James M Bullard

Summary

Affiliation: University of Texas-Pan American
Country: USA

Publications

  1. ncbi request reprint High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae
    Yanmei Hu
    Chemistry Department, SCIE 3 320, The University of Texas Pan American, 1201 W University Drive, Edinburg, TX 78541, USA
    Curr Drug Discov Technol 11:279-92. 2014
  2. pmc Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors
    Joseph W Guiles
    Replidyne, Inc, Louisville, CO, USA
    Org Med Chem Lett 2:5. 2012
  3. pmc Two homologous EF-G proteins from Pseudomonas aeruginosa exhibit distinct functions
    Stephanie O Palmer
    The University of Texas Pan American, Edinburg, Texas, United States of America
    PLoS ONE 8:e80252. 2013
  4. ncbi request reprint Reconstitution of a minimal DNA replicase from Pseudomonas aeruginosa and stimulation by non-cognate auxiliary factors
    Thale C Jarvis
    Replidyne, Inc, Louisville, Colorado 80027, USA
    J Biol Chem 280:7890-900. 2005
  5. ncbi request reprint Discovery and characterization of the cryptic psi subunit of the pseudomonad DNA replicase
    Thale C Jarvis
    Replidyne, Inc, Louisville, Colorado 80027, USA
    J Biol Chem 280:40465-73. 2005
  6. pmc Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity
    Louis S Green
    Replidyne, Inc, Louisville, CO 80027, USA
    Antimicrob Agents Chemother 53:86-94. 2009
  7. pmc Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors
    Wendy Ribble
    Chemistry Department, The University of Texas Pan American, 1201 W University Drive, Edinburg, TX 78541, USA
    Antimicrob Agents Chemother 54:4648-57. 2010
  8. pmc Structure of PolC reveals unique DNA binding and fidelity determinants
    Ronald J Evans
    Replidyne, Inc, Louisville, CO 80027, USA
    Proc Natl Acad Sci U S A 105:20695-700. 2008
  9. ncbi request reprint DNA polymerase III holoenzyme from Thermus thermophilus identification, expression, purification of components, and use to reconstitute a processive replicase
    James M Bullard
    Replidyne, Inc, Denver, Colorado 80206, USA
    J Biol Chem 277:13401-8. 2002
  10. pmc Cloning and characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa
    Stephanie O Palmer
    Chemistry Department, SCIE 3 320, The University of Texas Pan American, 1201 W University Drive, Edinburg, TX 78541, USA
    Biomed Res Int 2013:585748. 2013

Collaborators

  • Urs A Ochsner
  • Thale C Jarvis
  • Charles S McHenry
  • Ian A Critchley
  • Yanmei Hu
  • Stephanie O Palmer
  • Joseph W Guiles
  • Wendy Ribble
  • Nebojsa Janjic
  • Louis S Green
  • Edna Y Rangel
  • Alexis T Tran
  • Ronald J Evans
  • Megan Keniry
  • Edgar Guerrero
  • Joel Manrrique
  • Hector Munoz
  • Alberto E Montalvo
  • Kate C Ferguson
  • Andras Toro
  • Walter E Hill
  • David F Ayers
  • Frank Dean
  • Wendy K Ribble
  • Douglas R Davies
  • Jeffrey Christensen
  • Janice D Pata

