Affiliation: University of Florida
- Toward optimal treatments for major depressionPierre Blier
Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
CNS Spectr 7:148-50, 153-4. 2002..Ongoing research in this field continues to fuel the development of novel, better-tolerated, and more effective pharmacotherapies for depression...
- Pharmacology of rapid-onset antidepressant treatment strategiesP Blier
Department of Psychiatry, University of Florida, Gainesville 32610 0383, USA
J Clin Psychiatry 62:12-7. 2001..These neurobiological phenomena may underlie the apparently faster onset of action of mirtazapine compared with the SSRIs...
- The pharmacology of putative early-onset antidepressant strategiesPierre Blier
Department of Psychiatry, McKnight Brain Institute, University of Florida, Room L4 100, PO Box 100256, Gainesville, FL 32610 0383, USA
Eur Neuropsychopharmacol 13:57-66. 2003..Further studies are required to characterise in detail the interactions between NA and 5-HT systems and to definitively establish the early onset of candidate antidepressants such as mirtazapine, venlafaxine and pindolol augmentation...
- Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediationPierre Blier
Department of Psychiatry, McGill University, Montreal, Canada
Neuropsychopharmacology 27:301-8. 2002....
- Crosstalk between the norepinephrine and serotonin systems and its role in the antidepressant responseP Blier
Department of Psychiatry and Neuroscience, University of Florida Brain Institute, Gainesville, Fla, USA
J Psychiatry Neurosci 26:S3-10. 2001..Further experiments and long-term studies will increase knowledge of the mechanisms of action of various psychopharmacologic agents and may eventually lead to better therapeutic choices...
- Differential physiological effects of a low dose and high doses of venlafaxine in major depressionGuy Debonnel
Department of Psychiatry, McGill University, Montreal, QC, and Royal Ottawa Hospital, ON, Canada
Int J Neuropsychopharmacol 10:51-61. 2007....
- Mirtazapine and paroxetine in major depression: a comparison of monotherapy versus their combination from treatment initiationPierre Blier
Department of Psychiatry, McGill University, 1033 Avenue des Pins Ouest, Montreal, Quebec, Canada H3A 1A1
Eur Neuropsychopharmacol 19:457-65. 2009..Of these 30 patients, approximately 50% went on to achieve remission in the subsequent 2 weeks. These results indicate that the combined use of two antidepressants was well tolerated and produced a greater improvement than monotherapy...
- Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin functionGabriella Gobbi
Department of Psychiatry, McGill University, 1033 Pine Avenue, West Montreal, QC, Canada H3A 1A1
Eur Neuropsychopharmacol 17:328-38. 2007..In conclusion, NE neurons are essential for the action of NK1 antagonists on 5-HT neurons. In addition, the desensitization of 5-HT(1A) autoreceptors produced by NK1 receptor antagonism is not critical for enhancing 5-HT neuronal firing...
- Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteersPierre Blier
Department of Psychiatry, McGill University, Montreal, QC, Canada
Int J Neuropsychopharmacol 10:41-50. 2007..While the reasons for this unexpected lack of action remain unclear, venlafaxine appeared to be an effective NE reuptake agent in depressed patients using the same approach...
- Clinical evidence and potential neurobiological underpinnings of unresolved symptoms of depressionMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
J Clin Psychiatry 69:246-58. 2008..This article reviews research on the current understanding and management of residual symptoms, i.e., subthreshold depressive symptoms present after recovery from a major depressive episode...
- Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depressionPedro Rosa-Neto
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Arch Gen Psychiatry 61:556-63. 2004..Reduced synthesis of serotonin in the brain pathways mediating the expression of mood (ie, the limbic cortex) is a plausible candidate mechanism...
- Modification of serotonin neuron properties in mice lacking 5-HT1A receptorsMaxime Richer
Neurobiological Psychiatry Unit, McGill University, 1033 Avenue des Pins Ouest, H3A 1A1, Montreal, Quebec, Canada
Eur J Pharmacol 435:195-203. 2002..In addition, it was not associated with changes in the function of 5-HT1D and 5-HT1B autoreceptors and of alpha2-adrenergic heteroreceptors on 5-HT neurons, nor of that of alpha2-adrenoceptors on norepinephrine terminals...
- Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic studyYoshihiro Tohyama
Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
J Neurochem 80:788-98. 2002..The observed effects in the 7-day treatment could also be related to actions through the postsynaptic 5-HT(1B) sites and/or other 5-HT receptors since this compounds have limited selectivity...
