L Chang

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Addiction 102:16-32. 2007
  2. pmc Gray matter maturation and cognition in children with different APOE ε genotypes
    Linda Chang
    From the Department of Medicine L C, V D, K L, A P, T E, John A Burns School of Medicine, University of Hawaii and The Queen s Medical Center, Honolulu Department of Psychiatry, School of Medicine C B, Departments of Psychiatry and Cognitive Science T L J, N A, and Department of Pathology S S M, University of California San Diego, La Jolla Department of Psychiatry J F, D N K, University of Massachusetts Medical School, Boston Department of Psychiatry and Behavioral Sciences D G A, University of California, Davis Departments of Pediatrics and Investigative Medicine J G, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT Boston Children s Hospital W E K, Harvard Medical School, Boston, MA Sackler Institute for Developmental Psychobiology B J C, Weil Cornell Medical College, New York, NY Department of Pediatrics E S, University of Southern California, Los Angeles and Children s Hospital E S, Los Angeles, CA
    Neurology 87:585-94. 2016
  3. pmc Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI
    Ann Neurol . 2016
  4. pmc Neural correlates of working memory training in HIV patients: study protocol for a randomized controlled trial
    L Chang
    Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor UH Tower, Honolulu, HI, USA
    Trials 17:62. 2016
  5. pmc Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits
    Linda Chang
    From the Department of Medicine, Division of Neurology, John A Burns School of Medicine L C, C J, E C, S B, V D, T E, and Pacific Biosciences Research Center M A, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI
    Neurology 82:2213-22. 2014
  6. pmc Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS)
    Yan Jia
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA
    Clin Proteomics 9:9. 2012
  7. pmc Imaging biomarkers and the role of neuroinflammation in neuropathic pain
    Linda Chang
    University of Hawaii, Honolulu, HI, USA
    J Neuroimmune Pharmacol 8:448-51. 2013
  8. pmc Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, Neuroscience and Magnetic Resonance Research Program, The Queen s Medical Center, 1356 Lusitana Street, UH Tower 7th Floor, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 8:576-93. 2013
  9. pmc Lower cognitive reserve in the aging human immunodeficiency virus-infected brain
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
    Neurobiol Aging 34:1240-53. 2013
  10. pmc Lower glial metabolite levels in brains of young children with prenatal nicotine exposure
    Linda Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, 7th floor University Tower, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 7:243-52. 2012

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Addiction 102:16-32. 2007
    ..To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure...
  2. pmc Gray matter maturation and cognition in children with different APOE ε genotypes
    Linda Chang
    From the Department of Medicine L C, V D, K L, A P, T E, John A Burns School of Medicine, University of Hawaii and The Queen s Medical Center, Honolulu Department of Psychiatry, School of Medicine C B, Departments of Psychiatry and Cognitive Science T L J, N A, and Department of Pathology S S M, University of California San Diego, La Jolla Department of Psychiatry J F, D N K, University of Massachusetts Medical School, Boston Department of Psychiatry and Behavioral Sciences D G A, University of California, Davis Departments of Pediatrics and Investigative Medicine J G, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT Boston Children s Hospital W E K, Harvard Medical School, Boston, MA Sackler Institute for Developmental Psychobiology B J C, Weil Cornell Medical College, New York, NY Department of Pediatrics E S, University of Southern California, Los Angeles and Children s Hospital E S, Los Angeles, CA
    Neurology 87:585-94. 2016
    ....
  3. pmc Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI
    Ann Neurol . 2016
    ....
  4. pmc Neural correlates of working memory training in HIV patients: study protocol for a randomized controlled trial
    L Chang
    Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor UH Tower, Honolulu, HI, USA
    Trials 17:62. 2016
    ..This study also aims to assess whether subjects with the LMX1A-rs4657412 TT(AA) genotype show greater training effects from working memory training than TC(AG) or CC(GG)-carriers...
  5. pmc Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits
    Linda Chang
    From the Department of Medicine, Division of Neurology, John A Burns School of Medicine L C, C J, E C, S B, V D, T E, and Pacific Biosciences Research Center M A, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI
    Neurology 82:2213-22. 2014
    ..We aimed to evaluate the combined effects of HIV and APOE ε4 allele(s) on glial metabolite levels, and on known cognitive deficits associated with either condition, across the ages...
  6. pmc Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS)
    Yan Jia
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA
    Clin Proteomics 9:9. 2012
    ..At the same time, understanding the mechanisms that underlie SPMS is critical to the development of rational therapies for this untreatable stage of the disease...
  7. pmc Imaging biomarkers and the role of neuroinflammation in neuropathic pain
    Linda Chang
    University of Hawaii, Honolulu, HI, USA
    J Neuroimmune Pharmacol 8:448-51. 2013
    ..Furthermore, the use of telemedicine to disseminate knowledge and improve the diagnosis and treatment of pain syndromes is also discussed...
  8. pmc Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, Neuroscience and Magnetic Resonance Research Program, The Queen s Medical Center, 1356 Lusitana Street, UH Tower 7th Floor, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 8:576-93. 2013
    ....
  9. pmc Lower cognitive reserve in the aging human immunodeficiency virus-infected brain
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawai i at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
    Neurobiol Aging 34:1240-53. 2013
    ..While the SN and HIV+NC subjects compensated for their declining attention with age by using reserve and "top-down" attentional networks, older HAND subjects were unable to compensate which resulted in cognitive decline...
  10. pmc Lower glial metabolite levels in brains of young children with prenatal nicotine exposure
    Linda Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, 7th floor University Tower, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 7:243-52. 2012
    ..These alterations were not influenced by the amount of nicotine exposure prenatally. However, the effects of PNE on energy metabolism may be sex specific, with greater alterations in girls...
  11. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
    ..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
  12. ncbi request reprint Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai, Honolulu, HI, USA
    Antivir Ther 9:431-40. 2004
    ..The relationships between neurometabolites and macrophage chemoattractant protein (MCP-1) in serum and cerebrospinal fluid (CSF) were evaluated in HIV patients before and after antiretroviral treatment...
  13. ncbi request reprint Adaptation of the attention network in human immunodeficiency virus brain injury
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Ann Neurol 56:259-72. 2004
    ..Exceeding the brain reserve capacity may lead to attention deficits and cognitive impairment in HIV patients...
  14. ncbi request reprint Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i, HI 96813, USA
    Psychiatry Res 132:95-106. 2004
    ..These preliminary findings suggest prenatal Meth exposure may be neurotoxic to the developing brain...
  15. pmc Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, 1356 Lusitana St, 7th Floor, Honolulu, HI 96813, USA
    Am J Psychiatry 162:361-9. 2005
    ..The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities...
  16. pmc Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu 96813, USA
    Biol Psychiatry 57:967-74. 2005
    ....
  17. ncbi request reprint Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation
    L Chang
    Department of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Brain 129:1096-112. 2006
    ....
  18. ncbi request reprint Insights from recent positron emission tomographic studies of drug abuse and dependence
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
    Curr Opin Psychiatry 19:246-52. 2006
    ..Recent positron emission tomographic studies demonstrate a variety of abnormalities in the brains of addicted individuals. This review aims to discuss and highlight these findings...
  19. pmc Brain metabolite abnormalities in the white matter of elderly schizophrenic subjects: implication for glial dysfunction
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, Honolulu, Hawaii 96813, USA
    Biol Psychiatry 62:1396-404. 2007
    ....
  20. pmc Combined and independent effects of chronic marijuana use and HIV on brain metabolites
    L Chang
    Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 1:65-76. 2006
    ..These findings suggest chronic MJ use may lead to decreased neuronal and glial metabolites, but may normalize the decreased glutamate in HIV patients...
  21. pmc Antiretroviral treatment is associated with increased attentional load-dependent brain activation in HIV patients
    L Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, The Queen s Medical Center University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:95-104. 2008
    ....
  22. pmc Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuse
    Linda Chang
    Department of Medicine, University of Hawai i, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, HI 96813, USA
    Neuroimage 42:869-78. 2008
    ....
  23. pmc Effects of age and sex on brain glutamate and other metabolites
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Magn Reson Imaging 27:142-5. 2009
    ..These findings indicate that brain glutamate concentrations decline markedly with age, and may be especially useful as a marker for brain diseases that are affected by aging...
  24. pmc Greater than age-related changes in brain diffusion of HIV patients after 1 year
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, and the Queen s Medical Center, University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:265-74. 2008
    ..Measurements of MD in the genu may be useful for monitoring disease progression in HIV brain infection...
  25. pmc Altered neurometabolites and motor integration in children exposed to methamphetamine in utero
    L Chang
    Division of Neurology, Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
    Neuroimage 48:391-7. 2009
    ..These findings combined with their poorer performance on VMI also suggest accelerated but aberrant neuronal and glial development in these brain regions...
