001. 2008
  10. pmc Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor
    Jianping Su
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612, USA
    J Biomed Opt 13:030506. 2008

Research Grants

  1. HIGH SPEED HIGH RESOLUTION PHASE RESOLVED OCT/ODT
    Zhongping Chen; Fiscal Year: 2001
  2. Optical Biopsy Using MEMs Technology
    Zhongping Chen; Fiscal Year: 2006
  3. Fourier Domain Functional OCT
    Zhongping Chen; Fiscal Year: 2009

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. pmc Reference spectrum extraction and fixed-pattern noise removal in optical coherence tomography
    Sucbei Moon
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 18:24395-404. 2010
    ..The inverse Fourier transform of the obtained reference A-line well matched the reference spectrum obtained by a physical measurement as well...
  2. pmc Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
    Shanshan Liang
    Dalian University of Technology, School of Physics and Optoelectronic Engineering, Ganjingzi District, Dalian City, Liaoning Province, China
    J Biomed Opt 17:070501. 2012
    ..5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system...
  3. pmc A comparison of Doppler optical coherence tomography methods
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA
    Biomed Opt Express 3:2669-80. 2012
    ..The IBDV method was found to be able to obtain high resolution image with a relative simple processing procedure...
  4. pmc Phase-resolved acoustic radiation force optical coherence elastography
    Wenjuan Qi
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 17:110505. 2012
    ..Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties...
  5. pmc The future of medical diagnostics: review paper
    Waseem K Jerjes
    Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
    Head Neck Oncol 3:38. 2011
    ..The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions...
  6. pmc At the frontiers of surgery: review
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 3:7. 2011
    ..We review the salient advances in the field and propose further directions of investigation...
  7. pmc Head & neck optical diagnostics: vision of the future of surgery
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 1:25. 2009
    ..We are fortunate that this is indeed a possibility and may fundamentally change current clinical and surgical practice to improve our patients' lives...
  8. ncbi request reprint Use of polarization-sensitive optical coherence tomography to determine the directional polarization sensitivity of articular cartilage and meniscus
    Tuqiang Xie
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 11:064001. 2006
    ....
  9. pmc In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model
    Matthew Brenner
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 13:034001. 2008
    ..OCT is capable of quantitatively detecting regional changes in airway swelling following inhalation injury...
  10. pmc Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor
    Jianping Su
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612, USA
    J Biomed Opt 13:030506. 2008
    ..To couple with the system speed, an endoscope based on an improved 3-D microelectromechanical motor (diameter 1.5 mm, length 9.4 mm) was developed. In vivo 3-D imaging of the human airway was demonstrated...
  11. pmc Rotational multiphoton endoscopy with a 1 microm fiber laser system
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Opt Lett 34:2249-51. 2009
    ..034 microm and a repetition rate of 50 MHz. Second-harmonic-generation images of rat-tail tendon and fish scale are demonstrated with the rotational probe-based multiphoton system...
  12. ncbi request reprint In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror
    Woonggyu Jung
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, USA
    Opt Lett 32:3239-41. 2007
    ..The device was integrated with a conventional endoscope and utilized to generate in vivo 3-D clinical images in humans and animals...
  13. pmc Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx
    Shuguang Guo
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
    J Biomed Opt 14:014017. 2009
    ..In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis...
  14. pmc Real-time polarization-sensitive optical coherence tomography data processing with parallel computing
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, California 92612, USA
    Appl Opt 48:6365-70. 2009
    ..The real-time 2D and 3D polarization-sensitive imaging of chicken muscle and pig tendon is also demonstrated...
  15. pmc In vivo three-dimensional imaging of normal tissue and tumors in the rabbit pleural cavity using endoscopic swept source optical coherence tomography with thoracoscopic guidance
    Tuqiang Xie
    University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 14:064045. 2009
    ..The imaging probe of the system was found to be easily adaptable to various sites within the thoracic cavity and can be readily adapted to other sites, including rigid airway endoscopic examinations...
