Timothy J Bernard

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies
    Timothy J Bernard
    From the Section of Child Neurology T J B, J A W, R B, Section of Hematology Oncology BMT M J M J, Hemophilia and Thrombosis Center, Department of Pediatrics T J B, M J M J, J A W, A H, Department of Pediatrics T J B, M J M J, J A W, R B, Department of Biostatistics and Informatics, School of Public Health D W, and Department of Neurology S P, University of Colorado, Aurora Division of Child Neurology L A B, Department of Pediatrics L A B, and Department of Neurology L A B, Yale School of Medicine, New Haven, CT University of Washington C A L Department of Pediatrics W L, E S R and Department of Neurology W L, E S R, The Ohio State University and Nationwide Children s Hospital, Columbus Hospital for Sick Children, University of Toronto, Ontario, Canada G d V Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD N A G All Children s Research Institute, Johns Hopkins All Children s Hospital, St Petersburg, University of Muenster
    Stroke 47:2443-9. 2016
  2. pmc Overweight and obesity are increased in childhood-onset cerebrovascular disease
    Virginia Pearson
    School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Child Neurol 28:517-9. 2013
  3. doi request reprint Biomarkers of hypercoagulability and inflammation in childhood-onset arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO 80045 0507, USA
    J Pediatr 156:651-6. 2010
  4. pmc The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, Colorado, USA
    Thromb Res 127:6-12. 2011
  5. pmc Towards a consensus-based classification of childhood arterial ischemic stroke
    Timothy J Bernard
    Sections of Child Neurology and Hemophilia and Thrombosis Center, Department of Pediatrics, School of Public Health, University of Colorado, Aurora, CO, USA
    Stroke 43:371-7. 2012
  6. pmc Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke
    Neil A Goldenberg
    Division of Hematology, Departments of Pediatrics and Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Pediatr 162:1041-6.e1. 2013
  7. pmc Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: findings from the Colorado and German (COAG) collaboration
    Timothy J Bernard
    Pediatric Neurology, B155, The Children s Hospital, Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA
    Stroke 40:2869-71. 2009
  8. doi request reprint Antithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischaemic stroke: a multicentre, observational, cohort study
    Neil A Goldenberg
    Department of Pediatrics, University of Colorado Denver, Children s Hospital, and Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO, USA
    Lancet Neurol 8:1120-7. 2009
  9. doi request reprint Treatment of childhood arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, University of Colorado, The Children s Hospital, Denver, CO 80045, USA
    Ann Neurol 63:679-96. 2008
  10. pmc Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence
    Heather J Fullerton
    From the Departments of Neurology H J F, N K H, C K F, Pediatrics H J F, C K F, and Biostatistics and Epidemiology N K H, University of California San Francisco Department of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada G A d Departments of Pediatrics and Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX M M D Children s Neuroscience Centre, Royal Children s Hospital, Parkville, Victoria, Australia M T M Departments of Pediatrics and Clinical Neurosciences, University of Calgary, Alberta, Canada A K Department of Pediatrics, University of Alberta, Edmonton, Canada J Y Y Department of Pediatrics, University of Colorado, Denver T J B Departments of Pathology E A H and Neurology M S V E, Columbia University College of Physicians and Surgeons, New York, NY Department of Epidemiology, Mailman School of Public Health, New York, NY M S V E and Department of Radiology, Stanford University, Palo Alto, CA M W
    Stroke 47:2221-8. 2016

Collaborators

Detail Information

Publications28

  1. doi request reprint Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies
    Timothy J Bernard
    From the Section of Child Neurology T J B, J A W, R B, Section of Hematology Oncology BMT M J M J, Hemophilia and Thrombosis Center, Department of Pediatrics T J B, M J M J, J A W, A H, Department of Pediatrics T J B, M J M J, J A W, R B, Department of Biostatistics and Informatics, School of Public Health D W, and Department of Neurology S P, University of Colorado, Aurora Division of Child Neurology L A B, Department of Pediatrics L A B, and Department of Neurology L A B, Yale School of Medicine, New Haven, CT University of Washington C A L Department of Pediatrics W L, E S R and Department of Neurology W L, E S R, The Ohio State University and Nationwide Children s Hospital, Columbus Hospital for Sick Children, University of Toronto, Ontario, Canada G d V Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD N A G All Children s Research Institute, Johns Hopkins All Children s Hospital, St Petersburg, University of Muenster
    Stroke 47:2443-9. 2016
    ..Our purpose was to determine the CASCADE criteria's reliability in a population of children with stroke...
