Y Chai

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint A mouse mandibular culture model permits the study of neural crest cell migration and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 42:87-94. 1998
  2. ncbi request reprint PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Dev Dyn 213:500-11. 1998
  3. ncbi request reprint Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development
    Y Ito
    Center for Craniofacial Molecular Biology School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 276:44163-72. 2001
  4. ncbi request reprint TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Crit Rev Oral Biol Med 14:78-88. 2003
  5. ncbi request reprint Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 86:63-74. 1999
  6. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
  7. ncbi request reprint Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033
    Dev Biol 162:85-103. 1994
  8. ncbi request reprint Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis
    Y Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA
    Dev Biol 236:181-94. 2001
  9. pmc Molecular and cellular regulatory mechanisms of tongue myogenesis
    C Parada
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 91:528-35. 2012
  10. ncbi request reprint Epithelial fibroblast growth factor receptor 1 regulates enamel formation
    K Takamori
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 87:238-43. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A mouse mandibular culture model permits the study of neural crest cell migration and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 42:87-94. 1998
    ....
  2. ncbi request reprint PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Dev Dyn 213:500-11. 1998
    ..These data suggest that PDGF-A and its cognate receptor (PDGFR-alpha) regulate the size and stage of tooth development via an autocrine mechanism during odontogenesis in vitro...
  3. ncbi request reprint Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development
    Y Ito
    Center for Craniofacial Molecular Biology School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 276:44163-72. 2001
    ..The results indicate that Smads are critical factors in orchestrating TGF-beta-mediated gene regulation during embryonic tooth development. The effectiveness of TGF-beta signaling is highly sensitive to the level of Smad gene expression...
  4. ncbi request reprint TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Crit Rev Oral Biol Med 14:78-88. 2003
    ..The biological function of TGF-beta is carried out through the regulation of transcriptional factors during embryogenesis...
  5. ncbi request reprint Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 86:63-74. 1999
    ....
  6. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
    ..The optimization of TGF-beta signaling during early lung development therefore requires a finely-regulated competitive balance between both permissive and inhibitory members of the Smad family...
  7. ncbi request reprint Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033
    Dev Biol 162:85-103. 1994
    ..TGF-beta 3 appears to regulate Meckel's cartilage size without altering tooth size or shape. The results are discussed in terms of the regulatory functions of the TGF-beta subtypes during embryonic craniofacial morphogenesis...
  8. ncbi request reprint Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis
    Y Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA
    Dev Biol 236:181-94. 2001
    ..Collectively, our study presents the first in vivo evidence that, by providing an auto-feedback in TGF-beta signaling, Smad2 plays a pivotal role in regulating TGF-beta-mediated epidermal homeostasis...
  9. pmc Molecular and cellular regulatory mechanisms of tongue myogenesis
    C Parada
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 91:528-35. 2012
    ....
  10. ncbi request reprint Epithelial fibroblast growth factor receptor 1 regulates enamel formation
    K Takamori
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    J Dent Res 87:238-43. 2008
    ..Loss of Fgfr1 affects ameloblast organization at the enamel-secretory stage and, hence, the formation of enamel...
  11. ncbi request reprint Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    Y Chai
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 127:1671-9. 2000
    ..Furthermore, this transgenic model also provides a new tool for cell lineage analysis and genetic manipulation of neural-crest-derived components in normal and abnormal embryogenesis...
  12. pmc The mechanism of TGF-β signaling during palate development
    J Iwata
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Oral Dis 17:733-44. 2011
    ..Here, we highlight recent advances in our understanding of TGF-β signaling during palate development...
  13. ncbi request reprint Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts
    P S Sarkar
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Nat Genet 25:110-4. 2000
    ..Our data support the hypothesis that DM is a contiguous gene syndrome associated with the partial loss of both DMPK and SIX5...
  14. pmc TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
    H Chen
    Developmental Biology Program, Dept of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Eur Respir J 32:285-95. 2008
    ....
  15. ncbi request reprint [Identification and characterization of differentially expressed ESTs of Gossypium barbadense infected by Verticillium dahliae with suppression subtractive hybridization]
    K Zuo
    Mol Biol (Mosk) 39:214-23. 2005
    ..dahliae. To our knowledge, this is the first report on the isolation of global ESTs during sea-island cotton defense reaction...
  16. ncbi request reprint Induction of apoptosis by Elk-1 and deltaElk-1 proteins
    N Shao
    Department of Human Genetics, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    Oncogene 17:527-32. 1998
    ..These results indicate that constitutive expression of Elk-1 and deltaElk-1 proteins triggers apoptosis in Rat-1 fibroblasts and breast cancer cells when treated with calcium ionophore...
  17. ncbi request reprint The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease
    Y Chai
    Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 276:44889-97. 2001
    ..These results suggest that protein context-dependent recruitment of nuclear proteins to intranuclear microaggregates, and subsequently to NI, may contribute to selective neurotoxicity in polyQ diseases...
  18. ncbi request reprint c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells
    Y Chai
    Department of Medicine, Program of Cancer Genetics, Cancer Center, MCP Hahnemann University, 245 North 15th Street, New College Building, M S 481, Philadelphia, Pennsylvania 19102, USA
    Oncogene 20:1357-67. 2001
    ..All these results taken together suggest that one of the mechanisms by which BRCA1a/1b proteins function as growth/tumor suppressors is through inhibition of the expression of Elk-1 target genes like c-Fos...