  16. ncbi request reprint Depth-resolved birefringence and differential optical axis orientation measurements with fiber-based polarization-sensitive optical coherence tomography
    Shuguang Guo
    Beckman Laser Institute, Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 29:2025-7. 2004
    ..Experimental results with beef tendon and rabbit tendon and muscle show that this technique has promising potential for imaging the birefringent structure of multiple-layer samples with varying optical axes...
  17. ncbi request reprint Low-noise broadband light generation from optical fibers for use in high-resolution optical coherence tomography
    Yimin Wang
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, California 92612, USA
    J Opt Soc Am A Opt Image Sci Vis 22:1492-9. 2005
    ..The results showed that a single-mode fiber with a small core diameter is a useful way to generate low-noise, broadband light for high-resolution OCT imaging...
  18. ncbi request reprint Evaluation of tracheal imaging by optical coherence tomography
    Sukgu Han
    Department of Biomedical Engineering, Beckman Laser Institute Irvine, Irvine, California, USA
    Respiration 72:537-41. 2005
    ..Recent advances in data acquisition, analysis, and processing enable real-time imaging, and make OCT a potentially valuable tool for pulmonary airway diagnostic applications, including assisting directed airway biopsies...
  19. ncbi request reprint Determination of characteristics of degenerative joint disease using optical coherence tomography and polarization sensitive optical coherence tomography
    Tuqiang Xie
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 38:852-65. 2006
    ....
  20. ncbi request reprint Use of polar decomposition for the diagnosis of oral precancer
    Jungrae Chung
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Appl Opt 46:3038-45. 2007
    ..Our results indicate that polarimetry has potential as a method for the in vivo early detection and diagnosis of oral premalignancy...
  21. pmc Imaging vibrating vocal folds with a high speed 1050 nm swept source OCT and ODT
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 19:11880-9. 2011
    ..The quantitative transverse direction velocity distribution in the cross-sectional images was obtained with the Doppler variance images...
  22. ncbi request reprint Dynamic morphology of sutureless cataract wounds--effect of incision angle and location
    Mehran Taban
    Department of Ophthalmology, University of California Irvine, Irvine, California, USA
    Surv Ophthalmol 49:S62-72. 2004
    ..The purpose of this study was to evaluate the effect of intraocular pressure (IOP), location, and angle of cataract incisions on wound apposition and sealing in postmortem globes...
  23. ncbi request reprint Fiber-optic-bundle-based optical coherence tomography
    Tuqiang Xie
    Beckman Laser Institute, Department of Biomedical Engineering, Pulmonary and Critical Care Division, UC Irvine Medical Center, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 30:1803-5. 2005
    ....
  24. ncbi request reprint Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography
    Matthew Brenner
    University of California Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 12:051701. 2007
    ..These studies suggest that OCT may have the ability to provide information on potential early indicators of impending smoke-inhalation-induced airway compromise...
  25. pmc Optical coherence tomography-enhanced microlaryngoscopy: preliminary report of a noncontact optical coherence tomography system integrated with a surgical microscope
    David E Vokes
    Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California, USA
    Ann Otol Rhinol Laryngol 117:538-47. 2008
    ..This aim of this study was to develop and evaluate a novel OCT system integrated with a surgical microscope to allow hands-free OCT imaging of the VFs, which could be performed simultaneously with microscopic visualization...
  26. pmc Quantitative Evaluation of Adult Subglottic Stenosis Using Intraoperative Long-range Optical Coherence Tomography
    Giriraj K Sharma
    Department of Otolaryngology Head and Neck Surgery, University of California, Irvine, California, USA
    Ann Otol Rhinol Laryngol 125:815-22. 2016
    ....
  27. ncbi request reprint Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator
    Jun Zhang
    Beckman Laser Institute and the Center for Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 30:147-9. 2005
    ..The imaging range was doubled by cancellation of the mirror image. The elimination of low-frequency noises resulting from dc and autocorrelation terms increased the sensitivity by 20 dB...