- Physiologic mechanisms underlying the antidepressant discontinuation syndromePierre Blier
Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
J Clin Psychiatry 67:8-13. 2006..It also attempts to explain their implications in the therapeutic actions of antidepressants in patients with affective and anxiety disorders...
- Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugsGabriella Gobbi
Department of Psychiatry, Univ de Montreal and McGill University, 1033, Av des Pins Ouest, Montreal, Canada H3A 1A1
Peptides 26:1383-93. 2005..Further research is needed in order to develop more selective ligands for the human NK1 receptor and to gain better knowledge of required brain penetration and optimal pharmacodynamic conditions for their use in patients...
- Is there a role for 5-HT1A agonists in the treatment of depression?Pierre Blier
Departments of Psychiatry and Neuroscience, University of Florida Brain Institute, Gainesville, Florida 32610, USA
Biol Psychiatry 53:193-203. 2003..In sum, 5-HT1A receptor agonism represents a valuable and efficacious therapeutic approach to major depression...
- Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neuronsSteven T Szabo
Department of Neuroscience and Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0383, USA
J Pharmacol Exp Ther 302:983-91. 2002..This NE activity, resulting from 5-HT reuptake inhibition plus 5-HT(2A) receptor antagonism, might confer additional benefits in affective and anxiety disorders...
- Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorderAlexandre Berney
DERBH, Department of Psychiatry, McGill University, 1033 Pine Ave West, Montreal, QC H3A 1A1, Canada
Arch Gen Psychiatry 68:732-41. 2011..Serotonergic abnormalities in the unmedicated symptomatic state, however, remain to be fully characterized...
- A double-blind, placebo-controlled trial of olanzapine addition in fluoxetine-refractory obsessive-compulsive disorderNathan A Shapira
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida 32610 0256, USA
Biol Psychiatry 55:553-5. 2004..One of the few combination approaches to the treatment of obsessive-compulsive disorder (OCD) with encouraging support is the addition of an antipsychotic to a serotonin reuptake inhibitor...
- Preventing recurrent depression: long-term treatment for major depressive disorderPierre Blier
Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Canada
J Clin Psychiatry 68:e06. 2007..Maintenance therapy considerations for clinicians include assessing treatment guidelines, addressing nonadherent patients, and measuring medication treatment response...
- Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targetsSidney H Kennedy
University Health Network, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
J Affect Disord 132:S21-8. 2011..This is of particular importance when considering the long term use of antidepressant therapies for relapse prevention...
- Neurochemical and psychotropic effects of bupropion in healthy male subjectsGabriella Gobbi
Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
J Clin Psychopharmacol 23:233-9. 2003..Presumably it enhances synaptic availability of NE by increasing release. Yet, because its behavioral profile is different from that of methylphenidate, it may not share all the biochemical properties of psychostimulants...
- Effect of long-term administration of the antidepressant drug milnacipran on serotonergic and noradrenergic neurotransmission in the rat hippocampusMichel Weiss
Neurobiological Psychiatry Unit, Mc Gill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
Life Sci 81:166-76. 2007....
- Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxietyPierre Blier
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
J Clin Psychiatry 66:30-40. 2005..This effect may result in part from its antagonistic actions on dopaminergic receptors and alpha2-adrenoceptors on serotonin terminals...
- Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1)Luca Santarelli
Department of Pharmacology, Columbia University, New York, NY 10032, USA
J Clin Psychiatry 63:11-7. 2002..Future studies will attempt to delineate the interaction between the SP-NK1R system and various neurotransmitter pathways in greater detail and to address the specific role(s) of this system in different brain regions...
- In-vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic systemNasser Haddjeri
Laboratory of Neuropharmacology and Neurochemistry, Faculty of Pharmacy, University Claude Bernard Lyon I, INSERM U 512, 8 Avenue Rockefeller 69373 Lyon Cedex 08, France
Int J Neuropsychopharmacol 7:391-9. 2004..c.) and reduced 8-OH-DPAT (0.1 mg/kg s.c.)-induced hypothermia. In conclusion, the present study reports a functional role of muscarinic receptors in the modulation of pre- and post-synaptic 5-HT1A receptors mediated responses...
- Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neuronsEliyahu Dremencov
University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue Suite 6419, Ottawa, ON K1Z 7K4, Canada
Psychopharmacology (Berl) 194:63-72. 2007..While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites...
