M J Carvan
Affiliation: University of Wisconsin-Milwaukee
- Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollutionDaniel W Nebert
Environ Health Perspect 110:A15. 2002
- Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8,-tetrachlorodibenzo-p-dioxin: impacts on reproductive success of zebrafishTisha King Heiden
Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee Great Lakes WATER Institute, 53204, USA
Toxicol Sci 87:497-507. 2005..This study provides the necessary framework to utilize the zebrafish model system for further investigations into the molecular mechanisms by which TCDD exerts its reproductive toxic responses...
- Inhibition of follicular development, vitellogenesis, and serum 17beta-estradiol concentrations in zebrafish following chronic, sublethal dietary exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxinTisha King Heiden
Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53204, USA
Toxicol Sci 90:490-9. 2006..This suggests that long-term exposure to very low concentrations of TCDD could greatly affect fecundity and reproductive success in fishes...
- Gene expression changes related to endocrine function and decline in reproduction in fathead minnow (Pimephales promelas) after dietary methylmercury exposureRebecca Klaper
Great Lakes WATER Institute, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA
Environ Health Perspect 114:1337-43. 2006..Several studies have indicated potential changes in hormone levels as well as declines in vertebrates with increasing dietary MeHg exposure...
- Activation of transcription factors in zebrafish cell cultures by environmental pollutantsM J Carvan
Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
Arch Biochem Biophys 376:320-7. 2000....
- Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard rankingM J Carvan
Great Lakes WATER Institute and NIEHS Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, 53204, USA
Sci Total Environ 274:183-96. 2001....
- Fish models in toxicologyMichael J Carvan
Great Lakes Wisconsin Aquaculture Technology and Environmental Research WATER Institute, University of Wisconsin Milwaukee, 600 E Greenfield Avenue, Milwaukee, WI 53204, USA
Zebrafish 4:9-20. 2007
- Selenomethionine reduces visual deficits due to developmental methylmercury exposuresDaniel N Weber
Marine and Freshwater Biomedical Sciences Center, University of Wisconsin Milwaukee, 600 E Greenfield Ave, Milwaukee, WI 53204, United States
Physiol Behav 93:250-60. 2008..Electrophysiological deficits parallel behavioral patterns in MeHg-treated fish, i.e., initial reactions to the rotating bar were followed by periods of inactivity and then a resumption of responses...
- Characterization of the MTF-1 transcription factor from zebrafish and trout cellsT P Dalton
Department of Environmental Health, Center for Environmental Genetics CEG, University of Cincinnati Medical Center, OH 45267 0056, USA
Comp Biochem Physiol B Biochem Mol Biol 126:325-35. 2000..Similarly, Zn reversibly modulated MTF-1L binding, but, in contrast, such modulation occurred readily at 4 degrees C. This data demonstrate the conservation of binding specificity, binding properties, and regulation of MTF-1 in fishes...
- "Gene-swap knock-in" cassette in mice to study allelic differences in human genesD W Nebert
Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
Ann N Y Acad Sci 919:148-70. 2000..It is anticipated that mouse lines carrying numerous human alleles will become commonplace early in the next millennium...
- Detection of mercury in aquatic environments using EPRE reporter zebrafishBrandon W Kusik
Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI 53204, USA
Mar Biotechnol (NY) 10:750-7. 2008..Furthermore, expression was induced at HgCl(2) concentrations that do not result in obvious morphological defects, making this approach useful for the detection of low levels of oxidative contaminants in aquatic environments...
- Developmental selenomethionine and methylmercury exposures affect zebrafish learningLeigh E Smith
Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI 53204, United States
Neurotoxicol Teratol 32:246-55. 2010..01 microM MeHg. SeMet co-exposure ameliorated but did not prevent changes in telencephalon cell body density. In summary, MeHg affected both learning and brain structure, but SeMet only partially reversed the latter...
- Developmental expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio)A K Dasmahapatra
Great Lakes WATER Institute, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53204, USA
Biochem Biophys Res Commun 286:1082-6. 2001..Thus, differential ADH3 expression may be at least partly responsible for temporal variations in the sensitivity of zebrafish embryos to developmental alcohol exposure...
- Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesisMichael J Carvan
Great Lakes WATER Institute, University of Wisconsin Milwaukee, 600 E Greenfield Avenue, Milwaukee, WI 53204, USA
Neurotoxicol Teratol 26:757-68. 2004..This work provides the foundation for identifying genes and pathways involved in developmental alcohol toxicity in vertebrates, leading to a more complete mechanistic understanding of fetal alcohol disorders in humans...
- Strain-dependent effects of developmental ethanol exposure in zebrafishEvyn Loucks
Great Lakes WATER Institute, University of Wisconsin Milwaukee, Milwaukee, WI 53204, USA
Neurotoxicol Teratol 26:745-55. 2004....
- Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: insights into TCDD-induced endocrine disruption and reproductive toxicityTisha C King Heiden
Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI, USA
Reprod Toxicol 25:47-57. 2008..Data presented here provide further insight into the mechanisms by which TCDD disrupts follicular development and reproduction in fish, and can be used to formulate new hypotheses regarding previously documented ovarian toxicity...
- Fluorescence-based detection of thiols in vitro and in vivo using dithiol probesPhani Kumar Pullela
Chemical Proteomics Facility at Marquette, Department of Chemistry, Marquette University, Milwaukee, WI 53201, USA
Anal Biochem 352:265-73. 2006..In Escherichia coli, decreased thiol levels were detected in cells deficient in glutathione synthesis. In zebrafish embryos, the DSSA reagent permitted detection of unusually high thiol levels in the zebrafish chorion...
- Views on four key questions about zebrafish researchKeith C Cheng
Jake Gittlen Cancer Research Foundation, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Zebrafish 5:9-24. 2008
- Automated analysis of conserved syntenies for the zebrafish genomeJohn Postlethwait
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
Methods Cell Biol 77:255-71. 2004
- FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISHMICHAEL CARVAN; Fiscal Year: 2002..abstract_text> ..