  28. pmc Semi-resonant operation of a fiber-cantilever piezotube scanner for stable optical coherence tomography endoscope imaging
    Sucbei Moon
    Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA
    Opt Express 18:21183-97. 2010
    ..In addition, it has been found that the Lissajous scan strategy provides a means to compensate the relative axial motion of a sample for a correct imaged morphology...
  29. pmc Optical coherence tomography of the newborn airway
    James M Ridgway
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Irvine, California, USA
    Ann Otol Rhinol Laryngol 117:327-34. 2008
    ..We examined the ability of this noninvasive technique to characterize the newborn airway in a prospective clinical trial...
  30. pmc Quantitative phase evaluation of dynamic changes on cell membrane during laser microsurgery
    Lingfeng Yu
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 13:050508. 2008
    ..Such quantitation was not possible using conventional phase-contrast microscopy...
  31. ncbi request reprint Ultrahigh-resolution optical coherence tomography with a fiber laser source at 1 microm
    Hyungsik Lim
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 30:1171-3. 2005
    ..1 microm in air (<1.6 microm in biological tissue). The generation of a broad bandwidth is robust and efficient. We demonstrate ultrahigh-resolution, time-domain OCT imaging of in vitro and in vivo biological tissues...
  32. pmc Characterization of Fourier domain mode-locked wavelength swept laser for optical coherence tomography imaging
    Min Yong Jeon
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 16:3727-37. 2008
    ..With the FDML laser, the detection sensitivity up to 102 dB is achieved for the backward scans. The backward scans exhibit higher axial resolution and sensitivity than the forward scan...
  33. pmc Topographical variations in the polarization sensitivity of articular cartilage as determined by polarization-sensitive optical coherence tomography and polarized light microscopy
    Tuqiang Xie
    University of California, Irvine, College of Medicine, Beckman Laser Institute and Medical Clinic, Irvine, California 92612, USA
    J Biomed Opt 13:054034. 2008
    ....
  34. pmc Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography
    Kelly A Kreuter
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 14:044037. 2009
    ..OCT has the potential to be a high resolution imaging modality capable of detecting, assessing, and monitoring treatment for airway injury following mustard vesicant agent exposures...
  35. pmc Three-dimensional speckle suppression in Optical Coherence Tomography based on the curvelet transform
    Zhongping Jian
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Opt Express 18:1024-32. 2010
    ..We show the approach suppresses a significant amount of speckle noise, while in the mean time preserves and thus reveals many subtle features that could get attenuated in other approaches...
  36. pmc Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography
    Marie J Hammer-Wilson
    University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92612, USA
    J Biomed Opt 15:016017. 2010
    ..The submucosal and muscle layers of the cheek pouch tissue showed the greatest amount of structural alteration. Routine light microscope histology was performed to confirm the OCT observations...
  37. ncbi request reprint Quantification of a three-dimensional velocity vector using spectral-domain Doppler optical coherence tomography
    Yeh Chan Ahn
    Beckman Laser Institute, Department of Biomedical Engineering, University of California, Irvine, California 92617, USA
    Opt Lett 32:1587-9. 2007
    ..After calibration, an unknown velocity vector field inside a microtube was quantified by solving a three-dimensional minimization problem...
  38. ncbi request reprint Noninvasive imaging of oral premalignancy and malignancy
    Petra Wilder-Smith
    University of California, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 10:051601. 2005
    ..Our conclusions are that OCT/ODT and MPM/SHG are promising noninvasive in vivo diagnostic modalities for oral dysplasia and malignancy...
  39. pmc Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles
    Chang Soo Kim
    University of California, Irvine, Department of Chemical Engineering, Irvine, California 92697, USA
    J Biomed Opt 14:034008. 2009
    ....
  40. ncbi request reprint Office-based optical coherence tomographic imaging of human vocal cords
    Shuguang Guo
    University of California, Irvine, Department of Biomedical Engineering and Beckman Laser Institute, 92697, USA
    J Biomed Opt 11:30501. 2006
    ..Office-based OCT has the potential to guide surgical biopsies, direct therapy, and monitor disease. This is a promising imaging modality to study the larynx...
