Helen J Brown
Affiliation: University of California
- Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activatorHelen J Brown
Department of Microbiology, Division of Hematology Oncology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 285:25139-53. 2010..The association with CREB also highlights a novel connection and coordination between viral and cellular "immediate early" responses...
- Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 RTA reactivates murine gammaherpesvirus 68 from latencyTammy M Rickabaugh
Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
J Virol 79:3217-22. 2005..Our data suggest that the species specificity of MHV-68 RTA resides in the N-terminal DNA binding domain...
- Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latencyLi Peng
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
J Gen Virol 91:463-9. 2010..The data suggest that the PI3K-Akt pathway suppresses the activity of RTA and thereby contributes to the maintenance of viral latency and promotes tumorigenesis...
- Generation of a latency-deficient gammaherpesvirus that is protective against secondary infectionTammy M Rickabaugh
Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
J Virol 78:9215-23. 2004..The present study, by using MHV-68 as an in vivo model system, demonstrated that RTA plays a critical role in the control of viral latency and suggests that latency is a determinant of viral pathogenesis in vivo...
- Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirusHelen J Brown
Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA
Antivir Ther 10:745-51. 2005....
- beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTAMargaret Chang
Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
J Virol 79:13538-47. 2005..These findings also suggest novel therapeutic strategies for controlling the activity of this oncogenic gammaherpesvirus in vivo...
- Primary cell model for activation-inducible human immunodeficiency virusBryan Burke
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1678, USA
J Virol 81:7424-34. 2007..This model can therefore be used to study intricate molecular aspects of activation-inducible HIV infection in primary cells...
- Rapid expression of human immunodeficiency virus following activation of latently infected cellsPhilip A Arlen
David Geffen School of Medicine, University of California Los Angeles, 11 934 Factor Building, 650 Charles Young Drive South, Los Angeles, CA 90095, USA
J Virol 80:1599-603. 2006..This hierarchy also held true for viral protein production. These results may explain the rapid reemergence of viremia following termination of therapy...
- NF-kappaB inhibits gammaherpesvirus lytic replicationHelen J Brown
Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095, USA
J Virol 77:8532-40. 2003..They also suggest that NF-kappaB may be a novel target for the disruption of virus latency and therefore the treatment of gammaherpesvirus-related malignancies...