Wilbur H Chen

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Safety and Immunogenicity of a Parenterally Administered, Structure-Based Rationally Modified Recombinant Staphylococcal Enterotoxin B Protein Vaccine, STEBVax
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 23:918-925. 2016
  2. pmc Shigella Vaccine Development: Finding the Path of Least Resistance
    Wilbur H Chen
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 23:904-907. 2016
  3. pmc Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 23:73-7. 2015
  4. doi request reprint Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 14:269-78. 2008
  5. pmc Vaccination in the elderly: an immunological perspective
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Trends Immunol 30:351-9. 2009
  6. pmc Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 16:322-32. 2010
  7. pmc Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 29:2865-73. 2011
  8. pmc Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Immunol Lett 141:227-34. 2012
  9. doi request reprint Vaccines for enteric infections
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Gastroenterol 28:18-23. 2012
  10. pmc Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4
    Stephen H Gregory
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA
    Vaccine 28:2908-15. 2010

Detail Information

Publications24

  1. pmc Safety and Immunogenicity of a Parenterally Administered, Structure-Based Rationally Modified Recombinant Staphylococcal Enterotoxin B Protein Vaccine, STEBVax
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 23:918-925. 2016
    ..These data support its continued clinical development. (This study has been registered at ClinicalTrials.gov under registration no. NCT00974935.)...
  2. pmc Shigella Vaccine Development: Finding the Path of Least Resistance
    Wilbur H Chen
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 23:904-907. 2016
    ..A parenteral Shigella vaccine capable of eliciting protection in children of developing countries would be an important tool to reach this goal...
  3. pmc Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 23:73-7. 2015
    ..We previously reported the immunogenicity of an A/H5N1 vaccine extemporaneously mixed with the AS03 adjuvant for 42 days following vaccination. This report extends those findings to 1 year after vaccination. ..
  4. doi request reprint Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 14:269-78. 2008
    ..We conclude that further studies on the use of J5dLPS-OMP for the prevention of nosocomial pneumonia are warranted...
  5. pmc Vaccination in the elderly: an immunological perspective
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Trends Immunol 30:351-9. 2009
    ..However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines...
  6. pmc Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 16:322-32. 2010
    ..These observations provide further evidence for the inclusion of innate immune-based adjuvants during the development of next-generation vaccines...
  7. pmc Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 29:2865-73. 2011
    ....
  8. pmc Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Immunol Lett 141:227-34. 2012
    ..Alternatively activated macrophages (AAM) in the lungs may play a critical role in eliciting the hypersusceptibility to secondary bacterial pneumonia...
  9. doi request reprint Vaccines for enteric infections
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Gastroenterol 28:18-23. 2012
    ..To provide a review of currently licensed enteric vaccines and their efficacy based on completed field trials...
  10. pmc Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4
    Stephen H Gregory
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA
    Vaccine 28:2908-15. 2010
    ..tularensis. The efficacy of J5dLPS/OMP vaccine suggests its potential utility in immunizing the general population against several different gram-negative select agents concurrently...
  11. pmc Phase 2 assessment of the safety and immunogenicity of two inactivated pandemic monovalent H1N1 vaccines in adults as a component of the U.S. pandemic preparedness plan in 2009
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 30:4240-8. 2012
    ....
  12. pmc Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues
    Samer S El-Kamary
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 202:1649-58. 2010
    ..Noroviruses cause significant morbidity and mortality from acute gastroenteritis in all age groups worldwide...
  13. pmc The TLR4 antagonist Eritoran protects mice from lethal influenza infection
    Kari Ann Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
    Nature 497:498-502. 2013