  2. pmc Overweight and obesity are increased in childhood-onset cerebrovascular disease
    Virginia Pearson
    School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Child Neurol 28:517-9. 2013
    ..In conclusion, the prevalence of overweight/obese was significantly increased in cerebral sinovenous thrombosis patients as compared to both national and local controls. Results should be evaluated in a larger multi-institutional cohort...
  3. doi request reprint Biomarkers of hypercoagulability and inflammation in childhood-onset arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO 80045 0507, USA
    J Pediatr 156:651-6. 2010
    ....
  4. pmc The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, Colorado, USA
    Thromb Res 127:6-12. 2011
    ..Consensus-based guidelines have been developed, but future research must emphasize identification of additional prognostic factors and the initiation of cooperative randomized controlled clinical trials...
  5. pmc Towards a consensus-based classification of childhood arterial ischemic stroke
    Timothy J Bernard
    Sections of Child Neurology and Hemophilia and Thrombosis Center, Department of Pediatrics, School of Public Health, University of Colorado, Aurora, CO, USA
    Stroke 43:371-7. 2012
    ..In contrast, current classification and nomenclature in childhood AIS are often overlapping or contradictory. Our purpose was to develop a comprehensive consensus-based classification system for childhood AIS...
  6. pmc Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke
    Neil A Goldenberg
    Division of Hematology, Departments of Pediatrics and Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Pediatr 162:1041-6.e1. 2013
    ....
  7. pmc Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: findings from the Colorado and German (COAG) collaboration
    Timothy J Bernard
    Pediatric Neurology, B155, The Children s Hospital, Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA
    Stroke 40:2869-71. 2009
    ..We sought to investigate the safety of extended anticoagulation in childhood arterial ischemic stroke with nonmoyamoya arteriopathy, for which the risk of recurrent stroke is high...
  8. doi request reprint Antithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischaemic stroke: a multicentre, observational, cohort study
    Neil A Goldenberg
    Department of Pediatrics, University of Colorado Denver, Children s Hospital, and Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO, USA
    Lancet Neurol 8:1120-7. 2009
    ..We aimed to describe frequencies and predictors of acute treatments and early outcomes in the International Pediatric Stroke Study (IPSS), a large international series of childhood AIS...
  9. doi request reprint Treatment of childhood arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, University of Colorado, The Children s Hospital, Denver, CO 80045, USA
    Ann Neurol 63:679-96. 2008
    ..Ongoing and future multicenter cohort study efforts, and ultimately devoted pediatric clinical trials, will be essential to establish comprehensive evidence-based guidelines for the treatment of childhood AIS...
  10. pmc Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence
    Heather J Fullerton
    From the Departments of Neurology H J F, N K H, C K F, Pediatrics H J F, C K F, and Biostatistics and Epidemiology N K H, University of California San Francisco Department of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada G A d Departments of Pediatrics and Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX M M D Children s Neuroscience Centre, Royal Children s Hospital, Parkville, Victoria, Australia M T M Departments of Pediatrics and Clinical Neurosciences, University of Calgary, Alberta, Canada A K Department of Pediatrics, University of Alberta, Edmonton, Canada J Y Y Department of Pediatrics, University of Colorado, Denver T J B Departments of Pathology E A H and Neurology M S V E, Columbia University College of Physicians and Surgeons, New York, NY Department of Epidemiology, Mailman School of Public Health, New York, NY M S V E and Department of Radiology, Stanford University, Palo Alto, CA M W
    Stroke 47:2221-8. 2016
    ..We hypothesized that arteriopathy progression is an inflammatory process and that inflammatory biomarkers would predict recurrent AIS...
  11. doi request reprint Preparing for a "Pediatric Stroke Alert"
    Timothy J Bernard
    Hemophilia and Thrombosis Center, University of Colorado School of Medicine, Aurora, Colorado Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado Electronic address
    Pediatr Neurol 56:18-24. 2016
    ....
