Qi Chen

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 169:159-67. 2003
  2. pmc Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 72:13-22. 2003
  3. ncbi request reprint Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, University of Pittsburgh, PA 15261, USA
    Circulation 107:3146-51. 2003
  4. pmc Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study
    Qi Chen
    Department of Human Genetics, and Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 52:801-7. 2011
  5. ncbi request reprint Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus
    Laura M Tripi
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthritis Rheum 54:1928-39. 2006
  6. ncbi request reprint Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 68:285-99. 2004
  7. pmc Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Atherosclerosis 200:102-8. 2008
  8. ncbi request reprint Complete DNA sequence variation in the apolipoprotein H (beta-glycoprotein I) gene and identification of informative SNPs
    Qi Chen
    Department of Human Genetics, Graduate School of Public Heath, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 70:1-11. 2006
  9. ncbi request reprint A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I
    Haider Mehdi
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh 15261, USA
    Eur J Biochem 270:230-8. 2003
  10. ncbi request reprint Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12
    Erin Luedecking-Zimmer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Hum Genet 111:443-51. 2002

Collaborators

Detail Information

Publications44

  1. ncbi request reprint APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 169:159-67. 2003
    ..These data support the hypothesis that the APOE*4 allele is an independent risk factor not only for the presence of CAD and hyperlipidemia, but also for the angiographic severity of CAD in white women with a family history of disease...
  2. pmc Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 72:13-22. 2003
    ..26-10.68; P=.017) for PON2 codon 311 Cys/Cys. Our data indicate that the severity of CAD, in terms of the number of diseased vessels, may be affected by common genetic variation in the PON gene cluster, on chromosome 7...
  3. ncbi request reprint Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, University of Pittsburgh, PA 15261, USA
    Circulation 107:3146-51. 2003
    ..We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population...
  4. pmc Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study
    Qi Chen
    Department of Human Genetics, and Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 52:801-7. 2011
    ..020). Our data suggest that higher IgM anti-oxLDL levels may provide protection against coronary stenosis and that genetic variation in some candidate genes are determinants of anti-oxLDL levels...
  5. ncbi request reprint Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus
    Laura M Tripi
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthritis Rheum 54:1928-39. 2006
    ..This study was undertaken to examine the relationship of PON1 activity and genotype to risk of systemic lupus erythematosus (SLE)...
  6. ncbi request reprint Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 68:285-99. 2004
    ..We also found that these haplotypes are associated with the occurrence of APA. Recombinant APOH haplotypes, expressed in COS-1 cells, showed that these mutations also affect the binding of APOH to anionic PL...
  7. pmc Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Atherosclerosis 200:102-8. 2008
    ..0001) cells. In conclusion, this study demonstrates for the first time that the polymorphic HindIII site in the LPL gene is functional because it affects the binding of a transcription factor and it also has an impact on LPL expression...
  8. ncbi request reprint Complete DNA sequence variation in the apolipoprotein H (beta-glycoprotein I) gene and identification of informative SNPs
    Qi Chen
    Department of Human Genetics, Graduate School of Public Heath, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 70:1-11. 2006
    ..The discovery of a full range of sequence variation and identification of race-specific informative SNPs in the APOH gene may facilitate the rapid evaluation of this variation in relation to autoimmune diseases...
  9. ncbi request reprint A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I
    Haider Mehdi
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh 15261, USA
    Eur J Biochem 270:230-8. 2003
    ....
  10. ncbi request reprint Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12
    Erin Luedecking-Zimmer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Hum Genet 111:443-51. 2002
    ..Our data suggest that genetic variation in the OLR1 gene may modify the risk of AD in an APOE*4-dependent fashion...
  11. pmc MEGF10 association with schizophrenia
    Xiangning Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biol Psychiatry 63:441-8. 2008
    ..In this study, we carried out independent replication and expression studies of the MEGF10 gene...
  12. ncbi request reprint Association of G72/G30 with schizophrenia in the Chinese population
    Xiaoyan Wang
    Bio X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China
    Biochem Biophys Res Commun 319:1281-6. 2004
    ..7 x 10(-4)) and schizophrenia. Our data provide further evidence that markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population...
  13. ncbi request reprint No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study
    Shiwei Duan
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Neurosci Lett 376:93-7. 2005
    ..In conclusion, these data do not support the idea that HTR1B gene plays a major role in the etiopathogenesis of schizophrenia in Chinese Han population...
  14. pmc FBXL21 association with schizophrenia in Irish family and case-control samples
    Xiangning Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia
    Am J Med Genet B Neuropsychiatr Genet 147:1231-7. 2008
