M Alan Brookhart

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Comparative Short-term Safety of Sodium Ferric Gluconate Versus Iron Sucrose in Hemodialysis Patients
    M Alan Brookhart
    Department of Epidemiology, UNC Gillings School of Global Public Health UNC Chapel Hill, Chapel Hill, NC Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC Electronic address
    Am J Kidney Dis 67:119-27. 2016
  2. pmc Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients
    M Alan Brookhart
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Soc Nephrol 24:1151-8. 2013
  3. doi request reprint The comparative short-term effectiveness of iron dosing and formulations in US hemodialysis patients
    Abhijit V Kshirsagar
    University of North Carolina Kidney Center, UNC School of Medicine, Chapel Hill, NC 27599 7155, USA
    Am J Med 126:541.e1-541.e14. 2013
  4. doi request reprint Changing patterns of anemia management in US hemodialysis patients
    Janet K Freburger
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, USA
    Am J Med 125:906-14.e9. 2012
  5. doi request reprint Approaches to inverse-probability-of-treatment--weighted estimation with concurrent treatments
    Alan R Ellis
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, CB 7590, Chapel Hill, NC 27599 7590, USA
    J Clin Epidemiol 66:S51-6. 2013
  6. pmc Acute kidney injury in statin initiators
    J Bradley Layton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Division of Nephrology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 22:1061-70. 2013
  7. pmc Pretransplantation erythropoiesis-stimulating agent hyporesponsiveness is associated with increased kidney allograft failure and mortality
    Nadiesda A Costa
    1 Department of Medicine, Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC 2 Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 3 Pharmacoepidemiology Program Area, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 4 Address correspondence to Nadiesda Costa, M D, M P H, Division of Nephrology and Hypertension, Department of Medicine, University of Maryland School of Medicine, 20 South Greene Street, Room N3W143, Baltimore, MD 21201
    Transplantation 96:807-13. 2013
  8. doi request reprint Hospitalization and skilled nursing care are predictors of influenza vaccination among patients on hemodialysis: evidence of confounding by frailty
    Leah J McGrath
    Departments of Epidemiology, Gillings School of Global Public Health Medicine, Division of Nephrology and Hypertension Medicine, Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC
    Med Care 51:1106-13. 2013
  9. pmc The effect of altitude change on anemia treatment response in hemodialysis patients
    M Alan Brookhart
    Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC 27599 7435, USA
    Am J Epidemiol 173:768-77. 2011
  10. doi request reprint Comparative Effectiveness of Iron and Erythropoiesis-Stimulating Agent Dosing on Health-Related Quality of Life in Patients Receiving Hemodialysis
    Janet K Freburger
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC Electronic address
    Am J Kidney Dis 67:271-82. 2016

Collaborators

Detail Information

Publications39

  1. doi request reprint Comparative Short-term Safety of Sodium Ferric Gluconate Versus Iron Sucrose in Hemodialysis Patients
    M Alan Brookhart
    Department of Epidemiology, UNC Gillings School of Global Public Health UNC Chapel Hill, Chapel Hill, NC Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC Electronic address
    Am J Kidney Dis 67:119-27. 2016
    ..Despite different pharmacologic properties, little is known about the comparative safety of sodium ferric gluconate versus iron sucrose in hemodialysis patients...
  2. pmc Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients
    M Alan Brookhart
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Soc Nephrol 24:1151-8. 2013
    ..These results suggest that maintenance iron supplementation may result in fewer infections than bolus dosing, particularly among patients with a catheter...
  3. doi request reprint The comparative short-term effectiveness of iron dosing and formulations in US hemodialysis patients
    Abhijit V Kshirsagar
    University of North Carolina Kidney Center, UNC School of Medicine, Chapel Hill, NC 27599 7155, USA
    Am J Med 126:541.e1-541.e14. 2013
    ..Intravenous iron is used widely in hemodialysis, yet there are limited data on the effectiveness of contemporary dosing strategies or formulation type...
  4. doi request reprint Changing patterns of anemia management in US hemodialysis patients
    Janet K Freburger
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, USA
    Am J Med 125:906-14.e9. 2012
    ..Recent clinical and policy-related events have challenged this traditional paradigm, particularly in regard to erythropoiesis-stimulating agents. Less is known about the impact of these events on intravenous iron use...
  5. doi request reprint Approaches to inverse-probability-of-treatment--weighted estimation with concurrent treatments
    Alan R Ellis
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, CB 7590, Chapel Hill, NC 27599 7590, USA
    J Clin Epidemiol 66:S51-6. 2013
    ..We explore these two approaches in a study of intravenous iron use in hemodialysis patients treated concurrently with epoetin alfa (EPO)...
  6. pmc Acute kidney injury in statin initiators
    J Bradley Layton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Division of Nephrology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 22:1061-70. 2013
    ..We estimated the one-year risk of AKI associated with statin initiation and determined the comparative safety of individual statin formulations...
  7. pmc Pretransplantation erythropoiesis-stimulating agent hyporesponsiveness is associated with increased kidney allograft failure and mortality
    Nadiesda A Costa
    1 Department of Medicine, Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC 2 Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 3 Pharmacoepidemiology Program Area, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 4 Address correspondence to Nadiesda Costa, M D, M P H, Division of Nephrology and Hypertension, Department of Medicine, University of Maryland School of Medicine, 20 South Greene Street, Room N3W143, Baltimore, MD 21201
    Transplantation 96:807-13. 2013
    ..It is unclear whether the risk associated with poor ESA response during dialysis extends beyond kidney transplantation. We examined pretransplantation ESA response and its effect on allograft failure and mortality...
  8. doi request reprint Hospitalization and skilled nursing care are predictors of influenza vaccination among patients on hemodialysis: evidence of confounding by frailty
    Leah J McGrath
    Departments of Epidemiology, Gillings School of Global Public Health Medicine, Division of Nephrology and Hypertension Medicine, Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC
    Med Care 51:1106-13. 2013
    ..Indicators of health status and frailty suitable for attenuating this bias could be identified in administrative data...
  9. pmc The effect of altitude change on anemia treatment response in hemodialysis patients
    M Alan Brookhart
    Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC 27599 7435, USA
    Am J Epidemiol 173:768-77. 2011
    ..These results support the hypothesis that altitude-induced hypoxia reduces erythropoietin requirements in hemodialysis patients with treatment-refractory anemia...
  10. doi request reprint Comparative Effectiveness of Iron and Erythropoiesis-Stimulating Agent Dosing on Health-Related Quality of Life in Patients Receiving Hemodialysis
    Janet K Freburger
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC Electronic address
    Am J Kidney Dis 67:271-82. 2016
    ..We examined the independent associations of bolus versus maintenance iron dosing and high versus low ESA dosing on HRQoL...
  11. pmc Comparative Effectiveness of Oxaliplatin Versus 5-flourouricil in Older Adults: An Instrumental Variable Analysis
    Christina Defilippo Mack
    From the aDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC bQuintiles, Research Triangle Park, NC cDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA dLineberger Comprehensive Cancer Center and Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC eDepartment of Health Policy and Management, Gillings School of Global Public Health UNC, Chapel Hill, NC and fDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC
    Epidemiology 26:690-9. 2015
    ..Assuming instrument validity, instrumental variable analyses account for unmeasured confounding and are particularly valuable in sub-populations of unresolved effectiveness, such as older individuals...
  12. pmc Trends in Anemia Management in Hemodialysis Patients with Cancer
    Anne M Butler
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N C, USA
    Am J Nephrol 42:206-15. 2015
    ..However, anemia treatment patterns have not been described among ESRD patients undergoing hemodialysis with concurrent cancer, especially in the recent era of ESA-related safety concerns...
  13. pmc Intravenous iron supplementation practices and short-term risk of cardiovascular events in hemodialysis patients
    Abhijit V Kshirsagar
    University of North Carolina Kidney Center, UNC School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e78930. 2013
    ..We compared the safety of different intravenous iron dosing practices on the risk of adverse cardiovascular outcomes in a large population of hemodialysis patients...