Detail Information

Publications13

  1. ncbi request reprint High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae
    Yanmei Hu
    Chemistry Department, SCIE 3 320, The University of Texas Pan American, 1201 W University Drive, Edinburg, TX 78541, USA
    Curr Drug Discov Technol 11:279-92. 2014
    ..There was no inhibition of cytoplasmic protein synthesis, however, partial inhibition of the human mitochondrial PheRS was observed...
  2. pmc Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors
    Joseph W Guiles
    Replidyne, Inc, Louisville, CO, USA
    Org Med Chem Lett 2:5. 2012
    ..abstract:..
  3. pmc Two homologous EF-G proteins from Pseudomonas aeruginosa exhibit distinct functions
    Stephanie O Palmer
    The University of Texas Pan American, Edinburg, Texas, United States of America
    PLoS ONE 8:e80252. 2013
    ..Likewise, the activity of EF-G1B in ribosome dependent GTPase assays was completely inhibited by FA, while the activity of EF-G1A was not affected. ..
  4. ncbi request reprint Reconstitution of a minimal DNA replicase from Pseudomonas aeruginosa and stimulation by non-cognate auxiliary factors
    Thale C Jarvis
    Replidyne, Inc, Louisville, Colorado 80027, USA
    J Biol Chem 280:7890-900. 2005
    ....
  5. ncbi request reprint Discovery and characterization of the cryptic psi subunit of the pseudomonad DNA replicase
    Thale C Jarvis
    Replidyne, Inc, Louisville, Colorado 80027, USA
    J Biol Chem 280:40465-73. 2005
    ..This represents the first identification of a highly divergent branch of the Psi family and confirms the existence of Psi in several organisms in which Psi was not identifiable based on sequence similarity alone...
  6. pmc Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity
    Louis S Green
    Replidyne, Inc, Louisville, CO 80027, USA
    Antimicrob Agents Chemother 53:86-94. 2009
    ..These observations provide a potential mechanistic explanation for the reduced growth fitness observed with MetRS mutant strains relative to that with wild-type Staphylococcus aureus...
  7. pmc Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors
    Wendy Ribble
    Chemistry Department, The University of Texas Pan American, 1201 W University Drive, Edinburg, TX 78541, USA
    Antimicrob Agents Chemother 54:4648-57. 2010
    ..Assays were developed for the steps performed by each component of the system in order to ascertain the target of the compounds, and the ribosome was found to be the site of inhibition...
  8. pmc Structure of PolC reveals unique DNA binding and fidelity determinants
    Ronald J Evans
    Replidyne, Inc, Louisville, CO 80027, USA
    Proc Natl Acad Sci U S A 105:20695-700. 2008
    ..This ternary complex of a cellular replicative polymerase affords insights into polymerase fidelity, evolution, and structural diversity...
  9. ncbi request reprint DNA polymerase III holoenzyme from Thermus thermophilus identification, expression, purification of components, and use to reconstitute a processive replicase
    James M Bullard
    Replidyne, Inc, Denver, Colorado 80206, USA
    J Biol Chem 277:13401-8. 2002
    ..The minimal Tth DNA polymerase III holoenzyme displays an elongation rate of 350 bp/s at 72 degrees C and a processivity of greater than 8.6 kilobases, the length of the template that is fully replicated after a single association event...
  10. pmc Cloning and characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa
    Stephanie O Palmer
    Chemistry Department, SCIE 3 320, The University of Texas Pan American, 1201 W University Drive, Edinburg, TX 78541, USA
    Biomed Res Int 2013:585748. 2013
    ..aeruginosa ribosomes. P. aeruginosa EF-Tu was active in poly(U)-programmed polyphenylalanine protein synthesis system composed of all P. aeruginosa components...
  11. doi request reprint Identification of Chemical Compounds That Inhibit the Function of Glutamyl-tRNA Synthetase from Pseudomonas aeruginosa
    Yanmei Hu
    Chemistry Department, The University of Texas Pan American, Edinburg, TX, USA
    J Biomol Screen 20:1160-70. 2015
    ..BT_03F04 was found to be noncompetitive with both ATP and glutamic acid, and BT_04B09 was competitive with glutamic acid but noncompetitive with ATP. The compounds were not observed to be toxic to mammalian cells in MTT assays. ..
  12. doi request reprint Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections
    Ian A Critchley
    Replidyne, Inc, Louisville, CO 80027, USA
    J Antimicrob Chemother 63:954-63. 2009
    ..The aim of this study was to characterize the antimicrobial profile of REP3123, a novel inhibitor of methionyl-tRNA synthetase (MetRS) in development for the treatment of Clostridium difficile infection...
  13. ncbi request reprint A three-domain structure for the delta subunit of the DNA polymerase III holoenzyme delta domain III binds delta' and assembles into the DnaX complex
    James M Bullard
    Replidyne, Inc, Denver, Colorado 80206, USA
    J Biol Chem 277:13246-56. 2002
    ..These observations are consistent with a model where two tau subunits and one each of the gamma, delta', and delta subunits mutually interact to form a pentameric functional core for the DnaX complex...