Dhrubajyoti Chakravarti

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia
    D Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 456:17-32. 2000
  2. ncbi request reprint Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene
    D Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Oncogene 20:7945-53. 2001
  3. pmc Formation of template-switching artifacts by linear amplification
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Biomol Tech 19:184-8. 2008
  4. pmc The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198 6805, USA
    Mutat Res 649:161-78. 2008
  5. ncbi request reprint Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 588:158-65. 2005
  6. ncbi request reprint NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 117:56-66. 2009
  7. ncbi request reprint Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leuk Lymphoma 47:2635-44. 2006
  8. pmc Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteine
    Divya Venugopal
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 109:22-30. 2008
  9. ncbi request reprint Induction of A.T to G.C mutations by erroneous repair of depurinated DNA following estrogen treatment of the mammary gland of ACI rats
    Paula C Mailander
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Steroid Biochem Mol Biol 101:204-15. 2006
  10. ncbi request reprint Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation
    Muhammad Saeed
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 47:1075-81. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia
    D Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 456:17-32. 2000
    ..The multiplication of initiated stem cells during transient clonoplasia may be a factor determining the tumor-initiating potential of some PAH carcinogens...
  2. ncbi request reprint Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene
    D Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Oncogene 20:7945-53. 2001
    ..These results also suggest that E(2)-3,4-Q, a suspected endogenous carcinogen, is a genotoxic compound and could cause mutations...
  3. pmc Formation of template-switching artifacts by linear amplification
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Biomol Tech 19:184-8. 2008
    ....
  4. pmc The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198 6805, USA
    Mutat Res 649:161-78. 2008
    ..In conclusion, this study suggests that depurinating adducts play a major role in PAH mutagenesis...
  5. ncbi request reprint Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 588:158-65. 2005
    ..In summary, the inclusion of ARP in the DB[a,l]P-DNA adduct-forming reaction traps and protects the nascent abasic sites, allowing an improved quantification of abasic sites...
  6. ncbi request reprint NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 117:56-66. 2009
    ..Therefore, the inheritance of these NQO1 polymorphisms may favor the estrogen genotoxic mechanism of breast cancer...
  7. ncbi request reprint Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leuk Lymphoma 47:2635-44. 2006
    ..Thus, DNA damage induced by the ortho-quinones of benzene and estradiol may promote the growth of human blood mononuclear cells, including those that appear in large numbers in leukemia and lymphoma...
  8. pmc Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteine
    Divya Venugopal
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 109:22-30. 2008
    ..These results strongly implicate estrogen genotoxicity in mammary cell transformation. Since N-acetylcysteine is well tolerated in clinical studies, it may be a promising candidate for breast cancer prevention...
  9. ncbi request reprint Induction of A.T to G.C mutations by erroneous repair of depurinated DNA following estrogen treatment of the mammary gland of ACI rats
    Paula C Mailander
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Steroid Biochem Mol Biol 101:204-15. 2006
    ..T to G.C mutations down to pre-existing frequencies. Our results demonstrate that treatment with estradiol-3,4-quinone, an important metabolite of estrogens, produced A.T to G.C mutations in the DNA of the mammary gland of ACI rats...
  10. ncbi request reprint Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation
    Muhammad Saeed
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 47:1075-81. 2009
    ..This is the same mechanism as other weak carcinogens, such as the natural and synthetic estrogens, and benzene...
  11. ncbi request reprint Harvey-ras gene expression and epidermal cell proliferation in dibenzo[a,l]pyrene-treated early preneoplastic SENCAR mouse skin
    Gausal A Khan
    Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Invest Dermatol 125:567-74. 2005
    ..As this proliferation occurs in the absence of any promoting treatment, we propose that this phenomenon is a tumor initiation event...
  12. ncbi request reprint Prevalence of BER gene polymorphisms in sporadic breast cancer
    Mohamed F Ali
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncol Rep 19:1033-8. 2008
    ..Thus, the Gln allele was significantly more frequent in breast cancer cases (allele frequency, 0.52) than in controls (allele frequency, 0.35), suggesting that XRCC1 399Gln may enhance the risk of breast cancer...
  13. ncbi request reprint Initiation of cancer and other diseases by catechol ortho-quinones: a unifying mechanism
    E L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Cell Mol Life Sci 59:665-81. 2002
    ..These data suggest a unifying molecular mechanism of initiation for many cancers and neurodegenerative diseases and lay the groundwork for designing strategies to assess risk and prevent these diseases...
  14. ncbi request reprint Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncol Rep 14:1091-6. 2005
    ..These unbalances appear to be instrumental in causing excessive formation of catechol estrogen quinones that, by reacting with DNA, initiate the series of events leading to breast cancer...
  15. ncbi request reprint The role of endogenous catechol quinones in the initiation of cancer and neurodegenerative diseases
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Applied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Methods Enzymol 382:293-319. 2004
  16. ncbi request reprint Possible genotoxic modes of action for naphthalene
    David Brusick
    Department of Environmental Engineering, Carnegie Mellon University, USA
    Regul Toxicol Pharmacol 51:S43-50. 2008
    ..The report also outlines a set of six studies that could resolve some of these key uncertainties...
  17. ncbi request reprint Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol
    Zhonglin Zhao
    New York University Dental School, New York, New York 10010, USA
    Chem Res Toxicol 19:475-9. 2006
    ..Thus, the results of this study support the proposal that estradiol can contribute to carcinogenesis via a genotoxic pathway...