Ethan Bier

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands
    Takatoshi Nakagawa
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    Dev Dyn 233:1315-31. 2005
  2. pmc Dynein and Star interact in EGFR signaling and ligand trafficking
    Stanley J P Iyadurai
    University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, MN 55455, USA
    J Cell Sci 121:2643-51. 2008
  3. pmc dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog
    Kyung Hwa Kang
    Section of Cell and Developmental Biology, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Dev Biol 346:1-10. 2010
  4. doi request reprint EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92095 0349, USA
    Science 348:aaa5838. 2015
  5. doi request reprint Hedgehog: linking uracil to innate defense
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA Electronic address
    Cell Host Microbe 17:146-8. 2015
  6. pmc Deconstructing host-pathogen interactions in Drosophila
    Ethan Bier
    University of California, San Diego, La Jolla, CA 92039, USA
    Dis Model Mech 5:48-61. 2012
  7. pmc Antioxidants put Parkinson flies back in the PINK
    Ethan Bier
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0349, USA
    Proc Natl Acad Sci U S A 103:13269-70. 2006
  8. doi request reprint Intriguing extracellular regulation of BMP signaling
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Dev Cell 15:176-7. 2008
  9. pmc Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
    PLoS Biol 4:e313. 2006
  10. pmc Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein
    Kweon Yu
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, California 92093 0349, USA
    Genetics 166:1323-36. 2004

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands
    Takatoshi Nakagawa
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    Dev Dyn 233:1315-31. 2005
    ..The characterization of this protein extends our understanding of the rhomboid family of regulatory proteins...
  2. pmc Dynein and Star interact in EGFR signaling and ligand trafficking
    Stanley J P Iyadurai
    University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, MN 55455, USA
    J Cell Sci 121:2643-51. 2008
    ..Our direct observations of live S2 cells show that export of Spitz-GFP from the endoplasmic reticulum, as well as the trafficking of Spitz-GFP vesicles, depends on both Star and dynein...
  3. pmc dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog
    Kyung Hwa Kang
    Section of Cell and Developmental Biology, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Dev Biol 346:1-10. 2010
    ..Finally, we find that dHIP14 promotes the activity of Sog in vivo. These studies highlight the growing importance of lipid modification in regulating signaling at the level of ligand production and localization...
  4. doi request reprint EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92095 0349, USA
    Science 348:aaa5838. 2015
    ..In this Review, we summarize the variety of mechanisms that contribute to generating reliable developmental responses to BMP gradients and other morphogen systems. ..
  5. doi request reprint Hedgehog: linking uracil to innate defense
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA Electronic address
    Cell Host Microbe 17:146-8. 2015
    ..In this issue of Cell Host & Microbe, Lee et al. (2015) reveal how pathogen-secreted uracil acts at two steps to induce ROS via the Hedgehog pathway. ..
  6. pmc Deconstructing host-pathogen interactions in Drosophila
    Ethan Bier
    University of California, San Diego, La Jolla, CA 92039, USA
    Dis Model Mech 5:48-61. 2012
    ..Finally, we discuss novel strategies for how flies can be used as a tool to examine how specific isolated virulence factors act on an intact host...
  7. pmc Antioxidants put Parkinson flies back in the PINK
    Ethan Bier
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0349, USA
    Proc Natl Acad Sci U S A 103:13269-70. 2006
  8. doi request reprint Intriguing extracellular regulation of BMP signaling
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Dev Cell 15:176-7. 2008
    ..In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on a fine scale...
  9. pmc Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
    PLoS Biol 4:e313. 2006
    ..We propose that BMPs played an ancestral role in patterning the metazoan neuroectoderm by threshold-dependent repression of neural identity genes...
  10. pmc Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein
    Kweon Yu
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, California 92093 0349, USA
    Genetics 166:1323-36. 2004
    ..Cumulatively, our analysis suggests that CR domains interact physically with adjacent protein sequences to create forms of Sog with distinct BMP modulatory activities...