  41. pmc In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients
    Petra Wilder-Smith
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 41:353-7. 2009
    ..In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies...
  42. pmc Digital holographic microscopy for quantitative cell dynamic evaluation during laser microsurgery
    Lingfeng Yu
    Beckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA
    Opt Express 17:12031-8. 2009
    ..This system will permit quantitative evaluation of the damage and/or the repair of the cell or cell organelles in real time...
  43. pmc Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats
    Magdalene J Seiler
    Department of Anatomy and Neurobiology, University of California, Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Irvine, CA, United States
    J Neurosci Methods 188:250-7. 2010
    ..To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants...
  44. pmc Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue
    Yueqiao Qu
    Department of Biomedical Engineering, the Edwards Life Sciences Center for Advanced Cardiovascular Technology, and Beckman Laser Institute, University of California, Irvine, Irvine, CA 92697 USA
    IEEE J Sel Top Quantum Electron 22:. 2016
    ..We obtained 3-D elastograms of a healthy cornea and a highly cross-linked cornea. Finally we induced a stiffness change on a small portion of a cornea and observed the differences in displacement...
  45. ncbi request reprint Noninvasive measurement of ablation crater size and thermal injury after CO2 laser in the vocal cord with optical coherence tomography
    Behrooz A Torkian
    Department of Otolaryngology Head and Neck Surgery, Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road, Irvine, CA 92612, USA
    Otolaryngol Head Neck Surg 134:86-91. 2006
    ..To characterize tissue destruction after CO(2) laser-ablation of the vocal cords with the use of optical coherence tomography (OCT)...
  46. pmc Office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography
    Lingfeng Yu
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
    J Biomed Opt 14:064020. 2009
    ..Office-based OCT is a promising imaging modality to study the larynx for physicians in otolaryngology...
  47. pmc Optical coherence tomography of the larynx using the Niris system
    Marc Rubinstein
    Department of Otolaryngology Head and Neck Surgery and Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA
    J Otolaryngol Head Neck Surg 39:150-6. 2010
    ....
  48. pmc Intensity-based modified Doppler variance algorithm: application to phase instable and phase stable optical coherence tomography systems
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 19:11429-40. 2011
    ..In-vivo imaging of the human choroidal blood vessel network is demonstrated with the proposed method under the phase stable situation. Depth-resolved fine choroidal blood vessel networks are shown...
  49. ncbi request reprint In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe
    Peter H Tran
    Department of Biomedical Engineering and Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 29:1236-8. 2004
    ..Because our MEMS scanner does not require the coupling of a rotational single-mode fiber, a high scanning speed is possible while eliminating unstable optical signals caused by nonuniform coupling...
  50. ncbi request reprint Accurate measurement of blood vessel depth in port wine stained human skin in vivo using pulsed photothermal radiometry
    Bincheng Li
    University of California at Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 9:961-6. 2004
    ..The most superficial PWS depths determined in vivo by PPTR are in good agreement with those measured using optical Doppler tomography (ODT)...
  51. ncbi request reprint Digital holographic tomography based on spectral interferometry
    Lingfeng Yu
    Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 32:3005-7. 2007
    ..Experiments were performed to demonstrate the idea...
  52. ncbi request reprint Imaging of the pediatric airway using optical coherence tomography
    James Matthew Ridgway
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, CA 92617, USA
    Laryngoscope 117:2206-12. 2007
    ..A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess the utility of OCT technology in characterizing the microanatomy of the pediatric upper aerodigestive tract in vivo...
  53. pmc High-resolution imaging of microvasculature in human skin in-vivo with optical coherence tomography
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 20:7694-705. 2012
    ..2 mm in human skin. These results collectively demonstrated the potential of the method to monitor the microvasculature during disease progression and in response to therapeutic intervention...
  54. pmc Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography
    Claire Robertson
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
    J Biomed Opt 16:106011. 2011
    ..The technique may have applications in assessing airway mechanics in diseases such as asthma that are characterized by significant airway remodeling...
