IRVIN SY CHEN
Affiliation: University of California
- Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cellsMasakazu Kamata
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
PLoS Pathog 5:e1000342. 2009..Therefore, we conclude that the primary mechanism of HIV-1 restriction in quiescent CD4+ T-cells remains to be elucidated...
- Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAsMasakazu Kamata
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e11834. 2010..These findings demonstrate that a miRNA dependent reporter vector can be a useful tool to monitor living cells during reprogramming of hiPSC and subsequent differentiation to lineage specific cells...
- Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT miceGene Errol E Ringpis
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 7:e53492. 2012..These results demonstrate that transplantation of HSPCs engineered with our combination shRNA vector may be a potential therapy against HIV disease...
- Methodology and software to detect viral integration site hot-spotsAngela P Presson
Department of Biostatistics, University of California Los Angeles, School of Public Health, USA
BMC Bioinformatics 12:367. 2011..This is problematic for comparing hot-spot distributions across data sets and patients, where the VIS numbers may vary...
- Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5Saki Shimizu
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and UCLA AIDS Institute, University California, Los Angeles, Los Angeles, California 90095, USA
Genet Vaccines Ther 7:8. 2009..These results have implications for the application of RNAi technology for therapeutic purposes...
- Retargeting of Retroviral VectorsIrvin S Y Chen; Fiscal Year: 2010..abstract_text> ..
- PRIMATE LENTIVIRUS BASED THERAPY VECTORSIrvin Chen; Fiscal Year: 2005..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
- Structure/Function of HIV-1 Vpr Associated Cell ProteinsIrvin Chen; Fiscal Year: 2005..This understanding will, in turn, provide us with critical information needed to understand the role of Vpr/HHR23A interaction and to develop potential AIDS therapeutic agents based upon the interaction between these proteins. ..
- HIV-1 Vpr Induces G2 Cell Cycle Arrest and ApoptosisIrvin Chen; Fiscal Year: 2007..Aim 2) To characterize the newly described process of Vpr mediated transactivation of unintegrated HIV-1 DNA. Aim 3) To further characterize the role of Vpr in viral pathogenesis. ..
- Targeting Gene Delivery to the CNS Blood-Brain BarrierIrvin Chen; Fiscal Year: 2008..abstract_text> ..
- Molecular Imaging of Cancer In vivo via Targeted TransductionIrvin Chen; Fiscal Year: 2009..The proposed studies address fundamental questions regarding the mode of action of the targeting vector and its utility for molecular imaging. ..
- Modeling HIV-1 siRNA TherapyIrvin S Y Chen; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: Relevance RNA interference is a means to block the function of genes. We will investigate whether RNA interference can be used as a potential therapy for HIV-1 disease. ..