  11. pmc Formation of the BMP activity gradient in the Drosophila embryo
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Dev Cell 8:915-24. 2005
    ....
  12. pmc Gene length may contribute to graded transcriptional responses in the Drosophila embryo
    Peter McHale
    Center for Theoretical Biological Physics and Physics Department, University of California San Diego, La Jolla, CA 92037, USA
    Dev Biol 360:230-40. 2011
    ..These findings suggest that gene length may contribute to establishing graded responses to morphogen gradients by providing transient prepatterns that are subsequently amplified and stabilized by traditional cis-regulatory interactions...
  13. ncbi request reprint brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila
    Orna Cook
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Development 131:2113-24. 2004
    ..The similar mechanisms responsible for the induction of L5 and L2 development reveal how boundaries set by dosage-sensitive responses to a long-range morphogen specify distinct vein fates at precise locations...
  14. doi request reprint Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Nature 467:854-8. 2010
    ..This coordinated disruption of the Rab11/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection...
  15. pmc Anthrax lethal factor and edema factor act on conserved targets in Drosophila
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093 0349, USA
    Proc Natl Acad Sci U S A 103:3244-9. 2006
    ....
  16. pmc Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
    Jun Hee Lee
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego UCSD, La Jolla, CA 92093 0723, USA
    Science 327:1223-8. 2010
    ....
  17. ncbi request reprint Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila
    Karen Lunde
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Development 130:235-48. 2003
    ..These experiments provide a mechanistic basis for understanding how kni and knrl link AP patterning to morphogenesis of the L2 vein by orchestrating the expression of a selective subset of vein-promoting genes in the L2 primordium...
  18. pmc Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell Host Microbe 14:294-305. 2013
    ..cholerae infection, all of which can be rescued by Rab11 overexpression. These barrier-disrupting effects of CtxA may act in parallel with Cl(-) secretion to drive the pathophysiology of cholera...
  19. pmc Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase
    Lawrence T Reiter
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093, USA
    Hum Mol Genet 15:2825-35. 2006
    ....
  20. ncbi request reprint Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  21. pmc Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila
    Jean Karim Hériché
    Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus Street, San Francisco, CA 94143 0448, USA
    BMC Genet 4:9. 2003
    ..SCF action contributes to cell cycle progression but few of the key targets of its action have been identified...
  22. pmc Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects
    Tamar R Grossman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
    PLoS Genet 7:e1002344. 2011
    ....
  23. pmc New insights into the biological effects of anthrax toxins: linking cellular to organismal responses
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Microbes Infect 14:97-118. 2012
    ..We also summarize the effects of other potential virulence factors secreted by B. anthracis and consider the role of toxic factors in the evolutionarily recent emergence of this devastating disease...
  24. pmc Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila
    Michael F Wangler
    Department of Biology, University of California at San Diego, San Diego, CA 92093, USA
    Protein Cell 2:554-63. 2011
    ....
  25. ncbi request reprint Drosophila, the golden bug, emerges as a tool for human genetics
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92039, USA
    Nat Rev Genet 6:9-23. 2005
    ..The general principles by which D. melanogaster can be used to understand human disease, together with several specific examples, are considered in this review...
  26. ncbi request reprint Accentuate the negative: proteome comparisons using the negative proteome database
    Lawrence T Reiter
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093 0349, USA
    Fly (Austin) 1:164-71. 2007
    ..We anticipate that the NPD and the adaptable algorithm which can readily be used to duplicate this analysis on custom sets of proteomes will be an invaluable tool in the investigation of organism specific protein sets...
  27. pmc Sestrins at the crossroad between stress and aging
    Jun Hee Lee
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego UCSD, La Jolla, CA 92093 0723, USA
    Aging (Albany NY) 2:369-74. 2010
    ..We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints...
  28. ncbi request reprint Drosophila, an emerging model for cardiac disease
    Ethan Bier
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Gene 342:1-11. 2004
    ....