- Brand versus generic medications: the money, the patient and the researchPierre Blier
J Psychiatry Neurosci 28:167-8. 2003
- The usefulness of large studies in psychopharmacology: understanding their strong points and their drawbacksPierre Blier
J Psychiatry Neurosci 32:232-3. 2007
- Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesionsBruno P Guiard
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
Int J Neuropsychopharmacol 11:625-39. 2008..Indeed, based on the understanding of such interactions, it may be possible to develop strategies to improve the effectiveness of antidepressant drugs by preventing counter-productive negative feedback actions...
- Why treat depression differently from other medical problems?Pierre Blier
J Psychiatry Neurosci 27:231-2. 2002
- Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibitionMostafa El Mansari
University of Ottawa Institute of Mental Health Research, Ottawa, ON
J Psychiatry Neurosci 30:268-74. 2005..This study was undertaken to investigate if these OFC receptors adapt under such conditions...
- Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statementHans Jurgen Moller
Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336 Munich, Germany
Eur Arch Psychiatry Clin Neurosci 258:3-23. 2008..It is the major problem facing efforts to identify the possible 'suicidal effects' of antidepressants...
- Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal hippocampusBruno P Guiard
University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, K1Z 7K4, Ontario, Canada
Mol Pharmacol 74:1463-75. 2008..These findings might help in designing new antidepressant strategies aimed at enhancing DA and NE neurotransmission...
- Selecting methodologies for the evaluation of differences in time to response between antidepressantsStuart A Montgomery
Imperial College School of Medicine, London, United Kingdom
J Clin Psychiatry 63:694-9. 2002..The delay in the therapeutic effect of antidepressants is a considerable impediment to their successful clinical use, and attention has recently been focused on antidepressant drugs that may have a faster onset of action...
- Neurokinin-1 receptors are decreased in major depressive disorderCraig A Stockmeier
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson 39216, USA
Neuroreport 13:1223-7. 2002..024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex...
- Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neuronsSteven T Szabo
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 55:934-9. 2004..Of interest, the activity of locus coeruleus neurons is a reflective index of these above mentioned behavioral states...
- Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleusNasser Haddjeri
Laboratory of Neuropharmacology and Neurochemistry INSERM U512, University Claude Bernard, Avenue Rockfeller, Lyon, France
Neuropsychopharmacology 29:1800-6. 2004..When the fluctuations of the function of NE neurons normally produced by WAY 100,635 were prevented, a tonic activation of 5-HT(1A) autoreceptors by endogenous 5-HT was unmasked...
- Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorderMostafa El Mansari
University of Ottawa Institute of Mental Health Research, Lady Grey Building, 1145 Carling Avenue, Ottawa, ON, Canada K1Z 7K4
Prog Neuropsychopharmacol Biol Psychiatry 30:362-73. 2006....
- Catecholaminergic strategies for the treatment of major depressionPhilippe Tremblay
Institute of Mental Health Research, Lady Grey Building, Suite 2043, Royal Ottawa Hospital, University of Ottawa, Ottawa, Canada
Curr Drug Targets 7:149-58. 2006..Their use in treatment-resistant depressed patients is also addressed...
- How many good antidepressant medications have we missed?Pierre Blier
J Psychiatry Neurosci 29:248-9. 2004
- Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional researchAlan F Schatzberg
Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
J Clin Psychiatry 67:27-30. 2006..This article summarizes recommendations with respect to future research as well as clinical management recommendations for SRI discontinuation syndrome...
- Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic responsePierre Blier
University of Ottawa Institute of Mental Health Research, Ottawa, ON
J Psychiatry Neurosci 29:208-18. 2004..Taken together, these observations strongly suggest that NK1 antagonists could become a new class of antidepressant and anxiolytic agents...
- Media pressure and patient carePierre Blier
J Psychopharmacol 20:469-70. 2006
- Pharmacotherapies in the management of obsessive-compulsive disorderPierre Blier
Mood Disorders Research, University of Ottawa Institute of Mental Health Research, Ontario
Can J Psychiatry 51:417-30. 2006..We present this information to promote better understanding of the research endeavours needed to develop new pharmacotherapeutic approaches...
- Pregnancy, depression, antidepressants and breast-feedingPierre Blier
J Psychiatry Neurosci 31:226-8. 2006
- Psychopharmacology for the clinician. Treating depression with selective norepinephrine reuptake inhibitorsPierre Blier
University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ontario
J Psychiatry Neurosci 31:288. 2006
- Noradrenergic augmentation of escitalopram response by risperidone: electrophysiologic studies in the rat brainEliyahu Dremencov
University of Ottawa Institute of Mental Health Research, Ottawa, Canada
Biol Psychiatry 61:671-8. 2007....
- Do antidepressants really work?Pierre Blier
J Psychiatry Neurosci 33:89-90. 2008