Rosie Bocanegra

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis
    Rosie Bocanegra
    The University of Texas Health Science Center at San Antonio, Department of Medicine Division of Infectious Diseases MC 7881, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 49:5139-41. 2005
  2. doi request reprint Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis
    William R Kirkpatrick
    The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 67:970-6. 2012
  3. pmc Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility
    Gabriela E Brzankalski
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 62:1094-100. 2008
  4. pmc Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
    Ana C Vallor
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 52:2593-8. 2008
  5. pmc Posaconazole therapy of disseminated phaeohyphomycosis in a murine model
    John R Graybill
    Department of Medicine, Division of Infectious Diseases, Medicine ID Mail Code 7881, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 48:2288-91. 2004
  6. pmc Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays
    Gloria M Gonzalez
    Division of Infectious Diseases 7881, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Antimicrob Agents Chemother 47:1436-8. 2003
  7. pmc Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis
    Steve Hernandez
    Department of Medicine, Division Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:1382-3. 2004
  8. pmc Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Antimicrob Agents Chemother 57:745-50. 2013
  9. pmc Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories
    Laura K Najvar
    Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:758-64. 2004
  10. pmc The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Antimicrob Chemother 71:692-5. 2016

Detail Information

Publications30

  1. pmc Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis
    Rosie Bocanegra
    The University of Texas Health Science Center at San Antonio, Department of Medicine Division of Infectious Diseases MC 7881, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 49:5139-41. 2005
    ..Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone...
  2. doi request reprint Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis
    William R Kirkpatrick
    The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 67:970-6. 2012
    ..We evaluated the prophylactic efficacy of single dose administration of ABIP in a guinea pig model of invasive pulmonary aspergillosis...
  3. pmc Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility
    Gabriela E Brzankalski
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 62:1094-100. 2008
    ..We compared the in vitro potency and in vivo efficacy of aminocandin and caspofungin against clinical isolates of C. glabrata including those with reduced caspofungin susceptibility (MIC > 2 mg/L)...
  4. pmc Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
    Ana C Vallor
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 52:2593-8. 2008
    ..02). Confirmation of fungal tissue burden by two or more methods should provide a more precise account of the burden, allowing improved assessment of diagnostic and therapeutic strategies in invasive pulmonary aspergillosis...
  5. pmc Posaconazole therapy of disseminated phaeohyphomycosis in a murine model
    John R Graybill
    Department of Medicine, Division of Infectious Diseases, Medicine ID Mail Code 7881, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 48:2288-91. 2004
    ..Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain...
  6. pmc Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays
    Gloria M Gonzalez
    Division of Infectious Diseases 7881, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Antimicrob Agents Chemother 47:1436-8. 2003
    ..Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues...
  7. pmc Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis
    Steve Hernandez
    Department of Medicine, Division Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:1382-3. 2004
    ..We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs...
  8. pmc Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Antimicrob Agents Chemother 57:745-50. 2013
    ..These results demonstrate limited efficacy of miltefosine and suggest caution with the potential use of this agent for the treatment of C. neoformans infections...
  9. pmc Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories
    Laura K Najvar
    Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:758-64. 2004
    ..These studies do not confirm the antagonistic interaction of triazoles and polyenes reported by others...
  10. pmc The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Antimicrob Chemother 71:692-5. 2016
    ..The novel arylamidine T-2307 demonstrates potent in vitro antifungal activity against Candida species. Our objective was to evaluate the in vitro and in vivo activity of T-2307 against resistant C. glabrata...
  11. ncbi request reprint Combination antifungal therapy of murine aspergillosis: liposomal amphotericin B and micafungin
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases 7881, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 52:656-62. 2003
    ..AmBisome and micafungin were used alone and in combination in a series of studies designed to identify any additive or antagonistic effects of combination antifungal therapy...
  12. pmc Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 47:2373-5. 2003
    ..However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs...
  13. pmc New guinea pig model of Cryptococcal meningitis
    William R Kirkpatrick
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 51:3011-3. 2007
