Timothy J Brickman

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Bordetella interspecies allelic variation in AlcR inducer requirements: identification of a critical determinant of AlcR inducer responsiveness and construction of an alcR(Con) mutant allele
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 0312, USA
    J Bacteriol 184:1530-9. 2002
  2. pmc Alcaligin siderophore production by Bordetella bronchiseptica strain RB50 is not repressed by the BvgAS virulence control system
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312, USA
    J Bacteriol 184:7055-7. 2002
  3. pmc Differential expression of Bordetella pertussis iron transport system genes during infection
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, 925 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455 0312, USA
    Mol Microbiol 70:3-14. 2008
  4. pmc Temporal signaling and differential expression of Bordetella iron transport systems: the role of ferrimones and positive regulators
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, MMC 196, Minneapolis, MN 55455 0312, USA
    Biometals 22:33-41. 2009
  5. pmc Involvement of multiple distinct Bordetella receptor proteins in the utilization of iron liberated from transferrin by host catecholamine stress hormones
    Sandra K Armstrong
    Department of Microbiology, University of Minnesota Medical School, 925 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455 0312, USA
    Mol Microbiol 84:446-62. 2012
  6. ncbi request reprint Bordetella iron transport and virulence
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, MMC 196, 420 Delaware Street S E, Minneapolis, MN 55455 0312, USA
    Biometals 20:303-22. 2007
  7. pmc Bordetella AlcS transporter functions in alcaligin siderophore export and is central to inducer sensing in positive regulation of alcaligin system gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455 0312, USA
    J Bacteriol 187:3650-61. 2005
  8. pmc Iron and pH-responsive FtrABCD ferrous iron utilization system of Bordetella species
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, 925 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455 0312, USA
    Mol Microbiol 86:580-93. 2012
  9. pmc Impact of alcaligin siderophore utilization on in vivo growth of Bordetella pertussis
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street SE, Minneapolis, MN 55455 0312, USA
    Infect Immun 75:5305-12. 2007
  10. pmc Heme transport contributes to in vivo fitness of Bordetella pertussis during primary infection in mice
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, MN 55455 0312, USA
    Infect Immun 74:1741-4. 2006

Collaborators

Detail Information

Publications15

  1. pmc Bordetella interspecies allelic variation in AlcR inducer requirements: identification of a critical determinant of AlcR inducer responsiveness and construction of an alcR(Con) mutant allele
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 0312, USA
    J Bacteriol 184:1530-9. 2002
    ..These results indicate that AlcR residue 103 affects a critical determinant of alcaligin inducer dependence of AlcR-mediated transcriptional activation. The alcR(S103T) mutant allele is the first alcR(Con) mutant allele identified...
  2. pmc Alcaligin siderophore production by Bordetella bronchiseptica strain RB50 is not repressed by the BvgAS virulence control system
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312, USA
    J Bacteriol 184:7055-7. 2002
    ..In contrast, we report that alcaligin production by RB50 does not require Bvg phenotypic phase modulation and that isogenic Bvg(Con) and Bvg(-) phase-locked mutants both produce alcaligin in response to iron starvation...
  3. pmc Differential expression of Bordetella pertussis iron transport system genes during infection
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, 925 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455 0312, USA
    Mol Microbiol 70:3-14. 2008
    ..pertussis is iron-starved and responds to the presence of diverse iron sources during natural infection...
  4. pmc Temporal signaling and differential expression of Bordetella iron transport systems: the role of ferrimones and positive regulators
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, MMC 196, Minneapolis, MN 55455 0312, USA
    Biometals 22:33-41. 2009
    ..As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process...
  5. pmc Involvement of multiple distinct Bordetella receptor proteins in the utilization of iron liberated from transferrin by host catecholamine stress hormones
    Sandra K Armstrong
    Department of Microbiology, University of Minnesota Medical School, 925 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455 0312, USA
    Mol Microbiol 84:446-62. 2012
    ..bronchiseptica mechanism for iron uptake from transferrin that uses host stress hormones that not only deliver iron directly to catecholamine receptors, but also potentiate siderophore activity by acting as iron shuttles...
  6. ncbi request reprint Bordetella iron transport and virulence
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, MMC 196, 420 Delaware Street S E, Minneapolis, MN 55455 0312, USA
    Biometals 20:303-22. 2007
    ..Iron source sensing is mediated by distinct transcriptional activators that are responsive to the cognate iron source acting as the inducer...
  7. pmc Bordetella AlcS transporter functions in alcaligin siderophore export and is central to inducer sensing in positive regulation of alcaligin system gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455 0312, USA
    J Bacteriol 187:3650-61. 2005
    ....
  8. pmc Iron and pH-responsive FtrABCD ferrous iron utilization system of Bordetella species
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, 925 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455 0312, USA
    Mol Microbiol 86:580-93. 2012
    ..The pH of human airway surface fluids ranges from pH‚ÄČ5.5 to 7.9, and the FtrABCD system may supply ferrous iron necessary for Bordetella growth in acidic host microenvironments in which siderophores are ineffective for iron retrieval...
  9. pmc Impact of alcaligin siderophore utilization on in vivo growth of Bordetella pertussis
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street SE, Minneapolis, MN 55455 0312, USA
    Infect Immun 75:5305-12. 2007
    ..Alcaligin-mediated iron acquisition by B. pertussis may be critical for successful host colonization and establishment of infection...
  10. pmc Heme transport contributes to in vivo fitness of Bordetella pertussis during primary infection in mice
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, MN 55455 0312, USA
    Infect Immun 74:1741-4. 2006
    ..pertussis in the mouse infection model and indicate that heme utilization may be most important for adaptation to host conditions existing during the later stages of infection...
  11. pmc Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 193:4798-812. 2011
    ..These results indicate that iron starvation in the infected host is an important environmental cue influencing not only Bordetella iron transport gene expression but also the expression of other important virulence-associated genes...
  12. doi request reprint Essential role of Bordetella NadC in a quinolinate salvage pathway for NAD biosynthesis
    Timothy J Brickman
    Department of Microbiology and Immunology, University of Minnesota Medical School, 3 117 Microbiology Research Facility, 689 23rd Ave S E, Minneapolis, MN, 55455 1507, USA
    Mol Microbiol . 2016
    ..Expression of nadC in B. bronchiseptica was influenced by nicotinic acid and by a NadQ family transcriptional repressor, indicating that these organisms prioritize their use of pyridines for NAD biosynthesis...
  13. pmc Interspecies variations in Bordetella catecholamine receptor gene regulation and function
    Timothy J Brickman
    Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Infect Immun 83:4639-52. 2015
    ..pertussis. Additional evidence of the in vivo importance of the B. pertussis receptors was obtained from serologic studies demonstrating pertussis patient serum reactivity with the B. pertussis BfrD and BfrE proteins. ..
  14. doi request reprint Multicellular behavior in bacteria: communication, cooperation, competition and cheating
    Gary M Dunny
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455 0312, USA
    Bioessays 30:296-8. 2008
    ..Here we discuss the significance of two recent studies of the phenomenon of "cheating" mutants and their exploitation of cooperating microbial populations of Pseudomonas aeruginosa...
  15. pmc Identification of an AU-rich translational enhancer within the Escherichia coli fepB leader RNA
    India G Hook-Barnard
    Department of Molecular Microbiology andd Immunology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Bacteriol 189:4028-37. 2007
    ..Furthermore, we found that the TE-GUG sequence is conserved among the eight gram-negative strains examined that have fepB genes, suggesting that this organization may provide a selective advantage...