  14. doi request reprint Preschool motor skills following physical and occupational therapy services among non-disabled very low birth weight children
    Stephanie Watkins
    Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, 1700 Martin Luther King Blvd CB 7426, Chapel Hill, NC, 27599 7426, USA
    Matern Child Health J 18:821-8. 2014
    ..We found little effect of therapy on other endpoints. Providing therapy to VLBW children during early childhood may improve select preschool motor skills involving complex motor planning...
  15. doi request reprint Comparative mortality risk of anemia management practices in incident hemodialysis patients
    M Alan Brookhart
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA
    JAMA 303:857-64. 2010
    ..Controversy exists about optimal management of anemia in end-stage renal disease...
  16. pmc Matching on the disease risk score in comparative effectiveness research of new treatments
    Richard Wyss
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 24:951-61. 2015
    ....
  17. pmc Comparative short-term safety of bolus versus maintenance iron dosing in hemodialysis patients: a replication study
    Janet K Freburger
    Cecil G, Sheps Center for Health Services Research, University of North Carolina, 725 Martin Luther King, Jr, Blvd, CB 7590, Chapel Hill, NC 27599 7590, North Carolina
    BMC Nephrol 15:154. 2014
    ..We sought to determine whether these findings could be replicated using the same methods and a different data source...
  18. pmc Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010
    Catherine A Panozzo
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e73825. 2013
    ..Interventions to increase rotavirus vaccine coverage should consider targeting family physicians and encouraging completion of the vaccine series...
  19. pmc Effects of aggregation of drug and diagnostic codes on the performance of the high-dimensional propensity score algorithm: an empirical example
    Hoa V Le
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
    BMC Med Res Methodol 13:142. 2013
    ..How hd-PS performance is affected by aggregating medications or medical diagnoses has not been assessed...
  20. pmc Dynamics of cinacalcet use and biochemical control in hemodialysis patients: a retrospective New-user cohort design
    B Diane Reams
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC, USA
    BMC Nephrol 16:175. 2015
    ..Large-scale epidemiologic studies describing patterns of cinacalcet use, effects on parathyroid hormone (PTH), calcium, and phosphorous levels, and predictors of discontinuation have not been previously reported...
  21. pmc Using claims data to predict dependency in activities of daily living as a proxy for frailty
    Keturah R Faurot
    Department of Physical Medicine and Rehabilitation, School of Medicine, University of North Carolina, Chapel Hill, NC, USA Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 24:59-66. 2015
    ..Our objective was to develop an algorithm to predict dependency in activities of daily living (ADL) in a sample of Medicare beneficiaries...
  22. pmc Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000-2011
    Wendy Camelo Castillo
    Department of Epidemiology, Gillings School of Global Public Health, and the Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, and the Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina
    Obstet Gynecol 123:1177-84. 2014
    ..To describe trends and identify factors associated with choice of pharmacotherapy for gestational diabetes (GDM) from 2000-2011 using a healthcare claims database...
  23. pmc Influenza vaccine effectiveness in patients on hemodialysis: an analysis of a natural experiment
    Leah J McGrath
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Arch Intern Med 172:548-54. 2012
    ..Observational studies of vaccine effectiveness (VE) are challenging because vaccinated subjects may be healthier than unvaccinated subjects...
  24. pmc Effect of statin use on acute kidney injury risk following coronary artery bypass grafting
    J Bradley Layton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Cardiol 111:823-8. 2013
    ..7% vs 4.0%). In conclusion, statin initiation immediately before CABG may modestly reduce the risk for postoperative AKI, particularly in younger CABG patients...
  25. pmc Calendar time-specific propensity scores and comparative effectiveness research for stage III colon cancer chemotherapy
    Christina Defilippo Mack
    Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Pharmacoepidemiol Drug Saf 22:810-8. 2013
    ..We use calendar time-specific (CTS) PSs to examine the effect of oxaliplatin during dissemination from off-label to widespread use...
  26. doi request reprint Changing patterns of use of osteoporosis medications in the years after launch: implications for comparative effectiveness research
    B Diane Reams
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 23:251-60. 2014
    ..We sought to explore this issue by characterizing trends in oral and injectable prescription drug claims for the prevention and treatment of osteoporosis...
