W M Brooks
Affiliation: University of New Mexico
- 1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderlyW M Brooks
Center for Non Invasive Diagnosis, University of New Mexico, Albuquerque 87131, USA
Stroke 28:1940-3. 1997..Our aim was to discriminate white matter hyperintensities (WMH) on MRI in patients with SAE from similar appearing changes in normal elderly...
- Magnetic resonance spectroscopy in traumatic brain injuryW M Brooks
Clinical and Magnetic Resonance Research Center Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
J Head Trauma Rehabil 16:149-64. 2001..MRS can also detect alterations in high energy phosphates reflecting the energetic abnormalities seen after TBI. Accordingly, MRS may be useful to monitor cellular response to therapeutic interventions in TBI...
- Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance studyW M Brooks
Clinical and Magnetic Resonance Research Center, Department of Neurosciences, University of New Mexico, Albuquerque, USA
J Neurotrauma 17:629-40. 2000..002). 1H-MRS offers a noninvasive approach to assessing neuronal injury and inflammation following TBI, and may provide unique data for patient management and assessment of therapeutic efficacy...
- 1H-MRS at 4 tesla in minimally treated early schizophreniaJ R Bustillo
Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
Mol Psychiatry 15:629-36. 2010..We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity...
- Developmental instability and working memory ability in children: a magnetic resonance spectroscopy investigationR A Yeo
Department of Psychology, University of New Mexico, Albuquerque 87131, USA
Dev Neuropsychol 17:143-59. 2000..Working memory skills thus seem related to frontal lobe energy metabolism, which in turn is related to DI...
- Brain abnormalities in schizophrenia-spectrum children: implications for a neurodevelopmental perspectiveR A Yeo
Department of Psychology, University of New Mexico, Albuquerque 87131 1161, USA
Psychiatry Res 76:1-13. 1997..In conjunction with recent primate studies, the current results draw attention to the role of the amygdala as one relevant factor in the pathogenesis of schizophrenia...
- Gerstmann syndrome in systemic lupus erythematosus: neuropsychological, neuroimaging and spectroscopic findingsR E Jung
Clinical and Magnetic Resonance Research Center, Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA
Neurocase 7:515-21. 2001..Thus, GS in this first case in SLE would appear to comprise a focal neurological tetrad of disorders within a more general pattern of cognitive decline and metabolic derangement...
- Myths of neuropsychology: intelligence, neurometabolism, and cognitive abilityR E Jung
Clinical and Magnetic Resonance Research Center, Department of Psychology, University of New Mexico, Albuquerque 87131, USA
Clin Neuropsychol 14:535-45. 2000....
- Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophreniaJ R Bustillo
Department of Psychiatry, Research Division, University of New Mexico, 2400 Tucker NE, Albuquerque, NM 87131, USA
Psychiatry Res 107:135-49. 2001..Exposure to haloperidol-like drugs may in part account for the frontal NAA reductions previously reported in schizophrenia. Adjustment for proportion of voxel CSF should be considered in 1H-MRS studies...
- Serum leptin in elderly people: associations with sex hormones, insulin, and adipose tissue volumesR N Baumgartner
Center for Population Health, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque 87131, USA
Obes Res 7:141-9. 1999..Serum leptin would not be associated with sex hormone concentrations or serum fasting insulin after adjusting for body fat and fat distribution...
- The aging hippocampus: cognitive, biochemical and structural findingsIra Driscoll
Department of Psychology, The University of New Mexico, Albuquerque, New Mexico 87131, USA
Cereb Cortex 13:1344-51. 2003....
- Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS studyLaura M Rowland
Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
Am J Psychiatry 162:394-6. 2005..The authors' goal was to test in humans the hypothesis that N-methyl-d-aspartate receptor (NMDAR) antagonism results in increased cortical glutamate activity, as proposed by the NMDAR hypofunction model of schizophrenia...
