Mark E Burkard

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Feasibility of 4 cycles of docetaxel and cyclophosphamide every 14 days as an adjuvant regimen for breast cancer: a Wisconsin Oncology Network study
    Mark E Burkard
    University of Wisconsin Carbone Cancer Center, Madison, WI Hematology Oncology Division, Department of Medicine, University of Wisconsin, Madison, WI Electronic address
    Clin Breast Cancer 14:205-11. 2014
  2. pmc Validating cancer drug targets through chemical genetics
    Mark E Burkard
    University of Wisconsin Carbone Cancer Center and Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochim Biophys Acta 1806:251-7. 2010
  3. pmc Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer
    Ryan A Denu
    Division of Hematology Oncology, Medical Scientist Training Program and the Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Cancer 16:47. 2016
  4. pmc Targeting Estrogen Receptor Beta in a Phase 2 Study of High-Dose Estradiol in Metastatic Triple-Negative Breast Cancer: A Wisconsin Oncology Network Study
    Kari B Wisinski
    Carbone Cancer Center, University of Wisconsin, Madison, WI School of Medicine and Public Health, University of Wisconsin, Madison, WI Electronic address
    Clin Breast Cancer . 2016
  5. pmc Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin Hematology Oncology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Mol Cancer Ther 15:48-59. 2016
  6. pmc High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells
    Robert F Lera
    Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 287:42812-25. 2012
  7. pmc Aromatase inhibitors and calcium absorption in early stage breast cancer
    Amye Tevaarwerk
    University of Wisconsin School of Medicine and Public Health, Room 4124, 1685 Highland Avenue, Madison, WI, 53705 2281, USA
    Breast Cancer Res Treat 134:245-51. 2012
  8. pmc Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:13026-31. 2013
  9. pmc The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinases
    Robert F Lera
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Molecules 17:12172-86. 2012
  10. pmc Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles
    Lauren M Zasadil
    Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA
    Sci Transl Med 6:229ra43. 2014

Collaborators

  • Beth A Weaver
  • Robert F Lera
  • Anne M Traynor
  • Lee G Wilke
  • Kari B Wisinski
  • Lauren M Zasadil
  • Alka Choudhary
  • Ryan A Denu
  • Amye Tevaarwerk
  • Sandeep Saha
  • Craig Kanugh
  • Amye J Tevaarwerk
  • Jennifer J Laffin
  • Kyungmann Kim
  • Gabrielle Rocque
  • Josephine Harter
  • Amber Lasek
  • Hyunjung Kim
  • Josephine M Harter
  • Leah Dietrich
  • Wei Xu
  • Robert Hegeman
  • Jules Blank
  • Dhimant Patel
  • Brittany Zachek
  • Jennifer Laffin
  • Ronald T Raines
  • Kristen A Andersen
  • Dabin Yeum
  • Gabrielle B Rocque
  • Melissa L Martowicz
  • Kim Oxendine
  • Alice Boshoven
  • Erica Pettke
  • Lisa A Davis
  • Bonnie Waack
  • Jessica Engel
  • Martin M Shafer
  • Adedayo Onitilo
  • Shailly Rishi
  • Karen E Hansen
  • Elizabeth Crone
  • Jyothi Gogineni

Detail Information

Publications11

  1. pmc Feasibility of 4 cycles of docetaxel and cyclophosphamide every 14 days as an adjuvant regimen for breast cancer: a Wisconsin Oncology Network study
    Mark E Burkard
    University of Wisconsin Carbone Cancer Center, Madison, WI Hematology Oncology Division, Department of Medicine, University of Wisconsin, Madison, WI Electronic address
    Clin Breast Cancer 14:205-11. 2014
    ..We tested whether it is feasible to deliver TC on a dose-dense schedule, with therapy completed within 10 weeks...
  2. pmc Validating cancer drug targets through chemical genetics
    Mark E Burkard
    University of Wisconsin Carbone Cancer Center and Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochim Biophys Acta 1806:251-7. 2010
    ..One approach, referred to as chemical genetics, accomplishes this by genetic control of chemical susceptibility. Chemical genetics is a crucial tool for the rational development of cancer drugs...
  3. pmc Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer
    Ryan A Denu
    Division of Hematology Oncology, Medical Scientist Training Program and the Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Cancer 16:47. 2016
    ..However, previous reports have not shown how CA affects cellular differentiation and clinical outcomes in breast cancer...
  4. pmc Targeting Estrogen Receptor Beta in a Phase 2 Study of High-Dose Estradiol in Metastatic Triple-Negative Breast Cancer: A Wisconsin Oncology Network Study
    Kari B Wisinski
    Carbone Cancer Center, University of Wisconsin, Madison, WI School of Medicine and Public Health, University of Wisconsin, Madison, WI Electronic address
    Clin Breast Cancer . 2016
    ..Agonism of ERβ has antiproliferative effects in TNBC cells expressing ERβ. This phase 2 study evaluated single-agent high-dose estradiol in patients with advanced TNBC...
  5. pmc Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin Hematology Oncology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Mol Cancer Ther 15:48-59. 2016
    ..We conclude that polyploid breast cancers represent a high-risk subgroup and that DPBQ provides a functional core to develop polyploid-selective therapy. Mol Cancer Ther; 15(1); 48-59. ©2015 AACR. ..
  6. pmc High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells
    Robert F Lera
    Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 287:42812-25. 2012
    ..These results demonstrate that different thresholds of Plk1 activity can elicit distinct phenotypes, illustrating a general method for separating pleiotropic functions of a protein kinase even when these are executed close in time...
  7. pmc Aromatase inhibitors and calcium absorption in early stage breast cancer
    Amye Tevaarwerk
    University of Wisconsin School of Medicine and Public Health, Room 4124, 1685 Highland Avenue, Madison, WI, 53705 2281, USA
    Breast Cancer Res Treat 134:245-51. 2012
    ..The null effect of AI therapy on TFCA might relate to the brief duration of AI therapy, the minimal effect of AI therapy on estradiol levels, subjects' high calcium intake or excellent vitamin D status...
  8. pmc Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:13026-31. 2013
    ..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology--where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity...
  9. pmc The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinases
    Robert F Lera
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Molecules 17:12172-86. 2012
    ..We believe a complete "chemical genetic toolbox" will ultimately allow a comprehensive understanding of how protein kinases regulate mitosis...
  10. pmc Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles
    Lauren M Zasadil
    Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA
    Sci Transl Med 6:229ra43. 2014
    ..This mechanistic insight may be used to improve selection of future antimitotic drugs and to identify a biomarker with which to select patients likely to benefit from paclitaxel. ..
  11. pmc Adjuvant therapy for HER2+ breast cancer: practice, perception, and toxicity
    Gabrielle Rocque
    University of Wisconsin Carbone Cancer Center, Wisconsin Institutes for Medical Research, 6th Floor, 1111 Highland Avenue, Madison, WI, USA
    Breast Cancer Res Treat 131:713-21. 2012
    ..Myelosuppression from TCH is greater than AC-TH, but can be mitigated with routine G-CSF...