Genomes and Genes
Kyong Mi Chang
Affiliation: University of Pennsylvania
- Chronic hepatitis B: immune pathogenesis and emerging immunotherapeuticsKyong Mi Chang
University of Pennsylvania Perelman School of Medicine, USA Philadelphia Corporal Michael J Crescenz VA Medical Center, USA Electronic address
Curr Opin Pharmacol 30:93-105. 2016..In this review, we discuss aspects of host innate and adaptive immune regulatory and pathogenic responses relevant for HBV infection. We also highlight several immune modulatory approaches in clinical development to treat CHB...
- Hepatitis C virus: virology and life cycleChang Wook Kim
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea
Clin Mol Hepatol 19:17-25. 2013..Each of these steps provides potential targets for novel antiviral therapeutics to cure HCV infection and prevent the adverse consequences of progressive liver disease...
- Hepatitis B immunology for cliniciansKyong Mi Chang
Philadelphia VA Medical Center and University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Clin Liver Dis 14:409-24. 2010..In particular, the current concepts regarding the innate and adaptive immune components contributing to the clinical, virologic and therapeutic outcome in acute and chronic hepatitis B are examined...
- Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infectionK M Chang
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Hepatology 33:267-76. 2001..Furthermore, the relative rarity of circulating CD8(+) effector T cells in chronically infected patients may explain the chronic insidious nature of the liver inflammation and also why they fail to eliminate the virus...
- Immunopathogenesis of hepatitis C virus infectionKyong Mi Chang
University of Pennsylvania, University Avenue, A212 Medical Research, Philadelphia, PA 19104, USA
Clin Liver Dis 7:89-105. 2003..A better understanding of the relevant host and viral factors for clinical and virologic outcome, and the mechanism of selective immune defect against HCV, will be invaluable in our ability to treat the many patients infected with HCV...
- Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalizationNobuhiro Nakamoto
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Gastroenterology 134:1927-37, 1937.e1-2. 2008..As hepatitis C virus (HCV) persists in the liver with immune-mediated disease pathogenesis, we examined the role of PD-1/PD-L pathway in antigen-specific CD8 T-cell dysfunction in the liver and blood of HCV-infected patients...
- T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis CDavid E Kaplan
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
Hepatology 41:1365-75. 2005..The association between treatment outcome and phytohemagglutinin response suggests more global and antigen-nonspecific mechanisms for therapeutic HCV clearance...
- Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infectionKazushi Sugimoto
Department of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Hepatology 38:1437-48. 2003..The high frequency of CD4(+)CD25(+) regulatory T cells and their suppression of HCV-specific CD8 T cells ex vivo suggests a novel role for regulatory T cells in HCV persistence...
- Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune responseKazushi Sugimoto
Division of Gastroenterology, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
Hepatology 37:590-9. 2003..AA ethnicity is associated with a more robust antiviral CD4 T-cell response than CA ethnicity, although these T cells are limited in direct virus or disease control due to their dysfunctional nature...
- Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infectionKazushi Sugimoto
Department of Medicine, GI Division, University of Pennsylvania, and Philadelphia VAMC, A212 Medical Research, PVAMC, University and Woodland Avenues, Philadelphia, PA 19104, USA
J Virol 79:6976-83. 2005..These findings provide new insights into host-virus interactions in HCV infection that have implications for vaccine development...
- Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitisDavid E Kaplan
Research Section, Philadelphia VA Medical Center, Research A216, 3900 Woodland Avenue, Philadelphia, PA 19104, USA
J Hepatol 48:903-13. 2008..In this study, we examined the role of HCV-specific T-cell IL-10 response in patients with acute and chronic HCV infection...
- Racial difference in mortality among U.S. veterans with HCV/HIV coinfectionNathan A Merriman
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Gastroenterol 101:760-7. 2006..This study was performed to examine the impact of viral coinfections and race on clinical and virological outcome of hepatitis C virus (HCV) infection...
- Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockadeNobuhiro Nakamoto
Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
PLoS Pathog 5:e1000313. 2009....
- Homeostasis of peripheral FoxP3(+) CD4 (+) regulatory T cells in patients with early and late stage breast cancerAndrew J Rech
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 551 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
Cancer Immunol Immunother 59:599-607. 2010..Total CD4(+) T cell counts are not constant, however, suggesting that homeostatic mechanisms, or susceptibility to cytotoxic or malignant insults, fundamentally differ for regulatory and non-regulatory CD4(+) T cells...
- Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African AmericansRebecca A Harris
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19014, USA
Hepatology 48:70-9. 2008..Furthermore, although HLA DQB1*03, DRB1*11, and DRB3*02 genotypes were associated with increased HCV-specific CD4 T cell response in univariate analyses, these associations were lost when controlling for virological outcomes...
- Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell populationHiroyoshi Doi
Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Hepatology 55:709-19. 2012..Last, blockade of TLR4 and TLR9 signaling abrogated the activation of healthy donor B cells by cirrhotic plasma, suggesting a role for bacterial translocation in driving B-cell changes in cirrhosis...
- Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran populationBarbara A Piasecki
University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Hepatology 40:892-9. 2004..016), while HBV coinfection was positively associated with HCV clearance (unadjusted OR 5.0; 95% CI, 1.26-28.6; P =.008). In conclusion, the likelihood of spontaneous clearance of HCV may be influenced by alcohol and viral coinfections...
- A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patientsRobert M Weinrieb
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
J Clin Psychiatry 64:1502-10. 2003..Because there is an increased risk of bleeding in HCV-infected patients who have developed cirrhosis and either portal hypertension or hepatic failure or both, we critically reviewed the literature on SSRI-associated bleeding...
- Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infectionHirotoshi Ebinuma
Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
J Virol 82:5043-53. 2008..Detection of FoxP3 expression in non-HCV-specific CD4 T cells suggests that immune regulation through antigen-specific Treg induction extends beyond HCV...
- Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancersErica L Carpenter
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Cancer Res 15:4277-87. 2009..This study aimed to investigate whether B-cell physiology was altered in the presence of melanoma and other cancers...
- Hepatitis C virus transmission bottlenecks analyzed by deep sequencingGary P Wang
University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Virol 84:6218-28. 2010..These findings provide the most detailed sequence-based analysis of HCV transmission bottlenecks to date. The analytical methods described here are broadly applicable to studies of viral diversity using deep sequencing...
- Prevalence and risk factors for patient-reported joint pain among patients with HIV/hepatitis C coinfection, hepatitis C monoinfection, and HIV monoinfectionAlexis Ogdie
Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Penn Tower Room 1407, 1 Convention Ave, Philadelphia, PA 19104, USA
BMC Musculoskelet Disord 16:93. 2015....
- Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical centerJoseph Kluck
Department of Pharmacy, Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA Department of Pharmacy, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Hepat Res Treat 2013:653976. 2013..Conclusions. In conclusion, pretreatment liver biopsy was not a positive predictor for treatment completion, and the presence of mental health disorders was not a negative predictor for treatment completion...
- ALCOHOL/CELLULAR IMMUNITY IN HCV AND HIV INFECTIONKyong Mi Chang; Fiscal Year: 2004..In addition, we will determine the extent to which this may be reversed upon alcohol cessation. ..
- Cellular Immunity and the Outcome of Hepatitis C Virus InfectionKyong Mi Chang; Fiscal Year: 2010..The proposed studies will provide novel insights to underlying immunological mechanisms of T cell dysfunction and HCV persistence with potential therapeutic application. ..