  55. ncbi request reprint Low-voltage polymer-based scanning cantilever for in vivo optical coherence tomography
    Yuli Wang
    Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, California 92697, USA
    Opt Lett 30:53-5. 2005
    ..Low driving voltage ensures safety. Two different optical designs achieve both forward and sidewise scanning and make it possible to image everywhere within the human oral cavity. In vivo OCT imaging of the human tongue is demonstrated...
  56. ncbi request reprint High-resolution frequency-domain second-harmonic optical coherence tomography
    Jianping Su
    Department of Biomedical Engineering, Beckman Laser Institute, University of California, CA 92697, USA
    Appl Opt 46:1770-5. 2007
    ..Highly organized collagen fibrils can be visualized in the recorded images. Polarization dependence on the SH has been used to obtain polarization resolved images...
  57. pmc Speckle attenuation in optical coherence tomography by curvelet shrinkage
    Zhongping Jian
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Opt Lett 34:1516-8. 2009
    ..The speckle attenuation is controlled by a single parameter that determines the threshold in the curvelet domain. Applying the algorithm to OCT images shows significant improvement of image quality...
  58. pmc Optimal flushing agents for integrated optical and acoustic imaging systems
    Jiawen Li
    University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92617, United StatesbUniversity of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 2700, United States
    J Biomed Opt 20:56005. 2015
    ..We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging...
  59. pmc Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo
    Jiawen Li
    Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Rd Irvine, CA 92617, USA
    Sci Rep 5:18406. 2015
    ....
  60. ncbi request reprint In vivo optical coherence tomography of the nasal mucosa
    Usama Mahmood
    Department of Biomedical Engineering and Otolaryngology Head and Neck Surgery, Beckman Laser Institute, University of California at Irvine, Irvine, California 92612, USA
    Am J Rhinol 20:155-9. 2006
    ..OCT is analogous to ultrasound, but relies on interferometry and low-coherence optical sources to produce images of tissue structure at the histological level...
  61. pmc Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model
    Lingfeng Yu
    University of California, Department of Biomedical Engineering, Irvine, CA 92612 1475, USA
    J Biomed Opt 15:066006. 2010
    ....
  62. pmc Real-time bulk-motion-correction free Doppler variance optical coherence tomography for choroidal capillary vasculature imaging
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 19:3657-66. 2011
    ..High resolution images of choroidal capillary of the vasculature network with phased-resolved color Doppler and Doppler variance are shown...
  63. pmc Polarization-maintaining buffered Fourier domain mode-locked swept source for optical coherence tomography
    Jun Zhang
    Beckman Laser Institute and the Department of Biomedical Engineering, University of California, Irvine, California 92612, USA
    Opt Lett 36:4788-90. 2011
    ..The axial resolution of the SSOCT system is measured to be 9.4 µm in air. The sensitivity of the SSOCT system is 107.5 dB at a depth of 0.25 mm with a 6 dB roll-off at a depth of 2.25 mm...
  64. doi request reprint Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo
    Jiawen Li
    Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:3175-8. 2012
    ..In addition, in vitro imaging of cadaver coronary arteries were conducted to demonstrate the imaging capabilities of this integrated catheter to classify different atherosclerotic plaque types...
  65. pmc Combined multimodal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics
    Min Suk Shim
    Department of Chemical Engineering and Materials Science, University of California, Irvine, California 92697, USA
    J Am Chem Soc 132:8316-24. 2010
    ..This novel type of stimuli-responsive nanotheragnostics will provide a new paradigm for pinpointed, multimodal, and combined imaging and therapy for cancer...
  66. pmc Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display
    Jiawen Li
    University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612cUniversity of California, Irvine, Beckman Laser Institute, Irvine, California 92612eUniversity of California, Irvine, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Irvine, California 92617
    J Biomed Opt 18:100502. 2013
    ..Histology validation is also presented...
