Genomes and Genes
H F Chambers
Affiliation: University of California
- Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesisBinh An Diep
Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 3:e3198. 2008..Taken together, our data indicate a modest and transient positive effect of PVL in the acute phase of bacteremia, thereby providing evidence that PVL contributes to CA-MRSA pathogenesis...
- Waves of resistance: Staphylococcus aureus in the antibiotic eraHenry F Chambers
Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Nat Rev Microbiol 7:629-41. 2009..Here, we review the molecular epidemiology of the epidemic waves of penicillin- and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA...
- Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditisH F Chambers
San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
Antimicrob Agents Chemother 53:1463-7. 2009..Increasing the dose of daptomycin may improve its efficacy for infections caused by strains with reduced daptomycin susceptibility...
- Ceftobiprole: in-vivo profile of a bactericidal cephalosporinH F Chambers
University of California, San Francisco School of Medicine, San Francisco, California 94143, USA
Clin Microbiol Infect 12:17-22. 2006..The broad spectrum of activity may allow ceftobiprole to be used as monotherapy for serious hospital-acquired infections where combination therapy would otherwise be required...
- Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureusP Tattevin
Division of Infectious Diseases, San Francisco General Hospital, University of California, San Francisco, Room 3400, Building 30, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Antimicrob Agents Chemother 54:610-3. 2010..05 for each comparison). Anti-MRSA beta lactam agents such as ceftobiprole may represent a significant therapeutic advance over currently available agents for the treatment of MRSA endocarditis...
- Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureusH F Chambers
Department of Medicine, University of California, Division of Infectious Diseases, San Francisco General Hospital, San Francisco, California, USA
Antimicrob Agents Chemother 43:2742-6. 1999..aureus but not viridans group streptococcal infections in humans...
- A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococciH Z Zhang
Division of Infectious Diseases, San Francisco General Hospital, Department of Medicine, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Science 291:1962-5. 2001..Compounds that disrupt this regulatory pathway could restore the activity of beta-lactam antibiotics against drug-resistant strains of staphylococci...
- Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37RaT Kocagoz
Department of Medicine, University of California, San Francisco 94110, USA
Antimicrob Agents Chemother 40:1768-74. 1996..Because sparfloxacin is more active in vitro and selection of resistance appears to be less likely to occur, it may have important advantage over ofloxacin or ciprofloxacin for the treatment of tuberculosis...
- The changing epidemiology of Staphylococcus aureus?H F Chambers
University of California San Francisco and San Francisco General Hospital, San Francisco, California, USA
Emerg Infect Dis 7:178-82. 2001..aureus decades ago. Even though the origin (hospital or the community) of the emerging MRSA strains is not known, the prevalence of these strains in the community seems likely to increase substantially...
- Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococciM Sachdeva
Medical Service, San Francisco General Hospital, California 94110
Antimicrob Agents Chemother 31:1549-52. 1987..aureus and S. epidermidis that were resistant to all the beta-lactam antibiotics tested at 5 micrograms/ml. This resistant subpopulation produced progeny that were uniformly resistant to high concentrations of each of the beta-lactams...
- The abilities of a Staphylococcus epidermidis wild-type strain and its slime-negative mutant to induce endocarditis in rabbits are comparableF Perdreau-Remington
Institute of Medical Microbiology and Hygiene, University of Cologne, Cologne, Germany
Infect Immun 66:2778-81. 1998..Adhesion was equally promoted by addition of fibronectin. These data suggest that the in vitro phenomenon of accumulation described as slime production in the absence of serum may not be an important virulence determinant in vivo...
- Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implicationsH F Chambers
Medical Service, San Francisco General Hospital 94143, USA
Clin Microbiol Rev 10:781-91. 1997..Investigational agents that bind PBP 2a at low concentrations appear promising but have not been tested in humans. Alternatives to vancomycin are few due to the multiple drug resistances typical of methicillin-resistant staphylococci...
- A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus diseaseJ N Martin
Center for AIDS Prevention Studies, AIDS Research Institute, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
J Infect Dis 180:896-9. 1999..Five days of treatment with mupirocin eliminated S. aureus nasal carriage in HIV-infected patients for several weeks; however, since the effect waned over time, intermittent dosing regimens should be considered for long-term eradication...
- Methicillin-resistant Staphylococcus aureus. Mechanisms of resistance and implications for treatmentH F Chambers
Division of Infectious Diseases, Department of Medicine, University of California San Francisco, 3rd and Parnassus Aves, San Francisco, CA 94143, USA
Postgrad Med 109:43-50. 2001..Given the increasing prevalence of MRSA in hospitals and in community settings, alternative approaches are needed for treatment of infections caused by MRSA...
- Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosisW Peters
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
Proc Natl Acad Sci U S A 98:7958-63. 2001..These data demonstrate that cellular responses mediated by activation of CCR2 are essential in the initial immune response and control of infection with M. tuberculosis...
- Identifying pulmonary tuberculosis in patients with negative sputum smear resultsA M Kanaya
Divisions of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Chest 120:349-55. 2001..Culture results may take weeks, and delaying treatment may allow further transmission of disease...
- Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37RaC J Hackbarth
Department of Medicine, University of California, San Francisco 94143, USA
Antimicrob Agents Chemother 41:1182-5. 1997..tuberculosis-derived beta-lactamase in one of these recombinant clones. A sequence analysis identified it as a class A beta-lactamase whose expression correlated with the increased resistance phenotype...
- Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistanceC J Hackbarth
Division of Infectious Diseases, San Francisco General Hospital, California 94110
Antimicrob Agents Chemother 39:103-6. 1995..These structural and biochemical changes may contribute to the strains' resistance to beta-lactam antibiotics...
- PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUSHenry Chambers; Fiscal Year: 2003..To augment information about where PBPs localize, when they are expressed during the cell cycle will be determined by Northern blotting. ..
- Genetic Basis of Virulence of Community MRSA Clone USA300Henry F Chambers; Fiscal Year: 2010..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..