JORGE A BUSCIGLIO
Affiliation: University of Connecticut Health Center
- Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndromeJorge Busciglio
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Neuron 33:677-88. 2002..Thus, mitochondrial dysfunction in DS may lead to intracellular deposition of Abeta42, reduced levels of AbetaPPs, and a chronic state of increased neuronal vulnerability...