  67. pmc Real-time subglottic stenosis imaging using optical coherence tomography in the rabbit
    Jennifer L Lin
    Beckman Laser Institute, University of California Irvine, Irvine, CA 92617, USA
    JAMA Otolaryngol Head Neck Surg 139:502-9. 2013
    ..Subglottic stenosis (SGS) is a severe, acquired, potentially life-threatening disease that can be caused by endotracheal tube intubation. Newborns and neonates are particularly susceptible to SGS owing to the small caliber of their airway...
  68. ncbi request reprint Feasibility study of normal and septic tracheal imaging using optical coherence tomography
    Woonggyu Jung
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 35:121-7. 2004
    ..The goal of this study was to evaluate the feasibility of OCT to image tracheal pathology...
  69. ncbi request reprint In vivo optical coherence tomography for the diagnosis of oral malignancy
    Petra Wilder-Smith
    Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    Lasers Surg Med 35:269-75. 2004
    ..Objective was to investigate in vivo non-invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia-related epithelial, sub-epithelial changes throughout carcinogenesis...
  70. ncbi request reprint Characterization of submucosal lesions using optical coherence tomography in the rabbit subglottis
    Amir M Karamzadeh
    Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center, Orange, USA
    Arch Otolaryngol Head Neck Surg 131:499-504. 2005
    ..To evaluate the efficacy of optical coherence tomography in differentiating between several simulated subglottic lesions, using an ex vivo rabbit laryngotracheal model...
  71. ncbi request reprint In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography
    Petra Wilder-Smith
    Beckman Laser Institute, University of California at Irvine, CA 92612, USA
    Clin Cancer Res 13:2449-54. 2007
    ..To assess noninvasive optical coherence tomography (OCT) and optical Doppler tomography (ODT) for early detection and evaluation of chemotherapy-induced oral mucositis...
  72. ncbi request reprint In vivo optical coherence tomography-based scoring of oral mucositis in human subjects: a pilot study
    Hilari Kawakami-Wong
    University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 12:051702. 2007
    ..Chemotherapy-induced oral changes were identified prior to their clinical manifestation using OCT, and the proposed scoring system for oral mucositis was validated for the semiquantification of mucositic change...
  73. pmc Optical sectioning for microfluidics: secondary flow and mixing in a meandering microchannel
    Yeh Chan Ahn
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, CA, USA
    Lab Chip 8:125-33. 2008
    ..An alternating pair of counter-rotating and toroidal vortices cooperated to enhance two-liquid mixing...
  74. pmc Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging
    Khiet C Hoang
    University of California, Irvine, Department of Medicine, Division of Cardiology, 101 The City Drive, Building 53, Room 100, Route 81, Orange, California 92868, USA
    J Biomed Opt 14:034028. 2009
    ..From this proof-of-concept study, we demonstrate that endovascular flushing with an oxygen-carrying blood substitute (PFD) is optically superior to saline flushing for intravascular imaging...
  75. pmc Multiphoton microscopy system with a compact fiber-based femtosecond-pulse laser and handheld probe
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    J Biophotonics 4:34-9. 2011
    ..The packaged probe had a diameter of 16 mm. Second harmonic generation (SHG) images and two-photon excited fluorescence (TPEF) images of biological tissues were demonstrated using the system...
  76. pmc High-speed and wide bandwidth Fourier domain mode-locked wavelength swept laser with multiple SOAs
    Min Yong Jeon
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 16:2547-54. 2008
    ..4 mW for both the forward and backward scans. The measured system sensitivity is achieved up to 100.7 dB. We also demonstrate OCT imaging using the FDML wavelength swept laser with two semiconductor optical amplifiers...
  77. ncbi request reprint In vitro measurement of rabbit corneal epithelial thickness using ultrahigh resolution optical coherence tomography
    Bibiana J Reiser
    Department of Ophthalmology, University of California, Irvine, California, USA
    Vet Ophthalmol 8:85-8. 2005
    ..001). Rabbit corneal epithelium is thicker centrally than at the limbus when measured by ultrahigh resolution OCT. This technique will aid in delineating the pathophysiology of diseases of the anterior cornea...
