Patrick E Chappell
Affiliation: University of California
- Clocks and the black box: circadian influences on gonadotropin-releasing hormone secretionP E Chappell
Department of Reproductive Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0674, USA
J Neuroendocrinol 17:119-30. 2005..Multiple possible steroidal and neuronal contributions to GnRH surge generation are discussed, in addition to how these signals of disparate origin may be integrated at the cellular level to initiate this crucial reproductive event...
- Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neuronsRavid Sasson
Department of Reproductive Medicine, University of California at San Diego, La Jolla, CA 92093 0674, USA
Neuroendocrinology 84:353-63. 2006..It is suggested that the stimulatory effect of orexin A on GnRH transcription and release may also occur directly at the level of GnRH neurons in vivo...
- Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell linePatrick E Chappell
Department of Reproductive Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093 0674, USA
J Neurosci 23:11202-13. 2003..This effect persists in normal light/dark (LD) cycles, suggesting that a suprachiasmatic nucleus-independent endogenous clock in GnRH neurons is required for eliciting normal pulsatile patterns of GnRH secretion...
- The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in miceJ D Alvarez
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Biol Rhythms 23:26-36. 2008..Other hormonal defects in male Bmal1 KO mice suggest that BMAL1 also has functions in reproductive physiology outside of the testis. These results enhance understanding of how the circadian clock regulates reproduction...