  26. pmc Impact of apolipoprotein E ε4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain aging
    L Chang
    Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
    Neuroimage 58:1017-27. 2011
    ..Whether APOEε4 allele(s) and age may influence brain atrophy in HIV patients is unknown and was evaluated...
  27. ncbi request reprint Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
    ..To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1...
  28. ncbi request reprint A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age
    L Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Neuroimage 23:1336-47. 2004
    ..Therefore, a multicenter MRS consortium was formed to evaluate the neurometabolites in HIV patients with or without cognitive impairment...
  29. ncbi request reprint Increased glial metabolites predict increased working memory network activation in HIV brain injury
    T Ernst
    Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 19:1686-93. 2003
    ..The same mechanism may also contribute to cognitive dysfunction in other brain diseases that involve inflammation...
  30. pmc Perceptual responses in patients with inflammatory and functional bowel disease
    L Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gut 47:497-505. 2000
    ....
  31. ncbi request reprint Altered neurometabolite development in HIV-infected children: correlation with neuropsychological tests
    M A Keller
    Harbor UCLA Research and Education Institute, Torrance, CA, USA
    Neurology 62:1810-7. 2004
    ..HIV-infected children have abnormal cerebral metabolites, measured by proton MR spectroscopy ((1)H-MRS), but how these abnormalities relate to brain function is unclear...
  32. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
    ..Together, these sex-specific differences in brain activation during the VA task, at different cognitive and acoustic levels suggest differences in auditory gating of the thalamus for men and women...
  33. pmc Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
    ..Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain...
  34. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
    ..The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework...
  35. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  36. pmc Different activation patterns for working memory load and visual attention load
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
    Brain Res 1132:158-65. 2007
    ..Conversely, VA tasks activated more strongly an occipito-parietal network comprising the postcentral (PostCG) and the superior occipital (SOG) gyri, suggesting complex visual processing in this network...
  37. pmc Neuropsychological function and cerebral metabolites in HIV-infected youth
    R Nagarajan
    David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA
    J Neuroimmune Pharmacol 7:981-90. 2012
    ..Scy and Glu ratios are also potential markers of brain health in chronic, lifelong HIV infection in perinatally infected youths receiving antiretroviral therapy...
  38. pmc fMRI-acoustic noise alters brain activation during working memory tasks
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroimage 27:377-86. 2005
    ....
  39. pmc Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study
    J M Jarcho
    UCLA Center for Neurovisceral Sciences and Women s Health, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 28:344-52. 2008
    ..Factors predicting treatment responsiveness are not known, although we have demonstrated that symptom improvement with the 5-HT3R antagonist alosetron is correlated with reduced amygdala activity...
  40. pmc Lower diffusion in white matter of children with prenatal methamphetamine exposure
    C C Cloak
    Department of Medicine, John A Burns School of Medicine, Queen s University Tower, Honolulu, HI 96813, USA
    Neurology 72:2068-75. 2009
    ..Whether microstructural brain changes associated with prenatal methamphetamine exposure can be detected with diffusion tensor imaging (DTI) is unknown...
  41. ncbi request reprint Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Neuroimage 17:1638-48. 2002
    ..Metabolite concentrations, rather than metabolite ratios, should be measured since [CR], a commonly used reference for metabolite ratios, varies with disease severity in both frontal lobe and basal ganglia...
  42. ncbi request reprint Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV
    C C Cloak
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
    J Neuroimmunol 157:147-52. 2004
    ..43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients...
  43. ncbi request reprint Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 23:1414-21. 2004
    ..Since short-term practice-effects in the prefrontal cortex may be similar to attentional load-effects, studies of attentional load need to take practice effects into account...
  44. ncbi request reprint Approaches to the modulation of abdominal pain
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Can J Gastroenterol 13:65A-70A. 1999
    ....
  45. ncbi request reprint Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
    L Chang
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Pain 84:297-307. 2000
    ..Because there is a significant overlap of IBS and FM, shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS, somatic perception has not...
  46. ncbi request reprint Brain areas specific for attentional load in a motion-tracking task
    J Jovicich
    California Institute of Technology and Harbor UCLA Medical Center, CA, USA
    J Cogn Neurosci 13:1048-58. 2001
    ..Our results suggest a general role for posterior parietal areas in the deployment of visual of attentional resources...
