Paul S Brookes

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin
    Paul S Brookes
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2180, USA
    Free Radic Biol Med 32:1220-8. 2002
  2. ncbi request reprint High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes
    Paul S Brookes
    Department of Pathology, University of Alabama at Birmingham, Biomedical Research Building 2, 901 19th Street South, Birmingham, AL 35294, USA
    Proteomics 2:969-77. 2002
  3. ncbi request reprint Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide
    Maria Cecilia Barone
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 278:27520-4. 2003
  4. ncbi request reprint Mitochondria, nitric oxide, and cardiovascular dysfunction
    Anup Ramachandran
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 33:1465-74. 2002
  5. pmc Mechanisms of the interaction of nitroxyl with mitochondria
    Sruti Shiva
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 379:359-66. 2004
  6. ncbi request reprint Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state
    Paul S Brookes
    Departments of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 278:31603-9. 2003
  7. ncbi request reprint Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition
    Paul S Brookes
    Uiniversity of Alabama at Birmingham, Department of Pathology, 901 19th St South, Birmingham, AL 35294, USA
    Am J Physiol Heart Circ Physiol 286:H39-46. 2004
  8. ncbi request reprint Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide
    Paul S Brookes
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    Methods Enzymol 359:305-19. 2002
  9. ncbi request reprint Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide
    Aparna Venkatraman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hepatology 38:141-7. 2003
  10. ncbi request reprint Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
    Paul S Brookes
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 33:755-64. 2002

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin
    Paul S Brookes
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2180, USA
    Free Radic Biol Med 32:1220-8. 2002
    ..These results indicate that oral low dose quercetin is cardioprotective, possibly via a mechanism involving protection of mitochondrial function during I-R...
  2. ncbi request reprint High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes
    Paul S Brookes
    Department of Pathology, University of Alabama at Birmingham, Biomedical Research Building 2, 901 19th Street South, Birmingham, AL 35294, USA
    Proteomics 2:969-77. 2002
    ..Applications of this functional mitochondrial proteomics method are discussed...
  3. ncbi request reprint Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide
    Maria Cecilia Barone
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 278:27520-4. 2003
    ..These observations are discussed in the context of ONOO-/ascorbate reactivity and the interaction of CcOX with reactive nitrogen species...
  4. ncbi request reprint Mitochondria, nitric oxide, and cardiovascular dysfunction
    Anup Ramachandran
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 33:1465-74. 2002
    ..The interaction of NO with the various mitochondrial respiratory complexes and the role NO plays in modulating mitochondrial-mediated apoptosis in these systems will be discussed...
  5. pmc Mechanisms of the interaction of nitroxyl with mitochondria
    Sruti Shiva
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 379:359-66. 2004
    ....
  6. ncbi request reprint Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state
    Paul S Brookes
    Departments of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 278:31603-9. 2003
    ..dependent spectral species in the respiratory chain in this state. These results are discussed in the context of regulation of respiration by NO. in vivo and its implications for the control of vessel-parenchymal O2 gradients...
  7. ncbi request reprint Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition
    Paul S Brookes
    Uiniversity of Alabama at Birmingham, Department of Pathology, 901 19th St South, Birmingham, AL 35294, USA
    Am J Physiol Heart Circ Physiol 286:H39-46. 2004
    ..These studies suggest protein targets revealed by Ca(2+) include dehydrogenases and CoA - containing enzymes. These data are discussed in the context of the role of mitochondria, Ca(2+), and ONOO(-) in apoptotic signaling...
  8. ncbi request reprint Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide
    Paul S Brookes
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    Methods Enzymol 359:305-19. 2002
    ..Such experiments can provide insight into the intricate nature of the interaction between NO. and mitochondria and the variations in this system that can occur under both physiological and pathological conditions...
  9. ncbi request reprint Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide
    Aparna Venkatraman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hepatology 38:141-7. 2003
    ..We propose that this results in a greater vulnerability to hypoxia and the development of alcohol-induced hepatotoxicity...
  10. ncbi request reprint Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
    Paul S Brookes
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 33:755-64. 2002
    ....
  11. ncbi request reprint Intra-myocyte ion homeostasis during ischemia-reperfusion injury: effects of pharmacologic preconditioning and controlled reperfusion
    James E Davies
    Department of Surgery, Birmingham, University of Alabama at Birmingham, 35294, USA
    Ann Thorac Surg 76:1252-8; discussion 1258. 2003
    ..This study determines whether controlled reperfusion or diazoxide improves intramyocyte Na(+) homeostasis using a porcine model of severe ischemia-reperfusion injury...
  12. ncbi request reprint Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injury
    Stanley B Digerness
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Ala 35294 0007, USA
    J Thorac Cardiovasc Surg 125:863-71. 2003
    ....