  27. pmc Trends in antibiotic treatment of acute otitis media and treatment failure in children, 2000-2011
    Leah J McGrath
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e81210. 2013
    ..Initial declines in prescribing were shown, but it's unknown if they were sustained. We examine trends in antibiotic dispensing patterns to treat AOM among a large population of children. We also document trends in antibiotic failure...
  28. doi request reprint Trends and variations in intravenous vitamin D use among hemodialysis patients in the United States
    Anne C Beaubrun
    Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7573, USA
    Ren Fail 35:1-8. 2013
    ..Given the variations in use and known pharmacologic differences in vitamin D formulations, future research should focus on whether the formulations differentially affect patient outcomes...
  29. pmc Validation of Medicaid Claims-based Diagnosis of Myocardial Infarction Using an HIV Clinical Cohort
    Emily S Brouwer
    Department of Epidemiology, Gillings School of Global Public Health Department of Medicine, Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC College of Pharmacy, Institute for Pharmaceutical Outcomes and Policy, University of Kentucky, Lexington, KY Department of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill, NC
    Med Care 53:e41-8. 2015
    ..We aimed to validate claims-based myocardial infarction (MI) algorithms in a Medicaid population using an HIV clinical cohort as the gold standard...
  30. pmc Observation stays in administrative claims databases: underestimation of hospitalized cases
    Robert A Overman
    Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 23:902-10. 2014
    ..To understand the potential impact of observation stays on research using administrative healthcare data, we examine the trends of observation stays, short (≤2 days) inpatient admissions, and all inpatient admissions...
  31. pmc Assessing the component associations of the healthy worker survivor bias: occupational asbestos exposure and lung cancer mortality
    Ashley I Naimi
    Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, NC 27599, USA
    Ann Epidemiol 23:334-41. 2013
    ..Together, these associations result in time-varying confounding affected by prior exposure. We illustrate how these associations can be assessed using standard regression methods...
  32. doi request reprint Practicable confidence intervals for current status data
    Byeong Yeob Choi
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Stat Med 32:1419-28. 2013
    ..We provide an R package that can be used to compute the Wald-type and the bootstrap CIs and demonstrate its practical utility with two real data analyses...
  33. pmc Completeness of prescription information in US commercial claims databases
    Julie C Lauffenburger
    Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacoepidemiol Drug Saf 22:899-906. 2013
    ..This has implications for many research activities and quality improvement programs. We sought to estimate the percentage of missing prescriptions in US commercial claims data using a novel design...
  34. doi request reprint Nonparametric binary instrumental variable analysis of competing risks data
    Amy Richardson
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Biostatistics 18:48-61. 2017
    ....
  35. pmc Evidence of sample use among new users of statins: implications for pharmacoepidemiology
    Xiaojuan Li
    Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC
    Med Care 52:773-80. 2014
    ..These data do not capture patients' use of medication samples. This could potentially bias studies of short-term effects where date of initiation may be inaccurate...
  36. pmc Cancer incidence among US Medicare ESRD patients receiving hemodialysis, 1996-2009
    Anne M Butler
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC Electronic address
    Am J Kidney Dis 65:763-72. 2015
    ..However, contemporary cancer burden estimates in this population are sparse and do not account for the high competing risk of death characteristic of dialysis patients...
  37. doi request reprint Declining rates of work-related overexertion back injuries among union drywall installers in Washington State, 1989-2008: Improved work safety or shifting of care?
    Ashley L Schoenfisch
    Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina UNC Gillings School of Global Public Health, UNC Chapel Hill, Chapel Hill, North Carolina
    Am J Ind Med 57:184-94. 2014
    ..Little is known about the back injury experience and care seeking behavior among drywall installers, a high-risk workgroup regularly exposed to repetitive activities, awkward postures, and handling heavy building materials...
  38. pmc An empirical comparison of tree-based methods for propensity score estimation
    Stephanie Watkins
    Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, University of North Carolina, Chapel Hill, NC
    Health Serv Res 48:1798-817. 2013
    ....
  39. pmc Doubly robust estimation of causal effects
    Michele Jonsson Funk
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Epidemiol 173:761-7. 2011
    ..Cary, North Carolina) for doubly robust estimation, available for download at http://www.unc.edu/~mfunk/dr/...