Manisha Chandalia

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Metabolic complications of obesity: inflated or inflamed?
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology and Metabolism, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:128-36. 2007
  2. pmc Role of ENPP1 on adipocyte maturation
    Jian Liang
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 2:e882. 2007
  3. ncbi request reprint Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort
    Manisha Chandalia
    Division of Endocrinology and Metabolism and The Center for Human Nutrition, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:143-8. 2007
  4. pmc Insulin resistance and body fat distribution in South Asian men compared to Caucasian men
    Manisha Chandalia
    Departments of Internal Medicine, Endocrinology and Metabolism, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 2:e812. 2007
  5. ncbi request reprint Hyperhomocysteinemia in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:1089-95. 2003
  6. doi request reprint Ethnic difference in sex gap in high-density lipoprotein cholesterol between Asian Indians and Whites
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Investig Med 56:574-80. 2008
  7. ncbi request reprint ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    Nicola Abate
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    Diabetes 54:1207-13. 2005
  8. ncbi request reprint Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance
    Nicola Abate
    Center for Human Nutrition and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:5927-34. 2003
  9. pmc Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology, University of Texas Medical Branch at Galveston, Texas 77555 1060, USA
    J Clin Endocrinol Metab 97:4663-72. 2012
  10. ncbi request reprint Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:3773-6. 2003

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Metabolic complications of obesity: inflated or inflamed?
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology and Metabolism, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:128-36. 2007
    ..Our efforts in establishing markers to identify "at risk" population and finding newer therapeutic agents must focus on adipose tissue dysfunction and not on obesity alone...
  2. pmc Role of ENPP1 on adipocyte maturation
    Jian Liang
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 2:e882. 2007
    ..This study was performed to evaluate whether ENPP1 is regulated during adipogenesis and whether over-expression in adipocytes can affect adipocyte maturation, a potential novel mechanism of ENPP1-related insulin resistance...
  3. ncbi request reprint Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort
    Manisha Chandalia
    Division of Endocrinology and Metabolism and The Center for Human Nutrition, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Diabetes Complications 21:143-8. 2007
    ..Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups...
  4. pmc Insulin resistance and body fat distribution in South Asian men compared to Caucasian men
    Manisha Chandalia
    Departments of Internal Medicine, Endocrinology and Metabolism, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 2:e812. 2007
    ..South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians...
  5. ncbi request reprint Hyperhomocysteinemia in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:1089-95. 2003
    ..Lower plasma concentrations of vitamin B-12 and lower insulin sensitivity may contribute to this finding but only partially explained the ethnic-related hyperhomocysteinemia of the Asian Indians...
  6. doi request reprint Ethnic difference in sex gap in high-density lipoprotein cholesterol between Asian Indians and Whites
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9169, USA
    J Investig Med 56:574-80. 2008
    ....
  7. ncbi request reprint ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    Nicola Abate
    Department of Medicine, Division of Endocrinology and Metabolism and The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    Diabetes 54:1207-13. 2005
    ....
  8. ncbi request reprint Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance
    Nicola Abate
    Center for Human Nutrition and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:5927-34. 2003
    ..This finding indicates the need for expanded studies on the association between PC-1 K121Q and insulin resistance in a representative sample of the Asian Indian population...
  9. pmc Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1
    Manisha Chandalia
    Department of Medicine, Division of Endocrinology, University of Texas Medical Branch at Galveston, Texas 77555 1060, USA
    J Clin Endocrinol Metab 97:4663-72. 2012
    ....
  10. ncbi request reprint Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States
    Manisha Chandalia
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9169, USA
    J Clin Endocrinol Metab 88:3773-6. 2003
    ....
  11. ncbi request reprint Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Clin Endocrinol Metab 89:2750-5. 2004
    ..These differences may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease in nonobese Asian Indians...
  12. pmc ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes
    Magdalene Szuszkiewicz
    The Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Metab Syndr Relat Disord 9:25-9. 2011
    ..78). We conclude that black race and age are major and not modifiable risk factors for PTDM. The specific role of ENPP1 K121Q on ethnic susceptibility to PTDM deserves further investigation in larger cohorts of transplanted patients...
  13. pmc Metabolic consequences of ENPP1 overexpression in adipose tissue
    Wentong Pan
    Department of Medicine, Division of Endocrinology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1060, USA
    Am J Physiol Endocrinol Metab 301:E901-11. 2011
    ..Thus, our results show that, in the presence of a high-fat diet, ENPP1 overexpression in adipocytes induces fatty liver, hyperlipidemia, and dysglycemia, thus recapitulating key manifestations of the metabolic syndrome...
  14. pmc Altered subcutaneous abdominal adipose tissue lipid synthesis in obese, insulin-resistant humans
    Demidmaa Tuvdendorj
    Department of Medicine, Division of Endocrinology and Institute for Translational Science University of Texas Medical Branch at Galveston, Texas
    Am J Physiol Endocrinol Metab 305:E999-E1006. 2013
    ....
  15. pmc Fat distribution and insulin resistance in young adult nonobese Asian Indian women
    Magdalene Szuszkiewicz-Garcia
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Metab Syndr Relat Disord 10:326-30. 2012
    ..In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent...
  16. pmc Heterogeneity in subcutaneous adipose tissue morphology and metabolic complications in overweight and obese women
    Gracie Vargas
    Center for Biomedical Engineering, Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
    Metab Syndr Relat Disord 11:276-82. 2013
    ....
  17. ncbi request reprint Ethnicity, type 2 diabetes & migrant Asian Indians
    Nicola Abate
    The Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, U T Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Indian J Med Res 125:251-8. 2007
    ..This review examines epidemiological and pathophysiological aspects of the interaction between environment and ethnic predisposition to type 2 diabetes in Asian Indians migrated to the US...
  18. ncbi request reprint The impact of ethnicity on type 2 diabetes
    Nicola Abate
    Center for Human Nutrition, UT Southwestern Medical Center at Dallas, USA
    J Diabetes Complications 17:39-58. 2003
    ..This review examines epidemiological and pathophysiological aspects of the interaction between environment and ethnic predisposition to type 2 diabetes...
  19. ncbi request reprint Diet composition and the metabolic syndrome: what is the optimal fat intake?
    Scott M Grundy
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Am J Med 113:25S-29S. 2002
    ....
  20. pmc Adipose tissue collagen and inflammation in nonobese Asian Indian men
    Alejandro Munoz
    Division of Endocrinology and Metabolism, Department of Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Clin Endocrinol Metab 98:E1360-3. 2013
    ..The objective of this study was to determine whether these AT abnormalities can be found independent of obesity in the presence of systemic insulin resistance...
  21. ncbi request reprint The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance
    Nicola Abate
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9169, USA
    Kidney Int 65:386-92. 2004
    ....
  22. pmc Effect of a high-fiber diet compared with a moderate-fiber diet on calcium and other mineral balances in subjects with type 2 diabetes
    Meena Shah
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Diabetes Care 32:990-5. 2009
    ..It is not clear, however, how high levels of fiber affect mineral balance...
  23. doi request reprint Effects of N-3 fatty acids on hepatic triglyceride content in humans
    Gloria Lena Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
    J Investig Med 56:780-5. 2008
    ..Because dietary N-3 fatty acids reduce plasma triglycerides, they may also decrease hepatic triglyceride content. If so, N-3 fatty acids might constitute a therapy for fatty liver...
  24. ncbi request reprint Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors
    Nicola Abate
    University of Texas Southwestern Medical Center, Dallas 75390 9169, USA
    Nat Clin Pract Endocrinol Metab 2:694-701. 2006
    ..Understanding the mechanisms that regulate E-NPP1 expression and/or function might render this protein a new target for strategies to treat and prevent type 2 diabetes and cardiovascular disease...
  25. pmc Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses
    Hanaa S Sallam
    Division of Endocrinology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    J Neurochem 133:125-33. 2015
    ....
  26. ncbi request reprint Should all patients with metabolic syndrome be treated with statins?
    Nicola Abate
    Department of Internal Medicine, Center for Human Nutrition, Division of Endocrinology and Metabolism, UT Southwestern Medical Center at Dallas, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
    Curr Diab Rep 6:72-6. 2006
    ..This review looks at the clinical trial evidence to support the use of statins in metabolic syndrome...
  27. ncbi request reprint Metabolic correlates of nonalcoholic fatty liver in women and men
    Gloria Lena Vega
    The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Hepatology 46:716-22. 2007
    ..Obese subjects with hepatic steatosis had higher ratios of truncal-to-lower body fat and other indicators of adipose tissue dysfunction compared with obese subjects without steatosis...
  28. doi request reprint Adipose Tissue Insulin Resistance in Gestational Diabetes
    Batbayar Tumurbaatar
    1 Division of Endocrinology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
    Metab Syndr Relat Disord . 2017
    ..Our objective was to study ENPP1 expression in adipose tissue (AT) of obese pregnant women with or without GDM, as well as glucose tolerance in pregnant transgenic (Tg) mice with AT-specific overexpression of human ENPP1...
  29. pmc Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin
    Susan G Lakoski
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9046, USA
    J Clin Endocrinol Metab 95:800-9. 2010
    ..Therefore, optimal prevention will require long-term LDL-C reduction, making it important to select the most effective agent for each individual...
  30. ncbi request reprint Do current body mass index criteria for obesity surgery reflect cardiovascular risk?
    Edward H Livingston
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern School of Medicine, Dallas, Texas 75390, USA
    Surg Obes Relat Dis 3:577-85. 2007
    ..We hypothesized that the inconsistencies among the studies of the obesity-cardiovascular relationship were attributable to an irregular relationship between obesity and the presence of risk factors for CVD...
  31. ncbi request reprint Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease
    Marie K Schluterman
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Am J Med Genet A 143:817-23. 2007
    ....
  32. ncbi request reprint Other than potency, are all statins the same?
    Nicola Abate
    Department of Internal Medicine, UT Southwestern Medical Center, 6011 Harry Hines Boulevard, Dallas, TX 75390 9169, USA
    Curr Atheroscler Rep 8:26-31. 2006
    ..This review evaluates the available information on potential differences among statins in non-lipid effects...
  33. ncbi request reprint Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity
    Venkatesan Radha
    Department of Molecular Genetics, Madras Diabetes Research Foundation, Dr Mohan s Diabetes Specialties Centre, No 4, Conran Smith Road, Gopalapuram, Chennai 86, India
    Diabetes Care 29:1046-51. 2006
    ..To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians...
  34. ncbi request reprint The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects
    Jarred B McAteer
    Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 57:1125-30. 2008
    ..We therefore conducted a new meta-analysis that includes novel unpublished data from the ENPP1 Consortium and recent negative findings from large association studies to address the contribution of K121Q to type 2 diabetes...
  35. ncbi request reprint The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites
    Sabrina Prudente
    Unit of Diabetes and Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Obesity (Silver Spring) 15:1-4. 2007
    ..008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity...