Michele Carbone

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. pmc Consensus Report of the 2015 Weinman International Conference on Mesothelioma
    Michele Carbone
    Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii Electronic address
    J Thorac Oncol 11:1246-62. 2016
  2. pmc Evaluation of clonal origin of malignant mesothelioma
    Sabahattin Comertpay
    University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA
    J Transl Med 12:301. 2014
  3. pmc BAP1 and cancer
    Michele Carbone
    University of Hawaii Cancer Center, BSB200, 701 Ilalo Street, Honolulu, Hawaii 96813, USA
    Nat Rev Cancer 13:153-9. 2013
  4. pmc BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs
    Michele Carbone
    University of Hawai i Cancer Center, 677 Ala Moana Boulevard, Suite 901, Honolulu, HI 96813, USA
    J Transl Med 10:179. 2012
  5. pmc Erionite exposure in North Dakota and Turkish villages with mesothelioma
    Michele Carbone
    University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 108:13618-23. 2011
  6. pmc Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation
    Haining Yang
    Cancer Research Center of Hawaii, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 107:12611-6. 2010
  7. pmc Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma
    Sandro Jube
    University of Hawai i Cancer Center, John A Burns School of Medicine, University of Hawai i, Honolulu, Hawaii 96813, USA
    Cancer Res 72:3290-301. 2012
  8. pmc Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-α signaling
    Fang Qi
    University of Hawai i Cancer Center, University of Hawai i, Honolulu, Hawaii Department of Molecular Biosciences and Bioengineering, University of Hawai i, Honolulu, Hawaii
    Am J Pathol 183:1654-66. 2013
  9. pmc CSPG4 as a target of antibody-based immunotherapy for malignant mesothelioma
    Zeyana Rivera
    University of Hawai i Cancer Center, HI, USA
    Clin Cancer Res 18:5352-63. 2012
  10. pmc Mesothelioma epidemiology, carcinogenesis, and pathogenesis
    Haining Yang
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Curr Treat Options Oncol 9:147-57. 2008

Collaborators

Detail Information

Publications31

  1. pmc Consensus Report of the 2015 Weinman International Conference on Mesothelioma
    Michele Carbone
    Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii Electronic address
    J Thorac Oncol 11:1246-62. 2016
    ....
  2. pmc Evaluation of clonal origin of malignant mesothelioma
    Sabahattin Comertpay
    University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA
    J Transl Med 12:301. 2014
    ....
  3. pmc BAP1 and cancer
    Michele Carbone
    University of Hawaii Cancer Center, BSB200, 701 Ilalo Street, Honolulu, Hawaii 96813, USA
    Nat Rev Cancer 13:153-9. 2013
    ....
  4. pmc BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs
    Michele Carbone
    University of Hawai i Cancer Center, 677 Ala Moana Boulevard, Suite 901, Honolulu, HI 96813, USA
    J Transl Med 10:179. 2012
    ....
  5. pmc Erionite exposure in North Dakota and Turkish villages with mesothelioma
    Michele Carbone
    University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 108:13618-23. 2011
    ..Our findings indicate that implementation of novel preventive and early detection programs in ND and other erionite-rich areas of the United States, similar to efforts currently being undertaken in Turkey, is warranted...
  6. pmc Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation
    Haining Yang
    Cancer Research Center of Hawaii, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 107:12611-6. 2010
    ..Chemopreventive approaches aimed at inhibiting the chronic inflammatory response, and especially blocking HMGB1, may decrease the risk of malignant mesothelioma among asbestos-exposed cohorts...
  7. pmc Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma
    Sandro Jube
    University of Hawai i Cancer Center, John A Burns School of Medicine, University of Hawai i, Honolulu, Hawaii 96813, USA
    Cancer Res 72:3290-301. 2012
    ....
  8. pmc Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-α signaling
    Fang Qi
    University of Hawai i Cancer Center, University of Hawai i, Honolulu, Hawaii Department of Molecular Biosciences and Bioengineering, University of Hawai i, Honolulu, Hawaii
    Am J Pathol 183:1654-66. 2013
    ..Continuous administration of chrysotile was required for sustained high serum levels of HMGB1. These data support the hypothesis that differences in biopersistence influence the biological activities of these two asbestos fibers...
  9. pmc CSPG4 as a target of antibody-based immunotherapy for malignant mesothelioma
    Zeyana Rivera
    University of Hawai i Cancer Center, HI, USA
    Clin Cancer Res 18:5352-63. 2012
    ..Therefore, we explored CSPG4 as a suitable target for monoclonal antibody (mAb)-based immunotherapy for MM...
  10. pmc Mesothelioma epidemiology, carcinogenesis, and pathogenesis
    Haining Yang
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Curr Treat Options Oncol 9:147-57. 2008
    ..It is hoped that the identification of this putative mesothelioma gene will lead to novel mechanistically driven preventive and therapeutic approaches...
  11. pmc Investigating palygorskite's role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity
    David Larson
    a University of Hawai i Cancer Center, University of Hawai i, Honolulu, Hawai i, USA
    J Toxicol Environ Health B Crit Rev 19:213-230. 2016
    ..Therefore, palygorskite is not a likely contributor to the MM cases observed in southern Nevada...
  12. pmc Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma
    Michele Carbone
    Thoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
    Oncotarget . 2016
    ..Our study indicated that absence of nuclear BAP1 stain helps differentiate MM from lung carcinomas. We suggest that BAP1 staining should be added to the IHC panel that is currently used to distinguish these malignancies...
  13. pmc High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma
    Masaki Nasu
    University of Hawai i Cancer Center, University of Hawai i, Honolulu, Hawaii Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, Texas Department of Biomedical Sciences and Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania and Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York
    J Thorac Oncol 10:565-76. 2015
    ..However, the reported frequency of somatic BAP1 mutations in MM varies considerably, a discrepancy that appeared related to either methodological or ethnical differences across various studies...
  14. pmc Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival
    Francine Baumann
    University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Carcinogenesis 36:76-81. 2015
    ..Appropriate genetic counseling and clinical management should be considered for MM patients who are also BAP1 mutation carriers...
  15. doi The relationship between simian virus 40 and mesothelioma
    Zeyana Rivera
    Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, Honolulu, Hawaii, USA
    Curr Opin Pulm Med 14:316-21. 2008
    ..Simian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of simian virus 40 in malignant mesothelioma is discussed in this review...
  16. ncbi A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes
    Michele Carbone
    Cancer Research Center of Hawaii, Thoracic Oncology Program, Honolulu, Hawaii 96816, USA
    Nat Rev Cancer 7:147-54. 2007
    ....
  17. pmc Ranpirnase Interferes with NF-κB Pathway and MMP9 Activity, Inhibiting Malignant Mesothelioma Cell Invasiveness and Xenograft Growth
    Masaki Nasu
    University of Hawai i Cancer Center, University of Hawai i at Manoa, Honolulu, HI, USA
    Genes Cancer 2:576-84. 2011
    ..It is hoped that this information will also facilitate the identification of those patients who are more likely to benefit from this drug and will also open a new frontier for the use of this drug in tumor types other than MM...
  18. pmc Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes
    Lei Zhang
    University of Hawai i Cancer Center, Honolulu, HI, USA
    Genes Cancer 1:1008-20. 2010
    ..Our results provide a biological rationale to the observation that 1ESV40 is prevalently detected in brain tumors and wtSV40 in mesotheliomas...
  19. pmc Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s
    Michele Carbone
    Thoracic Oncology Program, University of Hawai i Cancer Center, Honolulu, Hawai i, United States of America
    PLoS Genet 11:e1005633. 2015
    ..We have also implemented early-detection strategies that help identify cancers at early-stage, when they can be cured (melanomas) or are more susceptible to therapy (MM and other malignancies). ..
  20. pmc Fowlpox-based survivin vaccination for malignant mesothelioma therapy
    Pietro Bertino
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawai i, Honolulu, HI 96813, USA
    Int J Cancer 133:612-23. 2013
    ..Our results demonstrate that vaccination with recombinant Fowlpox expressing survivin improves T-cell responses against aggressive MM tumors and may form the basis for promising clinical applications...
  21. pmc Simian virus 40 transformation, malignant mesothelioma and brain tumors
    Fang Qi
    University of Hawaii Cancer Center, Honolulu, HI, USA
    Expert Rev Respir Med 5:683-97. 2011
    ..However, it seems possible that SV40 may act as a cofactor in the pathogenesis of some tumors. In vitro and animal experiments showing cocarcinogenicity between SV40 and asbestos support this hypothesis...
  22. ncbi Chemotherapy of malignant pleural mesothelioma
    Pietro Bertino
    Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, 651 Ilalo Street, BSB Room 231, Honolulu, HI 96813, USA
    Expert Opin Pharmacother 10:99-107. 2009
    ..Although the outcome for patients remains poor, there has been definite progress in the systemic treatment of this disease within the past 5 years...
  23. pmc HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients
    Andrea Napolitano
    University of Hawaii Cancer Center, Honolulu, Hawaii Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii
    Clin Cancer Res 22:3087-96. 2016
    ..To determine whether serum levels of high mobility group box protein 1 (HMGB1) could differentiate malignant mesothelioma patients, asbestos-exposed individuals, and unexposed controls...
  24. pmc Preclinical development of HIvax: Human survivin highly immunogenic vaccines
    Peter R Hoffmann
    a Department of Cell and Molecular Biology John A Burns School of Medicine University of Hawai i Honolulu, HI, USA
    Hum Vaccin Immunother 11:1585-95. 2015
    ..These results provide a rationale for clinical testing of HIvax1 and HIvax2 vaccines in patients with survivin-expressing cancers. ..
  25. pmc Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma
    Michele Carbone
    University of Hawaii Cancer Center, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Clin Cancer Res 18:598-604. 2012
    ..The very recent discovery that germline BAP1 mutations cause a new cancer syndrome characterized by mesothelioma, uveal melanoma, and melanocytic tumors provides researchers with a novel target for prevention and early detection...
  26. pmc Malignant mesothelioma: facts, myths, and hypotheses
    Michele Carbone
    University of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Cell Physiol 227:44-58. 2012
    ..Genetic predisposition, radiation exposure and viral infection are co-factors that can alone or together with asbestos and erionite cause MM. J. Cell. Physiol. 227: 44-58, 2012. © 2011 Wiley Periodicals, Inc...
  27. ncbi The pathogenesis of mesothelioma
    Michele Carbone
    Thoracic Oncology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Semin Diagn Pathol 23:56-60. 2006
    ..Moreover, these data provide a rationale for the observation that only a fraction of heavily exposed asbestos workers developed mesothelioma, and novel targets for prevention and therapy...
  28. pmc Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies
    Angela Bononi
    a 1 University of Hawai i Cancer Center, University of Hawai i at Manoa, Honolulu, Hawai i, USA
    Expert Rev Respir Med 9:633-54. 2015
    ..We elaborate on the rationale behind new therapeutic strategies, and summarize available preclinical and clinical results, as well as efforts still ongoing. ..
  29. pmc A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells
    Michele Carbone
    Thoracic Oncology Program, Cancer Center of Hawaii and Department of Pathology, University of Hawaii Medical School, Honolulu, Hawaii 96813, USA
    Cancer Res 68:9488-96. 2008
    ..Our results reveal a novel biological mechanism responsible for the suppression of late viral gene products, an important step in viral carcinogenesis in humans...
  30. ncbi Gene expression profiles predict survival and progression of pleural mesothelioma
    Harvey I Pass
    Thoracic Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Clin Cancer Res 10:849-59. 2004
    ..We hypothesized that gene expression profiles could predict time to progression and survival in surgically cytoreduced pleural mesothelioma of all stages...
  31. pmc The Presence of Asbestos in the Natural Environment is Likely Related to Mesothelioma in Young Individuals and Women from Southern Nevada
    Francine Baumann
    Cancer Center, University of Hawaii, Honolulu, Hawaii Department of Geoscience, University of Nevada Las Vegas, Las Vegas, Nevada Department of Environmental, Geographical and Geological Sciences, Bloomsburg University of Pennsylvania, Pennsylvania and USDA, Natural Resources Conservation Service, Las Vegas, Nevada
    J Thorac Oncol 10:731-7. 2015
    ....