Myriam M Chaumeil

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Hyperpolarized (13)C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model.
    Caroline Guglielmetti
    Proc Natl Acad Sci U S A 114:E6982-E6991. 2017
  2. pmc Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street Box 2532, San Francisco, CA 94158, USA
    Neuroimage 59:193-201. 2012
  3. pmc Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma
    Humsa S Venkatesh
    University of California, San Francisco, San Francisco, CA 94158, USA
    Neuro Oncol 14:315-25. 2012
  4. pmc Metabolic reprogramming in mutant IDH1 glioma cells
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 10:e0118781. 2015
  5. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
  6. pmc Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Neuro Oncol 14:1050-61. 2012
  7. pmc MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival
    Marina Radoul
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
    Mol Cancer Ther 15:1113-22. 2016
  8. pmc Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA Graduate Group in Bioengineering University of California San Francisco, San Francisco, California, USA, and University of California Berkeley, Berkeley, California, USA
    Tomography 2:125-135. 2016
  9. pmc Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites
    Bertram L Koelsch
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Magn Reson Med 74:622-33. 2015
  10. pmc Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e108289. 2014

Collaborators

Detail Information

Publications17

  1. pmc Hyperpolarized (13)C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model.
    Caroline Guglielmetti
    Proc Natl Acad Sci U S A 114:E6982-E6991. 2017
    ..This approach could prove useful not only in MS but also in other neurological diseases presenting inflammatory components...
  2. pmc Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street Box 2532, San Francisco, CA 94158, USA
    Neuroimage 59:193-201. 2012
    ..It highlights the potential of HP lactate-to-pyruvate ratio as an early biomarker of response, thereby supporting further investigation of this non-invasive imaging approach for eventual clinical application...
  3. pmc Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma
    Humsa S Venkatesh
    University of California, San Francisco, San Francisco, CA 94158, USA
    Neuro Oncol 14:315-25. 2012
    ..This study highlights the potential of PC and hyperpolarized lactate as noninvasive MR biomarkers of response to targeted inhibitors in GBM...
  4. pmc Metabolic reprogramming in mutant IDH1 glioma cells
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 10:e0118781. 2015
    ..The goal of this work was to determine whether the IDH1 mutation leads to additional magnetic resonance spectroscopy (MRS)-detectable changes in the cellular metabolome...
  5. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
    ..In contrast, in cells that express mutant IDH1, hyperpolarized [1-(13)C] 2-hydroxyglutarate is also observed, both in cell lysates and in vivo in orthotopic tumours. ..
  6. pmc Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Neuro Oncol 14:1050-61. 2012
    ..In summary, our results indicate that hMSCs and fNSCs exhibit similar properties regarding tumor tropism and intratumoral dissemination, highlighting the potential of these 2 SC sources as adequate candidates for SC-based therapies...
  7. pmc MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival
    Marina Radoul
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
    Mol Cancer Ther 15:1113-22. 2016
    ..Mol Cancer Ther; 15(5); 1113-22. ©2016 AACR. ..
  8. pmc Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA Graduate Group in Bioengineering University of California San Francisco, San Francisco, California, USA, and University of California Berkeley, Berkeley, California, USA
    Tomography 2:125-135. 2016
    ..Furthermore, a T2-edited, ultra long echo time sequence was developed for sub-2 mm3 resolution 3D encoding of urea by exploiting relaxation differences in the vascular and filtrate pools...
  9. pmc Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites
    Bertram L Koelsch
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Magn Reson Med 74:622-33. 2015
    ..Thus, the ability to not only measure the production of hyperpolarized (13) C lactate but also understand its compartmentalization using diffusion-weighted MR will provide unique information for improved tumor characterization...
  10. pmc Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e108289. 2014
    ..The goal of this study was to determine whether PC serves as a source of TCA anaplerosis in IDH1 mutant cells wherein glutamine is used for 2-hydroxyglutarate production...
  11. pmc IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
    Cancer Res 75:2999-3009. 2015
    ..Taken together, our results established that the IDH1 mutation induces an MRS-detectable reprogramming of pyruvate metabolism, which is essential for cell proliferation and clonogenicity, with immediate therapeutic implications...
  12. pmc Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells
    Ilwoo Park
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California
    Cancer Res 74:7115-24. 2014
    ..Overall, our findings showed how TMZ-induced DNA damage is linked through PKM2 to changes in pyruvate metabolism, and how these changes can be exploited by MRI methods as an early sensor of TMZ therapeutic response...
  13. pmc Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
    Christopher S Ward
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:1296-305. 2010
    ....
  14. pmc Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine
    Chloé Najac
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Sci Rep 6:31397. 2016
    ..Hyperpolarized [6-(13)C]-arginine could therefore serve to image tumoral MDSC function and more broadly M2-like macrophages. ..
  15. pmc Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells
    Pavithra Viswanath
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Front Oncol 6:60. 2016
    ....
  16. doi Studies of Metabolism Using (13)C MRS of Hyperpolarized Probes
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Methods Enzymol 561:1-71. 2015
    ....
  17. pmc Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
    Arman Jahangiri
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94158, USA
    Clin Cancer Res 19:1773-83. 2013
    ..To identify mediators of glioblastoma antiangiogenic therapy resistance and target these mediators in xenografts...