  78. pmc Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy
    Woonggyu Jung
    Beckman Laser Institute, University of California, Irvine, CA 92697, USA
    Opt Lett 33:1324-6. 2008
    ..The completed probe was 1 cm in outer diameter and 14 cm in length. The developed probe was integrated into an MPM system and used to image fluorescent beads, paper, and biological specimens...
  79. pmc Fiber-based combined optical coherence and multiphoton endomicroscopy
    Gangjun Liu
    University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 16:036010. 2011
    ..Simultaneous optical coherence microscopic imaging, second harmonic generation imaging, and two-photon excitation fluorescence imaging are demonstrated in biological samples...
  80. pmc Mode-filtered large-core fiber for short-pulse delivery with reduced nonlinear effects
    Sucbei Moon
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92617, USA
    Opt Lett 36:3362-4. 2011
    ..It has been found that this fiber class is suitable for applications, such as an endoscopic multiphoton microscope, that demand a flexible short-distance (<4 m) delivery medium of ultrashort pulses...
  81. doi request reprint Gastrointestinal optical coherence tomography: clinical applications, limitations, and research priorities
    Jun Zhang
    Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, 92612, USA
    Gastrointest Endosc Clin N Am 19:243-59. 2009
    ..There are several potential clinical applications for optical coherence tomography, particularly with precancerous conditions of the gastrointestinal tract. The future of optical coherence tomography is discussed...
  82. ncbi request reprint Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model
    Alvin T Yeh
    University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 9:248-53. 2004
    ..This study illustrates the complementary features of linear and nonlinear light-tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues...
  83. pmc Fiber delivered probe for efficient CARS imaging of tissues
    Mihaela Balu
    Laser Microbeam and Medical Program LAMMP, Beckman Institute and Medical Clinic, 1002 Health Sciences Road East, University of California, Irvine, 92612, USA
    Opt Express 18:2380-8. 2010
    ..Different biological tissues were imaged ex vivo in order to assess the performance of our fiber-delivered probe for CARS imaging, a tool which we consider an important advance towards label-free, in vivo probing of superficial tissues...
  84. pmc Doppler variance imaging for three-dimensional retina and choroid angiography
    Lingfeng Yu
    University of California, Irvine, Irvine Beckman Laser Institute, Department of Biomedical Engineering, Irvine, California 92612, USA
    J Biomed Opt 15:016029. 2010
    ..Experiments were performed to demonstrate the effectiveness of the proposed method for 3-D vasculature imaging of human retina and choroid...
  85. pmc Preliminary investigation on use of high-resolution optical coherence tomography to monitor injury and repair in the rat sciatic nerve
    Cara A Chlebicki
    Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
    Lasers Surg Med 42:306-12. 2010
    ..The purpose of the study is to determine whether high-resolution OCT can be used to monitor nerve injury and regeneration in the rat sciatic nerve following crush injury, ligation, and transection with microsurgical repair...
  86. ncbi request reprint Clinical testing of a photoacoustic probe for port wine stain depth determination
    John A Viator
    Beckman Laser Institute and Medical Clinic, Irvine, California 92612, USA
    Lasers Surg Med 30:141-8. 2002
    ..We designed, constructed, and clinically tested a photoacoustic probe for PWS depth determination...
  87. ncbi request reprint Imaging the internal structure of the rat cochlea using optical coherence tomography at 0.827 microm and 1.3 microm
    Brian J F Wong
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Otolaryngol Head Neck Surg 130:334-8. 2004
    ..The purpose of this study was to use high-speed optical coherence tomography (OCT) to obtain cross-sectional images of the rat cochlea...
  88. ncbi request reprint In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patients
    Brian J F Wong
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California, USA
    Laryngoscope 115:1904-11. 2005
    ..Patients undergoing surgical head and neck endoscopy were examined using a fiberoptic OCT imaging probe to study and characterize microstructural anatomy and features of the larynx and benign laryngeal pathology in vivo...
  89. ncbi request reprint Optical coherence tomography of laryngeal cancer
    William B Armstrong
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California 92868, USA
    Laryngoscope 116:1107-13. 2006
    ..This prospective study evaluated the ability of OCT to identify the characteristics of laryngeal cancer and measure changes in the basement membrane, tissue microstructure, and the transition zone at the edge of tumors...
