Affiliation: University of Pennsylvania
- Influences of microbiota on intestinal immune system developmentJ J Cebra
Department of Biology, The University of Pennsylvania, Philadelphia 19104 6018, USA
Am J Clin Nutr 69:1046S-1051S. 1999..Neonatal conventionally reared mice and germ-free, deliberately colonized adult mice (gnotobiotic mice) were used to examine the efficacy of certain intestinal microbes...
- Orally administered microencapsulated reovirus can bypass suckled, neutralizing maternal antibody that inhibits active immunization of neonatesS B Periwal
Department of Biology, University of Pennsylvania, Philadelphia 19104 6018, USA
J Virol 71:2844-50. 1997..These observations seem relevant to the development of efficacious oral vaccines that also allow passive, protective immunity via suckled maternal antibodies while permitting active oral immunization of neonates...
- Gut colonization of mice with actA-negative mutant of Listeria monocytogenes can stimulate a humoral mucosal immune responseM Manohar
Department of Biology, University of Pennsylvania, Philadelphia, Pennysylvania 19104-6018, USA
Infect Immun 69:3542-9. 2001..monocytogenes. We detected IgA binding to antigenic proteins with molecular masses of 96, 60, 40, and 14 kDa in the Listeria sonicates...
- Timing, localization, and persistence of colonization by segmented filamentous bacteria in the neonatal mouse gut depend on immune status of mothers and pupsH Q Jiang
Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
Infect Immun 69:3611-7. 2001..Nevertheless, it is evident that the timing, localization, and persistence of colonization of the neonatal gut by SFB depends on the immune status of both mothers and pups...
- B2 but not B1 cells can contribute to CD4+ T-cell-mediated clearance of rotavirus in SCID miceN Kushnir
Department of Biology, University of Pennsylvania, Philadelphia 19104-6018, USA
J Virol 75:5482-90. 2001..Reconstitution of RV-infected SCID mice with B1 cells results in the outgrowth of contaminating, donor CD4+ T cells that are unable to clear RV, possibly because their oligoclonal specificities may be ineffective against RV antigens...
- REOVIRUSES AND PROBES OF MUCOSAL IMMUNE RESPONSESJOHN CEBRA; Fiscal Year: 2001..The results of these analyses should be extremely relevant for the development of efficacious vaccines vs. respiratory pathogens. ..