  12. pmc Childhood arterial ischemic stroke: a review of etiologies, antithrombotic treatments, prognostic factors, and priorities for future research
    Courtney A Lyle
    Division of Hematology Oncology, Department of Pediatrics, University of California, San Diego, California, USA
    Semin Thromb Hemost 37:786-93. 2011
    ..We also identify priorities for future research...
  13. pmc Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children
    Neil A Goldenberg
    All Children s Research Institute, All Children s Hospital Johns Hopkins Medicine, St Petersburg, FL, USA
    Haematologica 98:802-7. 2013
    ..Collaborative studies are warranted to investigate these findings further and, more broadly, to establish key risk factors for incident and recurrent arterial ischemic stroke in children...
  14. pmc The institution-based prospective inception cohort study: design, implementation, and quality assurance in pediatric thrombosis and stroke research
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, University of Colorado, Aurora, USA
    Semin Thromb Hemost 39:10-4. 2013
    ..Following multicenter validation, its findings can inform the design and execution of much-needed randomized controlled clinical trials...
  15. pmc Stroke in children with cardiac disease: report from the International Pediatric Stroke Study Group Symposium
    Adriane J Sinclair
    Division of Neurology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Neurol 52:5-15. 2015
    ..A multidisciplinary panel of clinicians was convened in February 2014 by the International Pediatric Stroke Study group to identify knowledge gaps and prioritize clinical research efforts for children with cardiac disease and stroke...
  16. pmc The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism
    Emily Joachim
    Department of Pediatrics and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children s Hospital Colorado, Aurora, CO, USA Department of Medicine and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children s Hospital Colorado, Aurora, CO, USA
    Thromb Res 132:170-4. 2013
    ..The objectives of this study were to determine the prevalences of elevated tHcy and MTHFR variant in a pediatric population with VTE or arterial ischemic stroke (AIS), and to determine associations with thrombus outcomes...
  17. doi request reprint Pediatric arterial ischemic stroke
    Timothy J Bernard
    Mountain States Regional Hemophilia and Thrombosis Center, P O Box 6507, Mail Stop F 416, Aurora, CO 80045 0507, USA
    Pediatr Clin North Am 55:323-38, viii. 2008
    ..Long-term outcomes of recurrent AIS and neuromotor, speech, cognitive, and behavioral deficits are considered. Emphasis is on evidence underlying current knowledge and key questions for further investigation...
  18. pmc Craniocervical arterial dissection in children: diagnosis and treatment
    Nicholas V Stence
    University of Colorado Hemophilia and Thrombosis Center, P O Box 6507, Aurora, CO, 80045 0507, USA
    Curr Treat Options Neurol 13:636-48. 2011
    ..We also educate our patients with CCAD about the signs and symptoms of recurrence and the importance of emergent evaluation...
  19. doi request reprint Pediatric arterial ischemic stroke
    Timothy J Bernard
    Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
    Hematol Oncol Clin North Am 24:167-80. 2010
    ..Long-term outcomes of recurrent AIS and neuromotor, speech, cognitive, and behavioral deficits are considered. Emphasis is on evidence underlying current knowledge and key questions for further investigation...
  20. doi request reprint Venous thromboembolism in children
    Neil A Goldenberg
    Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
    Hematol Oncol Clin North Am 24:151-66. 2010
    ..Prognostic indicators and long-term outcomes are considered, with emphasis on available evidence underlying current knowledge and key questions for further investigation...
  21. doi request reprint Cavernous Sinus Thrombosis in Children: Imaging Characteristics and Clinical Outcomes
    Craig A Press
    From the Departments of Pediatric Neurology C A P, T J B and Radiology A L, N V S, L Z F, D M M, Children s Hospital Colorado, University of Colorado Denver, Aurora
    Stroke 46:2657-60. 2015
    ..The imaging features of CST and related complications have been reported in adults, but rarely in children...