  47. pmc Sex specific alterations in autonomic function among patients with irritable bowel syndrome
    K Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 54:1396-401. 2005
    ..The few studies directly examining ANS measures have been suggestive of alterations in some IBS patients, but no studies to date have examined the potentially critical variables of sex differences or response to visceral stimulation...
  48. pmc Functional GI disorders: from animal models to drug development
    E A Mayer
    UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 57:384-404. 2008
    ....
  49. pmc Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?
    M A Adeyemo
    Center for Neurobiology of Stress, Los Angeles, CA 90095, USA
    Aliment Pharmacol Ther 32:738-55. 2010
    ..Studies suggest that sex and gender-related differences exist in irritable bowel syndrome (IBS), but data is often conflicting...
  50. pmc Characterization of symptoms in irritable bowel syndrome with mixed bowel habit pattern
    A M Su
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Department of Medicine, Stanford University, Stanford, CA, USA
    Neurogastroenterol Motil 26:36-45. 2014
    ..We aimed to characterize gastrointestinal (GI) and non-GI symptoms in IBS-M patients from a US patient population, and to compare them with IBS with constipation (IBS-C) and diarrhea (IBS-D)...
  51. ncbi request reprint Effect of aging on brain metabolism in antiretroviral-naive HIV patients
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    AIDS 18:S61-7. 2004
    ..The goal of this pilot study was to evaluate the interaction between aging and HIV infection in the brain using proton magnetic resonance spectroscopy (H-MRS)...
  52. ncbi request reprint Gender-related differences in IBS symptoms
    O Y Lee
    CURE Digestive Diseases Research Center/Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Am J Gastroenterol 96:2184-93. 2001
    ..The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance...
  53. ncbi request reprint Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero
    L M Smith
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
    Neurology 57:255-60. 2001
    ..To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS...
  54. ncbi request reprint Basic pathophysiologic mechanisms in irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Dig Dis 19:212-8. 2001
    ..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events...
  55. pmc Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale
    B Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 30:1159-70. 2009
    ..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...
  56. ncbi request reprint Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  57. ncbi request reprint Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease
    C C Cloak
    Medical Department, Brookhaven National Laboratory, Buliding 490, Upton, NY, USA
    J Neuroimmunol 147:16-20. 2004
    ..The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain...
  58. ncbi request reprint Traditional Chinese medicine based subgrouping of irritable bowel syndrome patients
    S Tan
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Chin Med 33:365-79. 2005
    ..This pilot study provides preliminary support for a methodology to identify novel subgroups of IBS patients related to the TCM classification, which may differ in underlying pathophysiology and treatment responses...
  59. pmc Autonomic response to a visceral stressor is dysregulated in irritable bowel syndrome and correlates with duration of disease
    P Cheng
    Gail and Gerald Oppenheimer Family Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurogastroenterol Motil 25:e650-9. 2013
    ..This study examined heart rate variability (HRV) and plasma catecholamines as an index of ANS responsiveness in IBS during flexible sigmoidoscopy (FS) and explored associations of HRV with clinical measures...
  60. ncbi request reprint Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    T Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurology 59:1343-9. 2002
    ..The current study aims to determine whether patients who are HIV-1 positive and have normal cognitive function also show increased brain activation on fMRI...
  61. ncbi request reprint Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Antivir Ther 8:17-26. 2003
    ..We aimed to evaluate whether brain abnormalities will improve 3 months after HAART...
  62. ncbi request reprint Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  63. pmc Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 Tesla
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Hum Brain Mapp 27:694-705. 2006
    ..The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network...
  64. ncbi request reprint V. Stress and irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
    Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001
    ..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome...
  65. ncbi request reprint HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis
    M Issakhanian
    Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
    J Neuroimaging 11:212-6. 2001
    ..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis...
  66. ncbi request reprint The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scale
    J S Labus
    Center for Neurovisceral Sciences and Women s Health, VA GLA Healthcare System, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 20:89-97. 2004
    ..Anxiety related to gastrointestinal sensations, symptoms or the contexts in which these may occur is thought to play a significant role in the pathophysiology as well as in the health outcomes of patients with irritable bowel syndrome...
  67. doi request reprint Validation of laparoscopic surgical skills training outside the operating room: a long road
    N J Hogle
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Surg Endosc 23:1476-82. 2009
    ..Surgical skills training outside the operating room is beneficial. The best methods have yet to be identified. The authors aimed to document the predictive validity of simulation training in three different studies...