    ..Thus, Eritoran blockade of TLR signalling represents a novel therapeutic approach for inflammation associated with influenza, and possibly other infections...
  14. pmc Safety and immunogenicity of single-dose live oral cholera vaccine strain CVD 103-HgR, prepared from new master and working cell banks
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 21:66-73. 2014
    ..This study has been registered at ClinicalTrials.gov under registration no. NCT01585181.). ..
  15. pmc Single-dose Live Oral Cholera Vaccine CVD 103-HgR Protects Against Human Experimental Infection With Vibrio cholerae O1 El Tor
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore
    Clin Infect Dis 62:1329-35. 2016
    ..We investigated the protection conferred by this vaccine in a human cholera challenge model...
  16. pmc Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans
    Monica A McArthur
    Center for Vaccine Development CVD, University of Maryland, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 11:e0005291. 2017
    ..Collectively, despite small numbers of volunteers, our results indicate a potential role for CD4+ T cells, in particular pTfh, in modulating disease outcome following exposure to wt ETEC in a volunteer experimental challenge model...
  17. pmc Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding
    Mihai Nita-Lazar
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA Institute of Marine and Environmental Technology, Columbus Center, 701 East Pratt Street, Baltimore, MD 21202, USA
    Mol Immunol 65:1-16. 2015
    ..The observed enhancement of pneumococcal adhesion may be a contributing factor to the observed hypersusceptibility to pneumonia of influenza patients. ..
  18. ncbi request reprint A case for immunization against nosocomial infections
    Alan S Cross
    Department of Medicine, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Leukoc Biol 83:483-8. 2008
    ..Such a strategy could reduce or ameliorate nosocomial infections and perhaps limit dissemination of nosocomial pathogens. Thus, a more aggressive effort to develop vaccines for nosocomial infections is warranted...
  19. pmc Role of Bacillus anthracis spore structures in macrophage cytokine responses
    Subhendu Basu
    Center for Vaccine Development, Department of Medicine, University of Maryland, 685 W Baltimore Street, HSF I 480, Baltimore, MD 21201, USA
    Infect Immun 75:2351-8. 2007
    ..anthracis involves multiple pattern recognition receptors and signaling pathways, and (iv) compared to other cytokines, IL-1beta is expressed at a lower spore concentration...
  20. pmc Herpes zoster vaccine for the elderly: boosting immunity
    Joel V Chua
    Division of Infectious Disease, University of Maryland School of Medicine, MD, USA, Tel 1 410 328 5039
    Aging health 6:169-176. 2010
    ..Future studies for improved vaccines and studies into the epidemiology of herpes zoster are required in order to address this significant public health burden...
  21. pmc Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind, randomised phase 4 trial
    Milagritos D Tapia
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet Infect Dis 16:1026-35. 2016
    ..We aimed to assess the safety, immunogenicity, and efficacy of maternal immunisation with trivalent inactivated influenza vaccine for protection of infants against a first episode of laboratory-confirmed influenza...
  22. pmc Safety and immunogenicity of escalating dosages of a single oral administration of peru-15 pCTB, a candidate live, attenuated vaccine against enterotoxigenic Escherichia coli and Vibrio cholerae
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 22:129-35. 2015
    ..These encouraging data support the ongoing clinical development of this candidate combined cholera and ETEC vaccine. (This study has been registered at ClinicalTrials.gov under registration no. NCT00654108.)...
  23. pmc Association between methicillin-resistant Staphylococcus aureus colonization and infection may not differ by age group
    Adebola O Ajao
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Control Hosp Epidemiol 34:93-5. 2013
    ..Among 7,405 patients (9,511 admissions), MRSA colonization was significantly associated with infection (adjusted odds ratio, 13.7 [95% confidence interval, 7.3-25.7]) but did not differ significantly by age group...
  24. pmc Bench-to-bedside review: vaccine protection strategies during pandemic flu outbreaks
    Joel V Chua
    Infectious Disease, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Crit Care 14:218. 2010
    ..These include the use of cell-culture-based growth systems, concomitant use of adjuvants, whole virus vaccines, recombinant protein vaccines, plasmid DNA vaccines, virus-like particle vaccines, and universal flu vaccines...