Lin Chen

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly
    Ju He
    MOE Key Laboratory for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Nucleic Acids Res 39:4464-74. 2011
  2. pmc In pursuit of the high-resolution structure of nicotinic acetylcholine receptors
    Lin Chen
    Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    J Physiol 588:557-64. 2010
  3. pmc Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling
    Xiaojun Zhang
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 42:2789-97. 2014
  4. pmc Altered neuronal intrinsic properties and reduced synaptic transmission of the rat's medial geniculate body in salicylate-induced tinnitus
    Yan Yan Su
    CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China
    PLoS ONE 7:e46969. 2012
  5. doi request reprint Construction and development of a mammalian cell-based full-length antibody display library for targeting hepatocellular carcinoma
    Feng Li
    Cancer Research Institute, Central South University, 110 Xiangya Road, Changsha, 410078, Hunan Province, China
    Appl Microbiol Biotechnol 96:1233-41. 2012
  6. pmc Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment
    Yongqing Wu
    Division of Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, RRI 204c, 1050 Childs Way, Los Angeles, CA 90089, USA
    J Mol Biol 397:520-33. 2010
  7. pmc Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer
    Yongheng Chen
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Structure 18:246-56. 2010
  8. ncbi request reprint Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanism
    Cosma D Dellisanti
    Molecular and Computational Biology, Department of Chemistry and Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 2910, USA
    Channels (Austin) 1:234-7. 2007
  9. pmc DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation
    Yongheng Chen
    Molecular and Computational Biology Program, Departments of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Cell Rep 2:1197-206. 2012
  10. pmc Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2
    Nimanthi Jayathilaka
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 40:5378-88. 2012