  68. ncbi request reprint Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973 5000, USA
    Psychiatry Res 114:65-79. 2002
    ..These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function...
  69. pmc The human immunodeficiency virus reduces network capacity: acoustic noise effect
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Ann Neurol 59:419-23. 2006
    ..Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients...
  70. pmc Regional variations and the effects of age and gender on glutamate concentrations in the human brain
    Napapon Sailasuta
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Magn Reson Imaging 26:667-75. 2008
    ..Our results also highlight the importance of brain region, age and gender matching in clinical studies...
  71. ncbi request reprint Functional imaging studies in cannabis users
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813
    Neuroscientist 13:422-32. 2007
    ..Considerable further work, employing longitudinal designs, is also required to determine whether cannabis use causes permanent functional alterations in the brains of adults...
  72. pmc Adaptation of brain glutamate plus glutamine during abstinence from chronic methamphetamine use
    Thomas Ernst
    Department of Medicine, John A Burns School of Medicine, The University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813, USA
    J Neuroimmune Pharmacol 3:165-72. 2008
    ..Since craving may contribute to relapse, medications that normalize GLX may minimize craving in METH users...
  73. pmc Association between psychiatric symptoms and craving in methamphetamine users
    Helenna Nakama
    Department of Psychiatry, John A Burns School of Medicine, The Queen s Medical Center, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Am J Addict 17:441-6. 2008
    ..Therefore, methamphetamine users, regardless of their usage patterns, may benefit from treatment of their psychiatric symptoms in order to minimize craving and subsequent relapse to drug use...
  74. pmc Building infrastructure for HIV/AIDS and mental health research at institutions serving minorities
    Richard Yanagihara
    Department of Pediatrics, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, BSB320L, Honolulu, HI 96813, USA
    Am J Public Health 99:S82-6. 2009
    ..Although our analysis is drawn from lessons learned at an institution serving a largely Asian and Pacific Islander population, analogous situations may be found for other institutions serving minorities...
  75. pmc Declined neural efficiency in cognitively stable human immunodeficiency virus patients
    Thomas Ernst
    Department of Medicine, University of Hawaii at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
    Ann Neurol 65:316-25. 2009
    ..To determine whether brain activation changes in clinically and neurocognitively normal human immunodeficiency virus (HIV)-infected and in HIV-seronegative control (SN) participants over a 1-year period...
  76. pmc Higher diffusion in striatum and lower fractional anisotropy in white matter of methamphetamine users
    Daniel Alicata
    Department of Psychiatry, John A Burns School of Medicine, Honolulu, HI 96813, USA
    Psychiatry Res 174:1-8. 2009
    ..The higher ADC in the basal ganglia suggests greater inflammation or less myelination in these brain regions of those with younger age of first METH use and greater METH usage...
  77. pmc Psychiatric symptoms and HPA axis function in adolescent methamphetamine users
    George King
    Department of Medicine, John A Burns School of Medicine, Honolulu, HI 96812, USA
    J Neuroimmune Pharmacol 5:582-91. 2010
    ..The results further suggest that treatment approaches should focus on stress-coping strategies to decrease the probability of relapse...
  78. pmc Neuropsychological deficits in adolescent methamphetamine abusers
    George King
    Department of Psychiatry, John A Burns School of Medicine, 1356 Lusitana St 4th Floor, Honolulu, HI 96813, USA
    Psychopharmacology (Berl) 212:243-9. 2010
    ..Methamphetamine (METH) is a widely abused psychostimulant that is associated with neurotoxicity and neurocognitive impairments in adults. However, the effects of METH use on neurocognitive performance of adolescents are unclear...
  79. pmc Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorder
    Thomas Ernst
    Department of Medicine, John A Burns School of Medicine, University of Hawai i, and Queen s Medical Center, Honolulu, Hawai i 96813, USA
    J Magn Reson Imaging 32:1045-53. 2010
    ..To determine whether subjects with human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) show altered concentrations of brain glutamate (GLU), and whether lower GLU levels correlate with cognitive deficits...
  80. ncbi request reprint Segmentation of progressive multifocal leukoencephalopathy lesions in fluid-attenuated inversion recovery magnetic resonance imaging
    L Itti
    Department of Computer Science, University of Southern California, Hedco Neuroscience Building, Room 30A, 3641 Watt Way, Los Angeles, CA 90089 2520, USA
    J Neuroimaging 11:412-7. 2001
    ..The authors compared the reproducibility of a manual and a semiautomated technique for the quantitation of white-matter lesions in magnetic resonance imaging (MRI)...