    ..0437) and was overrepresented in the ICCSS (P = 0.0177). For both samples, the associated alleles and haplotypes were identical. These data suggested that FBXL21 may be associated with schizophrenia in the Irish samples...
  15. ncbi request reprint Association of DAAO with schizophrenia in the Chinese population
    Xinmin Liu
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Huashan Road, P O Box 501, Shanghai 200030, PR China
    Neurosci Lett 369:228-33. 2004
    ....
  16. pmc Family-based association study of synapsin II and schizophrenia
    Qi Chen
    Neuropsychiatric and Human Genetics Group, Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    Am J Hum Genet 75:873-7. 2004
    ..6%; chi (2) = 20.8; P =.0000051). This confirms our previous study and provides further support for the role of synapsin II variants in susceptibility to schizophrenia...
  17. pmc CTCF-dependent chromatin boundary element between the latency-associated transcript and ICP0 promoters in the herpes simplex virus type 1 genome
    Qi Chen
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    J Virol 81:5192-201. 2007
    ....
  18. ncbi request reprint Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension
    Sheng Nan Wu
    Shanghai Key Laboratory of Vascular Biology at Ruijin Hospital and Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P R China
    Ann Hum Genet 71:519-25. 2007
    ..The present study aims to investigate the potential genetic contribution of the CYP2J2 gene to the etiology of essential hypertension (EH) and individual blood pressure...
  19. ncbi request reprint [Effect of transforming growth factor beta1/Smad signaling pathway on the expression and enzymatic activity of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cultured rat mesangial cells]
    Chen Yang
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Zhonghua Bing Li Xue Za Zhi 32:553-7. 2003
    ....
  20. ncbi request reprint [Effects of caveolin-1 on biologic behavior of laryngeal squamous cell carcinoma HEp2 cell line GU]
    Dong hua Gu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 29:329-33. 2007
    ..To investigate the effects of caveolin-1 on the biologic behavior of laryngeal squamous cell carcinoma HEp2 cell line in vitro...
  21. ncbi request reprint Caveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma and down regulates EGFR-MAPKs signaling pathway
    Donghua Gu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    Laryngoscope 117:1782-9. 2007
    ..To investigate the effects of caveolin-1 on the growth of laryngeal squamous cell cancer HEp2 cell line in vitro and in vivo...
  22. ncbi request reprint A genetic variant of apolipoprotein M increases susceptibility to coronary artery disease in a Chinese population
    Wei Wei Xu
    Atherosclerosis Research Center, Nanjing Medical University, Nanjing, China
    Clin Exp Pharmacol Physiol 35:546-51. 2008
    ..819, 95% confidence interval 1.142-2.898; P = 0.012). 4. In conclusion, the results of the present study suggest that the APOM T-855C polymorphism carries an increased risk for CAD in this Chinese population...
  23. ncbi request reprint [Changes of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expressions on cultured rat mesangial cells transfected with Smad 7 vector]
    Hong Yu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Zhonghua Bing Li Xue Za Zhi 32:544-7. 2003
    ....
  24. ncbi request reprint [Relationship between changes in activities of low density lipoprotein receptor and gene mutation in familial hypercholesterolemia]
    Qingfeng Pang
    Atherosclerosis Research Center, Nanjing Medical University Nanjing, 210029 China
    Zhonghua Nei Ke Za Zhi 41:667-70. 2002
    ..To analyse the LDL receptor (LDLR) function and gene mutation in a familial hypercholesterolemia (FH) patient and illustrate the effects of gene mutation type on LDL receptor function...
  25. doi request reprint Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation
    Sha Peng
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    Reproduction 135:367-75. 2008
    ..Taken together, Dkk1 secreted by decidual cells may induce trophoblast cell invasion in the mouse and beta-catenin may be involved in such functions of Dkk1...
  26. ncbi request reprint The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase
    Andrew Grey
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Endocrinology 143:4755-63. 2002
    ..These data demonstrate that LPA and S1P potently promote osteoblast survival in vitro, and that cell-type specificity exists in the antiapoptotic signaling pathways activated by phospholipids...
  27. doi request reprint The toxicity of beta-amyloid is attenuated by interaction with its specific human scFv E3 in vitro
    Shen Yue
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People s Republic of China
    Life Sci 82:1249-55. 2008
    ..Moreover, the Abeta toxicity to SK-N-SH cells was attenuated by addition of E3 scFv. Our results indicate that site-directed human scFv might be a potential therapeutic agent for Alzheimer's disease...
  28. pmc The Zur of Xanthomonas campestris functions as a repressor and an activator of putative zinc homeostasis genes via recognizing two distinct sequences within its target promoters
    Dong Liang Huang
    The Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, 100 Daxue Road, Nanning Guangxi 530004, China
    Nucleic Acids Res 36:4295-309. 2008
    ..These results reveal that the Xcc Zur functions as a repressor and an activator of putative zinc homeostasis genes via recognizing two distinct sequences within its target promoters...
  29. ncbi request reprint PCR-suppression effect: kinetic analysis and application to representative or long-molecule biased PCR-based amplification of complex samples
    Zhong Min Dai
    Institute of Cell Biology and Genetics, 317, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang 310058, China
    J Biotechnol 128:435-43. 2007
