David D Chaplin

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint 1. Overview of the immune response
    David D Chaplin
    University of Alabama at Birmingham, 845 19th Street South, BBRB 276 11, Birmingham, AL 35294 2170, USA
    J Allergy Clin Immunol 111:S442-59. 2003
  2. ncbi request reprint 1. Overview of the human immune response
    David D Chaplin
    University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA
    J Allergy Clin Immunol 117:S430-5. 2006
  3. pmc Overview of the immune response
    David D Chaplin
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Allergy Clin Immunol 125:S3-23. 2010
  4. ncbi request reprint Cell cooperation in development of eosinophil-predominant inflammation in airways
    David D Chaplin
    Department of Microbiology, University of Alabama at Birmingham, 35294 2170, USA
    Immunol Res 26:55-62. 2002
  5. pmc MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways
    Yong Woo Jung
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Immunol 39:2281-92. 2009
  6. pmc Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism
    Jean Marc Tadie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    Mol Med 18:659-68. 2012
  7. pmc Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice
    Yong Woo Jung
    Department of Pathology, University of Alabama at Birmingham, 35294 2170, USA
    Am J Pathol 168:1425-34. 2006
  8. pmc AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils
    Hong Beom Bae
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    FASEB J 25:4358-68. 2011
  9. pmc Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
    Hui Chen Hsu
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Rheum 63:2038-48. 2011
  10. pmc Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity
    John H Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:442-51. 2010

