David A Buchner

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mamm Genome 23:431-42. 2012
  2. pmc Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis
    Soha N Yazbek
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Genome Res 21:1065-73. 2011
  3. pmc Ancestral paternal genotype controls body weight and food intake for multiple generations
    Soha N Yazbek
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 19:4134-44. 2010
  4. pmc Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:917-24. 2011
  5. pmc Diet-induced hepatocellular carcinoma in genetically predisposed mice
    Annie E Hill-Baskin
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 18:2975-88. 2009
  6. pmc Contrasting genetic architectures in different mouse reference populations used for studying complex traits
    David A Buchner
    Department of Genetics and Genome Sciences, Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genome Res 25:775-91. 2015
  7. pmc Resistance to diet-induced obesity in mice with a single substituted chromosome
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Physiol Genomics 35:116-22. 2008
  8. ncbi request reprint Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions
    Miriam H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genetica 122:37-45. 2004
  9. ncbi request reprint SCNM1, a putative RNA splicing factor that modifies disease severity in mice
    David A Buchner
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109 0618, USA
    Science 301:967-9. 2003
  10. ncbi request reprint Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6)
    Jennifer A Kearney
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Hum Mol Genet 11:2765-75. 2002

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mamm Genome 23:431-42. 2012
    ..Moreover, as juxtaparanodal proteins have previously been implicated in various neurological disorders, our results suggest a potential genetic and molecular link between obesity and diseases such as autism and epilepsy...
  2. pmc Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis
    Soha N Yazbek
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Genome Res 21:1065-73. 2011
    ..This work demonstrated the unique power of CSSs as a platform for studying complex genetic traits and identifying QTLs...
  3. pmc Ancestral paternal genotype controls body weight and food intake for multiple generations
    Soha N Yazbek
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 19:4134-44. 2010
    ..Persistence of these phenotypes across multiple generations raises the possibility that transgenerational genetic effects contribute to current metabolic conditions...
  4. pmc Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:917-24. 2011
    ..These data suggests the importance of hepatic mitochondrial function in the development of obesity and insulin resistance...
  5. pmc Diet-induced hepatocellular carcinoma in genetically predisposed mice
    Annie E Hill-Baskin
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 18:2975-88. 2009
    ..A similar diet modification may have important implications for prevention of HCCs in humans...
  6. pmc Contrasting genetic architectures in different mouse reference populations used for studying complex traits
    David A Buchner
    Department of Genetics and Genome Sciences, Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genome Res 25:775-91. 2015
    ....
  7. pmc Resistance to diet-induced obesity in mice with a single substituted chromosome
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Physiol Genomics 35:116-22. 2008
    ..A better understanding of these genotype-phenotype relationships may enable a more individualized diagnosis and treatment of obesity and the metabolic syndrome...
  8. ncbi request reprint Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions
    Miriam H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genetica 122:37-45. 2004
    ..These mutations demonstrate the value of mouse models to elucidate the pathophysiology of human disease...
  9. ncbi request reprint SCNM1, a putative RNA splicing factor that modifies disease severity in mice
    David A Buchner
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109 0618, USA
    Science 301:967-9. 2003
    ..Our finding that genetic variation in a putative RNA splicing factor influences disease susceptibility in mice raises the possibility that a similar mechanism modifies the severity of human inherited disorders...
  10. ncbi request reprint Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6)
    Jennifer A Kearney
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Hum Mol Genet 11:2765-75. 2002
    ..medJ mice provide a model for the physiological effects of sodium channel deficiency and the molecular mechanism of bigenic disease...
  11. ncbi request reprint Three ENU-induced neurological mutations in the pore loop of sodium channel Scn8a (Na(v)1.6) and a genetically linked retinal mutation, rd13
    David A Buchner
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Mamm Genome 15:344-51. 2004
    ..The new alleles of Scn8a will be valuable for analysis of sodium channel physiology and disease...
  12. ncbi request reprint High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot
    David A Buchner
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109 0618, USA
    Genomics 82:452-9. 2003
    ..5 cM/Mb. The role of the modifier in other disorders in human and mouse can be tested with linked markers described here...
  13. ncbi request reprint Mutations of voltage-gated sodium channels in movement disorders and epilepsy
    Miriam H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor, 48109 0618, USA
    Novartis Found Symp 241:72-81; discussion 82-6, 226-32. 2002
    ..Advances in molecular methods coupled with genomic sequences from the Human Genome Project will permit identification of many new patient mutations and generation of animal models to dissect their physiological and cellular consequences...

Research Grants1

  1. Chemical and Genetic Modifiers of the Protein C Pathway
    David Buchner; Fiscal Year: 2007
    ..Successfully rescuing compounds can be quickly tested in human plasma coagulation assays and in vivo mouse models to determine their target and evaluate their therapeutic potential. ..