Collaborators

Detail Information

Publications36

  1. pmc Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly
    Ju He
    MOE Key Laboratory for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Nucleic Acids Res 39:4464-74. 2011
    ..Our results also support a model wherein p300 promotes the assembly of a higher-order enhanceosome by simultaneous interactions with multiple DNA-bound transcription factors...
  2. pmc In pursuit of the high-resolution structure of nicotinic acetylcholine receptors
    Lin Chen
    Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    J Physiol 588:557-64. 2010
    ..Here we will review some of the recent efforts in this area and use the high-resolution structure of the extracellular domains of nAChR alpha1 to illustrate the potential insights one may gain at higher resolution...
  3. pmc Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling
    Xiaojun Zhang
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 42:2789-97. 2014
    ..This work reveals mechanisms of p53-DNA recognition, and establishes a new experimental/computational approach for studying DNA shape in solution that has far-reaching implications for studying protein-DNA interactions. ..
  4. pmc Altered neuronal intrinsic properties and reduced synaptic transmission of the rat's medial geniculate body in salicylate-induced tinnitus
    Yan Yan Su
    CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China
    PLoS ONE 7:e46969. 2012
    ..Our results demonstrate that NaSal alters neuronal intrinsic properties and reduces the synaptic transmission of the MGB, which may cause abnormal thalamic outputs to the auditory cortex and contribute to NaSal-induced tinnitus...
  5. doi request reprint Construction and development of a mammalian cell-based full-length antibody display library for targeting hepatocellular carcinoma
    Feng Li
    Cancer Research Institute, Central South University, 110 Xiangya Road, Changsha, 410078, Hunan Province, China
    Appl Microbiol Biotechnol 96:1233-41. 2012
    ..Anti-GOLPH2 display antibody was successfully isolated from the library...
  6. pmc Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment
    Yongqing Wu
    Division of Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, RRI 204c, 1050 Childs Way, Los Angeles, CA 90089, USA
    J Mol Biol 397:520-33. 2010
    ..The apo structure presented here can also serve as a target for virtual screening and soaking studies of small molecules that can modulate the function of MEF2 as research tools and therapeutic leads...
  7. pmc Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer
    Yongheng Chen
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Structure 18:246-56. 2010
    ..The extensive protein-protein and protein-DNA interactions explain the high cooperativity and kinetic stability of p53 binding to contiguous decameric sites and the conservation of such binding-site configuration in vivo...
  8. ncbi request reprint Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanism
    Cosma D Dellisanti
    Molecular and Computational Biology, Department of Chemistry and Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 2910, USA
    Channels (Austin) 1:234-7. 2007
    ..These analyses not only help understand the structural determinants for neurotoxin sensitivity in muscle-type nAChR, but also shed light on its gating mechanism...
  9. pmc DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation
    Yongheng Chen
    Molecular and Computational Biology Program, Departments of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Cell Rep 2:1197-206. 2012
    ..These findings not only provide insights into the structure and function of GATA proteins but also shed light on the molecular basis of long-range gene regulation...
  10. pmc Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2
    Nimanthi Jayathilaka
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 40:5378-88. 2012
    ..These compounds can be used as tools to study MEF2 and class IIa HDACs in vivo and as leads for drug development...
  11. pmc Mining 3D genome structure populations identifies major factors governing the stability of regulatory communities
    Chao Dai
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, 1050 Childs Way, Los Angeles, California 90089, USA
    Nat Commun 7:11549. 2016
    ..Finally, we show that the regulatory communities differ substantially from cell to cell, indicating that expression variability could be impacted by genome structures. ..
  12. pmc Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
    Yongheng Chen
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA, Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital and State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, China, Department of Chemistry, Norris Comprehensive Cancer Center, Department of Physics and Astronomy and Department of Computer Science, University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 41:8368-76. 2013
    ..Our results provide a structural insight into the mechanism by which p53 binds to discontinuous sites with one base-pair spacer. ..
  13. pmc Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist
    Shu Xing Li
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California, USA
    Nat Neurosci 14:1253-9. 2011
    ..The structures provide a realistic template for structure-aided drug design and for defining structure-function relationships of α(7) AChRs...
  14. doi request reprint Modulation of major voltage- and ligand-gated ion channels in cultured neurons of the rat inferior colliculus by lidocaine
    Mu Yu
    Auditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Acta Pharmacol Sin 29:1409-18. 2008
    ..The purpose of the present study was to explore how lidocaine as a therapeutic drug for tinnitus targets voltage- and ligand-gated ion channels and changes the excitability of central auditory neurons...
  15. doi request reprint An aliasing artifacts reducing approach with random undersampling for spatiotemporally encoded single-shot MRI
    Lin Chen
    Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China
    J Magn Reson 237:115-24. 2013
    ..The efficiency of this hybrid scheme was demonstrated by numerical simulations and experiments on water phantom and in vivo rat brain. The hybrid scheme provided herein would benefit the SPEN approach in vast undersampling situation. ..
  16. doi request reprint Anti-hepatoma human single-chain Fv antibody and adriamycin conjugates with potent antitumor activity
    Lin Chen
    Tumor Immunobiology Laboratory of Cancer Research Institute, Cancer Research Institution, Xiangya Medical School, Central South University, 410078 Changsha, Hunan, China Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education, Cancer Research Institution, Xiangya Medical School, Central South University, 410078 Changsha, Hunan, China Key Laboratory of Carcinogenesis Ministry of Health, Cancer Research Institution, Xiangya Medical School, Central South University, 410078 Changsha, Hunan, China
    Int Immunopharmacol 18:20-6. 2014
    ..These data indicate that the targeted drug, ADM-Dex-ScFv-SA3, may be a highly potent and selective therapy for the treatment of hepatoma. ..
  17. pmc Physical tethering and volume exclusion determine higher-order genome organization in budding yeast
    Harianto Tjong
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Genome Res 22:1295-305. 2012
    ....
  18. pmc A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex
    Raja Dey
    Department of Biological Sciences, Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 4:e5188. 2009
    ..Our studies here reveal a potential cytokine-cytokine interaction that participates in the assembly of the dodecamer complex, thus linking cytokine binding to receptor activation...
  19. doi request reprint Auditory brainstem response as a possible objective indicator for salicylate-induced tinnitus in rats
    Xiao peng Liu
    CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Brain Res 1485:88-94. 2012
    ..Our study raises the possibility of using the ABR as an objective indicator for NaSal-induced tinnitus in animals. This article is part of a Special Issue entitled: Tinnitus Neuroscience...
  20. pmc The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase
    Lin Chen
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, USA
    Biochemistry 47:5368-77. 2008
    ..Overall, these results substantiate the functional importance of the tunnel for substrate binding and product release...
  21. pmc Population-based 3D genome structure analysis reveals driving forces in spatial genome organization
    Harianto Tjong
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089
    Proc Natl Acad Sci U S A 113:E1663-72. 2016
    ..By explicitly considering genome structural variability, our population-based method provides an important tool for revealing novel insights into the key factors shaping the spatial genome organization. ..
  22. pmc Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR
    James C Stroud
    Molecular and Computational Biology, Department of Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 2910, USA
    J Mol Biol 393:98-112. 2009
    ..This phenomenon is unlikely restricted to the HIV-1 LTR but probably represents a general mechanism for the function of composite DNA elements in transcription...
  23. doi request reprint Activation of presynaptic GABAB receptors modulates GABAergic and glutamatergic inputs to the medial geniculate body
    Bin Luo
    CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Hear Res 280:157-65. 2011
    ..Our study provides electrophysiological evidence for the presence of functional presynaptic GABA(B) receptors in the MGB and suggests an age-dependent role of these receptors in the synaptic transmission in this central auditory region...
  24. ncbi request reprint In search of allosteric modulators of a7-nAChR by solvent density guided virtual screening
    Raja Dey
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    J Biomol Struct Dyn 28:695-715. 2011
    ....
  25. ncbi request reprint Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution
    Cosma D Dellisanti
    Molecular and Computation Biology, University of Southern California, 1050 Childs Way, RIH201, Los Angeles, California 90089 2910, USA
    Nat Neurosci 10:953-62. 2007
    ..Our structural and functional studies show essential features of the nAChR and provide new insights into the gating mechanism...
  26. doi request reprint Cross-talk between NMDA and GABA(A) receptors in cultured neurons of the rat inferior colliculus
    Danni Cong
    Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, China
    Sci China Life Sci 54:560-6. 2011
    ..The presence of cross-talk between these receptors suggests that the mechanisms underlying information processing in the central auditory system may be more complex than previously believed...
  27. doi request reprint Behavioral oscillations in attention: rhythmic α pulses mediated through θ band
    Kun Song
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China, Department of Psychological Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, and University of Chinese Academy of Sciences, Beijing, 100049, China
    J Neurosci 34:4837-44. 2014
    ..Our data also speak to a neural mechanism for item attention based on successive cycles (θ) of a sequential attentional sampling (α) process. ..
  28. ncbi request reprint The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition
    Neng Gong
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Neuropharmacology 54:454-63. 2008
    ..Given the capability of aspirin to penetrate the blood-brain barrier, the present data imply that aspirin intake may cause network hyperactivity and be potentially harmful in susceptible subpopulations...
  29. doi request reprint Human anti-EGFL7 recombinant full-length antibodies selected from a mammalian cell-based antibody display library
    Feng Li
    Cancer Research Institute, Central South University, Changsha, Hunan, China
    Mol Cell Biochem 365:77-84. 2012
    ..The mammalian cell-based full-length antibody display library is a great potential application for rapid identification and cloning of human mAbs of targeting hepatocellular carcinoma...
  30. pmc Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1
    Hong Wei Dong
    Department of Neurology, Laboratory of Neuro Imaging, School of Medicine, University of California, Los Angeles, CA 90095 7334, USA
    Proc Natl Acad Sci U S A 106:11794-9. 2009
    ..Insights emerging from this genomic-anatomic approach provide a starting point for a detailed analysis of differential hippocampal structure-function organization...
  31. ncbi request reprint [Association study between Y-chromosome haplo group and susceptibility to spermatogenisis impairment in Han People from Southwest China]
    Jing Ran
    School of Life Sciences, Si Chuan University, Chengdu, China
    Yi Chuan 35:73-8. 2013
    ..032, 0.022, 0.009, 0.009, 0.017, <0.05). The results suggest that Y chromosome haplogroup plays a important role in spermatogenic impairment...
  32. doi request reprint (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells
    Sufang Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Key Laboratory for Cancer and Invasion of Ministry of Education, Changsha, Hunan 410078, China
    Carcinogenesis 34:627-37. 2013
    ..Therefore, one of the mechanisms by which EGCG inhibits EBV spontaneous lytic infection appears to involve the suppression of the activation of MEK/ERK1/2 and PI3-K/Akt signaling...
  33. doi request reprint Partial Fourier transform reconstruction for single-shot MRI with linear frequency-swept excitation
    Ying Chen
    Department of Electronics Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
    Magn Reson Med 69:1326-36. 2013
    ....
  34. doi request reprint Memory traces for tonal language words revealed by auditory event-related potentials
    Feng Gu
    CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, China
    Psychophysiology 49:1353-60. 2012
    ..This effect was most prominent 164 ms after the word recognition point. Our study indicates an activation of memory traces for tonal language words...
  35. pmc Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains
    Chen Wang
    State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China
    PLoS Biol 11:e1001493. 2013
    ..Together, the elegant architecture of VicK with a signal transducer and sensor domain suggests a model where DHp helical bending and a CA swing movement are likely coordinated for autokinase activation...
  36. pmc Genome architectures revealed by tethered chromosome conformation capture and population-based modeling
    Reza Kalhor
    Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 30:90-8. 2012
    ..Statistical analysis of the resulting population demonstrates that the indiscriminate properties of interchromosomal interactions are consistent with the well-known architectural features of the human genome...