Research Grants

  1. Acquisition of a 200 kV Cryo-Electron Microscope
    David Chaplin; Fiscal Year: 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint 1. Overview of the immune response
    David D Chaplin
    University of Alabama at Birmingham, 845 19th Street South, BBRB 276 11, Birmingham, AL 35294 2170, USA
    J Allergy Clin Immunol 111:S442-59. 2003
    ..This overview describes key mechanisms used by the immune system to respond to invading microbes and identifies settings in which disturbed immune function exacerbates tissue injury...
  2. ncbi request reprint 1. Overview of the human immune response
    David D Chaplin
    University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA
    J Allergy Clin Immunol 117:S430-5. 2006
    ..This overview describes the major mechanisms used by the immune system to respond to invading microbes and identifies settings in which disturbed immune function exacerbates tissue injury...
  3. pmc Overview of the immune response
    David D Chaplin
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Allergy Clin Immunol 125:S3-23. 2010
    ..This overview identifies key mechanisms used by the immune system to respond to invading microbes and other exogenous threats and identifies settings in which disturbed immune function exacerbates tissue injury...
  4. ncbi request reprint Cell cooperation in development of eosinophil-predominant inflammation in airways
    David D Chaplin
    Department of Microbiology, University of Alabama at Birmingham, 35294 2170, USA
    Immunol Res 26:55-62. 2002
    ....
  5. pmc MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways
    Yong Woo Jung
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Immunol 39:2281-92. 2009
    ..These data suggest that antigen challenge via the airway activates Gr-1(+) cells and consequently MMP to facilitate the recruitment of Th cells in the airway inflammatory response...
  6. pmc Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism
    Jean Marc Tadie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    Mol Med 18:659-68. 2012
    ..These results suggest that nuclear to cytoplasmic translocation of HMGB1 in TLR4-activated cells potentiates inflammatory responses by binding to LKB1, thereby inhibiting the antiinflammatory effects of AMPK activation...
  7. pmc Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice
    Yong Woo Jung
    Department of Pathology, University of Alabama at Birmingham, 35294 2170, USA
    Am J Pathol 168:1425-34. 2006
    ..Our findings demonstrate the importance of both antigen and endotoxin acting in a synergistic manner in the development of airway inflammation...
  8. pmc AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils
    Hong Beom Bae
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    FASEB J 25:4358-68. 2011
    ..control (P<0.05). These results demonstrate a novel function for AMPK in enhancing the phagocytic activity of neutrophils and macrophages...
  9. pmc Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
    Hui Chen Hsu
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Rheum 63:2038-48. 2011
    ..To determine whether functional suppression of the catalytic domain of activation-induced cytidine deaminase (AID) can suppress the hyperreactive germinal center (GC) responses in BXD2 mice...
  10. pmc Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity
    John H Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:442-51. 2010
    ....
  11. pmc Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae
    Jen Feng Lai
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e14417. 2010
    ..Thus, MyD88-NFκB signaling in macrophages is essential for clearance of Mp from the lungs...
  12. pmc Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways
    Hong Beom Bae
    Department of Medicine, University of Alabama at Birmingham Division of Pulmonary, Allergy and Critical Care Medicine, 901 19th Street South, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 46:790-6. 2012
    ..Increased numbers of apoptotic neutrophils were present in the lungs of LPS-treated transgenic vitronectin-deficient mice, as compared with control mice. These results demonstrate a novel antiapoptotic function for vitronectin...
  13. pmc IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
    Carlene L Zindl
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 110:12768-73. 2013
    ..This study establishes a role for neutrophils in providing IL-22-dependent mucosal epithelial support that contributes to the resolution of colitis. ..
  14. ncbi request reprint Induction of a late asthmatic response associated with airway inflammation in mice
    Takeshi Nabe
    Department of Microbiology, University of Alabama at Birmingham, 859 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Eur J Pharmacol 521:144-55. 2005
    ..Thus, this experimental late asthmatic response is associated with Th2 cytokine production from inflammatory cells recruited as a consequence of the 1st-3rd challenges...
  15. pmc Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease
    Jessy S Deshane
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Ala Department of Microbiology, University of Alabama at Birmingham, Birmingham, Ala Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Ala Comprehensive Arthritis, Musculoskeletal and Autoimmunity Center, University of Alabama at Birmingham, Birmingham, Ala Electronic address
    J Allergy Clin Immunol 135:413-424.e15. 2015
    ....
  16. ncbi request reprint Taking control of follicular dendritic cells
    David D Chaplin
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Immunity 24:13-5. 2006
    ..Follicular dendritic cells signal the formation of B cell follicles as well as B cell activation, proliferation, and maturation. However, the precise molecular pathways controlling these processes are just beginning to be unraveled...
  17. ncbi request reprint Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 9:166-75. 2008
    ..These findings suggest a mechanism by which IL-17 drives autoimmune responses by promoting the formation of spontaneous GCs...
  18. pmc Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells
    Thuc vy L Le
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:6027-37. 2008
    ..In contrast, when 10(6) B1-8 cells were transferred, affinity maturation did not occur. These data indicate that restricting the frequency of clonally related B cells is required to support affinity maturation...
  19. ncbi request reprint T helper type 1 cells in asthma: friend or foe?
    Robin Stephens
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA
    Curr Opin Allergy Clin Immunol 2:31-7. 2002
    ..In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored...
  20. pmc Inhibition of neutrophil apoptosis by PAI-1
    Jaroslaw W Zmijewski
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Am J Physiol Lung Cell Mol Physiol 301:L247-54. 2011
    ..These results demonstrate a novel antiapoptotic role for PAI-1 that may contribute to its participation in neutrophil-associated inflammatory responses...
  21. pmc Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection
    Jessica L Werner
    Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Infect Immun 79:3966-77. 2011
    ..In summary, Dectin-1-dependent IL-17A production in the lungs during invasive fungal infection is mediated in part by CD11b(+) Ly-6G(+) neutrophils in an IL-23-dependent manner...
  22. pmc Elevated levels of NO are localized to distal airways in asthma
    John T Anderson
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 50:1679-88. 2011
    ..These results indicate that cellular mechanisms are activated in the distal airways of asthmatics and must be considered in the development of therapeutic strategies for this chronic inflammatory disorder...
  23. ncbi request reprint Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma
    Robin Stephens
    Center for Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:5458-67. 2002
    ..This implies that circulating Th2 cells in allergic individuals could enter the lungs in response to infection or inflammation and become activated to trigger allergy...
  24. ncbi request reprint Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation
    James W Verbsky
    Center for Immunology, Department of Medicine, and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:2475-82. 2002
    ..This requirement for nonhematopoietic expression of Jak3 represents the first demonstration of a physiological function of Jak3 outside of the lymphoid lineages...
  25. ncbi request reprint Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin
    Mitchell H Grayson
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8122, 660 S Euclid Avenue, St Louis, MO 63110 USA
    ScientificWorldJournal 3:484-96. 2003
    ..Finally, we show that neither L-, E-, or P-selectin appears to play a significant role in the accumulation of lymphocytes in the white pulp.)..
  26. ncbi request reprint IgE cross-linking or lipopolysaccharide treatment induces recruitment of Th2 cells to the lung in the absence of specific antigen
    Robin Stephens
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110
    J Immunol 169:5468-76. 2002
    ..They demonstrate further that recruitment can occur independently of Ag-dependent activation...
  27. ncbi request reprint Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Heart Circ Physiol 284:H2213-26. 2003
    ....

Research Grants1

  1. Acquisition of a 200 kV Cryo-Electron Microscope
    David Chaplin; Fiscal Year: 2005
    ..Data collected using this technology will support ongoing and high-priority initiatives in structural biology, virology, trans-membrane channels, bio-defense, and vaccine development. ..