Lisa A Briand
Affiliation: University of Pennsylvania
- Not all stress is equal: CREB is not necessary for restraint stress reinstatement of cocaine-conditioned rewardLisa A Briand
Department of Pharmacology, The University of Pennsylvania School of Medicine, 125 S 31st Street, Philadelphia, PA, United States
Behav Brain Res 246:63-8. 2013..Our findings suggest that not all stressors engage the same circuits or molecular mechanisms to elicit reinstatement behavior...
- Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in miceLisa A Briand
Department of Pharmacology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA
Eur J Neurosci 35:932-9. 2012..These results suggest that the molecular mechanisms underlying aversive and appetitive extinction are distinct from one another and BDNF may play opposing roles in the two phenomena...
- Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behaviorLisa A Briand
Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
Learn Mem 22:109-15. 2015..Strikingly, our findings show that CREB phosphorylation at Ser133 is not necessary for CREB binding to CRE sites, CREB-mediated transcription, or CREB-mediated behavioral phenotypes associated with learning and memory. ..
- Ventral tegmental afferents in stress-induced reinstatement: the role of cAMP response element-binding proteinLisa A Briand
Department of Pharmacology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:16149-59. 2010....
- Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator τBrigitta B Gundersen
Departments of Pharmacology and Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Neurosci 33:13673-85. 2013..The current results suggest that activation of CREMτ may provide a means to accelerate the therapeutic efficacy of current antidepressant treatment. ..
- Cocaine-related behaviors in mice with deficient gliotransmissionJill R Turner
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 226:167-76. 2013..However, while astrocytes are capable of releasing chemical transmitters that can modulate neuronal function, the role of these gliotransmitters in mediating behaviors associated with drugs of abuse has been largely unexplored...
- Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neuronsPavel I Ortinski
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, USA
Neuropharmacology 92:80-9. 2015....
- Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive DisordersBrigid K Jensen
From the Department of Neuroscience, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania BKJ, MVM Department of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania BKJ, hm, JBG Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania BKJ, PJG, CAE, MAE, KLJ S Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana AJB K Department of Pathology, University of Texas Medical Branch, Galveston, Texas BBG Department of Psychology, College of Liberal Arts, Temple University, Philadelphia, Pennsylvania LAB Center for Neurobiology and Behavior, Department of Psychiatry, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania CP
J Neuropathol Exp Neurol 74:1093-118. 2015..These findings demonstrate that antiretrovirals can impact myelin integrity and have implications for myelination in juvenile HIV patients and myelin maintenance in adults on lifelong therapy...
- Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapseLisa A Briand
Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 39:759-69. 2014..These effects are associated with changes in vulnerability to cocaine relapse and highlight GRIP as a novel target for the development of cocaine addiction therapeutics. ..
- Molecular and genetic substrates linking stress and addictionLisa A Briand
Department of Pharmacology, The University of Pennsylvania School of Medicine, TRL, 125 South 31 st Street, USA
Brain Res 1314:219-34. 2010..Focus on these molecules could provide us with new targets for pharmacological treatments for addiction...