  29. ncbi request reprint Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins
    Lawrence T Reiter
    University of California, San Diego, Section of Cell and Developmental Biology, La Jolla, California 92093 0349, USA
    Expert Opin Ther Targets 6:387-99. 2002
    ....
  30. pmc A screen for dominant mutations applied to components in the Drosophila EGF-R pathway
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Proc Natl Acad Sci U S A 99:3752-7. 2002
    ..The isolation of dominant alleles in several different genes suggests that NOVA mutagenesis should be widely applicable and emerge as an effective tool for generating dominant mutations in genes of unknown function...
  31. pmc Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3
    Jun Hee Lee
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, San Diego, CA 92093, USA
    Cell Metab 16:311-21. 2012
    ..These results demonstrate an important homeostatic function for the stress-inducible Sestrin protein family in the control of mammalian lipid and glucose metabolism...
  32. pmc EvoD/Vo: the origins of BMP signalling in the neuroectoderm
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, 92093 0349, USA
    Nat Rev Genet 9:663-77. 2008
    ....
  33. pmc RAB11-mediated trafficking in host-pathogen interactions
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Microbiol 12:624-34. 2014
    ..In this Review, we discuss the various mechanisms that pathogens have evolved to disrupt or subvert RAB11-dependent pathways as part of their infection strategy...
  34. pmc Booly: a new data integration platform
    Long H Do
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    BMC Bioinformatics 11:513. 2010
    ..Furthermore, Booly features a collaborative sharing system and a public repository so that users can retrieve new datasets while contributors can easily disseminate new content...
  35. pmc Evolution of development: diversified dorsoventral patterning
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093 0349, USA
    Curr Biol 21:R591-4. 2011
    ..Patterning of the dorsoventral axis by graded BMP signaling is conserved in the evolution of animals. However, this system has also proven to be highly adaptable, as is now highlighted by its short-range function in the leech Helobdella...
  36. ncbi request reprint Creation of a Sog morphogen gradient in the Drosophila embryo
    Shaila Srinivasan
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Cell 2:91-101. 2002
    ..In addition, we find that Dynamin-dependent retrieval of Sog acts in parallel with degradation by Tld as a dorsal sink for active Sog...
  37. pmc Homophila: human disease gene cognates in Drosophila
    Samson Chien
    San Diego Supercomputer Center and Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Nucleic Acids Res 30:149-51. 2002
    ..Homophila is a relational database that allows searching based on human disease descriptions, OMIM number, human or fly gene names, and sequence similarity, and can be accessed at http://homophila.sdsc.edu...
  38. pmc BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms
    Francisco F Esteves
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America
    PLoS Genet 10:e1004625. 2014
    ..These findings suggest that the mechanisms by which the BMP gradient patterns the dorsal neuroectoderm have reversed since the divergence of these two ancient lineages. ..
  39. ncbi request reprint Integrins modulate Sog activity in the Drosophila wing
    Helena Araujo
    Departamento de Histologia e Embriologia, Universidade Federal do Rio de Janeiro, 21941 970, Rio de Janeiro, Brazil
    Development 130:3851-64. 2003
    ..We propose that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism...

Research Grants3

  1. Genetic Analysis of Bacterial Toxins in Drosophia
    Ethan Bier; Fiscal Year: 2005
    ..DN alleles 2-2: Characterize molecular lesion in DN-toxin NOVA alleles 2-3: Confirm that DN-toxin alleles interfere with wild-type toxin gene function 2-4: Determine whether DN-toxin alleles function in mammalian cells ..
  2. Analysis of Early Wing Vein Development in Drosophila
    Ethan Bier; Fiscal Year: 2007
    ..Thus, knowledge gained from these studies should have broad applications to understanding vertebrate development as well as offering possible insights into mechanisms of human disease. ..
  3. MOLECULAR GENETICS OF EARLY NEUROGENESIS
    Ethan Bier; Fiscal Year: 2010
    ..These studies may provide the framework for our future studies relevant to human disease and drug abuse. ..