  81. ncbi request reprint Anti-hyperalgesic effect of octreotide in patients with irritable bowel syndrome
    I Schwetz
    CNS WH Center for Neurovisceral Sciences and Women s Health, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 19:123-31. 2004
    ..Octreotide has been found to be beneficial in the treatment of chronic pain, although the mechanisms underlying its therapeutic effect are incompletely understood...
  82. pmc Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity
    S H Park
    Oppenheimer Family Center for the Neurobiology of Stress and Resilience, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Neurogastroenterol Motil 28:1252-60. 2016
    ....
  83. ncbi request reprint Human fear-related motor neurocircuitry
    T Butler
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, Box 140, 1300 York Avenue, New York, NY 10021, USA
    Neuroscience 150:1-7. 2007
    ....
  84. ncbi request reprint Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood
    J G Buckwalter
    Andrus Gerontology Center, University of Southern California, Los Angeles 90089, USA
    Psychoneuroendocrinology 24:69-84. 1999
    ..Studies beginning earlier in pregnancy and continuing for an extended period of time after delivery are needed to confirm and expand these observations...
  85. ncbi request reprint Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study
    T Ernst
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 100 West Carson Street, B 4, 90509, Torrance, CA, USA
    Psychiatry Res 99:63-74. 2000
    ..The hypoperfusion in the cortex and deep gray matter of the cocaine users is consistent with previous results. The increased rCBF in the white matter of cocaine users may be due to the presence of reactive glia...
  86. pmc Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome
    L Chang
    Center for Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:149-59. 2009
    ..05). Although dysregulations in stress-responsive systems such as the HPA axis and mucosal immune function are demonstrated in IBS, they do not appear to have a primary role in modulating IBS severity and abdominal pain...
  87. ncbi request reprint Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders
    Linda Chang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    J Clin Psychiatry 64:7-14. 2003
    ..Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder...
  88. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  89. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  90. pmc Imaging the addicted human brain
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Sci Pract Perspect 3:4-16. 2007
    ..The authors give examples of key findings illustrating how each technique has extended and deepened our knowledge of the neurobiological bases of drug abuse and addiction, and they address potential clinical and therapeutic applications...
  91. pmc Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children
    V Douet
    Department of Medicine, John A Burns School of Medicine, University of Hawaii and Queen s Medical Center, Honolulu, HI, USA
    Transl Psychiatry 4:e392. 2014
    ....
  92. pmc Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass index
    U Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
    Nutr Diabetes 1:e6. 2011
    ..This may contribute to their elevated metabolic risk for obesity-related diseases...
  93. ncbi request reprint The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
    E A Mayer
    CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 16:1357-66. 2002
    ....
  94. ncbi request reprint Review article: epidemiology and quality of life in functional gastrointestinal disorders
    L Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 20:31-9. 2004
    ..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders...
  95. ncbi request reprint The effects of tamoxifen and estrogen on brain metabolism in elderly women
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Natl Cancer Inst 94:592-7. 2002
    ..Consequently, we assessed the effects of tamoxifen and estrogen on the brain chemistry of elderly women...
  96. ncbi request reprint k-Space based summary motion detection for functional magnetic resonance imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 20:1411-8. 2003
    ..This method makes it possible to evaluate brain motion within seconds after a scan and to decide whether a study needs to be repeated...
  97. pmc The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  98. ncbi request reprint A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis
    Patricia Lani Lee
    NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
    J Magn Reson Imaging 17:625-33. 2003
    ....
  99. ncbi request reprint Neuropsychological effects of 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) in recreational users
    Carla Back-Madruga
    Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Clin Neuropsychol 17:446-59. 2003
    ..Our results suggest that a subgroup of MDMA patients, specifically heavy MDMA users, evidence declines in nonverbal (visual) memory, however, other cognitive areas appear to be spared...
  100. ncbi request reprint Regional patterns of brain metabolites in AIDS dementia complex
    Constantin T Yiannoutsos
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
    Neuroimage 23:928-35. 2004
    ..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
  101. ncbi request reprint A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Magn Reson Imaging 21:325-33. 2005
    ..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia...

Research Grants4

  1. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  2. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2008
    ..g. neuroprotective or anti-inflammatory treatments). [unreadable] [unreadable] [unreadable]..
  3. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..