  13. ncbi request reprint Oxidation of 10-formyltetrahydrofolate to 10-formyldihydrofolate by complex IV of rat mitochondria
    Paul S Brookes
    Department of Pathology and Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Biochemistry 41:5633-6. 2002
    ....
  14. pmc Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury
    Sergiy M Nadtochiy
    Department of Anesthesiology, PO Box 604, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Cell Cardiol 42:812-25. 2007
    ..Overall these data suggest that mitochondrial S-nitrosation and complex I inhibition constitute a protective signaling pathway that is amenable to pharmacologic augmentation...
  15. pmc Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
    Sruti Shiva
    Vascular Medicine Branch, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2089-102. 2007
    ..These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet...
  16. ncbi request reprint Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition
    Andrew J Tompkins
    Departments of Anesthesiology, and Biochemistry and Molecular Biology, Box 604, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester NY 14642, USA
    Biochim Biophys Acta 1762:223-31. 2006
    ..These thiol modifications were accompanied by enhanced ROS generation from CxI, but not complex III. Implications for the pathology of cardiac I-R injury are discussed...
  17. ncbi request reprint Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells
    Seigo Itoh
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:26383-96. 2005
    ..These data suggest a role for mitochondrial Dok-4 as an anchoring molecule for the tyrosine kinase c-Src, and in turn as a regulator of TNF-alpha-mediated ROS production and NF-kappaB activation...
  18. ncbi request reprint Mitochondrial H(+) leak and ROS generation: an odd couple
    Paul S Brookes
    Department of Anesthesiology, University of Rochester, Medical Center Box 604, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 38:12-23. 2005
    ..Herein the molecular basis of both ROS generation and H(+) leak will be reviewed and the consequences of their interaction for mitochondrial function discussed...
  19. ncbi request reprint Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury
    Lindsay S Burwell
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 10:579-99. 2008
    ..These direct effects of NO* on mitochondria are the focus of this review...
  20. pmc The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning
    Andrew P Wojtovich
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochim Biophys Acta 1777:882-9. 2008
    ..Together, these observations suggest that complex II inhibition by endogenously formed malonate may represent an important activation pathway for mK(ATP) channels during IPC...
  21. pmc Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function
    Ana Guijarro
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Ann Surg 247:779-90. 2008
    ..To determine the physiologic importance of endocannabinoids and mitochondrial function in the long-term outcome using a rat model of Roux-en-Y gastric bypass (RYGB) surgery...
  22. ncbi request reprint Methods for measuring the regulation of respiration by nitric oxide
    Sruti Shiva
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Cell Biol 80:395-416. 2007
  23. ncbi request reprint The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore
    Paul S Brookes
    Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 67:1793-802. 2007
    ....
  24. ncbi request reprint Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling
    David L Hoffman
    Box 604 Anesthesiology, Univ of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 292:H101-8. 2007
    ..The implications for hypoxic cell signaling are discussed...
  25. ncbi request reprint A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress"
    Paul S Brookes
    Department of Anesthesiology, University of Rochester Medical Center, Box 604, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 41:41-5. 2006
  26. pmc Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection
    Sergiy M Nadtochiy
    Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem J 395:611-8. 2006
    ..71). In conclusion, these data suggest that the modulation of H+ leak may have important implications for the outcome of IR injury...
  27. pmc Direct evidence for S-nitrosation of mitochondrial complex I
    Lindsay S Burwell
    Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14620, USA
    Biochem J 394:627-34. 2006
    ..The implications of these results for the physiological regulation of respiration, for reactive oxygen species generation and for a potential role of S-nitrosation in cardioprotection are discussed...
  28. pmc The basal proton conductance of mitochondria depends on adenine nucleotide translocase content
    Martin D Brand
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 392:353-62. 2005
    ..We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions...
  29. ncbi request reprint Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach
    Tsu Kung Lin
    Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
    J Biol Chem 277:17048-56. 2002
    ..In addition the methodology has the potential to identify novel redox-dependent modulation of mitochondrial proteins...
  30. ncbi request reprint Calcium, ATP, and ROS: a mitochondrial love-hate triangle
    Paul S Brookes
    University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 287:C817-33. 2004
    ..Overall, a "two-hit" hypothesis is developed, in which Ca(2+) plus another pathological stimulus can bring about mitochondrial dysfunction...
  31. pmc The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning
    Andrew P Wojtovich
    Department of Pharmacology and Physiology, Box 604, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 376:625-8. 2008
    ..Since C. elegans also exhibit IPC, our observations provide a framework to study the role of mK(ATP) in IR injury in a genetic model organism...