    ..This study provides a general guide for the design of PS-effect related PCR and is useful for representative or long-transcript enriched cDNA library construction, especially when only a small amount of total RNA is available...
  30. ncbi request reprint Characterization of a novel coronavirus associated with severe acute respiratory syndrome
    Paul A Rota
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 300:1394-9. 2003
    ..Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses...
  31. ncbi request reprint Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population
    Qing Ying Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China
    J Psychiatr Res 41:428-34. 2007
    ..Our findings also would encourage further studies, particularly family-based association studies with larger samples, to analyze the association between DISC1 and schizophrenia...
  32. ncbi request reprint Real time quantitative PCR as a method to evaluate xenotropic murine leukemia virus removal during pharmaceutical protein purification
    Liming Shi
    Process Sciences, Genentech, Inc, 1 DNA Way, South San Francisco, CA, USA
    Biotechnol Bioeng 87:884-96. 2004
    ..Its availability should greatly facilitate and reduce the cost of viral clearance evaluations for new biologic product development...
  33. ncbi request reprint Direct sequencing of SARS-coronavirus S and N genes from clinical specimens shows limited variation
    Suxiang Tong
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS G17, Atlanta, GA 30333, USA
    J Infect Dis 190:1127-31. 2004
    ..These findings are a part of the expanding investigation of the evolution of how this virus adapts to a new host...
  34. ncbi request reprint Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance
    Hui Wang
    The National Plant Gene Research Center Beijing, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 10081, China
    Plant Mol Biol 55:183-92. 2004
    ..These results indicate that JERF3 functions as a linker in ethylene- and osmotic stress-signaling pathways...
  35. ncbi request reprint Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth
    Qi Chen
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 25:281-90. 2005
    ..MOCA accumulates during neuronal differentiation, and its expression enhances NGF-induced neurite outgrowth and morphological complexity. We conclude that MOCA regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth...
  36. ncbi request reprint Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population
    Qing Ying Chen
    Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China
    Schizophr Res 73:269-74. 2005
    ..Sakurai) and the disease (X2=31.591, P<0.000001, OR=1.745, 95% CI=1.435-2.121). Our results confirm the positive association between CHL1 gene and schizophrenia and indicate that CHL1 may be involved in the etiology of schizophrenia...
  37. ncbi request reprint A family-based association study of the MOG gene with schizophrenia in the Chinese population
    Xinmin Liu
    Bio X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, P R China
    Schizophr Res 73:275-80. 2005
    ..01982). Our results would indicate that the MOG gene may play a significant role in schizophrenia in the Han Chinese. However, further study is required using other methods and involving other populations...
  38. ncbi request reprint Positive association between synapsin II and schizophrenia
    Qi Chen
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    Biol Psychiatry 56:177-81. 2004
    ..The synapsin II gene is located on 3p25, a region that has been implicated to be associated with schizophrenia by genetic linkage. All these findings suggest synapsin II as a candidate gene for schizophrenia...
  39. ncbi request reprint A family-based association study of schizophrenia with polymorphisms at three candidate genes
    Shiwei Duan
    Bio X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China
    Neurosci Lett 379:32-6. 2005
    ..However, we found significant evidence of preferential transmission of the -432C allele of the PIK3C3 gene in the entire trios (Z=2.91, d.f.=1, P=0.0036) and the male probands trios (Z=2.66, d.f.=1, P=0.0079)...
  40. ncbi request reprint Impact of multiple re-use of anion-exchange chromatography media on virus removal
    Lenore Norling
    Department of Recovery Sciences, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    J Chromatogr A 1069:79-89. 2005
    ....
  41. ncbi request reprint A genetic variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population
    Yibo Tang
    Atherosclerosis Research Center, Nanjing Medical University, No 140 Hanzhong Road, Nanjing 210029, China
    Atherosclerosis 185:433-7. 2006
    ..089 (95% CI = 1.140-3.830, P = 0.017), in comparison to the individuals without the T allele. These results suggest that the APOA5 c.553G > T polymorphism is an important predictor for hypertriglyceridemia and CAD...
  42. ncbi request reprint Association between the brain-derived neurotrophic factor (BDNF) gene and schizophrenia in the Chinese population
    Qing Ying Chen
    Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China
    Neurosci Lett 397:285-90. 2006
    ..Thus, our data suggest that the BDNF gene may not be an important factor in susceptibility to schizophrenia...
  43. ncbi request reprint A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population
    Qi Chen
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Schizophr Res 73:21-6. 2005
    ..0017). Our results partially support the previous studies in other ethnic groups and indicate that the GRM3 gene may play an important role in the etiology of schizophrenia in the Han Chinese...
  44. ncbi request reprint Involvement of MAPK/ERK kinase-ERK pathway in exogenous bFGF-induced Egr-1 binding activity enhancement in anoxia-reoxygenation injured astrocytes
    Ying Liu
    Department of Pathology, Shanghai Medical College Fudan University, Shanghai, China
    Neurosci Bull 23:221-8. 2007
    ..This study was designed to investigate the molecular mechanism, especially the signal transduction pathways, involved in this protective role of bFGF...