Genomes and Genes
Affiliation: University of Washington
- PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencingD A Nickerson
Department of Molecular Biotechnology, Box 357730, University of Washington, Seattle, WA 98195 7730, USA
Nucleic Acids Res 25:2745-51. 1997....
- DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase geneD A Nickerson
Department of Molecular Biotechnology, University of Washington, Seattle 98125, USA
Nat Genet 19:233-40. 1998....
- Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E geneD A Nickerson
Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195, USA
Genome Res 10:1532-45. 2000..The sequence data described in this paper have been submitted to the GenBank data library under accession no. AF261279.]..
- Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular diseaseGail P Jarvik
Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Wash, USA
Arterioscler Thromb Vasc Biol 23:1465-71. 2003..The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated...
- TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular diseaseChristopher S Carlson
The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, The University of Washington, Seattle, USA
J Lipid Res 47:1014-24. 2006....
- Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) studyA P Reiner
Departments of Epidemiology and Genome Sciences, University of Washington, Seattle, WA 98101 1448, USA
J Thromb Haemost 4:1279-87. 2006..Previous genotype-phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and between major ethnic groups in FGB, FGA, and FGG...
- Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart StudyD L Ellsworth
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Int J Obes Relat Metab Disord 26:928-37. 2002....
- Linkage disequilibrium structure and its impact on the localization of a candidate functional mutationQ Huang
Human Genetics Center, University of Texas Health Science Center at Houston, 6901 Bertner, Houston, TX 77030, USA
Genet Epidemiol 21:S620-5. 2001..These data indicate that simple association studies will not identify the functional mutation, but rather will identify candidate functional mutations that are in very tight linkage disequilibrium with the functional mutation...
- Evidence for non-additive influence of single nucleotide polymorphisms within the apolipoprotein E geneS C Hamon
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
Ann Hum Genet 68:521-35. 2004....
- Power of a simplified multivariate test for genetic linkageO Y Gorlova
Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Hum Genet 66:407-17. 2002..The method identified meaningful combinations of traits that showed significant linkage on chromosome 2 and suggestive linkage to regions on chromosomes 16 and 17...
- APOE genotype and cognitive decline in a middle-aged cohortC K Blair
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Neurology 64:268-76. 2005..However, most studies involved elderly samples (aged 65+) and were not large enough to examine the three APOE alleles separately...
- Influence of lipoprotein lipase gene Ser447Stop and beta1-adrenergic receptor gene Arg389Gly polymorphisms and their interaction on obesity from childhood to adulthood: the Bogalusa Heart StudyS Li
Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Int J Obes (Lond) 30:1183-8. 2006..To investigate the influence of lipoprotein lipase (LPL) Ser447Stop and beta1-adrenergic receptor (ADRB1) Arg389Gly gene polymorphisms, individually and in combination, on obesity from childhood to adulthood...
- Antihypertensive therapy, the alpha-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment StudyB R Davis
School of Public Health, University of Texas Houston, Houston, TX 77030, USA
Pharmacogenomics J 7:112-22. 2007..This must be confirmed to have implications for hypertension treatment...
- The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variabilityC M Brown
Department of Human Genetics, University of Michigan, Ann Arbor, 48109, USA
J Mol Med (Berl) 84:561-72. 2006..Our findings illustrate the impact of context-dependence on SNP selection for prediction of CVD risk factor variability...
- Gene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities studyM L Grove
The University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, Houston, TX 77030, USA
Int J Obes (Lond) 31:919-26. 2007..The purpose of this study was to investigate the interaction between the G-protein beta-3 (GNB3) 825C>T polymorphism and physical activity in relation to prevalent obesity and hypertension...
- Genomic regions that influence plasma levels of inflammatory markers in hypertensive sibshipsK Ding
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
J Hum Hypertens 22:102-10. 2008..Plasma CRP and fibrinogen levels are heritable and genetically correlated. Linkage analyses identified several chromosomal regions that may harbour genes influencing CRP and fibrinogen levels and exert pleiotropic effects on both traits...
- Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa heart studyW Chen
Department of Epidemiology, Tulane Center for Cardiovascular Health, Tulane School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2140, New Orleans, LA 70112, USA
Atherosclerosis 159:367-73. 2001..Thus, the X447 allele of the LPL gene is associated with an increase in HDLC and a decrease in TG in adults, tracking of HDLC since childhood, and a lower family history of CAD...
- Combined effects of endothelial nitric oxide synthase gene polymorphism (G894T) and insulin resistance status on blood pressure and familial risk of hypertension in young adults: the Bogalusa Heart StudyW Chen
Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
Am J Hypertens 14:1046-52. 2001..5% v 51.3%, P = .006, adjusted for race). Thus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension...
- Association and linkage analysis of the alpha-adducin gene and blood pressureM S Bray
Institute for Molecular Medicine, University of Texas-Houston Health Science Center, 77225, USA
Am J Hypertens 13:699-703. 2000..Therefore, variation within the alpha-adducin gene does not appear to have a major influence on measures of blood pressure in white families from Rochester, Minnesota...
- Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphismS M Fullerton
Institute of Molecular Evolutionary Genetics, Department of Biology, and Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Am J Hum Genet 67:881-900. 2000....
- Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitusY Horikawa
Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA
Nat Genet 26:163-75. 2000..This finding suggests a novel pathway that may contribute to the development of type 2 diabetes...
- Platelet Pl(A2) allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) StudyN Aleksic
Division of Hematology and Vascular Biology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
Circulation 102:1901-5. 2000..The purpose of this study was to determine whether Pl(A2) is a risk factor for incident CHD and whether it is correlated with increased platelet activation in a case-cohort study nested within a prospective epidemiologic investigation...
- Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibriumC L Pfaff
Department of Anthropology, Pennsylvania State University, University Park, PA, 16802, USA
Am J Hum Genet 68:198-207. 2001....
- TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) studyS J Bielinski
Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
Diabetologia 51:968-70. 2008..We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ in diabetic and non-diabetic persons...
- G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical strokeA C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Institute of Molecular Medicine, Houston, Texas, USA
Stroke 32:822-9. 2001....
- Beta-fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: the Atherosclerosis Risk in Communities (ARIC) StudyA R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Ann Epidemiol 11:166-70. 2001..The -455G/A (HaeIII) polymorphism of the beta-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease...
- Validity of the aldosterone-renin ratio used to screen for primary aldosteronismV M Montori
Division of Endocrinology, Metabolism, Nutrition and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 76:877-82. 2001....
- Sex-specific effects of AGT-6 and ACE I/D on pulse pressure after 6 months on antihypertensive treatment: the GenHAT studyA I Lynch
University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, Minnesota, USA
Ann Hum Genet 71:735-45. 2007..For ACE-I/D no evidence for a genotype-by-sex interaction was detected. This finding of genotype-by-sex interaction on PP helps our understanding of the complexity of genetic effects on blood pressure...
- The Ser(447)-Stop polymorphism of lipoprotein lipase is associated with variation in longitudinal serum high-density lipoprotein-cholesterol profiles: the Bogalusa Heart StudyD M Hallman
Human Genetics Center and Institute of Molecular Medicine, University of Texas, Houston Health Science Center, Houston, TX 77225, USA
Metabolism 50:894-904. 2001..Thus, we found evidence of LPL genotype effects that vary within individuals with age. Possible mechanisms, which could account for age-related changes in the effects of LPL variants, are discussed...
- Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcificationD L Ellsworth
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive MSC 7934, Bethesda, MD 20892 7934, USA
J Mol Med (Berl) 79:390-8. 2001....
- Genome-wide linkage analysis reveals evidence of multiple regions that influence variation in plasma lipid and apolipoprotein levels associated with risk of coronary heart diseaseK L Klos
Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618, USA
Arterioscler Thromb Vasc Biol 21:971-8. 2001....
- Multilocus effects of the renin-angiotensin-aldosterone system genes on blood pressure response to a thiazide diureticL Frazier
The University of Texas Houston School of Nursing, Human Genetic Center and Institute of Molecular Medicine, Houston, TX, USA
Pharmacogenomics J 4:17-23. 2004..Variation in RAA system genes has been reported to influence interindividual differences in BP levels and the occurrence of hypertension (HTN)...
- C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diureticS T Turner
Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Hypertension 37:739-43. 2001..Thus, the C825T polymorphism of the G protein beta(3)-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy...
- Thrombomodulin Ala455Val polymorphism and risk of coronary heart diseaseK K Wu
Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
Circulation 103:1386-9. 2001..Whether this single nucleotide polymorphism predicts risk of developing coronary heart disease (CHD) is unclear...
- An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart StudyW Chen
Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Int J Obes Relat Metab Disord 28:462-9. 2004..To examine genetic loci linked to a long-term burden and trend of obesity traits, such as body mass index (BMI), from childhood to adulthood...
- Linkage analysis of plasma ApoE in three ethnic groups: multiple genes with context-dependent effectsK L E Klos
Human Genetics Center, School of Public Health, University of Texas Health Science Center, PO Box 20186, Houston, TX 77225, USA
Ann Hum Genet 69:157-67. 2005....
- An autosomal genomic scan for loci linked to type 2 diabetes in northern Han ChineseJ Y Zhao
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 100005, Beijing, China
J Mol Med (Berl) 83:209-15. 2005..We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses...
- FINDING & GENOTYPING SNPS BY AUTOMATED SEQUENCE ANALYSISDeborah Nickerson; Fiscal Year: 2001....
- MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASEDeborah Nickerson; Fiscal Year: 2001..These studies will provide an unprecedented ..
- UW-FHCRC VARIATION DISCOVERY RESOURCEDeborah Nickerson; Fiscal Year: 2007..abstract_text> ..
- UW-FHCRC VARIATION DISCOVERY RESOURCEDeborah Nickerson; Fiscal Year: 2007..abstract_text> ..
- SeattleSeqDeborah Nickerson; Fiscal Year: 2009..The principal investigator (PI) proposes to evaluate two different methods that will capture approximately 1% of the human genome that represents the protein coding genome (PCG). ..