- Late proton MR spectroscopy in children after traumatic brain injury: correlation with cognitive outcomesJill V Hunter
Department of O I, Baylor College of Medicine, Houston, TX 77030, USA
AJNR Am J Neuroradiol 26:482-8. 2005..We studied the relationship of frontoparietal NAA, choline (Cho), and creatine (Cr) to test the hypothesis that reduction in NAA is predictive of cognitive outcome...
- Sex differences in N-acetylaspartate correlates of general intelligence: an 1H-MRS study of normal human brainRex E Jung
Department of Neurology, University of New Mexico, Albuquerque, NM 87151, USA
Neuroimage 26:965-72. 2005..84, P < .001; adjusted r2 = .82]. Our results highlight a biochemical substrate of normal intellectual performance, mediated by sex, within white matter association fibers linking posterior to frontal brain regions...
- NAA and higher cognitive function in humansRonald A Yeo
Department of Neurology University of New Mexico, Albuquerque, NM 87131, USA
Adv Exp Med Biol 576:215-26; discussion 361-3. 2006
- Relationships between person and health factors and job characteristics in women with systemic lupus erythematosusJanet L Poole
University of New Mexico Occupational Therapy Graduate Program, Department of Pediatrics, Albuquerque, NM 87131 0001, USA
Work 28:95-100. 2007..The results indicate that even persons with SLE who have mild disease are significantly different from healthy controls and might be at risk for discontinuing working...
- Longitudinal magnetic resonance spectroscopic imaging of primary progressive multiple sclerosis patients treated with glatiramer acetate: multicenter studyB R Sajja
Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, TX 77030, USA
Mult Scler 14:73-80. 2008..No significant difference in number of patients with lipids between the two groups over a period of 3 years was found...
- Magnetic resonance spectroscopy detects brain injury and predicts cognitive functioning in children with brain injuriesRonald A Yeo
Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA
J Neurotrauma 23:1427-35. 2006..Anterior NAA/Cre increased and anterior Cho/Cre decreased from 3 to 21 weeks post-injury, suggesting neurometabolic recovery...
- Reproducibility of 1H-MRS measurements in schizophrenic patientsPaul G Mullins
MIND Imaging Center, University of New Mexico, Albuquerque, New Mexico 87131, USA
Magn Reson Med 50:704-7. 2003..These results extend previous studies of healthy, normal subjects, and establish that it is possible to obtain reliable measures of brain metabolites in clinical populations...
- Fluid Attenuated Inversion Recovery (FLAIR) imaging in neuropsychiatric systemic lupus erythematosusWilmer L Sibbitt
Department of Internal Medicine, 5th Floor ACC, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Rheumatol 30:1983-9. 2003..Magnetic resonance imaging (MRI) is commonly used to evaluate NPSLE. However, the specific role of FLAIR versus conventional PD/T2 methods in NPSLE remains uncertain...
- High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophreniaJuan R Bustillo
Department of Psychiatry, University of New Mexico School of Medicine, 87131, USA
Am J Psychiatry 159:130-3. 2002..Proton magnetic resonance spectroscopy ((1)H-MRS) studies of medicated patients with schizophrenia suggest high choline levels in the caudate nucleus. However, assessments of antipsychotic-naive patients are needed...
- Biochemical markers of mood: a proton magnetic resonance spectroscopy study of normal human brainRex E Jung
Clinical and Magnetic Resonance Research Center, University of New Mexico, Albuquerque, New Mexico, Mexico
Biol Psychiatry 51:224-9. 2002..e., orbitofrontal and cingulate) cortices in patients with mood disorders utilizing Proton Magnetic Resonance Spectroscopy (1H-MRS). We sought to determine the relationship between Cho and mood in a cohort of healthy young subjects...
- Proton magnetic resonance spectroscopy investigation of the right frontal lobe in children with attention-deficit/hyperactivity disorderRonald A Yeo
University of New Mexico, Albuquerque, USA
J Am Acad Child Adolesc Psychiatry 42:303-10. 2003..To investigate neurometabolite concentrations in right prefrontal white matter in children with attention-deficit/hyperactivity disorder (ADHD) and relations of neurometabolites with attention skill and frontal anatomy...
- Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary resultsGerardo Villarreal
PTSD Clinic, Veterans Administration Hospital, Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA
Can J Psychiatry 47:666-70. 2002..However, other areas of the brain need to be explored. The objective of this study was to investigate the specificity of hippocampal NAA concentration changes in PTSD by also examining a control region, the occipital white matter (OWM)...
- A mouse model of sensorimotor controlled cortical impact: characterization using longitudinal magnetic resonance imaging, behavioral assessments and histologyGregory Onyszchuk
Hoglund Brain Imaging Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1052, Kansas City, KS 66160, USA
J Neurosci Methods 160:187-96. 2007....
- The incidence and prevalence of neuropsychiatric syndromes in pediatric onset systemic lupus erythematosusWilmer L Sibbitt
Clinical and Magnetic Resonance Research Center, Department of Internal Medicine, The University of New Mexico Health Sciences Center, Albuquerque 87131, USA
J Rheumatol 29:1536-42. 2002..To determine the incidence and prevalence of neuropsychiatric systemic lupus erythematosus (NPSLE) and glomerulonephritis in ethnically diverse pediatric onset SLE inpatient and outpatient populations...
- Neural mechanisms underlying hyperphagia in Prader-Willi syndromeLaura M Holsen
Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, 66160, USA
Obesity (Silver Spring) 14:1028-37. 2006..We used functional magnetic resonance imaging to study the neural mechanisms underlying responses to visual food stimuli, before and after eating, in individuals with PWS and a healthy weight control (HWC) group...
- Neural mechanisms underlying food motivation in children and adolescentsLaura M Holsen
Hoglund Brain Imaging Center, University of Kansas Medical Center, KS 66160, USA
Neuroimage 27:669-76. 2005..These findings provide evidence that normal patterns of neural activity related to food motivation begin in childhood. Results have implications for obese children and adults, who may have abnormal hunger and satiation mechanisms...
- Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposureJuan R Bustillo
Department of Psychiatry, Research Division, University of New Mexico, 2400 Tucker NE, Albuquerque, NM 87131, USA
Schizophr Res 58:313-21. 2002..The well-described reduced frontal NAA in schizophrenia may not be a trait of the illness but may represent medication effect or progression of the disease...
- Virtual navigation in humans: the impact of age, sex, and hormones on place learningIra Driscoll
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive Lethbridge, Alberta, Canada T1H 6P4
Horm Behav 47:326-35. 2005..Our findings indicate that the persistence of male spatial advantage may be related to circulating testosterone, but not cortisol levels, and independent of generalized age-related cognitive decline...
- Skeletal muscle mitochondrial function and lean body mass in healthy exercising elderlyDebra L Waters
Department of Internal Medicine, University of New Mexico School of Medicine, 2701 Frontier Pl NE Surge Bldg Rm 215, Albuquerque, NM 87131, USA
Mech Ageing Dev 124:301-9. 2003..However, investigators have yet to reach a consensus as to whether a decline in mitochondrial function can be attenuated by physical activity has yet to reach a consensus...
- Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosusG P Th Bosma
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 50:3195-202. 2004....
- Reduced area of the corpus callosum in posttraumatic stress disorderGerardo Villarreal
New Mexico VA Healthcare System, PTSD Program 116A, 1501 San Pedro Drive SE, Albuquerque, NM 87108, USA
Psychiatry Res 131:227-35. 2004..These findings are similar to previous results in children with PTSD and suggest specific changes in the CC...
- Effects of intermittent cycle exercise on intramyocellular lipid use and recoveryLesley J White
Human Performance Laboratory, University of New Mexico, Albuquerque, New Mexico 87106, USA
Lipids 38:9-13. 2003..05) and did not recover. In contrast, a nonexercising control group showed no change in IMCL. Our results suggest that IMCL decreased significantly following 45 min of interval cycling, with little recovery in the hour following...