Siu Lung Chan
Affiliation: University of Vermont
- Treatment for cerebral small vessel disease: effect of relaxin on the function and structure of cerebral parenchymal arterioles during hypertensionSiu Lung Chan
1Department of Neurological Sciences, University of Vermont, 149 Beaumont Ave, HSRF 416, Burlington, VT 05405, USA
FASEB J 27:3917-27. 2013..VEGF appears to be involved in remodeling of PAs, but not relaxin-induced increased distensibility...
- Determination of PPARγ activity in adipose tissue and spleenSiu Lung Chan
Department of Neurology, University of Vermont, Burlington, Vermont, USA
J Immunoassay Immunochem 33:314-24. 2012..Validation of the assay with each individual tissue is recommended...
- Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γSiu Lung Chan
Department of Neurology, University of Vermont, Burlington, VT 05401 USA
FASEB J 25:3229-39. 2011..These results suggest that relaxin produced during pregnancy may be partly responsible for selective remodeling of PAs during pregnancy through a mechanism involving PPARγ..
- Effect of pregnancy and nitric oxide on the myogenic vasodilation of posterior cerebral arteries and the lower limit of cerebral blood flow autoregulationAbbie C Chapman
Neuroscience Graduate Program, University of Vermont College of Medicine, Burlington, VT 05405, USA
Reprod Sci 20:1046-54. 2013..The shift in the autoregulatory curve to lower pressures during pregnancy is likely protective of ischemic injury during hemorrhage and appears to be independent of NOS. ..
- Effect of hypertension and carotid occlusion on brain parenchymal arteriole structure and reactivityJulie G Sweet
Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, and Pharmacology, University of Vermont College of Medicine, Burlington, Vermont
J Appl Physiol (1985) 119:817-23. 2015..The increased tone of PAs from SHRSP animals, combined with lack of response to chronic hypoperfusion, may contribute to the propensity for ischemic lesions and increased perfusion deficit during hypertension. ..
- Effect of pregnancy on autoregulation of cerebral blood flow in anterior versus posterior cerebrumMarilyn J Cipolla
Department of Neurology, University of Vermont, 149 Beaumont Ave, HSRF 416, Burlington, VT 05405, USA
Hypertension 60:705-11. 2012..These findings suggest that, although pregnancy shifted the cerebral blood flow autoregulatory curve to higher pressures in both the anterior and posterior cortices, it did not protect from edema during acute hypertension...
- Effect of PPARγ inhibition during pregnancy on posterior cerebral artery function and structureSiu Lung Chan
Department of Neurology, University of Vermont Burlington, VT, USA
Front Physiol 1:130. 2010..Down-regulation of PPARγ and AT1R in cerebral arteries may be responsible for the lack of effect of PPARγ in cerebral vasculature and may be part of the vascular adaptation to pregnancy...
- Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsiaAbbie Chapman Johnson
Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, United States of America
PLoS ONE 9:e113670. 2014..Thus, reducing neuroinflammation may be one mechanism by which MgSO4 prevents eclampsia during severe preeclampsia...
- Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivityMarilyn J Cipolla
Department of Neurological Sciences, University of Vermont, Burlington, Vermont Department of Pharmacology, University of Vermont, Burlington, Vermont and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, Vermont
J Appl Physiol (1985) 117:53-9. 2014..Thus increased myogenic tone in PAs appears related to differences in ion channel activity that promotes VSM membrane depolarization but not to a direct sensitization of the contractile apparatus to calcium. ..
- Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsiaMarilyn J Cipolla
Department of Neurology, Univ of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
J Appl Physiol (1985) 110:329-39. 2011....