Research Grants5

  1. Structure and Function of the FOXP Family of Transcription Factors
    Lin Chen; Fiscal Year: 2009
    ..These insights may lead to new approaches to diagnosing and treating human diseases incurred by malfunction of FOXP proteins. ..
  2. STRUCTURAL STUDIES OF TELOMERIC PROTEIN--SSDNA COMPLEXES
    Lin Chen; Fiscal Year: 2003
    ..These studies will yield new insights into telomere structure and function, single-strand DNA binding and recognition, and kinetic pathways for assembling complex macromolecular nucleoprotein structures. ..
  3. Develop Peptide Inhibitors of the NFAT/AP-1 Complex
    Lin Chen; Fiscal Year: 2003
    ..These inhibitors may be important tools for studying the basic molecular mechanisms of tolerance induction and may lead to clinical drugs for invoking antigen specific long-term immune tolerance. ..
  4. X-Ray Optics and Area Detector
    Lin Chen; Fiscal Year: 2004
    ..The new equipment will benefit the research programs of five major users (Robert Batey, Thomas Cech, Lin Chen, Norman Pace and Marcelo Sousa) and a number of minor users between the departments of Chemistry and Biochemistry ..
  5. Structure and Function of the MEF2 Pathway
    Lin Chen; Fiscal Year: 2009
    ..These studies will not only provide insights into the basic mechanisms of calcium/MEF2-mediated biological responses in a variety of cells but also help drug development in treating human heart diseases. ..