  22. doi request reprint Proteomic and other mass spectrometry based "omics" biomarker discovery and validation in pediatric venous thromboembolism and arterial ischemic stroke: current state, unmet needs, and future directions
    Neil A Goldenberg
    Clinical and Translational Research Organization, All Children s Research Institute, All Children s Hospital Johns Hopkins Medicine, St Petersburg, FL, USA Johns Hopkins Medicine Pediatric Thrombosis Program, All Children s Hospital Johns Hopkins Medicine, St Petersburg, FL, USA and Johns Hopkins Bloomberg Children s Center, Baltimore, MD, USA Johns Hopkins Medicine Pediatric Stroke Program, All Children s Hospital Johns Hopkins Medicine, St Petersburg, FL, USA and Johns Hopkins Children s Center, Baltimore, MD, USA Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Proteomics Clin Appl 8:828-36. 2014
    ....
  23. pmc Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke?
    Sita Kedia
    Section of Child Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    Headache 52:674-8. 2012
    ..Both sporadic and familial forms of HMs are genetically heterogenous with little information on neuroimaging during and after acute attacks. We report 2 cases of children with presumed HM and late cytotoxic edema...
  24. doi request reprint Neurocognitive outcomes following neonatal encephalopathy
    Jennifer Armstrong-Wells
    Department of Pediatrics, Section of Neurology, University of Colorado Denver, Aurora, CO 80045, USA
    NeuroRehabilitation 26:27-33. 2010
    ....
  25. doi request reprint Venous thromboembolism in children
    Neil A Goldenberg
    Mountain States Regional Hemophilia and Thrombosis Center, P O Box 6507, Mail Stop F 416, Aurora, CO 80045 0507, USA
    Pediatr Clin North Am 55:305-22, vii. 2008
    ..Prognostic indicators and long-term outcomes are considered, with emphasis on available evidence underlying current knowledge and key questions for further investigation...
  26. pmc Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study
    Max Wintermark
    From the Neuroradiology Division, Department of Radiology, Stanford University, CA M W Department of Neurology N K H, K S, H J F, Departments of Biostatistics and Epidemiology N K H, Department of Radiology A J B, and Department of Pediatrics A J B, H J F, University of California at San Francisco Department of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada G A d Departments of Neurology and Epidemiology, Columbia University College of Physicians and Surgeons and Mailman School of Public Health, New York, NY M S V E Department of Neurology, Military General Hospital of Beijing PLA, Beijing, China G Z Department of Radiology, University of Virginia, Charlottesville, VA C L S Department of Neurology, Guangdong No 2 Provincial People s Hospital, Guangzhou, China Q H Departments of Pediatrics and Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas M M D Department of Pediatrics, University of Colorado, Denver T J B Center for Pediatric Neurology, Neurological Institute, Cleveland Clinic, OH N R F and Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Children s Hospital of Philadelphia R N I
    Stroke 45:3597-605. 2014
    ..We studied the role of clinical data and follow-up imaging in diagnosing cerebral and cervical arteriopathy in children with arterial ischemic stroke...
  27. pmc Emergence of the primary pediatric stroke center: impact of the thrombolysis in pediatric stroke trial
    Timothy J Bernard
    From the Department of Neurology, Children s Hospital Colorado, Aurora T J B Departments of Neurology, Psychiatry and Radiology, Boston Children s Hospital, MA M J R Department of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada G d V, Department of Neurology, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, AB, Canada A K Department of Pediatrics, Medical College of Wisconsin, Milwaukee, and BloodCenter of Wisconsin J C G Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada A K C Department of Pediatrics, Dell Children s Medical Center, Austin, TX C A H, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia R N I Department of Neurology, Memorial Hermann Hospital, Houston, TX J C G Division of Pediatric Neurology, Vanderbilt University, Nashville, TN L C J Department of Neurology, Primary Children s Medical Center, Salt Lake City, UT S B Department of Neurology, Cleveland Clinic, OH N R F Department of Pediatrics and Neurology, UT Southwestern Medical Center, Dallas TX M M D Department of Neurology, Stanford University
    Stroke 45:2018-23. 2014
    ..We describe the development of primary pediatric stroke centers through preparation of participating centers in the Thrombolysis in Pediatric Stroke (TIPS) trial...
  28. ncbi request reprint Athletic participation after acute ischemic childhood stroke: a survey of pediatric stroke experts
    Timothy J Bernard
    Department of Pediatrics, Child Neurology Training Program, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    J Child Neurol 22:1050-3. 2007
    ..Many experts would not allow high impact sports after a dissection, but disagree about recommendations after idiopathic acute ischemic stroke...