    ..Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy...
  14. pmc The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Antimicrob Agents Chemother 59:1341-3. 2015
    ..Thus, T-2307 may have potential use in the treatment of echinocandin-resistant C. albicans infections. ..
  15. pmc The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant Candida albicans
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Antimicrob Agents Chemother 59:690-2. 2015
    ..These results demonstrate the potential use of E1210 against resistant C. albicans infections. ..
  16. pmc In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model
    Qiu N Sun
    Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 46:2310-2. 2002
    ..25 to 8 microg/ml, respectively. The in vitro MIC range for amphotericin B is 0.125 to 0.25 microg/ml. At twice-daily doses of >or=15 mg/kg of body weight, posaconazole prolonged the survival of the mice and reduced tissue burden...
  17. pmc Interlaboratory and interstudy reproducibility of a novel lateral-flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Clin Microbiol 51:459-65. 2013
    ..These results demonstrate that the LFD assay is reproducible between different laboratories and studies. However, the sensitivity of this assay and other markers of IPA may be reduced with serum in the presence of antifungal therapy...
  18. pmc Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bantiana
    Hail M Al-Abdely
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas, USA
    Antimicrob Agents Chemother 49:1701-7. 2005
    ..We concluded that posaconazole shows promise for the treatment of C. bantiana brain infections...
  19. pmc Antifungal therapy of murine Aspergillus terreus infection
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases mail code 7881, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 48:3715-9. 2004
    ..Caspofungin and posaconazole both appeared beneficial and may be reasonable treatment alternatives for infection with A. terreus...
  20. ncbi request reprint Improving the mouse model for studying the efficacy of voriconazole
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases 7881, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 51:1373-6. 2003
    ..The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses...
  21. pmc In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera
    Nathan P Wiederhold
    UTHSCSA, PERC, MSC 6220, San Antonio, TX 78229, USA
    Antimicrob Agents Chemother 51:1616-20. 2007
    ..The superior in vitro activity of anidulafungin did not confer enhanced in vivo efficacy against C. glabrata...
  22. pmc Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis
    Nathan P Wiederhold
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Antimicrob Agents Chemother 60:5600-3. 2016
    ..Concentrations of isavuconazole in plasma and brain tissue also demonstrated that the greatest improvements in survival and fungal burden were associated with elevated exposures. ..
  23. pmc Comparison of lateral flow technology and galactomannan and (1->3)-beta-D-glucan assays for detection of invasive pulmonary aspergillosis
    Nathan P Wiederhold
    University of Texas at Austin College of Pharmacy, Austin, Texas, USA
    Clin Vaccine Immunol 16:1844-6. 2009
    ..The lateral flow device became positive earlier (day 3) than the (1-->3)-beta-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7...
  24. pmc Efficacy of posaconazole as treatment and prophylaxis against Fusarium solani
    Nathan P Wiederhold
    University of Texas at Austin College of Pharmacy, Austin, Texas, USA
    Antimicrob Agents Chemother 54:1055-9. 2010
    ..In this model high dosages of posaconazole were effective as treatment and prophylaxis against disseminated fusariosis caused by F. solani...
  25. pmc Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis
    Nathan P Wiederhold
    The University of Texas at Austin College of Pharmacy, Austin, Texas, USA
    Antimicrob Agents Chemother 52:1176-8. 2008
    ..Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents...
  26. pmc In vitro and in vivo activities of posaconazole against Coccidioides immitis
    Gloria M Gonzalez
    Department of Medicine, Division of Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 46:1352-6. 2002
    ..No sterilization of whole spleens and livers from mice treated with ITRA was seen. POSA displayed potent in vivo activity against the two strains of C. immitis tested...
  27. ncbi request reprint Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis
    Carlos A Alvarez
    The University of Texas at Austin College of Pharmacy, 1 University Station, A1900, Austin, TX 78712, USA
    J Infect 55:68-74. 2007
    ..We evaluated the effectiveness of an aerosolized nanostructured formulation of itraconazole produced by spray freezing into liquid (SFL) as prophylaxis against invasive pulmonary aspergillosis caused by A. fumigatus...
  28. pmc Standardization of an experimental murine model of invasive pulmonary aspergillosis
    Donald C Sheppard
    McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada
    Antimicrob Agents Chemother 50:3501-3. 2006
    ....
  29. pmc In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis
    Barbara J Hoeben
    University of Texas Health at Austin College of Pharmacy, TX, USA
    Antimicrob Agents Chemother 50:1552-4. 2006
    ..Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure...
  30. pmc Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis
    Gloria M Gonzalez
    Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Antimicrob Agents Chemother 48:2140-3. 2004
    ..003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis...