Genomes and Genes
Jian Fu Chen
Affiliation: University of Colorado Denver
- The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signalingJianfu Chen
Howard Hughes Medical Institute, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children s Hospital Colorado, Aurora, CO 80045, USA
Genes Dev 26:803-15. 2012..Thus, mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 stability, but through FGF signaling...
- Transgenic overexpression of miR-133a in skeletal muscleZhongliang Deng
Department of Orthopaedic Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China
BMC Musculoskelet Disord 12:115. 2011....
- Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain sizeJian Fu Chen
1 Howard Hughes Medical Institute, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children s Hospital Colorado, Aurora, Colorado 80045, USA 2 Department of Genetics, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
Nat Commun 5:3885. 2014..Our results suggest that Wdr62 interacts with Aurora A to control mitotic progression, and loss of these interactions leads to mitotic delay and cell death of NPCs, which could be a potential cause of human microcephaly. ..