  90. pmc Imaging the human tympanic membrane using optical coherence tomography in vivo
    Hamid R Djalilian
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, CA 92868, USA
    Otol Neurotol 29:1091-4. 2008
    ..Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions...
  91. pmc A biological global positioning system: considerations for tracking stem cell behaviors in the whole body
    Shengwen Calvin Li
    Center for Neuroscience and Stem Cell Research, Children s Hospital of Orange County Research Institute, University of California Irvine, 455 South Main Street, Orange, CA 92868, USA
    Stem Cell Rev 6:317-33. 2010
    ..We then discuss an ideal procedure for labeling and tracking stem cells in vivo, finally, we present a novel imaging system based on our experiments...
  92. ncbi request reprint Determination of burn depth by polarization-sensitive optical coherence tomography
    Shyam M Srinivas
    Beckman Laser Institute, Department of Biomedical Engineering and Surgery, University of California Irvine, Irvine, CA 92612, USA
    J Biomed Opt 9:207-12. 2004
    ..PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients...
  93. pmc High-dynamic-range quantitative phase imaging with spectral domain phase microscopy
    Jun Zhang
    Beckman Laser Institute and the Center for Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 34:3442-4. 2009
    ..Two-dimensional quantitative phase imaging of human neonatal dermal keratinocyte cells was demonstrated to evaluate the performance of the system for cell imaging...
  94. ncbi request reprint Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber
    Yimin Wang
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 28:182-4. 2003
    ..The system employed a dynamic-focusing tracking method to maintain high lateral resolution over a large imaging depth. Subcellular imaging is demonstrated...
  95. ncbi request reprint Second-harmonic optical coherence tomography
    Yi Jiang
    Beckman Laser Institute, Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 29:1090-2. 2004
    ..Because of the strong dependence of second-harmonic generation on molecular and tissue structures, this technique imparts contrast and resolution enhancement to conventional optical coherence tomography...
  96. ncbi request reprint Dynamic morphology of clear corneal cataract incisions
    Peter J McDonnell
    Department of Ophthalmology, University of California Irvine, Irvine, California, USA
    Ophthalmology 110:2342-8. 2003
    ..The goal of this study was to examine in vitro dynamic changes in unhealed clear corneal cataract incisions that might adversely affect the risk of intraocular infection...
  97. ncbi request reprint Optical coherence tomography of malignancy in hamster cheek pouches
    Erin S Matheny
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    J Biomed Opt 9:978-81. 2004
    ..The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis...
  98. ncbi request reprint Effect of pulse duration on two-photon excited fluorescence and second harmonic generation in nonlinear optical microscopy
    Shuo Tang
    J Biomed Opt 11:020501. 2006
    ..Because of improved signal-to-noise ratio, sub-20-fs pulses were used to enhance MPM imaging depth by approximately 160%, compared to 120-fs pulses, in human skin...
  99. ncbi request reprint Combined multiphoton microscopy and optical coherence tomography using a 12-fs broadband source
    Shuo Tang
    J Biomed Opt 11:020502. 2006
    ..The combined MPM/OCT microscope is capable of providing simultaneous functional and structural information from cells and extracellular matrix and is potentially a powerful tool for studying biological processes in thick tissues...

Research Grants3

  1. HIGH SPEED HIGH RESOLUTION PHASE RESOLVED OCT/ODT
    Zhongping Chen; Fiscal Year: 2001
    ..abstract_text> ..
  2. Optical Biopsy Using MEMs Technology
    Zhongping Chen; Fiscal Year: 2006
    ..project involving scientists, engineers, and clinicians at UCI Beckman Laser Institute and Medical Clinic (Zhongping Chen), UCI Department of Medicine and Endoscopic Ultrasound Center (Kenneth Chang), UCI Department of Electrical ..
  3. Fourier Domain Functional OCT
    Zhongping Chen; Fiscal Year: 2009
    ....